Affiliation: University of Cincinnati
- Current challenges in the management of epilepsyMichael Privitera
University of Cincinnati College of Medicine and Epilepsy Center at UC Neuroscience Institute, Cincinnati, OH 45267, USA
Am J Manag Care 17:S195-203. 2011..Patients with medication-resistant epilepsy may be candidates for epilepsy surgery, a highly effective treatment that is underutilized in this population...
- Detection of epileptogenic focal cortical dysplasia by depth, not subdural electrodesM D Privitera
University of Cincinnati College of Medicine, Department of Neurology, OH 45267 0525, USA
Neurosurg Rev 23:49-51. 2000..We conclude that although subdural electrodes have many advantages when recording seizures outside the temporal lobes, depth electrodes may provide superior recordings when the epileptogenic region is beneath the cortical surface...
- Postictal language functionMichael Privitera
Department of Neurology, University of Cincinnati, Cincinnati, OH, USA
Epilepsy Behav 19:140-5. 2010..This highly cost-effective test provides important information on seizure localization and spread; is easily taught to technologists, nurses, and family members; and should be added to testing procedures in all epilepsy monitoring units...
- Assessment of adverse events and quality of life in epilepsy: design of a new community-based trialMichael Privitera
University of Cincinnati Medical Center 0525, 231 Albert B Sabin Way, Cincinnati, OH 45267 0525, USA
Epilepsy Behav 5:841-6. 2004..To identify appropriate instruments that could measure these factors, here we review several epilepsy-specific scales used to monitor adverse events and HRQOL and discuss their potential utility in the context of the proposed trial...
- Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsyM D Privitera
Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
Acta Neurol Scand 107:165-75. 2003..To compare topiramate (TPM) with investigator's choice of carbamazepine (CBZ) or valproate (VPA) for initial treatment in patients with newly diagnosed epilepsy...
- Efficacy of levetiracetam: a review of three pivotal clinical trialsM Privitera
University of Cincinnati Medical Center, Department of Neurology, Cincinnati, Ohio 45267 0525, USA
Epilepsia 42:31-5. 2001..Levetiracetam was generally well tolerated in all studies. Results from these three pivotal studies demonstrate that levetiracetam, as adjunctive therapy, is a safe and effective treatment for refractory partial-onset seizures in adults...
- Effects of breastfeeding in children of women taking antiepileptic drugsK J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
Neurology 75:1954-60. 2010..Animal and human studies have demonstrated that some AEDs can adversely affect the immature brain. However, no investigation has examined effects of breastfeeding during AED therapy on subsequent cognitive abilities in children...
- Cognitive function at 3 years of age after fetal exposure to antiepileptic drugsKimford J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Bldg, 101 Woodruff Cir, Suite 6000, Atlanta, GA 30322, USA
N Engl J Med 360:1597-605. 2009....
- Improved tolerability and efficacy in epilepsy patients with extended-release carbamazepineD M Ficker
Department of Neurology, University of Cincinnati Medical Center, 231 Albert B Sabin Way, Cincinnati, OH 45267, USA
Neurology 65:593-5. 2005..Using validated, epilepsy-specific measures the authors found that switching to CBZ-ERC significantly improved patients' adverse events and quality-of-life measures. Switching to CBZ-ERC also improved seizure control...
- Levetiracetam induces a rapid and sustained reduction of generalized spike-wave and clinical absenceJennifer Cavitt
The Neuroscience Institute, Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
Arch Neurol 61:1604-7. 2004..Levetiracetam may be effective in generalized-onset epilepsy, and randomized, controlled trials are indicated...
- Antiepileptic drug use in women of childbearing ageKimford J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Mail Stop 1930 001 1AN, Atlanta, GA 30322, USA
Epilepsy Behav 15:339-43. 2009..Except for the top two AED monotherapies, there were marked differences in other monotherapies and in polytherapies between U.S. and UK centers. Future investigations are needed to examine reasons for drug choice...
- What does the family pictures subtest of the Wechsler Memory Scale-III measure? Insight gained from patients evaluated for epilepsy surgeryMario F Dulay
Department of Psychology, University of Cincinnati, Cincinnati, OH 45221 0376, USA
Clin Neuropsychol 16:452-62. 2002..These results raise questions about the appropriateness of including FP task performance in the calculations of the WMS-III Visual Index scores...
- Large clinical trials in epilepsy: funding by the NIH versus pharmaceutical industryMichael Privitera
Epilepsy Res 68:52-6. 2006....