Affiliation: University of Minnesota
Country: USA


  1. Prohaska J, Gybina A. Rat brain iron concentration is lower following perinatal copper deficiency. J Neurochem. 2005;93:698-705 pubmed
    ..44, p < 0.05. No change in P50 -Cu rat brain TfR1 or Fe content was detected despite a 50% reduction in plasma Fe. The results suggest that brain Fe accumulation depends on adequate Cu nutriture during perinatal development. ..
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    Prohaska J, Brokate B. Dietary copper deficiency alters protein levels of rat dopamine beta-monooxygenase and tyrosine monooxygenase. Exp Biol Med (Maywood). 2001;226:199-207 pubmed
    ..Further research will be required to determine the chemical signal responsible for this induction and if DBM or TM protein levels change in other tissues. ..
  3. Prohaska J, Broderius M. Copper deficiency has minimal impact on ferroportin expression or function. Biometals. 2012;25:633-42 pubmed publisher
    ..Fpn steady state levels appear to be regulated by a complex set of factors. Changes in Fpn do not explain the anemia of CuD. ..
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    Prohaska J, Geissler J, Brokate B, Broderius M. Copper, zinc-superoxide dismutase protein but not mRNA is lower in copper-deficient mice and mice lacking the copper chaperone for superoxide dismutase. Exp Biol Med (Maywood). 2003;228:959-66 pubmed
    ..These results in mice are comparable with rats and suggest a posttranscriptional mechanism for reduction of SOD1 protein when Cu is limiting in SOD1. ..
  5. Prohaska J, Gybina A, Broderius M, Brokate B. Peptidylglycine-alpha-amidating monooxygenase activity and protein are lower in copper-deficient rats and suckling copper-deficient mice. Arch Biochem Biophys. 2005;434:212-20 pubmed