Research Topics
| ERIC R contact PROSSNITZSummaryAffiliation: University of New Mexico Country: USA Publications
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Publications
Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinasesTimothy E Graham
New Mexico Veterans Affairs Health Care System, Albuquerque, New Mexico 87108, USA
J Biol Chem 277:10876-82. 2002....- Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestinsMei Shi
Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Biochemistry 42:7283-93. 2003..Together, these results indicate that complex interactions exist between GPCRs, in their unphosphorylated and phosphorylated states, G proteins, and arrestins, which result in the highly regulated control of GPCR function... - N-formyl peptide receptors internalize but do not recycle in the absence of arrestinsCharlotte M Vines
Department of Cell Biology and Physiology, The University of New Mexico Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
J Biol Chem 278:41581-4. 2003..Our results suggest a novel role for arrestins in the post-endocytic trafficking of GPCRs... - Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transductionPeter C Simons
Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
J Biol Chem 279:13514-21. 2004..The assemblies can be further generalized to other G protein coupled receptor protein-protein interactions... - High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligandsSusan M Young
Cytometry and Department of Pathology, Cancer Research and Treatment Center, University of New Mexico, Health Sciences Center, Albuquerque, NM 87131, USA
J Biomol Screen 10:374-82. 2005..The HyperCyt system was therefore demonstrated to be a robust, sensitive, and highly quantitative method with which to screen lead compound libraries in a 96-well format... 
Steroid-binding G-protein-coupled receptors: new drug discovery targets for old ligandsEric R Prossnitz
Department of Cell Biology and Physiology, MSC08 4750 University of New Mexico, Albuquerque, NM 87131, USA
Expert Opin Drug Discov 1:137-50. 2006..Finally, comments are made on the future directions regarding GPCRs, steroids and drug discovery...
The G-protein-coupled estrogen receptor GPER in health and diseaseEric R Prossnitz
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Nat Rev Endocrinol 7:715-26. 2011....- Multiple activation steps of the N-formyl peptide receptorE R Prossnitz
Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque 87131, USA
Biochemistry 38:2240-7. 1999..Models of receptor activation based on the observed results are discussed... - GPR30: A G protein-coupled receptor for estrogenEric R Prossnitz
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States
Mol Cell Endocrinol 265:138-42. 2007..This article will summarize recent literature and address the relationship between GPR30 and conventional estrogen receptor signaling... - Modulation of GPCR conformations by ligands, G-proteins, and arrestinsE R Prossnitz
Department of Cell Biology and Physiology, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque NM 87131, USA
Ernst Schering Found Symp Proc 2:211-28. 2006..Here we summarize results of these studies as they pertain to the regulation of GPCR conformations and affinities for interacting species... - GPR30: a novel therapeutic target in estrogen-related diseaseEric R Prossnitz
Department of Cell Biology and Physiology and Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Trends Pharmacol Sci 29:116-23. 2008.... - Estrogen signaling through the transmembrane G protein-coupled receptor GPR30Eric R Prossnitz
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Annu Rev Physiol 70:165-90. 2008..In this review, we provide an overview of the evidence for the cellular and physiological actions of GPR30 in estrogen-dependent processes and discuss the relationship of GPR30 with classical estrogen receptors... - The ins and outs of GPR30: a transmembrane estrogen receptorEric R Prossnitz
Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131, USA
J Steroid Biochem Mol Biol 109:350-3. 2008..In this review, we will describe recent work to further our understanding of the role of GPR30 in estrogen biology... - Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPEREric R Prossnitz
Department of Cell Biology and Physiology and UNM Cancer Center, University of New Mexico, Albuquerque, NM 87131, USA
Prostaglandins Other Lipid Mediat 89:89-97. 2009.... - Mechanisms of estrogen signaling and gene expression via GPR30Eric R Prossnitz
Department of Cell Biology and Physiology and Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM 87131, USA
Mol Cell Endocrinol 308:32-8. 2009..In this review, we will provide an overview of GPR30 function, focusing on the rapid signaling events that culminate in the transcriptional activation of certain genes... - Novel roles for arrestins in the post-endocytic trafficking of G protein-coupled receptorsEric R Prossnitz
Department of Cell Biology and Physiology and UNM Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Life Sci 75:893-9. 2004..This review will summarize recent advances in our understanding of the roles of arrestins in post-endocytic GPCR trafficking... - Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstrictionMatthias R Meyer
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Hypertension 59:507-12. 2012..These findings may be important for understanding and treating diseases associated with increased endothelial vasoconstrictor prostanoid activity such as hypertension and obesity... - Chemokines and chemokine receptors--Keystone Symposium 7-12 January 2003, Breckenridge, CO, USAEric R Prossnitz
University of New Mexico, Albuquerque, NM 87131, USA
IDrugs 6:191-4. 2003 - Alpha4beta1 integrin affinity changes govern cell adhesionAlexandre Chigaev
Department of Pathology and Cancer Center, University of New Mexico HSC, Albuquerque, New Mexico 87131, USA
J Biol Chem 278:38174-82. 2003..Taken together, these data are consistent with the idea that affinity regulation is a major factor that governs the avidity of cell adhesion mediated by the alpha4 integrin... - Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotidesYang Wu
Department of Pathology and Cancer Research Facility, University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM 87131, USA
Anal Biochem 371:10-20. 2007..These results are compatible with a cell activation model involving G protein conformational changes rather than disassembly of Galphabetagamma heterotrimer... - A transmembrane intracellular estrogen receptor mediates rapid cell signalingChetana M Revankar
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Science 307:1625-30. 2005..Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology... - Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestinsT Alexander Key
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Traffic 6:87-99. 2005.... - Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agentsTapan K Nayak
Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, New Mexico 87131, USA
ACS Chem Biol 5:681-90. 2010.... - N-formyl peptide receptors cluster in an active raft-associated state prior to phosphorylationMei Xue
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA
J Biol Chem 279:45175-84. 2004..Our results demonstrate for the first time that formation of a clustered activated receptor state precedes receptor phosphorylation, arrestin binding, and internalization... - GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancerHugo Arias-Pulido
Translational Therapeutics Laboratory, The University of New Mexico Cancer Center, Albuquerque, NM, USA
Breast Cancer Res Treat 123:51-8. 2010..These findings suggest potential new therapeutic targets for IBC such as novel endocrine agents or direct modulation of GPR30... - Adaptor protein-2 interaction with arrestin regulates GPCR recycling and apoptosisBrant M Wagener
Department of Cell Biology and Physiology and UNM Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Traffic 10:1286-300. 2009.... - Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry systemMark K Haynes
University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico 87131, USA
J Biomol Screen 14:596-609. 2009..The most potent agents exhibited submicromolar efficacy in LNCaP and PC3 cells... - Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancersTapan K Nayak
Department of Cell Biology and Physiology, School of Medicine, University of New Mexico Health Science Center, Albuquerque, New Mexico 87131, USA
J Nucl Med 49:978-86. 2008..In this study, we describe a new structural class of neutral tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivatives for potential use in breast and endometrial cancer imaging... - Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platformBruce S Edwards
Cytometry, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Nat Protoc 1:59-66. 2006.... - GPR30: a novel indicator of poor survival for endometrial carcinomaHarriet O Smith
Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Am J Obstet Gynecol 196:386.e1-9; discussion 386.e9-11. 2007..This study was undertaken to evaluate the relationship between GPR30, classical steroidal receptor expression, and clinical outcome in patients with endometrial carcinoma... - Estrogen and progesterone receptor status and outcome in epithelial ovarian cancers and low malignant potential tumorsHugo Arias-Pulido
Translational Therapeutics Laboratory, The University of New Mexico Cancer Center, Albuquerque, NM 87131 5636, USA
Gynecol Oncol 114:480-5. 2009..This study was conducted to determine if ER and PR expression patterns are predictive of outcome in patients with epithelial ovarian cancer (EOC) or ovarian low malignant potential (LMP) tumors... - High-content screening: flow cytometry analysisBruce S Edwards
Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM, USA
Methods Mol Biol 486:151-65. 2009.... - Virtual and biomolecular screening converge on a selective agonist for GPR30Cristian G Bologa
Division of Biocomputing, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Nat Chem Biol 2:207-12. 2006..The development of compounds specific to estrogen receptor family members provides the opportunity to increase our understanding of these receptors and their contribution to estrogen biology... - Flow cytometric analysis of ligand-receptor interactions and molecular assembliesLarry A Sklar
Cancer Center and Departments of Pathology and Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131, USA
Annu Rev Biophys Biomol Struct 31:97-119. 2002..Temperature dependence can be evaluated with Peltier temperature control. Many assembly endpoints can be assessed through new tools for high-throughput flow cytometry using plate-based assay formats and small volume samples... - Post-high-throughput screening analysis: an empirical compound prioritization schemeTudor I Oprea
Division of Biocomputing and Cancer Research and Treatment Center, University of New Mexico, Albuquerque 87131, USA
J Biomol Screen 10:419-26. 2005..The decision-making process is discussed for a set of G-protein coupled receptor antagonists and validated on a literature example for dihydrofolate reductase inhibition... - Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30Chetana M Revankar
Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
ACS Chem Biol 2:536-44. 2007..To our knowledge, this is the first definitive demonstration of a functional intracellular transmembrane estrogen receptor... - FRET detection of cellular alpha4-integrin conformational activationAlexandre Chigaev
Department of Pathology and Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Biophys J 85:3951-62. 2003..The coordination between the extension of alpha4-integrin and its affinity provides a mechanism for Dembo's catch-bond concept... - Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probesSusan M Young
University of New Mexico, Albuquerque, 87131, USA
Cytometry A 75:253-63. 2009..The duplex assay format reduced assay time, minimized reagent requirements, and provided selectivity information at every screening stage, thus proving to be an efficient means to screen for selective receptor ligand probes... - In vivo effects of a GPR30 antagonistMegan K Dennis
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
Nat Chem Biol 5:421-7. 2009..The identification of this antagonist will accelerate the evaluation of the roles of GPR30 in human physiology... - A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry systemMegan K Dennis
Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Cytometry A 73:390-9. 2008.... - A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligandJ Jacob Strouse
Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
Cytometry A 75:264-70. 2009..The differential affinities of known peptide ligands were observed with the use of this fluorescent probe in high throughput screening flow cytometry... - Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activationAlexandre Chigaev
Department of Pathology and The Cancer Center, University of New Mexico Health Sciences Center, Albequerque, 87131, USA
J Biol Chem 279:32435-43. 2004..Based on this result and differences in the kinetics of integrin activation, we conclude that conformational activation of VLA-4 by inside-out signaling is independent of and additive to reduction-regulated integrin activation... - Techniques: GPCR assembly, pharmacology and screening by flow cytometryAnna Waller
Department of Pathology and Cancer Center, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA
Trends Pharmacol Sci 25:663-9. 2004..These analyses can produce quantitative pharmacological data analogous to radioligand assays, and, in some cases, the probes can be integrated into the assembly as fluorescent fusion proteins... - Activated N-formyl peptide receptor and high-affinity IgE receptor occupy common domains for signaling and internalizationMei Xue
Department of Pathology and Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM 87131, USA
Mol Biol Cell 18:1410-20. 2007..The observation of receptors in lightly coated membrane invaginations suggests that, despite the lack of caveolin, hematopoietic cells harbor caveolae-like structures that are candidates for nonclathrin-mediated endocytosis... - Arrestins block G protein-coupled receptor-mediated apoptosisChetana M Revankar
Department of Cell Biology and Physiology and University of New Mexico Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
J Biol Chem 279:24578-84. 2004.... - Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSHMathewos Tessema
Department of Pathology, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Cytometry A 69:326-34. 2006..Although a system may have the disadvantage that it has a low affinity and a correspondingly quick off-rate in solution, it may remain on beads if the site density can be increased to offer a slow apparent off rate... - Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonistsBruce S Edwards
Department of Cytometry, University of New Mexico, Albuquerque, NM 87131-0001, USA
Mol Pharmacol 68:1301-10. 2005..This virtual screening approach improved the physical screening hit rate by 12-fold (versus 0.1% hit-rate in a random compound collection), providing an efficient process for identifying small molecule antagonists... - Flow cytometry for high-throughput, high-content screeningBruce S Edwards
Department of Cell Biology and Physiology, University of New Mexico Cancer Research and Treatment Center, Albuquerque, New Mexico 87131, USA
Curr Opin Chem Biol 8:392-8. 2004..These new developments, and its broad usage, position flow cytometry as an attractive analysis platform for high-throughput, high-content biological testing and drug discovery... - Regulation of N-formyl peptide-mediated degranulation by receptor phosphorylationCharlotte M Vines
Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA
J Immunol 169:6760-6. 2002..Degranulation by this mutant FPR was indistinguishable from that of the DeltaST mutant, indicating that FPR phosphorylation or binding of arrestin but not internalization terminates the degranulation response... - Arrestin variants display differential binding characteristics for the phosphorylated N-formyl peptide receptor carboxyl terminusRoss M Potter
Department of Cell Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
J Biol Chem 277:8970-8. 2002..The results suggest that the carboxyl terminus of arrestin is a critical determinant in regulating the binding affinity of arrestin for the phosphorylated domains of GPCRs... - Enhancement of somatostatin-receptor-targeted (177)Lu-[DOTA(0)-Tyr(3)]-octreotide therapy by gemcitabine pretreatment-mediated receptor uptake, up-regulation and cell cycle modulationTapan K Nayak
College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
Nucl Med Biol 35:673-8. 2008..This study evaluates the potential for combination therapy with gemcitabine in an effort to improve clinical outcomes... - Regulation of N-formyl peptide receptor signaling and trafficking by individual carboxyl-terminal serine and threonine residuesRoss M Potter
Department of Cell Biology and Physiology, University of New Mexico Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
J Immunol 176:5418-25. 2006..This study is among the first detailed analyses of a complex regulatory site in a GPCR, and provides insight into GPCR regulatory mechanisms... - Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beadsTione Buranda
Department of Pathology and Cancer Center, University of New Mexico Health Science Center, Albuquerque, New Mexico 87131, USA
Adv Protein Chem 74:95-135. 2007..The data and concepts are discussed in the context of a review of current literature on signaling mechanism based on structural and spectroscopic (FRET) studies of ternary complex components... - Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometryJennifer M Carter
Department of Chemistry, University of New Mexico, Albuquerque, NM 87131, USA
J Mol Biol 351:865-78. 2005.... - N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinityT Alexander Key
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA
J Biol Chem 278:4041-7. 2003..Furthermore, this is the first demonstration that agonist affinity of a GPCR and the affinity of arrestin binding to the phosphorylated receptor are regulated by distinct receptor phosphodomains... - Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cellsGeetanjali Sharma
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Endocrinology 152:3030-9. 2011..The results of this study suggest that the activation of downstream signaling pathways by the GPER-selective ligand G-1 could represent a novel therapeutic strategy in the treatment of diabetes... - Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cellsTapan K Nayak
Radiopharmaceutical Sciences Program, College of Pharmacy, University of New Mexico, Albuquerque, NM 87131 0001, USA
Nucl Med Biol 34:185-93. 2007.... - Mechanisms of G protein-coupled receptor-mediated degranulationCharlotte M Vines
Department of Cell Biology and Physiology, The University of New Mexico Cancer Research and Treatment Center, University of New Mexico, 915 Camino de Salud, Albuquerque 87131, USA
FEMS Microbiol Lett 236:1-6. 2004..This review summarizes the current understanding of the mechanisms involved in the regulation of degranulation through GPCRs... - High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screeningSusan M Young
Cytometry, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, USA
J Biomol Screen 9:103-11. 2004..With single-cell readout systems for protein expression libraries, this technology offers the promise of screening millions of discrete compound interactions per day... - Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptideHaixun Guo
College of Pharmacy, Cancer Research Treatment Center, Department of Cell Biology and Physiology, Department of Pathology, Department of Dermatology, University of New Mexico, Albuquerque, New Mexico 87131, USA
Bioconjug Chem 20:2162-8. 2009.... - Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelatesChinnasamy Ramesh
Department of Chemistry and Biochemistry MSC 3C, New Mexico State University, P.O. Box 30001, Las Cruces, New Mexico 88003, USA
J Am Chem Soc 128:14476-7. 2006..These results suggest that in vitro assays will facilitate the development of targeted imaging agents for intracellular receptors and the feasibility of targeting GPR30 and ERalpha/beta for diagnostic tumor imaging... - G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophilsAyako Makino
Dept. of Bioengineering, The Whitaker Institute of Biomedical Engineering, Univ. of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
Am J Physiol Cell Physiol 290:C1633-9. 2006..These results suggest that GPCRs serve as mechanosensors for fluid shear stress in neutrophils by decreasing its constitutive activity and reducing pseudopod projection... - Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous systemEugen Brailoiu
Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
J Endocrinol 193:311-21. 2007.... - G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cellsLidia Albanito
Departments of Pharmaco Biology and Cell Biology, University of Calabria, 87030 Rende Cosenza, Italy
Cancer Res 67:1859-66. 2007.... - Expression of G protein-coupled receptor 30 in the hamster ovary: differential regulation by gonadotropins and steroid hormonesCheng Wang
Department of Obstetrics and Gynecology, University of Nebraska Medical Center, 984515 Nebraska Medical Center, Omaha, NE 68198 4515, USA
Endocrinology 148:4853-64. 2007..The unique pattern of GPR30 expression suggests that gonadotropin-regulated follicular cell functions may involve GPR30 activity... - Expression of G protein-coupled receptor-30, a G protein-coupled membrane estrogen receptor, in oxytocin neurons of the rat paraventricular and supraoptic nucleiHirotaka Sakamoto
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Endocrinology 148:5842-50. 2007..In addition, the expression of GPR30 is also detected in the neurohypophysis. These results suggest that GPR30 may serve primarily as a nongenomic transducer of estrogen actions in the hypothalamo-neurohypophyseal system... - Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptorBent Postma
Eijkman Winkler Institute, University Medical Center Utrecht, Utrecht, The Netherlands
J Immunol 172:6994-7001. 2004..This selectivity and high-affinity binding with potent antagonistic effects makes CHIPS a promising lead for the development of new anti-inflammatory compounds for diseases in which damage by neutrophils plays a key role... - The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferationJian Teng
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
Endocrinology 149:4024-34. 2008..These results suggest that GPR30-mediated inhibition of urothelial cell proliferation is the result of decreased cyclin D1 by down-regulation of activation protein-1 signaling... - Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formationKenichi Matsuda
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto, Japan
Neurosci Lett 441:94-9. 2008..Expression levels were not different among male, female in proestrus and female in estrus at the adult stage, but were higher in newborn male than newborn female... - G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovaryCheng Wang
Department of Obstetrics Gynecology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4515, USA
Endocrinology 149:4452-61. 2008..These results suggest that a membrane estrogen receptor, GPR30, is expressed in the ovary during perinatal development and mediates E2 action on primordial follicle formation...
Research Grants
- Development of GPR30-Selective LigandsEric Prossnitz; Fiscal Year: 2009..The goal of this work is to develop novel compounds that can specifically target this new receptor to either activate or inhibit its activity without affecting other estrogen receptors. ..
- Arrestin activation probed with mass spectrometryEric Prossnitz; Fiscal Year: 2007..Our results will contribute to our basic knowledge of this key signaling molecule and provide the basis for the design of therapeutic agents related to GPCR signaling. ..
- A novel intracellular 7TM estrogen receptor in breastEric Prossnitz; Fiscal Year: 2007....
- The Role of GPR30 in Advanced Endometrial CancerEric Prossnitz; Fiscal Year: 2007....
- The Role of GPR30 in Advanced Endometrial CancerEric Prossnitz; Fiscal Year: 2009..abstract_text> ..
- A novel intracellular 7TM estrogen receptor in breastEric R Prossnitz; Fiscal Year: 2010..abstract_text> ..
- Development of GPR30-Selective LigandsERIC R contact PROSSNITZ; Fiscal Year: 2010..The goal of this work is to develop novel compounds that can specifically target this new receptor to either activate or inhibit its activity without affecting other estrogen receptors. ..
- Development of GPR30-Selective LigandsEric Prossnitz; Fiscal Year: 2009..The goal of this work is to develop novel compounds that can specifically target this new receptor to either activate or inhibit its activity without affecting other estrogen receptors. ..
- MECHANISMS OF LEUKOCYTE ACTIVATION AND CHEMOTAXISEric Prossnitz; Fiscal Year: 2002....
- Development of GPR30-Selective LigandsERIC R contact PROSSNITZ; Fiscal Year: 2010..abstract_text> ..