W R Proctor

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice
    W R Proctor
    Department of Veterans Affairs Medical Center, Research Service, Denver, Colorado, USA
    J Pharmacol Exp Ther 305:264-70. 2003
  2. ncbi Differential effects of ethanol on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice
    William R Proctor
    Veterans Affairs Eastern Colorado Health Care System, Denver, Colorado, USA
    Alcohol Clin Exp Res 28:1277-83. 2004
  3. pmc Synaptic GABAergic and glutamatergic mechanisms underlying alcohol sensitivity in mouse hippocampal neurons
    W R Proctor
    VA Eastern Colorado Health Care System, Denver, CO80220, USA
    J Physiol 575:145-59. 2006
  4. pmc Modulation of mammalian dendritic GABA(A) receptor function by the kinetics of Cl- and HCO3- transport
    K J Staley
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Physiol 519:693-712. 1999
  5. ncbi Differential GABAB Receptor Modulation of Ethanol Effects on GABA(A) synaptic activity in hippocampal CA1 neurons
    Peter H Wu
    Dept of Psychiatry C 261, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    J Pharmacol Exp Ther 312:1082-9. 2005

Research Grants

  1. Alcohol Modulation of Cerebellar Synaptic Currents
    William Proctor; Fiscal Year: 2006

Detail Information

Publications5

  1. ncbi Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice
    W R Proctor
    Department of Veterans Affairs Medical Center, Research Service, Denver, Colorado, USA
    J Pharmacol Exp Ther 305:264-70. 2003
    ..These results suggest that PKCgamma and PKCepsilon signaling pathways reciprocally modulate both ethanol enhancement of GABA(A) receptor function and hypnotic sensitivity to ethanol...
  2. ncbi Differential effects of ethanol on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice
    William R Proctor
    Veterans Affairs Eastern Colorado Health Care System, Denver, Colorado, USA
    Alcohol Clin Exp Res 28:1277-83. 2004
    ..These congenic mouse strains are ideally suited for asking which QTL regions might correlate with other phenotypes that differ between ILS and ISS mice. Here we used the congenics to investigate altered GABAA responses to ethanol...
  3. pmc Synaptic GABAergic and glutamatergic mechanisms underlying alcohol sensitivity in mouse hippocampal neurons
    W R Proctor
    VA Eastern Colorado Health Care System, Denver, CO80220, USA
    J Physiol 575:145-59. 2006
    ..Furthermore, these results provide essential information to focus better on appropriate target sites for more effective drug development for the treatment of alcohol abuse...
  4. pmc Modulation of mammalian dendritic GABA(A) receptor function by the kinetics of Cl- and HCO3- transport
    K J Staley
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Physiol 519:693-712. 1999
    ..5. Using a standard model of membrane potential, these conditions are demonstrated to be sufficient to produce the experimentally observed, activity-dependent GABA(A) depolarizing response in pyramidal cell dendrites...
  5. ncbi Differential GABAB Receptor Modulation of Ethanol Effects on GABA(A) synaptic activity in hippocampal CA1 neurons
    Peter H Wu
    Dept of Psychiatry C 261, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    J Pharmacol Exp Ther 312:1082-9. 2005
    ....

Research Grants2

  1. Alcohol Modulation of Cerebellar Synaptic Currents
    William Proctor; Fiscal Year: 2006
    ..The combination of our proposed and ongoing genetic studies may aid the identification of more sensitive drug targets and the development of novel drugs for rational therapeutic approaches to alcoholism. ..