ERIC R contact PROSSNITZ

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. pmc Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers
    Tapan K Nayak
    Department of Cell Biology and Physiology, School of Medicine, University of New Mexico Health Science Center, Albuquerque, New Mexico 87131, USA
    J Nucl Med 49:978-86. 2008
  2. ncbi request reprint Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases
    Timothy E Graham
    New Mexico Veterans Affairs Health Care System, Albuquerque, New Mexico 87108, USA
    J Biol Chem 277:10876-82. 2002
  3. ncbi request reprint Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins
    Mei Shi
    Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Biochemistry 42:7283-93. 2003
  4. ncbi request reprint N-formyl peptide receptors internalize but do not recycle in the absence of arrestins
    Charlotte M Vines
    Department of Cell Biology and Physiology, The University of New Mexico Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Biol Chem 278:41581-4. 2003
  5. ncbi request reprint Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction
    Peter C Simons
    Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Biol Chem 279:13514-21. 2004
  6. pmc In vivo effects of a GPR30 antagonist
    Megan K Dennis
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    Nat Chem Biol 5:421-7. 2009
  7. pmc Estrogen biology: new insights into GPER function and clinical opportunities
    Eric R Prossnitz
    Department of Cell Biology and Physiology, UNM Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87120, USA Electronic address
    Mol Cell Endocrinol 389:71-83. 2014
  8. pmc GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state
    Geetanjali Sharma
    Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico 87131
    Endocrinology 154:4136-45. 2013
  9. doi request reprint Steroid-binding G-protein-coupled receptors: new drug discovery targets for old ligands
    Eric R Prossnitz
    Department of Cell Biology and Physiology, MSC08 4750 University of New Mexico, Albuquerque, NM 87131, USA
    Expert Opin Drug Discov 1:137-50. 2006
  10. pmc The G-protein-coupled estrogen receptor GPER in health and disease
    Eric R Prossnitz
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Nat Rev Endocrinol 7:715-26. 2011

Research Grants

  1. Development of GPR30-Selective Ligands
    Eric Prossnitz; Fiscal Year: 2009
  2. Arrestin activation probed with mass spectrometry
    Eric Prossnitz; Fiscal Year: 2007
  3. A novel intracellular 7TM estrogen receptor in breast
    Eric Prossnitz; Fiscal Year: 2007
  4. The Role of GPR30 in Advanced Endometrial Cancer
    Eric Prossnitz; Fiscal Year: 2007
  5. A novel intracellular 7TM estrogen receptor in breast
    Eric Prossnitz; Fiscal Year: 2009
  6. The Role of GPR30 in Advanced Endometrial Cancer
    Eric Prossnitz; Fiscal Year: 2009
  7. A novel intracellular 7TM estrogen receptor in breast
    Eric R Prossnitz; Fiscal Year: 2010
  8. Development of GPR30-Selective Ligands
    ERIC R contact PROSSNITZ; Fiscal Year: 2010
  9. Development of GPR30-Selective Ligands
    Eric Prossnitz; Fiscal Year: 2009
  10. A novel intracellular 7TM estrogen receptor in breast
    Eric Prossnitz; Fiscal Year: 2006

Collaborators

Detail Information

Publications73

  1. pmc Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers
    Tapan K Nayak
    Department of Cell Biology and Physiology, School of Medicine, University of New Mexico Health Science Center, Albuquerque, New Mexico 87131, USA
    J Nucl Med 49:978-86. 2008
    ..In this study, we describe a new structural class of neutral tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivatives for potential use in breast and endometrial cancer imaging...
  2. ncbi request reprint Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases
    Timothy E Graham
    New Mexico Veterans Affairs Health Care System, Albuquerque, New Mexico 87108, USA
    J Biol Chem 277:10876-82. 2002
    ....
  3. ncbi request reprint Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins
    Mei Shi
    Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Biochemistry 42:7283-93. 2003
    ..Together, these results indicate that complex interactions exist between GPCRs, in their unphosphorylated and phosphorylated states, G proteins, and arrestins, which result in the highly regulated control of GPCR function...
  4. ncbi request reprint N-formyl peptide receptors internalize but do not recycle in the absence of arrestins
    Charlotte M Vines
    Department of Cell Biology and Physiology, The University of New Mexico Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Biol Chem 278:41581-4. 2003
    ..Our results suggest a novel role for arrestins in the post-endocytic trafficking of GPCRs...
  5. ncbi request reprint Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction
    Peter C Simons
    Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Biol Chem 279:13514-21. 2004
    ..The assemblies can be further generalized to other G protein coupled receptor protein-protein interactions...
  6. pmc In vivo effects of a GPR30 antagonist
    Megan K Dennis
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    Nat Chem Biol 5:421-7. 2009
    ..The identification of this antagonist will accelerate the evaluation of the roles of GPR30 in human physiology...
  7. pmc Estrogen biology: new insights into GPER function and clinical opportunities
    Eric R Prossnitz
    Department of Cell Biology and Physiology, UNM Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87120, USA Electronic address
    Mol Cell Endocrinol 389:71-83. 2014
    ..We will also highlight novel opportunities for clinical development towards GPER-targeted therapeutics, for molecular imaging, as well as for theranostic approaches and personalized medicine. ..
  8. pmc GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state
    Geetanjali Sharma
    Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico 87131
    Endocrinology 154:4136-45. 2013
    ..In conclusion, our study demonstrates for the first time that in male mice, GPER regulates metabolic parameters associated with obesity and diabetes. ..
  9. doi request reprint Steroid-binding G-protein-coupled receptors: new drug discovery targets for old ligands
    Eric R Prossnitz
    Department of Cell Biology and Physiology, MSC08 4750 University of New Mexico, Albuquerque, NM 87131, USA
    Expert Opin Drug Discov 1:137-50. 2006
    ..Finally, comments are made on the future directions regarding GPCRs, steroids and drug discovery...
  10. pmc The G-protein-coupled estrogen receptor GPER in health and disease
    Eric R Prossnitz
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Nat Rev Endocrinol 7:715-26. 2011
    ....
  11. ncbi request reprint Multiple activation steps of the N-formyl peptide receptor
    E R Prossnitz
    Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque 87131, USA
    Biochemistry 38:2240-7. 1999
    ..Models of receptor activation based on the observed results are discussed...
  12. ncbi request reprint Novel roles for arrestins in the post-endocytic trafficking of G protein-coupled receptors
    Eric R Prossnitz
    Department of Cell Biology and Physiology and UNM Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Life Sci 75:893-9. 2004
    ..This review will summarize recent advances in our understanding of the roles of arrestins in post-endocytic GPCR trafficking...
  13. pmc The ins and outs of GPR30: a transmembrane estrogen receptor
    Eric R Prossnitz
    Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131, USA
    J Steroid Biochem Mol Biol 109:350-3. 2008
    ..In this review, we will describe recent work to further our understanding of the role of GPR30 in estrogen biology...
  14. doi request reprint Estrogen signaling through the transmembrane G protein-coupled receptor GPR30
    Eric R Prossnitz
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Annu Rev Physiol 70:165-90. 2008
    ..In this review, we provide an overview of the evidence for the cellular and physiological actions of GPR30 in estrogen-dependent processes and discuss the relationship of GPR30 with classical estrogen receptors...
  15. ncbi request reprint Modulation of GPCR conformations by ligands, G-proteins, and arrestins
    E R Prossnitz
    Department of Cell Biology and Physiology, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque NM 87131, USA
    Ernst Schering Found Symp Proc . 2006
    ..Here we summarize results of these studies as they pertain to the regulation of GPCR conformations and affinities for interacting species...
  16. doi request reprint GPR30: a novel therapeutic target in estrogen-related disease
    Eric R Prossnitz
    Department of Cell Biology and Physiology and Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Trends Pharmacol Sci 29:116-23. 2008
    ....
  17. pmc Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER
    Eric R Prossnitz
    Department of Cell Biology and Physiology and UNM Cancer Center, University of New Mexico, Albuquerque, NM 87131, USA
    Prostaglandins Other Lipid Mediat 89:89-97. 2009
    ....
  18. pmc Mechanisms of estrogen signaling and gene expression via GPR30
    Eric R Prossnitz
    Department of Cell Biology and Physiology and Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Cell Endocrinol 308:32-8. 2009
    ..In this review, we will provide an overview of GPR30 function, focusing on the rapid signaling events that culminate in the transcriptional activation of certain genes...
  19. pmc GPR30: A G protein-coupled receptor for estrogen
    Eric R Prossnitz
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States
    Mol Cell Endocrinol 265:138-42. 2007
    ..This article will summarize recent literature and address the relationship between GPR30 and conventional estrogen receptor signaling...
  20. pmc Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction
    Matthias R Meyer
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Hypertension 59:507-12. 2012
    ..These findings may be important for understanding and treating diseases associated with increased endothelial vasoconstrictor prostanoid activity such as hypertension and obesity...
  21. ncbi request reprint Chemokines and chemokine receptors--Keystone Symposium 7-12 January 2003, Breckenridge, CO, USA
    Eric R Prossnitz
    University of New Mexico, Albuquerque, NM 87131, USA
    IDrugs 6:191-4. 2003
  22. pmc Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides
    Yang Wu
    Department of Pathology and Cancer Research Facility, University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM 87131, USA
    Anal Biochem 371:10-20. 2007
    ..These results are compatible with a cell activation model involving G protein conformational changes rather than disassembly of Galphabetagamma heterotrimer...
  23. ncbi request reprint Alpha4beta1 integrin affinity changes govern cell adhesion
    Alexandre Chigaev
    Department of Pathology and Cancer Center, University of New Mexico HSC, Albuquerque, New Mexico 87131, USA
    J Biol Chem 278:38174-82. 2003
    ..Taken together, these data are consistent with the idea that affinity regulation is a major factor that governs the avidity of cell adhesion mediated by the alpha4 integrin...
  24. pmc Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents
    Tapan K Nayak
    Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, New Mexico 87131, USA
    ACS Chem Biol 5:681-90. 2010
    ....
  25. ncbi request reprint A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    Chetana M Revankar
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Science 307:1625-30. 2005
    ..Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology...
  26. ncbi request reprint Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins
    T Alexander Key
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Traffic 6:87-99. 2005
    ....
  27. ncbi request reprint N-formyl peptide receptors cluster in an active raft-associated state prior to phosphorylation
    Mei Xue
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA
    J Biol Chem 279:45175-84. 2004
    ..Our results demonstrate for the first time that formation of a clustered activated receptor state precedes receptor phosphorylation, arrestin binding, and internalization...
  28. pmc GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancer
    Hugo Arias-Pulido
    Translational Therapeutics Laboratory, The University of New Mexico Cancer Center, Albuquerque, NM, USA
    Breast Cancer Res Treat 123:51-8. 2010
    ..These findings suggest potential new therapeutic targets for IBC such as novel endocrine agents or direct modulation of GPR30...
  29. doi request reprint High-content screening: flow cytometry analysis
    Bruce S Edwards
    Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM, USA
    Methods Mol Biol 486:151-65. 2009
    ....
  30. pmc Adaptor protein-2 interaction with arrestin regulates GPCR recycling and apoptosis
    Brant M Wagener
    Department of Cell Biology and Physiology and UNM Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Traffic 10:1286-300. 2009
    ....
  31. pmc Estrogen and progesterone receptor status and outcome in epithelial ovarian cancers and low malignant potential tumors
    Hugo Arias-Pulido
    Translational Therapeutics Laboratory, The University of New Mexico Cancer Center, Albuquerque, NM 87131 5636, USA
    Gynecol Oncol 114:480-5. 2009
    ..This study was conducted to determine if ER and PR expression patterns are predictive of outcome in patients with epithelial ovarian cancer (EOC) or ovarian low malignant potential (LMP) tumors...
  32. ncbi request reprint Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform
    Bruce S Edwards
    Cytometry, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Nat Protoc 1:59-66. 2006
    ....
  33. ncbi request reprint GPR30: a novel indicator of poor survival for endometrial carcinoma
    Harriet O Smith
    Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    Am J Obstet Gynecol 196:386.e1-9; discussion 386.e9-11. 2007
    ..This study was undertaken to evaluate the relationship between GPR30, classical steroidal receptor expression, and clinical outcome in patients with endometrial carcinoma...
  34. pmc Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system
    Mark K Haynes
    University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico 87131, USA
    J Biomol Screen 14:596-609. 2009
    ..The most potent agents exhibited submicromolar efficacy in LNCaP and PC3 cells...
  35. ncbi request reprint Virtual and biomolecular screening converge on a selective agonist for GPR30
    Cristian G Bologa
    Division of Biocomputing, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Nat Chem Biol 2:207-12. 2006
    ..The development of compounds specific to estrogen receptor family members provides the opportunity to increase our understanding of these receptors and their contribution to estrogen biology...
  36. ncbi request reprint Flow cytometric analysis of ligand-receptor interactions and molecular assemblies
    Larry A Sklar
    Cancer Center and Departments of Pathology and Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131, USA
    Annu Rev Biophys Biomol Struct 31:97-119. 2002
    ..Temperature dependence can be evaluated with Peltier temperature control. Many assembly endpoints can be assessed through new tools for high-throughput flow cytometry using plate-based assay formats and small volume samples...
  37. ncbi request reprint Post-high-throughput screening analysis: an empirical compound prioritization scheme
    Tudor I Oprea
    Division of Biocomputing and Cancer Research and Treatment Center, University of New Mexico, Albuquerque 87131, USA
    J Biomol Screen 10:419-26. 2005
    ..The decision-making process is discussed for a set of G-protein coupled receptor antagonists and validated on a literature example for dihydrofolate reductase inhibition...
  38. pmc A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand
    J Jacob Strouse
    Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
    Cytometry A 75:264-70. 2009
    ..The differential affinities of known peptide ligands were observed with the use of this fluorescent probe in high throughput screening flow cytometry...
  39. ncbi request reprint Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30
    Chetana M Revankar
    Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    ACS Chem Biol 2:536-44. 2007
    ..To our knowledge, this is the first definitive demonstration of a functional intracellular transmembrane estrogen receptor...
  40. pmc A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system
    Megan K Dennis
    Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Cytometry A 73:390-9. 2008
    ....
  41. pmc FRET detection of cellular alpha4-integrin conformational activation
    Alexandre Chigaev
    Department of Pathology and Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Biophys J 85:3951-62. 2003
    ..The coordination between the extension of alpha4-integrin and its affinity provides a mechanism for Dembo's catch-bond concept...
  42. pmc Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes
    Susan M Young
    University of New Mexico, Albuquerque, 87131, USA
    Cytometry A 75:253-63. 2009
    ..The duplex assay format reduced assay time, minimized reagent requirements, and provided selectivity information at every screening stage, thus proving to be an efficient means to screen for selective receptor ligand probes...
  43. ncbi request reprint Techniques: GPCR assembly, pharmacology and screening by flow cytometry
    Anna Waller
    Department of Pathology and Cancer Center, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA
    Trends Pharmacol Sci 25:663-9. 2004
    ..These analyses can produce quantitative pharmacological data analogous to radioligand assays, and, in some cases, the probes can be integrated into the assembly as fluorescent fusion proteins...
  44. ncbi request reprint High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands
    Susan M Young
    Cytometry and Department of Pathology, Cancer Research and Treatment Center, University of New Mexico, Health Sciences Center, Albuquerque, NM 87131, USA
    J Biomol Screen 10:374-82. 2005
    ..The HyperCyt system was therefore demonstrated to be a robust, sensitive, and highly quantitative method with which to screen lead compound libraries in a 96-well format...
  45. ncbi request reprint Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation
    Alexandre Chigaev
    Department of Pathology and The Cancer Center, University of New Mexico Health Sciences Center, Albequerque, 87131, USA
    J Biol Chem 279:32435-43. 2004
    ..Based on this result and differences in the kinetics of integrin activation, we conclude that conformational activation of VLA-4 by inside-out signaling is independent of and additive to reduction-regulated integrin activation...
  46. ncbi request reprint Flow cytometry for high-throughput, high-content screening
    Bruce S Edwards
    Department of Cell Biology and Physiology, University of New Mexico Cancer Research and Treatment Center, Albuquerque, New Mexico 87131, USA
    Curr Opin Chem Biol 8:392-8. 2004
    ..These new developments, and its broad usage, position flow cytometry as an attractive analysis platform for high-throughput, high-content biological testing and drug discovery...
  47. ncbi request reprint Arrestins block G protein-coupled receptor-mediated apoptosis
    Chetana M Revankar
    Department of Cell Biology and Physiology and University of New Mexico Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Biol Chem 279:24578-84. 2004
    ....
  48. ncbi request reprint Regulation of N-formyl peptide-mediated degranulation by receptor phosphorylation
    Charlotte M Vines
    Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA
    J Immunol 169:6760-6. 2002
    ..Degranulation by this mutant FPR was indistinguishable from that of the DeltaST mutant, indicating that FPR phosphorylation or binding of arrestin but not internalization terminates the degranulation response...
  49. ncbi request reprint Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH
    Mathewos Tessema
    Department of Pathology, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Cytometry A 69:326-34. 2006
    ..Many protein-protein interactions have been established by using GST fusion proteins and measuring binding of fusion protein binding partners by GST pulldown assays, usually monitored by Western blot methodology...
  50. ncbi request reprint Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists
    Bruce S Edwards
    Department of Cytometry, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Mol Pharmacol 68:1301-10. 2005
    ..This virtual screening approach improved the physical screening hit rate by 12-fold (versus 0.1% hit-rate in a random compound collection), providing an efficient process for identifying small molecule antagonists...
  51. pmc Activated N-formyl peptide receptor and high-affinity IgE receptor occupy common domains for signaling and internalization
    Mei Xue
    Department of Pathology and Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Biol Cell 18:1410-20. 2007
    ..The observation of receptors in lightly coated membrane invaginations suggests that, despite the lack of caveolin, hematopoietic cells harbor caveolae-like structures that are candidates for nonclathrin-mediated endocytosis...
  52. ncbi request reprint Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads
    Tione Buranda
    Department of Pathology and Cancer Center, University of New Mexico Health Science Center, Albuquerque, New Mexico 87131, USA
    Adv Protein Chem 74:95-135. 2007
    ..The data and concepts are discussed in the context of a review of current literature on signaling mechanism based on structural and spectroscopic (FRET) studies of ternary complex components...
  53. ncbi request reprint Enhancement of somatostatin-receptor-targeted (177)Lu-[DOTA(0)-Tyr(3)]-octreotide therapy by gemcitabine pretreatment-mediated receptor uptake, up-regulation and cell cycle modulation
    Tapan K Nayak
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Nucl Med Biol 35:673-8. 2008
    ..This study evaluates the potential for combination therapy with gemcitabine in an effort to improve clinical outcomes...
  54. ncbi request reprint N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity
    T Alexander Key
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA
    J Biol Chem 278:4041-7. 2003
    ..Furthermore, this is the first demonstration that agonist affinity of a GPCR and the affinity of arrestin binding to the phosphorylated receptor are regulated by distinct receptor phosphodomains...
  55. ncbi request reprint Regulation of N-formyl peptide receptor signaling and trafficking by individual carboxyl-terminal serine and threonine residues
    Ross M Potter
    Department of Cell Biology and Physiology, University of New Mexico Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Immunol 176:5418-25. 2006
    ..This study is among the first detailed analyses of a complex regulatory site in a GPCR, and provides insight into GPCR regulatory mechanisms...
  56. ncbi request reprint Arrestin variants display differential binding characteristics for the phosphorylated N-formyl peptide receptor carboxyl terminus
    Ross M Potter
    Department of Cell Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Biol Chem 277:8970-8. 2002
    ..The results suggest that the carboxyl terminus of arrestin is a critical determinant in regulating the binding affinity of arrestin for the phosphorylated domains of GPCRs...
  57. ncbi request reprint Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry
    Jennifer M Carter
    Department of Chemistry, University of New Mexico, Albuquerque, NM 87131, USA
    J Mol Biol 351:865-78. 2005
    ....
  58. pmc Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells
    Geetanjali Sharma
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Endocrinology 152:3030-9. 2011
    ..The results of this study suggest that the activation of downstream signaling pathways by the GPER-selective ligand G-1 could represent a novel therapeutic strategy in the treatment of diabetes...
  59. ncbi request reprint Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cells
    Tapan K Nayak
    Radiopharmaceutical Sciences Program, College of Pharmacy, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Nucl Med Biol 34:185-93. 2007
    ....
  60. ncbi request reprint High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening
    Susan M Young
    Cytometry, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, USA
    J Biomol Screen 9:103-11. 2004
    ..With single-cell readout systems for protein expression libraries, this technology offers the promise of screening millions of discrete compound interactions per day...
  61. pmc Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide
    Haixun Guo
    College of Pharmacy, Cancer Research Treatment Center, Department of Cell Biology and Physiology, Department of Pathology, Department of Dermatology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Bioconjug Chem 20:2162-8. 2009
    ....
  62. ncbi request reprint Mechanisms of G protein-coupled receptor-mediated degranulation
    Charlotte M Vines
    Department of Cell Biology and Physiology, The University of New Mexico Cancer Research and Treatment Center, University of New Mexico, 915 Camino de Salud, Albuquerque 87131, USA
    FEMS Microbiol Lett 236:1-6. 2004
    ..This review summarizes the current understanding of the mechanisms involved in the regulation of degranulation through GPCRs...
  63. pmc The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation
    Jian Teng
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Endocrinology 149:4024-34. 2008
    ..These results suggest that GPR30-mediated inhibition of urothelial cell proliferation is the result of decreased cyclin D1 by down-regulation of activation protein-1 signaling...
  64. ncbi request reprint G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils
    Ayako Makino
    Dept of Bioengineering, The Whitaker Institute of Biomedical Engineering, Univ of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Am J Physiol Cell Physiol 290:C1633-9. 2006
    ..These results suggest that GPCRs serve as mechanosensors for fluid shear stress in neutrophils by decreasing its constitutive activity and reducing pseudopod projection...
  65. pmc G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary
    Cheng Wang
    Department of Obstetrics Gynecology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4515, USA
    Endocrinology 149:4452-61. 2008
    ..These results suggest that a membrane estrogen receptor, GPR30, is expressed in the ovary during perinatal development and mediates E2 action on primordial follicle formation...
  66. ncbi request reprint Expression of G protein-coupled receptor-30, a G protein-coupled membrane estrogen receptor, in oxytocin neurons of the rat paraventricular and supraoptic nuclei
    Hirotaka Sakamoto
    Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Endocrinology 148:5842-50. 2007
    ..In addition, the expression of GPR30 is also detected in the neurohypophysis. These results suggest that GPR30 may serve primarily as a nongenomic transducer of estrogen actions in the hypothalamo-neurohypophyseal system...
  67. pmc Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates
    Chinnasamy Ramesh
    Department of Chemistry and Biochemistry MSC 3C, New Mexico State University, P O Box 30001, Las Cruces, New Mexico 88003, USA
    J Am Chem Soc 128:14476-7. 2006
    ..These results suggest that in vitro assays will facilitate the development of targeted imaging agents for intracellular receptors and the feasibility of targeting GPR30 and ERalpha/beta for diagnostic tumor imaging...
  68. doi request reprint Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation
    Kenichi Matsuda
    Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto, Japan
    Neurosci Lett 441:94-9. 2008
    ..Expression levels were not different among male, female in proestrus and female in estrus at the adult stage, but were higher in newborn male than newborn female...
  69. ncbi request reprint Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor
    Bent Postma
    Eijkman Winkler Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Immunol 172:6994-7001. 2004
    ..This selectivity and high-affinity binding with potent antagonistic effects makes CHIPS a promising lead for the development of new anti-inflammatory compounds for diseases in which damage by neutrophils plays a key role...
  70. ncbi request reprint G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells
    Lidia Albanito
    Departments of Pharmaco Biology and Cell Biology, University of Calabria, 87030 Rende Cosenza, Italy
    Cancer Res 67:1859-66. 2007
    ....
  71. ncbi request reprint Expression of G protein-coupled receptor 30 in the hamster ovary: differential regulation by gonadotropins and steroid hormones
    Cheng Wang
    Department of Obstetrics and Gynecology, University of Nebraska Medical Center, 984515 Nebraska Medical Center, Omaha, NE 68198 4515, USA
    Endocrinology 148:4853-64. 2007
    ..The unique pattern of GPR30 expression suggests that gonadotropin-regulated follicular cell functions may involve GPR30 activity...
  72. ncbi request reprint Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system
    Eugen Brailoiu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Endocrinol 193:311-21. 2007
    ....

Research Grants28

  1. Development of GPR30-Selective Ligands
    Eric Prossnitz; Fiscal Year: 2009
    ..The goal of this work is to develop novel compounds that can specifically target this new receptor to either activate or inhibit its activity without affecting other estrogen receptors. ..
  2. Arrestin activation probed with mass spectrometry
    Eric Prossnitz; Fiscal Year: 2007
    ..Our results will contribute to our basic knowledge of this key signaling molecule and provide the basis for the design of therapeutic agents related to GPCR signaling. ..
  3. A novel intracellular 7TM estrogen receptor in breast
    Eric Prossnitz; Fiscal Year: 2007
    ....
  4. The Role of GPR30 in Advanced Endometrial Cancer
    Eric Prossnitz; Fiscal Year: 2007
    ....
  5. A novel intracellular 7TM estrogen receptor in breast
    Eric Prossnitz; Fiscal Year: 2009
    ..abstract_text> ..
  6. The Role of GPR30 in Advanced Endometrial Cancer
    Eric Prossnitz; Fiscal Year: 2009
    ..abstract_text> ..
  7. A novel intracellular 7TM estrogen receptor in breast
    Eric R Prossnitz; Fiscal Year: 2010
    ..abstract_text> ..
  8. Development of GPR30-Selective Ligands
    ERIC R contact PROSSNITZ; Fiscal Year: 2010
    ..The goal of this work is to develop novel compounds that can specifically target this new receptor to either activate or inhibit its activity without affecting other estrogen receptors. ..
  9. Development of GPR30-Selective Ligands
    Eric Prossnitz; Fiscal Year: 2009
    ..The goal of this work is to develop novel compounds that can specifically target this new receptor to either activate or inhibit its activity without affecting other estrogen receptors. ..
  10. A novel intracellular 7TM estrogen receptor in breast
    Eric Prossnitz; Fiscal Year: 2006
    ....
  11. Arrestin activation probed with mass spectrometry
    Eric Prossnitz; Fiscal Year: 2006
    ..Our results will contribute to our basic knowledge of this key signaling molecule and provide the basis for the design of therapeutic agents related to GPCR signaling. ..
  12. MECHANISMS OF LEUKOCYTE ACTIVATION AND CHEMOTAXIS
    Eric Prossnitz; Fiscal Year: 1999
    ....
  13. MECHANISMS OF LEUKOCYTE ACTIVATION AND CHEMOTAXIS
    Eric Prossnitz; Fiscal Year: 2000
    ....
  14. MECHANISMS OF LEUKOCYTE ACTIVATION AND CHEMOTAXIS
    Eric Prossnitz; Fiscal Year: 2001
    ....
  15. MECHANISMS OF LEUKOCYTE ACTIVATION AND CHEMOTAXIS
    Eric Prossnitz; Fiscal Year: 2001
    ....
  16. MECHANISMS OF LEUKOCYTE ACTIVATION AND CHEMOTAXIS
    Eric Prossnitz; Fiscal Year: 2002
    ....
  17. Arrestin activation probed with mass spectrometry
    Eric Prossnitz; Fiscal Year: 2004
    ..Our results will contribute to our basic knowledge of this key signaling molecule and provide the basis for the design of therapeutic agents related to GPCR signaling. ..
  18. Arrestin activation probed with mass spectrometry
    Eric Prossnitz; Fiscal Year: 2005
    ..Our results will contribute to our basic knowledge of this key signaling molecule and provide the basis for the design of therapeutic agents related to GPCR signaling. ..
  19. Development of GPR30-Selective Ligands
    ERIC R contact PROSSNITZ; Fiscal Year: 2010
    ..abstract_text> ..