GAIL S contact PRINS

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules
    Cleida A Oliveira
    Department of Veterinary Biosciences, University of Illinois, 2001 S, Lincoln, Urbana, IL 61802, USA
    Reprod Biol Endocrinol 1:75. 2003
  2. ncbi request reprint Estrogen receptor-beta messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats
    G S Prins
    Department of Urology, University of Illinois College of Medicine, Chicago 60612, USA
    Endocrinology 139:874-83. 1998
  3. pmc Developmental estrogen exposures predispose to prostate carcinogenesis with aging
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, 820 South Wood Street, MC 955, Chicago, IL 60612, United States
    Reprod Toxicol 23:374-82. 2007
  4. ncbi request reprint Estrogenic regulation of signaling pathways and homeobox genes during rat prostate development
    Liwei Huang
    Department of Urology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Androl 25:330-7. 2004
  5. pmc The role of estrogens in normal and abnormal development of the prostate gland
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, 820 South Wood, Chicago, IL 60612, USA
    Ann N Y Acad Sci 1089:1-13. 2006
  6. pmc The role of estrogens and estrogen receptors in normal prostate growth and disease
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Steroids 73:233-44. 2008
  7. pmc Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, Chicago, IL, USA
    Basic Clin Pharmacol Toxicol 102:134-8. 2008
  8. pmc Molecular signaling pathways that regulate prostate gland development
    Gail S Prins
    Department of Urology, College of Medicine, University of Illinois at Chicago Chicago, IL 606012, USA
    Differentiation 76:641-59. 2008
  9. ncbi request reprint Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure
    Gail S Prins
    Department of Urology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    Endocrinology 143:3628-40. 2002
  10. pmc Endocrine disruptors and prostate cancer risk
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocr Relat Cancer 15:649-56. 2008

Collaborators

Detail Information

Publications34

  1. pmc The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules
    Cleida A Oliveira
    Department of Veterinary Biosciences, University of Illinois, 2001 S, Lincoln, Urbana, IL 61802, USA
    Reprod Biol Endocrinol 1:75. 2003
    ..Although ICI 182,780 causes severe alterations in testicular and efferent ductule morphology and function, the effects on the expression of estrogen and androgen receptors in the male have not been shown...
  2. ncbi request reprint Estrogen receptor-beta messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats
    G S Prins
    Department of Urology, University of Illinois College of Medicine, Chicago 60612, USA
    Endocrinology 139:874-83. 1998
    ..The differences in ER beta mRNA imprinting in the separate lobes may account for or reflect the lobe-specific neonatal estrogen imprints previously observed in the rat prostate...
  3. pmc Developmental estrogen exposures predispose to prostate carcinogenesis with aging
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, 820 South Wood Street, MC 955, Chicago, IL 60612, United States
    Reprod Toxicol 23:374-82. 2007
    ....
  4. ncbi request reprint Estrogenic regulation of signaling pathways and homeobox genes during rat prostate development
    Liwei Huang
    Department of Urology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Androl 25:330-7. 2004
  5. pmc The role of estrogens in normal and abnormal development of the prostate gland
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, 820 South Wood, Chicago, IL 60612, USA
    Ann N Y Acad Sci 1089:1-13. 2006
    ..We hypothesize that these molecular changes initiated early in life predispose the prostate to the neoplastic state upon aging...
  6. pmc The role of estrogens and estrogen receptors in normal prostate growth and disease
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Steroids 73:233-44. 2008
    ....
  7. pmc Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, Chicago, IL, USA
    Basic Clin Pharmacol Toxicol 102:134-8. 2008
    ..In total, these findings indicate that low-dose exposures to ubiquitous environmental oestrogens impact the prostate epigenome during development and in so doing, promote prostate disease with ageing...
  8. pmc Molecular signaling pathways that regulate prostate gland development
    Gail S Prins
    Department of Urology, College of Medicine, University of Illinois at Chicago Chicago, IL 606012, USA
    Differentiation 76:641-59. 2008
    ..Except where otherwise indicated, results from rodent models will be presented since studies that examine molecular signaling in the developing human prostate gland are sparse at the present time...
  9. ncbi request reprint Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure
    Gail S Prins
    Department of Urology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    Endocrinology 143:3628-40. 2002
    ..Thus, we hypothesize that alterations in morphogenesis as well as dysplasia in the adult prostate may be mediated in part through augmentation of transcriptional signals in the retinoid pathway...
  10. pmc Endocrine disruptors and prostate cancer risk
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocr Relat Cancer 15:649-56. 2008
    ..Thus infants and children may be considered a highly susceptible population for ED exposures and increased risk of prostate cancers with aging...
  11. pmc Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats
    Gail S Prins
    Department of Urology, 820 S Wood St, MC 955, University of Illinois at Chicago, Chicago, IL 60612, USA
    Reprod Toxicol 31:1-9. 2011
    ..These findings on prostate health are directly relevant to humans at current BPA exposure levels...
  12. ncbi request reprint Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with alphaERKO and betaERKO mice
    G S Prins
    Department of Urology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 61:6089-97. 2001
    ..If epithelial ERbeta is involved in some component of estrogen imprinting, its role would be considered minor and would require the presence of ERalpha expression in the prostatic stromal cells...
  13. pmc Estrogen-initiated transformation of prostate epithelium derived from normal human prostate stem-progenitor cells
    Wen Yang Hu
    Department of Urology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocrinology 152:2150-63. 2011
    ..These findings provide the first direct evidence that human prostate progenitor cells are estrogen targets and that estradiol in an androgen-supported milieu is a carcinogen for human prostate epithelium...
  14. ncbi request reprint The role of Fgf10 signaling in branching morphogenesis and gene expression of the rat prostate gland: lobe-specific suppression by neonatal estrogens
    Liwei Huang
    Department of Urology, University of Illinois at Chicago, 820 Wood Street, M C 955 Chicago, IL 60612, USA
    Dev Biol 278:396-414. 2005
    ....
  15. ncbi request reprint Alterations in gap junction protein expression in human benign prostatic hyperplasia and prostate cancer
    Helga Habermann
    Department of Urology, University of Graz, Graz, Austria
    J Urol 167:655-60. 2002
    ..To understand the potential involvement in prostate disease connexin 32 and 43 expression was evaluated in a series of normal prostate, BPH and prostate cancer specimens that were surgically removed due to bladder outlet obstruction...
  16. ncbi request reprint Localization of androgen and estrogen receptors in adult male mouse reproductive tract
    Qing Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    J Androl 23:870-81. 2002
    ..This study demonstrates that the reproductive tracts of male mice differ considerably from those of rats in expression of ARs and ERs and that caution is needed when extrapolating nuclear steroid receptor data across mammalian species...
  17. ncbi request reprint The role of prolactin in the prostatic inflammatory response to neonatal estrogen
    Jason P Gilleran
    Department of Urology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocrinology 144:2046-54. 2003
    ..As prostatic inflammation or prostatitis in humans is associated with benign prostatic hyperplasia and prostatic carcinoma, this animal model may provide mechanistic insight with regards to age-associated prostatic lesions...
  18. ncbi request reprint Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells
    Jason J Derry
    Department of Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Oncogene 22:4212-20. 2003
    ..Altered BRK localization and/or activity may provide a prognostic indicator for prostate tumor progression and be a potential target for therapeutic intervention...
  19. ncbi request reprint Neonatal estrogen down-regulates prostatic androgen receptor through a proteosome-mediated protein degradation pathway
    Carl Woodham
    Department of Urology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocrinology 144:4841-50. 2003
    ..Taken together, the present data show that exposure to neonatal estrogens down-regulates AR protein levels in the ventral prostate gland by accelerating AR degradation, which is mediated through the proteosome pathway...
  20. pmc Androgen regulation of prostate morphoregulatory gene expression: Fgf10-dependent and -independent pathways
    Yongbing Pu
    Department of Urology, MC 955, University of Illinois at Chicago, 820 South Wood Street, Chicago, Illinois 60612, USA
    Endocrinology 148:1697-706. 2007
    ..Lobe-specific responses may provide a developmental basis for prostate gland heterogeneity...
  21. pmc Posterior Hox gene expression and differential androgen regulation in the developing and adult rat prostate lobes
    Liwei Huang
    Department of Urology, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA
    Endocrinology 148:1235-45. 2007
    ..We suggest that this timely Hox code participates in determining lobe-specific prostatic identity and cellular differentiation...
  22. pmc Differential hormonal regulation of estrogen receptors ERalpha and ERbeta and androgen receptor expression in rat efferent ductules
    Cleida A Oliveira
    Department of Veterinary Biosciences, University of Illinois, 2001 S Lincoln, Urbana, Illinois 61802, USA
    Reproduction 128:73-86. 2004
    ..This differential modulation of the steroid hormone receptors highlights the importance of maintaining a physiological androgen-estrogen balance to regulate the structure and function of efferent ductules in the male...
  23. ncbi request reprint Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse
    Zhuohua Wang
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 60612 7231, USA
    Endocrinology 146:5188-96. 2005
    ..These results indicate that disruption of GH signaling significantly inhibits prostate carcinogenesis...
  24. pmc Distinct regulatory elements mediate the dynamic expression pattern of Nkx3.1
    Hui Chen
    Department of Biological Sciences, University of Maryland Baltimore County, 21250, USA
    Dev Dyn 234:961-73. 2005
    ..1 cis-regulatory elements provides a unique starting point to dissect signaling pathways involved in prostate organogenesis and pathogenesis and provides a system to perturb gene expression throughout prostate development...
  25. pmc Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching
    Yongbing Pu
    Department of Urology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Dev Biol 273:257-75. 2004
    ....
  26. pmc Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4
    Shuk Mei Ho
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA
    Cancer Res 66:5624-32. 2006
    ..In total, these findings indicate that low-dose exposures to ubiquitous environmental estrogens affect the prostate epigenome during development and, in so doing, promote prostate disease with aging...
  27. pmc Transient neonatal estrogen exposure to estrogen-deficient mice (aromatase knockout) reduces prostate weight and induces inflammation in late life
    Joseph John Bianco
    Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    Am J Pathol 168:1869-78. 2006
    ..Finally, this study establishes the ArKO mouse model of estrogen deficiency as a unique approach to study the effects of estrogens, estrogenic factors, and endocrine disruptors on prostate development...
  28. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  29. pmc Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat
    Zhuohua Wang
    Department of Medicinal Chemistry and Pharmacognosy, Univeresity od Illinois at Chicago, Chicago, Illinois 60612 7231
    Endocrinology 149:1366-76. 2008
    ....
  30. pmc An evaluation of evidence for the carcinogenic activity of bisphenol A
    Ruth A Keri
    Department of Pharmacology and Division of General Medical Sciences Oncology, Case Western Reserve University, Cleveland, OH 44160, USA
    Reprod Toxicol 24:240-52. 2007
    ..The present review consists of the consensus report on the evidence for a role of BPA in carcinogenesis, examining the available evidence in humans and animal models with recommendations for future areas of research...
  31. pmc Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic model
    Veda Diwadkar-Navsariwala
    Department of Human Nutrition, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 103:8179-84. 2006
    ....
  32. pmc Developmental exposure to bisphenol A increases prostate cancer susceptibility in adult rats: epigenetic mode of action is implicated
    Gail S Prins
    Department of Urology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Fertil Steril 89:e41. 2008
  33. ncbi request reprint Androgenic regulation of expression of androgen receptor protein in the perineal motoneurons of aged male rats
    Akira Matsumoto
    Department of Anatomy, Juntendo University School of Medicine, Hongo, Tokyo 113 0033, Japan
    J Comp Neurol 443:383-7. 2002
    ..These results suggest that expression of AR in motoneurons of the SNB in aged male rats is up-regulated in response to androgen and that androgen may be, at least in part, involved in the process of aging of the SNB in male rats...
  34. pmc MHC class I and class II molecules are expressed in both human and mouse prostate tumor microenvironment
    Navreet K Nanda
    Department of Microbiology, Georgetown University Medical Center, Washington, District of Columbia, USA
    Prostate 66:1275-84. 2006
    ..Using newer anti-MHC class I and MHC class II antibody reagents, we re-examined the expression of MHC in both human and mouse prostate tumors and their microenvironments...

Research Grants27

  1. Development Estrogenization of the Rat Prostate Gland
    Gail Prins; Fiscal Year: 2007
    ..Results will further define the mechanisms of estrogen's actions on the prostate gland during early development and lead to a better understanding of the hormonal and developmental basis for abnormal prostate growth with aging...
  2. Epigenetic Basis for Prostate Carcinogenesis following Early Estrogenic Exposures
    Gail Prins; Fiscal Year: 2009
    ..In Aim 3, we will directly test whether the genes epigenetically modified by estrogenic exposures play an active role in prostate gland carcinogenesis using a variety of in vitro and in vivo studies. ..
  3. Epigenetic Basis for Prostate Carcinogenesis following Early Estrogenic Exposures
    GAIL S contact PRINS; Fiscal Year: 2010
    ..In Aim 3, we will directly test whether the genes epigenetically modified by estrogenic exposures play an active role in prostate gland carcinogenesis using a variety of in vitro and in vivo studies. ..
  4. Epigenetic Basis for Prostate Carcinogenesis following Early Estrogenic Exposures
    Gail Prins; Fiscal Year: 2009
    ..In Aim 3, we will directly test whether the genes epigenetically modified by estrogenic exposures play an active role in prostate gland carcinogenesis using a variety of in vitro and in vivo studies. ..
  5. Epigenetic Basis for Prostate Carcinogenesis following Early Estrogenic Exposures
    Shuk Mei Ho; Fiscal Year: 2011
    ..In Aim 3, we will directly test whether the genes epigenetically modified by estrogenic exposures play an active role in prostate gland carcinogenesis using a variety of in vitro and in vivo studies. ..
  6. ESTROGEN IMPRINTING OF PROSTATE GLAND VIA METHYLATON
    Gail Prins; Fiscal Year: 2005
    ....
  7. DEVELOPMENTAL ESTROGENIZATION OF RAT PROSTATE
    Gail Prins; Fiscal Year: 2004
    ....
  8. DEVELOPMENTAL ESTROGENIZATION OF THE RAT PROSTATE
    Gail Prins; Fiscal Year: 1999
    ....
  9. Development Estrogenization of the Rat Prostate Gland
    Gail S Prins; Fiscal Year: 2010
    ..Results will further define the mechanisms of estrogen's actions on the prostate gland during early development and lead to a better understanding of the hormonal and developmental basis for abnormal prostate growth with aging...