Theodore J Price

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi ZIPping to pain relief: the role (or not) of PKMζ in chronic pain
    Theodore J Price
    Department of Pharmacology, The University of Arizona School of Medicine, Arizona, USA
    Mol Pain 9:6. 2013
  2. ncbi Fragile X mental retardation protein (FMRP) and the spinal sensory system
    Theodore J Price
    Department of Pharmacology, The University of Arizona School of Medicine, Tucson, AZ, USA
    Results Probl Cell Differ 54:41-59. 2012
  3. ncbi Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR
    Theodore J Price
    McGill University, Anesthesia Research Unit, Faculty of Dentistry and McGill Centre for Research on Pain, Montreal, Quebec, Canada H3G 1Y6
    J Neurosci 27:13958-67. 2007
  4. ncbi Chloride regulation in the pain pathway
    Theodore J Price
    University of Arizona, Department of Pharmacology, USA
    Brain Res Rev 60:149-70. 2009
  5. ncbi Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology
    Theodore J Price
    The University of Arizona, School of Medicine, Department of Pharmacology, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Eur J Neurosci 29:2253-63. 2009
  6. ncbi Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization
    Marina N Asiedu
    Department of Pharmacology, The University of Arizona College of Medicine, Tucson, AZ 85721, USA
    J Neurosci 31:6646-53. 2011
  7. ncbi Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain
    Ohannes K Melemedjian
    Department of Pharmacology, University of Arizona, N Campbell Ave, Tucson, 85724, USA
    Mol Pain 7:70. 2011
  8. ncbi Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain
    Dipti V Tillu
    Department of Pharmacology, University of Arizona, 1501 N Campbell Ave, PO Box 245050, Tucson, AZ 85724, USA
    Mol Pain 8:5. 2012
  9. ncbi Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain
    Tamara King
    Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA
    Pain 153:1263-73. 2012
  10. ncbi Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering
    Andrea N Flynn
    2Department of Physiology, Arizona Respiratory Center, Arizona Health Sciences Center, 1501 N Campbell Ave, Tucson, AZ 85724 5030, USA
    FASEB J 27:1498-510. 2013

Research Grants

  1. Axonal translation as a novel mechanism of nociceptor plasticity
    Theodore J Price; Fiscal Year: 2010
  2. Chloride cation co-transporters and hyperalgesic states
    THEODORE PRICE; Fiscal Year: 2007

Collaborators

Detail Information

Publications26

  1. ncbi ZIPping to pain relief: the role (or not) of PKMζ in chronic pain
    Theodore J Price
    Department of Pharmacology, The University of Arizona School of Medicine, Arizona, USA
    Mol Pain 9:6. 2013
    ....
  2. ncbi Fragile X mental retardation protein (FMRP) and the spinal sensory system
    Theodore J Price
    Department of Pharmacology, The University of Arizona School of Medicine, Tucson, AZ, USA
    Results Probl Cell Differ 54:41-59. 2012
    ....
  3. ncbi Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR
    Theodore J Price
    McGill University, Anesthesia Research Unit, Faculty of Dentistry and McGill Centre for Research on Pain, Montreal, Quebec, Canada H3G 1Y6
    J Neurosci 27:13958-67. 2007
    ..These observations also support the hypothesis that the persistence of self-injurious behavior observed in fragile X mental retardation patients could be related to deficits in nociceptive sensitization...
  4. ncbi Chloride regulation in the pain pathway
    Theodore J Price
    University of Arizona, Department of Pharmacology, USA
    Brain Res Rev 60:149-70. 2009
    ....
  5. ncbi Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology
    Theodore J Price
    The University of Arizona, School of Medicine, Department of Pharmacology, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Eur J Neurosci 29:2253-63. 2009
    ..We believe that an increased understanding of this process will lead to the identification of novel targets for the treatment of chronic pain...
  6. ncbi Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization
    Marina N Asiedu
    Department of Pharmacology, The University of Arizona College of Medicine, Tucson, AZ 85721, USA
    J Neurosci 31:6646-53. 2011
    ....
  7. ncbi Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain
    Ohannes K Melemedjian
    Department of Pharmacology, University of Arizona, N Campbell Ave, Tucson, 85724, USA
    Mol Pain 7:70. 2011
    ..Therefore, injury-induced dysregulation of translation control underlies pathology leading to neuropathic pain and reveals AMPK as a novel therapeutic target for the potential treatment of neuropathic pain...
  8. ncbi Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain
    Dipti V Tillu
    Department of Pharmacology, University of Arizona, 1501 N Campbell Ave, PO Box 245050, Tucson, AZ 85724, USA
    Mol Pain 8:5. 2012
    ....
  9. ncbi Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain
    Tamara King
    Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA
    Pain 153:1263-73. 2012
    ..In the spinal cord, however, both PKMζ-dependent and independent mechanisms contribute to amplification of evoked responses, but apparently not spontaneous pain...
  10. ncbi Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering
    Andrea N Flynn
    2Department of Physiology, Arizona Respiratory Center, Arizona Health Sciences Center, 1501 N Campbell Ave, Tucson, AZ 85724 5030, USA
    FASEB J 27:1498-510. 2013
    ..Flynn, A. N., Hoffman, J., Tillu, D. V., Sherwood, C. L., Zhang, Z., Patek, R., Asiedu, M. N. K., Vagner, J., Price, T. J., Boitano, S. Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering...
  11. ncbi Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain
    Milena De Felice
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Pain 152:2701-9. 2011
    ..Engagement of descending inhibition protects in the transition from acute to chronic pain. These unexpected findings might provide a mechanistic explanation for medications that engage descending inhibition or mimic its consequences...
  12. ncbi Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice
    Marina N Asiedu
    Department of Pharmacology, The University of Arizona School of Medicine, Tucson, AZ 85724, USA
    J Pain 13:546-54. 2012
    ..PERSPECTIVE: Our work suggests that drug discovery efforts for the treatment of chronic pain disorders should target benzodiazepine or ∂-subunit-containing sites at the GABA(A) complex...
  13. ncbi BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state
    Ohannes K Melemedjian
    Department of Pharmacology, The University of Arizona School of Medicine, Tucson, AZ, USA
    Mol Pain 9:12. 2013
    ..Here we have tested the hypothesis that brain derived neurotrophic factor (BDNF) regulates PKMζ, and possibly other aPKCs, to maintain a centralized chronic pain state...
  14. ncbi Lanthanide labeling of a potent protease activated receptor-2 agonist for time-resolved fluorescence analysis
    Justin Hoffman
    Department of Physiology, Arizona Health Sciences Center, 1501 North Campbell Avenue, Tucson, AZ 85724 5030, USA
    Bioconjug Chem 23:2098-104. 2012
    ..This ligand can serve as a critical tool in the screening and development of PAR(2) ligands...
  15. ncbi Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6)
    Jin Yan
    Department of Pharmacology, University of Arizona College of Medicine, 1501 N Campbell Ave, PO Box 245050, Tucson, AZ 85724, USA
    Mol Pain 8:6. 2012
    ..Intracranial interleukin-6 (IL-6) levels have been shown to be elevated during migraine attacks, suggesting that this cytokine may facilitate pain signaling from the meninges and contribute to the development of headache...
  16. ncbi IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex
    Ohannes K Melemedjian
    Department of Pharmacology, University of Arizona School of Medicine, Tucson, Arizona 85724, USA
    J Neurosci 30:15113-23. 2010
    ..These results establish IL-6- and NGF-mediated cap-dependent translation of local proteins as a new model for nociceptive plasticity...
  17. ncbi Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse
    Theodore J Price
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio San Antonio, TX, USA
    J Pain 8:263-72. 2007
    ..Taken together, the present findings dictate prudence when extrapolating experimental conclusions about the neurochemical classification of neurons between sensory ganglia or between species, including humans...
  18. ncbi Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia
    Mark H Pitcher
    McGill University, Anesthesia Research Unit, Faculty of Medicine, Faculty of Dentistry and McGill Centre for Research on Pain, Montreal, QC, Canada
    Mol Pain 3:17. 2007
    ..TRPV1 receptors transduce diverse chemical and natural stimuli in nociceptors and are critical for inflammatory hyperalgesia...
  19. ncbi Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist
    Marina Vardanyan
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Pain 151:257-65. 2010
    ..Strategies targeting IL-6 actions through small molecule antagonists may offer novel approaches to improve the therapy of chronic pancreatitis and other chronic pain states...
  20. ncbi The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl-LIGRL-NH2 and 6-aminonicotinyl-LIGRL-NH2 stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo
    Andrea N Flynn
    Department of Physiology, BIO5 Collaborative Research Institute, Arizona Respiratory Center, Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    J Biol Chem 286:19076-88. 2011
    ..We have characterized three high potency ligands that can be used to explore the physiological role of PAR(2) in a variety of systems and pathologies...
  21. ncbi Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment
    Ohannes K Melemedjian
    Department of Pharmacology, The University of Arizona School of Medicine, 1501 N Campbell Ave, Tucson, AZ, 85724, USA
    Mol Pain 9:14. 2013
    ....
  22. ncbi Protein expression and mRNA cellular distribution of the NKCC1 cotransporter in the dorsal root and trigeminal ganglia of the rat
    Theodore J Price
    McGill University, Departments of Anesthesia and Dentistry and McGill Centre for Research on Pain, 3655 Prom Sir William Osler, Montreal, QC, Canada H3G 1Y6
    Brain Res 1112:146-58. 2006
    ..Moreover, these results suggest the possibility of a functional role of NKCC1 in the glial cells closely apposed to primary sensory afferents...
  23. ncbi Acetazolamide and midazolam act synergistically to inhibit neuropathic pain
    Marina Asiedu
    The University of Arizona School of Medicine, Department of Pharmacology, Tucson, AZ 85724, USA
    Pain 148:302-8. 2010
    ..These findings indicate that the combined use of CA inhibitors and benzodiazepines may be effective in the clinical management of neuropathic pain in humans...
  24. ncbi The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin
    Amol M Patwardhan
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 103:11393-8. 2006
    ..Collectively, these data demonstrate that cannabinoids such as WIN directly inhibit TRPV1 functional activities via a calcineurin pathway that represents a mechanism of cannabinoid actions at peripheral sites...
  25. ncbi Pharmacological interactions between calcium/calmodulin-dependent kinase II alpha and TRPV1 receptors in rat trigeminal sensory neurons
    Theodore J Price
    The University of Texas Health Science Center at San Antonio, Department of Endodontics, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Neurosci Lett 389:94-8. 2005
    ....
  26. ncbi Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia
    Theodore J Price
    Anesthesia Research Unit (Faculty of Medicine, Faculty of Dentistry and McGill Center for Pain Research. McGill University, , , Canada
    Curr Top Med Chem 5:547-55. 2005
    ..Pharmacological targeting of these cation chloride cotransporters to restore normal GABA-/glycinergic transmission in the spinal cord represents an entirely novel approach to the development of analgesics...

Research Grants2

  1. Axonal translation as a novel mechanism of nociceptor plasticity
    Theodore J Price; Fiscal Year: 2010
    ....
  2. Chloride cation co-transporters and hyperalgesic states
    THEODORE PRICE; Fiscal Year: 2007
    ..These hypotheses comprise an integrated series of studies that test hypotheses concerning Abeta-fiber driven pain leading to possible therapeutic strategies for the alleviation of inflammatory pain. ..