Mayumi Prins

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Repeated mild traumatic brain injury: mechanisms of cerebral vulnerability
    Mayumi L Prins
    Department of Neurosurgery, University of California, School of Medicine, Los Angeles, CA 90095, USA
    J Neurotrauma 30:30-8. 2013
  2. pmc Cerebral ketone metabolism during development and injury
    Mayumi L Prins
    Department of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7039, USA
    Epilepsy Res 100:218-23. 2012
  3. doi request reprint Repeat traumatic brain injury in the developing brain
    M L Prins
    UCLA David Geffen School of Medicine, Department of Neurosurgery, United States
    Int J Dev Neurosci 30:185-90. 2012
  4. pmc Repeat traumatic brain injury in the juvenile rat is associated with increased axonal injury and cognitive impairments
    M L Prins
    Department of Neurosurgery, UCLA David Geffen School of Medicine, Los Angeles, Calif, USA
    Dev Neurosci 32:510-8. 2010
  5. pmc The effects of age and ketogenic diet on local cerebral metabolic rates of glucose after controlled cortical impact injury in rats
    Mayumi L Prins
    Department of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, California 90095 7039, USA
    J Neurotrauma 26:1083-93. 2009
  6. pmc Diet, ketones, and neurotrauma
    Mayumi Prins
    Department of Neurosurgery, UCLA David Geffen School of Medicine, Los Angeles, California 90095 7039, USA
    Epilepsia 49:111-3. 2008
  7. ncbi request reprint Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult rats
    M L Prins
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7039, USA
    Dev Neurosci 28:447-56. 2006
  8. ncbi request reprint Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury
    M L Prins
    Division of Neurosurgery, UCLA David Geffen School of Medicine, Los Angeles, California 90095 7039, USA
    J Neurosci Res 82:413-20. 2005
  9. ncbi request reprint Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats
    M L Prins
    Division of Neurosurgery, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 7039, USA
    J Neurochem 90:666-72. 2004
  10. ncbi request reprint Developing experimental models to address traumatic brain injury in children
    Mayumi L Prins
    Division of Neurosurgery, UCLA School of Medicine, Los Angeles, California 90095 7039, USA
    J Neurotrauma 20:123-37. 2003

Research Grants

Detail Information

Publications16

  1. pmc Repeated mild traumatic brain injury: mechanisms of cerebral vulnerability
    Mayumi L Prins
    Department of Neurosurgery, University of California, School of Medicine, Los Angeles, CA 90095, USA
    J Neurotrauma 30:30-8. 2013
    ..Results suggest that the duration of metabolic depression reflects the time-course of vulnerability to second injury in the juvenile brain and could serve as a valuable biomarker in establishing window of vulnerability guidelines...
  2. pmc Cerebral ketone metabolism during development and injury
    Mayumi L Prins
    Department of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7039, USA
    Epilepsy Res 100:218-23. 2012
    ....
  3. doi request reprint Repeat traumatic brain injury in the developing brain
    M L Prins
    UCLA David Geffen School of Medicine, Department of Neurosurgery, United States
    Int J Dev Neurosci 30:185-90. 2012
    ..It is intended to reveal the critical areas that need to be addressed so that age-relevant clinical management guidelines can be established to protect this population...
  4. pmc Repeat traumatic brain injury in the juvenile rat is associated with increased axonal injury and cognitive impairments
    M L Prins
    Department of Neurosurgery, UCLA David Geffen School of Medicine, Los Angeles, Calif, USA
    Dev Neurosci 32:510-8. 2010
    ..This study marks the first critical step in experimentally addressing the consequences of concussions and the cumulative effects of RTBI in the developing brain...
  5. pmc The effects of age and ketogenic diet on local cerebral metabolic rates of glucose after controlled cortical impact injury in rats
    Mayumi L Prins
    Department of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, California 90095 7039, USA
    J Neurotrauma 26:1083-93. 2009
    ..These results suggest that conditions of reduced glucose utilization and increased alternative substrate metabolism may be preferable acutely after TBI in the younger rat...
  6. pmc Diet, ketones, and neurotrauma
    Mayumi Prins
    Department of Neurosurgery, UCLA David Geffen School of Medicine, Los Angeles, California 90095 7039, USA
    Epilepsia 49:111-3. 2008
    ..This altered dietary approach may have tremendous therapeutic potential for both the pediatric and adult head-injured populations...
  7. ncbi request reprint Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult rats
    M L Prins
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7039, USA
    Dev Neurosci 28:447-56. 2006
    ..The increased MCT2 expression was temporally correlated with an age-related increase in cerebral uptake of ketones, when ketones were made available after injury...
  8. ncbi request reprint Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury
    M L Prins
    Division of Neurosurgery, UCLA David Geffen School of Medicine, Los Angeles, California 90095 7039, USA
    J Neurosci Res 82:413-20. 2005
    ..The age-dependent ketogenic neuroprotection is likely related to age-related differences in cerebral metabolism of ketones and suggests that alternative substrate therapy has potential applications for younger head-injured patients...
  9. ncbi request reprint Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats
    M L Prins
    Division of Neurosurgery, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 7039, USA
    J Neurochem 90:666-72. 2004
    ..7-fold increase in 14CO2 production relative to sham betaHB-infused animals. The TBI-induced 20% decrease in ipsilateral cortical ATP concentration was alleviated by 3 h of betaHB infusion beginning immediately after CCI injury...
  10. ncbi request reprint Developing experimental models to address traumatic brain injury in children
    Mayumi L Prins
    Division of Neurosurgery, UCLA School of Medicine, Los Angeles, California 90095 7039, USA
    J Neurotrauma 20:123-37. 2003
    ..It also addresses unique considerations to modeling pediatric brain injury that require special attention when modeling and designing studies: age appropriateness, injury severity, evaluation of recovery, plasticity, and anesthesia...
  11. ncbi request reprint The effects of combined fluid percussion traumatic brain injury and unilateral entorhinal deafferentation on the juvenile rat brain
    Mayumi L Prins
    Department of Anatomy and Neurobiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA
    Brain Res Dev Brain Res 140:93-104. 2003
    ..Moreover, when deafferented tissue is assessed morphologically, evidence exists for aberrant plasticity and abnormal synaptic reorganization in the juvenile brain...
  12. pmc Cerebral metabolic adaptation and ketone metabolism after brain injury
    Mayumi L Prins
    1UCLA Division of Neurosurgery, Los Angeles, California 90095, USA
    J Cereb Blood Flow Metab 28:1-16. 2008
    ..It is clear that in addition to glucose, other substrates must be considered along with fuel interactions, metabolic challenges, and cerebral maturation...
  13. ncbi request reprint Mapping cerebral glucose metabolism during spatial learning: interactions of development and traumatic brain injury
    M L Prins
    Department of Neurobiology, Los Angeles, California, USA
    J Neurotrauma 18:31-46. 2001
    ....
  14. ncbi request reprint Fluid percussion brain injury in the developing and adult rat: a comparative study of mortality, morphology, intracranial pressure and mean arterial blood pressure
    M L Prins
    Division of Neurosurgery, UCLA School of Medicine 90025 7039, USA
    Brain Res Dev Brain Res 95:272-82. 1996
    ..The utilization of this model will allow for future studies addressing the consequences of traumatic brain injury when it is sustained early in development...
  15. ncbi request reprint Age-dependency of 45calcium accumulation following lateral fluid percussion: acute and delayed patterns
    C L Osteen
    Department of Physiological Science, UCLA, Los Angeles, California 90024 7039, USA
    J Neurotrauma 18:141-62. 2001
    ..The age-dependency of posttraumatic 45Ca2+ accumulation may be attributed to differential biomechanical consequences of the LFP injury and/or the presence or lack of secondary cell death...
  16. pmc The pathophysiology of traumatic brain injury at a glance
    Mayumi Prins
    Department of Neurosurgery, UCLA, Los Angeles, CA 90095, USA
    Dis Model Mech 6:1307-15. 2013
    ..Recognition of these recurrent features could allow elucidation of potential therapeutic targets for early intervention. ..

Research Grants3

  1. Age-Dependent Ketone Metabolism After Brain Injury
    Mayumi Prins; Fiscal Year: 2005
    ..abstract_text> ..
  2. Age-Dependent Ketone Metabolism After Brain Injury
    Mayumi Prins; Fiscal Year: 2006
    ..abstract_text> ..
  3. Age-Dependent Ketone Metabolism After Brain Injury
    Mayumi Prins; Fiscal Year: 2007
    ..abstract_text> ..