Mark N Prichard
Affiliation: University of Alabama at Birmingham
- Prichard M, Williams A, Keith K, Harden E, Kern E. Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs. Antiviral Res. 2006;71:1-6 pubmed..Additional screening against orthopoxviruses will be required to identify nucleoside analogs that are efficiently activated by their type II TK...
- Prichard M, Keith K, Johnson M, Harden E, McBrayer A, Luo M, et al. Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase. Antimicrob Agents Chemother. 2007;51:1795-803 pubmed..This unexpected result suggests that selective phosphorylation by the viral kinase may be a promising new approach in the discovery of highly selective inhibitors of orthopoxvirus replication. ..
- Prichard M, Kern E, Quenelle D, Keith K, Moyer R, Turner P. Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine. Virol J. 2008;5:39 pubmed publisher..The recombinant virus is hypersensitive to (N)-methanocarbathymidine and may reflect metabolic differences in the mutant virus. ..
- Prichard M, Sztul E, Daily S, Perry A, Frederick S, Gill R, et al. Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes. J Virol. 2008;82:5054-67 pubmed publisher..These data also suggest a potential link between RB function and the formation of aggresomes. ..
- Prichard M, Kern E. Orthopoxvirus targets for the development of new antiviral agents. Antiviral Res. 2012;94:111-25 pubmed publisher..Progress that has been achieved in recent years should yield new drugs for the treatment of these infections and might also reveal new approaches for antiviral drug development with other viruses. ..