Theodore J Price

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc AMPK: An emerging target for modification of injury-induced pain plasticity
    Theodore J Price
    Department of Pharmacology, The University of Arizona School of Medicine, United States Bio5 Institute, The University of Arizona School of Medicine, United States Graduate Interdisciplinary Program in Neuroscience, The University of Arizona School of Medicine, United States Electronic address
    Neurosci Lett 557:9-18. 2013
  2. pmc ZIPping to pain relief: the role (or not) of PKMζ in chronic pain
    Theodore J Price
    Department of Pharmacology, The University of Arizona School of Medicine, Arizona, USA
    Mol Pain 9:6. 2013
  3. pmc Fragile X mental retardation protein (FMRP) and the spinal sensory system
    Theodore J Price
    Department of Pharmacology, The University of Arizona School of Medicine, Tucson, AZ, USA
    Results Probl Cell Differ 54:41-59. 2012
  4. pmc Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology
    Theodore J Price
    The University of Arizona, School of Medicine, Department of Pharmacology, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Eur J Neurosci 29:2253-63. 2009
  5. pmc Chloride regulation in the pain pathway
    Theodore J Price
    University of Arizona, Department of Pharmacology, USA
    Brain Res Rev 60:149-70. 2009
  6. pmc Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR
    Theodore J Price
    McGill University, Anesthesia Research Unit, Faculty of Dentistry and McGill Centre for Research on Pain, Montreal, Quebec, Canada H3G 1Y6
    J Neurosci 27:13958-67. 2007
  7. pmc Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization
    Marina N Asiedu
    Department of Pharmacology, The University of Arizona College of Medicine, Tucson, AZ 85721, USA
    J Neurosci 31:6646-53. 2011
  8. pmc Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering
    Andrea N Flynn
    Department of Physiology, Arizona Health Sciences Center, Tucson, AZ 85724 5030, USA
    FASEB J 27:1498-510. 2013
  9. pmc BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state
    Ohannes K Melemedjian
    Department of Pharmacology, The University of Arizona School of Medicine, Tucson, AZ, USA
    Mol Pain 9:12. 2013
  10. pmc Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain
    Ohannes K Melemedjian
    Department of Pharmacology, University of Arizona, N Campbell Ave, Tucson, 85724, USA
    Mol Pain 7:70. 2011

Research Grants

Collaborators

Detail Information

Publications33

  1. pmc AMPK: An emerging target for modification of injury-induced pain plasticity
    Theodore J Price
    Department of Pharmacology, The University of Arizona School of Medicine, United States Bio5 Institute, The University of Arizona School of Medicine, United States Graduate Interdisciplinary Program in Neuroscience, The University of Arizona School of Medicine, United States Electronic address
    Neurosci Lett 557:9-18. 2013
    ..Altogether, the physiology, pharmacology and therapeutic opportunities surrounding AMPK make it an attractive target for novel intervention for chronic pain and its prevention...
  2. pmc ZIPping to pain relief: the role (or not) of PKMζ in chronic pain
    Theodore J Price
    Department of Pharmacology, The University of Arizona School of Medicine, Arizona, USA
    Mol Pain 9:6. 2013
    ....
  3. pmc Fragile X mental retardation protein (FMRP) and the spinal sensory system
    Theodore J Price
    Department of Pharmacology, The University of Arizona School of Medicine, Tucson, AZ, USA
    Results Probl Cell Differ 54:41-59. 2012
    ....
  4. pmc Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology
    Theodore J Price
    The University of Arizona, School of Medicine, Department of Pharmacology, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Eur J Neurosci 29:2253-63. 2009
    ..We believe that an increased understanding of this process will lead to the identification of novel targets for the treatment of chronic pain...
  5. pmc Chloride regulation in the pain pathway
    Theodore J Price
    University of Arizona, Department of Pharmacology, USA
    Brain Res Rev 60:149-70. 2009
    ....
  6. pmc Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR
    Theodore J Price
    McGill University, Anesthesia Research Unit, Faculty of Dentistry and McGill Centre for Research on Pain, Montreal, Quebec, Canada H3G 1Y6
    J Neurosci 27:13958-67. 2007
    ..These observations also support the hypothesis that the persistence of self-injurious behavior observed in fragile X mental retardation patients could be related to deficits in nociceptive sensitization...
  7. pmc Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization
    Marina N Asiedu
    Department of Pharmacology, The University of Arizona College of Medicine, Tucson, AZ 85721, USA
    J Neurosci 31:6646-53. 2011
    ....
  8. pmc Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering
    Andrea N Flynn
    Department of Physiology, Arizona Health Sciences Center, Tucson, AZ 85724 5030, USA
    FASEB J 27:1498-510. 2013
    ..Our results demonstrate that the STL approach is a powerful tool for increasing ligand potency at PAR₂ and represent opportunities for drug development at other protease activated receptors and across GPCRs...
  9. pmc BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state
    Ohannes K Melemedjian
    Department of Pharmacology, The University of Arizona School of Medicine, Tucson, AZ, USA
    Mol Pain 9:12. 2013
    ..Here we have tested the hypothesis that brain derived neurotrophic factor (BDNF) regulates PKMζ, and possibly other aPKCs, to maintain a centralized chronic pain state...
  10. pmc Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain
    Ohannes K Melemedjian
    Department of Pharmacology, University of Arizona, N Campbell Ave, Tucson, 85724, USA
    Mol Pain 7:70. 2011
    ..Therefore, injury-induced dysregulation of translation control underlies pathology leading to neuropathic pain and reveals AMPK as a novel therapeutic target for the potential treatment of neuropathic pain...
  11. pmc The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl-LIGRL-NH2 and 6-aminonicotinyl-LIGRL-NH2 stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo
    Andrea N Flynn
    Department of Physiology, BIO5 Collaborative Research Institute, Arizona Respiratory Center, Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    J Biol Chem 286:19076-88. 2011
    ..We have characterized three high potency ligands that can be used to explore the physiological role of PAR(2) in a variety of systems and pathologies...
  12. pmc Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain
    Tamara King
    Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA
    Pain 153:1263-73. 2012
    ..In the spinal cord, however, both PKMζ-dependent and independent mechanisms contribute to amplification of evoked responses, but apparently not spontaneous pain...
  13. pmc Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain
    Dipti V Tillu
    Department of Pharmacology, University of Arizona, 1501 N Campbell Ave, PO Box 245050, Tucson, AZ 85724, USA
    Mol Pain 8:5. 2012
    ....
  14. pmc mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK
    Ohannes K Melemedjian
    Department of Pharmacology, University of Arizona, Tucson, AZ, USA
    Pain 154:1080-91. 2013
    ..Our findings highlight the physiological relevance of feedback signaling through mTORC1 inhibition and have important implications for development of pain therapeutics that target the mTOR pathway...
  15. pmc Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice
    Marina N Asiedu
    Department of Pharmacology, The University of Arizona School of Medicine, Tucson, AZ 85724, USA
    J Pain 13:546-54. 2012
    ..These results indicate that the KCC2-dependent Cl(-) extrusion capacity differentially regulates the analgesic efficacy of agonists and allosteric modulators at the GABA(A) receptor complex...
  16. pmc Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6)
    Jin Yan
    Department of Pharmacology, University of Arizona College of Medicine, 1501 N Campbell Ave, PO Box 245050, Tucson, AZ 85724, USA
    Mol Pain 8:6. 2012
    ..Intracranial interleukin-6 (IL-6) levels have been shown to be elevated during migraine attacks, suggesting that this cytokine may facilitate pain signaling from the meninges and contribute to the development of headache...
  17. pmc Lanthanide labeling of a potent protease activated receptor-2 agonist for time-resolved fluorescence analysis
    Justin Hoffman
    Department of Physiology, Arizona Health Sciences Center, 1501 North Campbell Avenue, Tucson, AZ 85724 5030, USA
    Bioconjug Chem 23:2098-104. 2012
    ..This ligand can serve as a critical tool in the screening and development of PAR(2) ligands...
  18. pmc Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain
    Milena De Felice
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Pain 152:2701-9. 2011
    ..Engagement of descending inhibition protects in the transition from acute to chronic pain. These unexpected findings might provide a mechanistic explanation for medications that engage descending inhibition or mimic its consequences...
  19. pmc Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice
    Yael Kusne
    Neuroscience Graduate Program, Arizona State University, Phoenix, AZ, 85287, USA
    Age (Dordr) 36:199-212. 2014
    ..These results underscore the importance of screening individual mTOR inhibitors on different organs and physiological processes for potential adverse effects that may compromise health span. ..
  20. pmc Competing molecular interactions of aPKC isoforms regulate neuronal polarity
    Sara S Parker
    Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 110:14450-5. 2013
    ..In contrast, the overexpression of PKM-ζ prevents axon specification. Our studies suggest a molecular model wherein mutually antagonistic intermolecular competition between aPKC isoforms directs the establishment of neuronal polarity. ..
  21. pmc Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia
    Theodore J Price
    Anesthesia Research Unit Faculty of Medicine, Faculty of Dentistry and McGill Center for Pain Research McGill University, Montreal, Quebec, Canada
    Curr Top Med Chem 5:547-55. 2005
    ..Pharmacological targeting of these cation chloride cotransporters to restore normal GABA-/glycinergic transmission in the spinal cord represents an entirely novel approach to the development of analgesics...
  22. pmc IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex
    Ohannes K Melemedjian
    Department of Pharmacology, University of Arizona School of Medicine, Tucson, Arizona 85724, USA
    J Neurosci 30:15113-23. 2010
    ..These results establish IL-6- and NGF-mediated cap-dependent translation of local proteins as a new model for nociceptive plasticity...
  23. pmc Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse
    Theodore J Price
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio San Antonio, TX, USA
    J Pain 8:263-72. 2007
    ..Thus, whereas only an approximately 10% overlap was observed in TG neurons of mouse, significantly greater overlap (approximately 35%) was observed in those of rat...
  24. pmc Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist
    Marina Vardanyan
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Pain 151:257-65. 2010
    ..Strategies targeting IL-6 actions through small molecule antagonists may offer novel approaches to improve the therapy of chronic pancreatitis and other chronic pain states...
  25. pmc Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia
    Mark H Pitcher
    McGill University, Anesthesia Research Unit, Faculty of Medicine, Faculty of Dentistry and McGill Centre for Research on Pain, Montreal, QC, Canada
    Mol Pain 3:17. 2007
    ..TRPV1 receptors transduce diverse chemical and natural stimuli in nociceptors and are critical for inflammatory hyperalgesia...
  26. doi request reprint Inhibition of Carbonic Anhydrase Augments GABAA Receptor-Mediated Analgesia via a Spinal Mechanism of Action
    Marina N Asiedu
    Department of Pharmacology, The University of Arizona School of Medicine, Tucson, Arizona
    J Pain 15:395-406. 2014
    ..We suggest that carbonic anhydrase inhibitors, many of which are clinically available, might be advantageously employed for the treatment of pathologic pain states...
  27. pmc Protein expression and mRNA cellular distribution of the NKCC1 cotransporter in the dorsal root and trigeminal ganglia of the rat
    Theodore J Price
    McGill University, Departments of Anesthesia and Dentistry and McGill Centre for Research on Pain, 3655 Prom Sir William Osler, Montreal, QC, Canada H3G 1Y6
    Brain Res 1112:146-58. 2006
    ..Moreover, these results suggest the possibility of a functional role of NKCC1 in the glial cells closely apposed to primary sensory afferents...
  28. pmc Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment
    Ohannes K Melemedjian
    Department of Pharmacology, The University of Arizona School of Medicine, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Mol Pain 9:14. 2013
    ....
  29. doi request reprint Bidirectional regulation of P body formation mediated by eIF4F complex formation in sensory neurons
    Ohannes K Melemedjian
    Department of Pharmacology, University of Arizona, Tucson, AZ, United States Electronic address
    Neurosci Lett 563:169-74. 2014
    ..These studies indicate that P body formation is intricately linked to cap-dependent translation in mammalian sensory neurons suggesting an important role for these organelles in the regulation of mRNA metabolism in the adult PNS. ..
  30. pmc Potent agonists of the protease activated receptor 2 (PAR2)
    Scott Boitano
    Arizona Respiratory Center and Department of Physiology, University of Arizona, 1501 N Campbell Avenue, Tucson, Arizona 85724, United States
    J Med Chem 54:1308-13. 2011
    ..Together these will lead to discovery of more potent agonists and antagonists of PAR(2)...
  31. pmc The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin
    Amol M Patwardhan
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 103:11393-8. 2006
    ..Collectively, these data demonstrate that cannabinoids such as WIN directly inhibit TRPV1 functional activities via a calcineurin pathway that represents a mechanism of cannabinoid actions at peripheral sites...
  32. pmc Acetazolamide and midazolam act synergistically to inhibit neuropathic pain
    Marina Asiedu
    The University of Arizona School of Medicine, Department of Pharmacology, Tucson, AZ 85724, USA
    Pain 148:302-8. 2010
    ..These findings indicate that the combined use of CA inhibitors and benzodiazepines may be effective in the clinical management of neuropathic pain in humans...
  33. pmc Pharmacological interactions between calcium/calmodulin-dependent kinase II alpha and TRPV1 receptors in rat trigeminal sensory neurons
    Theodore J Price
    The University of Texas Health Science Center at San Antonio, Department of Endodontics, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Neurosci Lett 389:94-8. 2005
    ....

Research Grants2

  1. Axonal translation as a novel mechanism of nociceptor plasticity
    Theodore J Price; Fiscal Year: 2010
    ....
  2. Chloride cation co-transporters and hyperalgesic states
    THEODORE PRICE; Fiscal Year: 2007
    ..These hypotheses comprise an integrated series of studies that test hypotheses concerning Abeta-fiber driven pain leading to possible therapeutic strategies for the alleviation of inflammatory pain. ..