Affiliation: University of California
- Repeated mild traumatic brain injury: mechanisms of cerebral vulnerabilityMayumi L Prins
Department of Neurosurgery, University of California, School of Medicine, Los Angeles, CA 90095, USA
J Neurotrauma 30:30-8. 2013..Results suggest that the duration of metabolic depression reflects the time-course of vulnerability to second injury in the juvenile brain and could serve as a valuable biomarker in establishing window of vulnerability guidelines...
- Cerebral ketone metabolism during development and injuryMayumi L Prins
Department of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7039, USA
Epilepsy Res 100:218-23. 2012....
- Repeat traumatic brain injury in the developing brainM L Prins
UCLA David Geffen School of Medicine, Department of Neurosurgery, United States
Int J Dev Neurosci 30:185-90. 2012..It is intended to reveal the critical areas that need to be addressed so that age-relevant clinical management guidelines can be established to protect this population...
- Repeat traumatic brain injury in the juvenile rat is associated with increased axonal injury and cognitive impairmentsM L Prins
Department of Neurosurgery, UCLA David Geffen School of Medicine, Los Angeles, Calif, USA
Dev Neurosci 32:510-8. 2010..This study marks the first critical step in experimentally addressing the consequences of concussions and the cumulative effects of RTBI in the developing brain...
- The effects of age and ketogenic diet on local cerebral metabolic rates of glucose after controlled cortical impact injury in ratsMayumi L Prins
Department of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, California 90095 7039, USA
J Neurotrauma 26:1083-93. 2009..These results suggest that conditions of reduced glucose utilization and increased alternative substrate metabolism may be preferable acutely after TBI in the younger rat...
- Diet, ketones, and neurotraumaMayumi Prins
Department of Neurosurgery, UCLA David Geffen School of Medicine, Los Angeles, California 90095 7039, USA
Epilepsia 49:111-3. 2008..This altered dietary approach may have tremendous therapeutic potential for both the pediatric and adult head-injured populations...
- Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult ratsM L Prins
Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7039, USA
Dev Neurosci 28:447-56. 2006..The increased MCT2 expression was temporally correlated with an age-related increase in cerebral uptake of ketones, when ketones were made available after injury...
- Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injuryM L Prins
Division of Neurosurgery, UCLA David Geffen School of Medicine, Los Angeles, California 90095 7039, USA
J Neurosci Res 82:413-20. 2005..The age-dependent ketogenic neuroprotection is likely related to age-related differences in cerebral metabolism of ketones and suggests that alternative substrate therapy has potential applications for younger head-injured patients...
- Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult ratsM L Prins
Division of Neurosurgery, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 7039, USA
J Neurochem 90:666-72. 2004..7-fold increase in 14CO2 production relative to sham betaHB-infused animals. The TBI-induced 20% decrease in ipsilateral cortical ATP concentration was alleviated by 3 h of betaHB infusion beginning immediately after CCI injury...
- Developing experimental models to address traumatic brain injury in childrenMayumi L Prins
Division of Neurosurgery, UCLA School of Medicine, Los Angeles, California 90095 7039, USA
J Neurotrauma 20:123-37. 2003..It also addresses unique considerations to modeling pediatric brain injury that require special attention when modeling and designing studies: age appropriateness, injury severity, evaluation of recovery, plasticity, and anesthesia...
- The effects of combined fluid percussion traumatic brain injury and unilateral entorhinal deafferentation on the juvenile rat brainMayumi L Prins
Department of Anatomy and Neurobiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA
Brain Res Dev Brain Res 140:93-104. 2003..Moreover, when deafferented tissue is assessed morphologically, evidence exists for aberrant plasticity and abnormal synaptic reorganization in the juvenile brain...
- Cerebral metabolic adaptation and ketone metabolism after brain injuryMayumi L Prins
1UCLA Division of Neurosurgery, Los Angeles, California 90095, USA
J Cereb Blood Flow Metab 28:1-16. 2008..It is clear that in addition to glucose, other substrates must be considered along with fuel interactions, metabolic challenges, and cerebral maturation...
- Mapping cerebral glucose metabolism during spatial learning: interactions of development and traumatic brain injuryM L Prins
Department of Neurobiology, Los Angeles, California, USA
J Neurotrauma 18:31-46. 2001....
- Fluid percussion brain injury in the developing and adult rat: a comparative study of mortality, morphology, intracranial pressure and mean arterial blood pressureM L Prins
Division of Neurosurgery, UCLA School of Medicine 90025 7039, USA
Brain Res Dev Brain Res 95:272-82. 1996..The utilization of this model will allow for future studies addressing the consequences of traumatic brain injury when it is sustained early in development...
- Age-dependency of 45calcium accumulation following lateral fluid percussion: acute and delayed patternsC L Osteen
Department of Physiological Science, UCLA, Los Angeles, California 90024 7039, USA
J Neurotrauma 18:141-62. 2001..The age-dependency of posttraumatic 45Ca2+ accumulation may be attributed to differential biomechanical consequences of the LFP injury and/or the presence or lack of secondary cell death...
- The pathophysiology of traumatic brain injury at a glanceMayumi Prins
Department of Neurosurgery, UCLA, Los Angeles, CA 90095, USA
Dis Model Mech 6:1307-15. 2013..Recognition of these recurrent features could allow elucidation of potential therapeutic targets for early intervention. ..
- Age-Dependent Ketone Metabolism After Brain InjuryMayumi Prins; Fiscal Year: 2007..abstract_text> ..