Paul Price

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Minerals form a continuum phase in mature cancellous bone
    Po Yu Chen
    Materials Science and Engineering Program, Department of Mechanical and Aerospace Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0411, USA
    Calcif Tissue Int 88:351-61. 2011
  2. pmc YKL-40 tissue expression and plasma levels in patients with ovarian cancer
    Estrid V S Høgdall
    Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    BMC Cancer 9:8. 2009
  3. ncbi request reprint Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves
    P A Price
    Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
    Arterioscler Thromb Vasc Biol 18:1400-7. 1998
  4. ncbi request reprint Evidence for a serum factor that initiates the re-calcification of demineralized bone
    Paul A Price
    Division of Biology, University of California, San Diego, La Jolla, California 92093 0368, USA
    J Biol Chem 279:19169-80. 2004
  5. ncbi request reprint The elastic lamellae of devitalized arteries calcify when incubated in serum: evidence for a serum calcification factor
    Paul A Price
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0368, USA
    Arterioscler Thromb Vasc Biol 26:1079-85. 2006
  6. ncbi request reprint Artery calcification in uremic rats is increased by a low protein diet and prevented by treatment with ibandronate
    P A Price
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0368, USA
    Kidney Int 70:1577-83. 2006
  7. ncbi request reprint The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complex
    Paul A Price
    Division of Biology, University of California San Diego, La Jolla, CA 92093 0368, USA
    J Biol Chem 278:22144-52. 2003
  8. ncbi request reprint Biochemical characterization of the serum fetuin-mineral complex
    Paul A Price
    Division of Biology 0368, University of California San Diego, La Jolla, CA 92093 0368, USA
    J Biol Chem 278:22153-60. 2003
  9. doi request reprint Tissue-nonspecific alkaline phosphatase is required for the calcification of collagen in serum: a possible mechanism for biomineralization
    Paul A Price
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0368, USA
    J Biol Chem 284:4594-604. 2009
  10. ncbi request reprint The amino bisphosphonate ibandronate prevents calciphylaxis in the rat at doses that inhibit bone resorption
    P A Price
    Division of Biology, 0368, University of California, San Diego, La Jolla, CA 92093 0368, USA
    Calcif Tissue Int 71:356-63. 2002

Collaborators

Detail Information

Publications44

  1. pmc Minerals form a continuum phase in mature cancellous bone
    Po Yu Chen
    Materials Science and Engineering Program, Department of Mechanical and Aerospace Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0411, USA
    Calcif Tissue Int 88:351-61. 2011
    ..Results were compared with commercially available heat-deproteinized bone (Bio-Oss(®)), and evidence showed consistency in bone mineral structure. A two-phase interpenetrating composite model of mature bone is proposed and discussed...
  2. pmc YKL-40 tissue expression and plasma levels in patients with ovarian cancer
    Estrid V S Høgdall
    Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    BMC Cancer 9:8. 2009
    ..The aim of the study was to determine the expression of YKL-40 in tumor tissue and plasma in patients with borderline ovarian tumor or epithelial ovarian cancer (OC), and investigate prognostic value of this marker...
  3. ncbi request reprint Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves
    P A Price
    Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
    Arterioscler Thromb Vasc Biol 18:1400-7. 1998
    ..The results indicate that the improved warfarin plus vitamin K treatment protocol developed in this study should provide a useful model to investigate the role of MGP in preventing calcification of arteries and heart valves...
  4. ncbi request reprint Evidence for a serum factor that initiates the re-calcification of demineralized bone
    Paul A Price
    Division of Biology, University of California, San Diego, La Jolla, California 92093 0368, USA
    J Biol Chem 279:19169-80. 2004
    ..The speed, matrix-type specificity, and extent of the serum-induced re-calcification of demineralized bone suggest that the serum calcification factor identified in these studies may participate in the normal calcification of bone...
  5. ncbi request reprint The elastic lamellae of devitalized arteries calcify when incubated in serum: evidence for a serum calcification factor
    Paul A Price
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0368, USA
    Arterioscler Thromb Vasc Biol 26:1079-85. 2006
    ..To determine whether serum contains an activity that induces artery calcification...
  6. ncbi request reprint Artery calcification in uremic rats is increased by a low protein diet and prevented by treatment with ibandronate
    P A Price
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0368, USA
    Kidney Int 70:1577-83. 2006
    ..5% protein diet containing 0.75% adenine produces consistent and dramatic medial calcification in adult rats within just 4 weeks...
  7. ncbi request reprint The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complex
    Paul A Price
    Division of Biology, University of California San Diego, La Jolla, CA 92093 0368, USA
    J Biol Chem 278:22144-52. 2003
    ..The complex found at 24 h to 14 days is identical to the fetuin-mineral complex found in the serum of etidronate-treated rats, whereas the complex found between 1 and 20 h is less stable...
  8. ncbi request reprint Biochemical characterization of the serum fetuin-mineral complex
    Paul A Price
    Division of Biology 0368, University of California San Diego, La Jolla, CA 92093 0368, USA
    J Biol Chem 278:22153-60. 2003
    ..Exogenous spp24 associated strongly with the FMC when added to serum containing it. These observations suggest that spp24 may, like fetuin and MGP, play a role in inhibiting calcification...
  9. doi request reprint Tissue-nonspecific alkaline phosphatase is required for the calcification of collagen in serum: a possible mechanism for biomineralization
    Paul A Price
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0368, USA
    J Biol Chem 284:4594-604. 2009
    ..4) A large protein (fetuin) that selectively inhibits growth of crystals remaining in solution, thereby ensuring that only crystals within fibrils grow ( Toroian, D. T., and Price, P. A. (2008) Calcif. Tissue Int. 82, 116-126 )...
  10. ncbi request reprint The amino bisphosphonate ibandronate prevents calciphylaxis in the rat at doses that inhibit bone resorption
    P A Price
    Division of Biology, 0368, University of California, San Diego, La Jolla, CA 92093 0368, USA
    Calcif Tissue Int 71:356-63. 2002
    ....
  11. pmc Mineralization by inhibitor exclusion: the calcification of collagen with fetuin
    Paul A Price
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0368, USA
    J Biol Chem 284:17092-101. 2009
    ..Future studies will be needed to evaluate the possible role of this mechanism in bone mineralization...
  12. ncbi request reprint SB 242784, a selective inhibitor of the osteoclastic V-H+ATPase, inhibits arterial calcification in the rat
    Paul A Price
    Department of Biology, University of California, San Diego, La Jolla, Calif 92093 0368, USA
    Circ Res 91:547-52. 2002
    ....
  13. ncbi request reprint The amino bisphosphonate ibandronate prevents vitamin D toxicity and inhibits vitamin D-induced calcification of arteries, cartilage, lungs and kidneys in rats
    P A Price
    Division of Biology, University of California, San Diego, La Jolla, CA 92093 0368, USA
    J Nutr 131:2910-5. 2001
    ....
  14. ncbi request reprint Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D
    P A Price
    Division of Biology, University of California, San Diego, La Jolla, USA
    Arterioscler Thromb Vasc Biol 21:1610-6. 2001
    ..These results support the hypothesis that arterial calcification is linked to bone resorption...
  15. ncbi request reprint Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption
    P A Price
    Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
    Arterioscler Thromb Vasc Biol 21:817-24. 2001
    ..These results support the hypothesis that artery calcification is linked to bone resorption. The mechanism of this linkage remains to be established, however, and an alternative explanation for the present results is also considered...
  16. ncbi request reprint Warfarin-induced artery calcification is accelerated by growth and vitamin D
    P A Price
    Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
    Arterioscler Thromb Vasc Biol 20:317-27. 2000
    ..These observations indicate that although the gamma-carboxyglutamate residues of matrix Gla protein are apparently required for its function as a calcification inhibitor, they are not required for its accumulation at calcification sites...
  17. ncbi request reprint Serum levels of the fetuin-mineral complex correlate with artery calcification in the rat
    Paul A Price
    Division of Biology, University of California, La Jolla, CA 92093 0368, USA
    J Biol Chem 279:1594-600. 2004
    ....
  18. ncbi request reprint Bone origin of the serum complex of calcium, phosphate, fetuin, and matrix Gla protein: biochemical evidence for the cancellous bone-remodeling compartment
    Paul A Price
    Division of Biology, University of California, San Diego, La Jolla 92093 0368, USA
    J Bone Miner Res 17:1171-9. 2002
    ....
  19. ncbi request reprint The size exclusion characteristics of type I collagen: implications for the role of noncollagenous bone constituents in mineralization
    Damon Toroian
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0368, USA
    J Biol Chem 282:22437-47. 2007
    ....
  20. ncbi request reprint Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated rats
    Paul A Price
    Division of Biology, University of California, San Diego, La Jolla, California 92093 0368, USA
    J Biol Chem 277:3926-34. 2002
    ....
  21. pmc Fetuin-A and BMD in older persons: the Health Aging and Body Composition (Health ABC) study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    J Bone Miner Res 24:514-21. 2009
    ..Future studies should evaluate whether fetuin-A may refine fracture risk assessment in older women...
  22. ncbi request reprint The essential role of fetuin in the serum-induced calcification of collagen
    Damon Toroian
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0368, USA
    Calcif Tissue Int 82:116-26. 2008
    ....
  23. ncbi request reprint Structural evidence of a fourth Gla residue in fish osteocalcin: biological implications
    Carlos Frazao
    ITQB UNL, Av da Republica, 2784 505 Oeiras, Portugal
    Biochemistry 44:1234-42. 2005
    ..This further suggests that the known high affinity of osteocalcin for bone mineral may be derived from the clustering of calcium binding sites on this surface of the molecules...
  24. ncbi request reprint Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates
    Vincent Laizé
    Centro de Ciências do Mar CCMar, Universidade do Algarve, 8005 139 Faro, Portugal
    J Biol Chem 280:26659-68. 2005
    ..We also propose a highly specific pattern definition for the Gla domain of BGP and MGP...
  25. pmc Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification
    Christopher J O'Donnell
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 26:2769-74. 2006
    ..Matrix Gla protein (MGP) is an inhibitor of calcification in vivo. However, little is known regarding the distribution of circulating MGP and its associations with CHD risk factors or with CAC in humans...
  26. ncbi request reprint High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer
    Benny Vittrup Jensen
    Department of Oncology, Herlev Hospital, Hvidovre Hospital, University of Copenhagen, DK 2750 Herlev Denmark
    Clin Cancer Res 9:4423-34. 2003
    ....
  27. ncbi request reprint YKL-40 protein expression in the early developing human musculoskeletal system
    Julia S Johansen
    Department of Rheumatology, Q 107, Herlev Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Histochem Cytochem 55:1213-28. 2007
    ..This indicates that YKL-40 is associated with cell proliferation, differentiation, and tissue morphogenesis during development of the human musculoskeletal system...
  28. ncbi request reprint High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival
    Anne Roslind
    Department of Oncology, Herlev Hospital, University of Copenhagen, Denmark
    Int J Cancer 122:857-63. 2008
    ..Immunohistochemical analysis showed YKL-40 expression in the malignant tumor cells. In conclusion, serum YKL-40 was demonstrated to be an independent prognostic biomarker of recurrence-free and overall survival in patients with HNSCC...
  29. ncbi request reprint YKL-40 expression in benign and malignant lesions of the breast: a methodologic study
    Anne Roslind
    Department of Oncology, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Copenhagen, Denmark
    Appl Immunohistochem Mol Morphol 15:371-81. 2007
    ..No nuclear and membrane staining was found. A subpopulation of cells of macrophage morphology in normal breast tissue and in malignant lesions showed strong YKL-40 immunoreactivity...
  30. ncbi request reprint Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity?
    Julia S Johansen
    Department of Rheumatology, Herlev Hospital, University of Copenhagen, Denmark
    Respir Med 99:396-402. 2005
    ....
  31. ncbi request reprint High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival
    Christina Cintin
    Department of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Denmark
    Cancer 95:267-74. 2002
    ..In the current study the authors evaluated the value of serum YKL-40 in monitoring patients with colorectal carcinoma...
  32. ncbi request reprint Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease
    Gitte Kronborg
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    Scand J Infect Dis 34:323-6. 2002
    ..002). In conclusion, high serum levels of YKL40 indicated a poorer prognosis for patients with S. pneumoniae bacteremia...
  33. ncbi request reprint Plasma YKL-40, as a prognostic tumor marker in recurrent ovarian cancer
    Hannah Dehn
    Gynecologic Clinic, The Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark
    Acta Obstet Gynecol Scand 82:287-93. 2003
    ..High serum YKL-40 has been associated with poor prognosis for patients with colorectal and recurrent breast cancer...
  34. ncbi request reprint Changes of biochemical markers of bone turnover and YKL-40 following hormonal treatment for metastatic prostate cancer are related to survival
    Julia S Johansen
    Department of Rheumatology, Herlev Hospital, Denmark
    Clin Cancer Res 13:3244-9. 2007
    ..In this study, we evaluated the value of these biomarkers in monitoring the patients during hormonal treatment...
  35. ncbi request reprint High serum YKL-40 level in patients with small cell lung cancer is related to early death
    Julia S Johansen
    Department of Medicine, Division of Rheumatology Q, Herlev Hospital, Herlev Ringvej 75, Herlev DK 2730, Denmark
    Lung Cancer 46:333-40. 2004
    ..02) is independent of prognostic variables for survival within the first 6 months. Studies are needed to determine the function of YKL-40 in SCLC...
  36. ncbi request reprint High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survival
    Julia S Johansen
    Connective Tissue Laboratory, Department of Rheumatology, H S Hvidovre Hospital, Denmark
    Breast Cancer Res Treat 80:15-21. 2003
    ..Further studies are required to determine the biological function of YKL-40 in breast cancer...
  37. ncbi request reprint Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma
    Klaus Brasso
    Department of Urology, H S Rigshospitalet, University of Copenhagen, Cophenhagen, Denmark
    Prostate 66:503-13. 2006
    ..To examine the prognostic value of markers of bone metabolism (serum PINP, BAP, and CTX-I) and serum YKL-40 in metastatic prostate carcinoma (PC)...
  38. ncbi request reprint Serum YKL-40, a new prognostic biomarker in cancer patients?
    Julia S Johansen
    Department of Rheumatology Q107, Herlev Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Cancer Epidemiol Biomarkers Prev 15:194-202. 2006
    ....
  39. ncbi request reprint High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival
    Estrid V S Høgdall
    Institute of Cancer Epidemiology, Danish Cancer Society, DK 2100 Copenhagen Ø, Denmark
    Oncol Rep 10:1535-8. 2003
    ..In conclusion, plasma levels of YKL-40 proved of prognostic value in stage III OC patients...
  40. ncbi request reprint Identification of an osteocalcin isoform in fish with a large acidic prodomain
    Vincent Laizé
    Centro de Ciencias do Mar, Universidade do Algarve, 8005 139 Faro, Portugal
    J Biol Chem 281:15037-43. 2006
    ....
  41. ncbi request reprint Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease
    Camilla Nøjgaard
    Department of Gastroenterology and Alcohol Unit, Hvidovre Hospital, Hvidovre, Denmark
    J Hepatol 39:179-86. 2003
    ..The aim was to evaluate the prognostic value of serum YKL-40 and PIIINP levels in patients with alcoholic liver disease...
  42. ncbi request reprint Is YKL-40 a new therapeutic target in cancer?
    Julia S Johansen
    Herlev Hospital, University of Copenhagen, Department of Rheumatology Q107, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Expert Opin Ther Targets 11:219-34. 2007
    ..Drugs inhibiting YKL-40 should be explored as new cancer therapeutics...
  43. ncbi request reprint YKL-40 protein expression in normal adult human tissues--an immunohistochemical study
    Merete Ringsholt
    Department of Pathology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    J Mol Histol 38:33-43. 2007
    ..In conclusion, all cells with a functioning nucleus appeared to be capable of expressing YKL-40 in their cytoplasm, the intensity of which was dependent on cellular activity...
  44. doi request reprint Serum levels of YKL-40 increases in patients with acute myocardial infarction
    Camilla Nøjgaard
    Department of Gastroenterology, Hvidovre Hospital, Denmark
    Coron Artery Dis 19:257-63. 2008
    ..The aim was to examine the sequential changes in serum YKL-40 in patients with acute myocardial infarction (AMI), with and without thrombolytic therapy, as compared with patients with stable coronary artery disease (CAD)...

Research Grants20

  1. MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATION
    Paul Price; Fiscal Year: 2001
    ..The investigators will further study the demonstrated ability of MGP to inhibit calcification in supersaturated solutions, and will investigate the ability of MGP to inhibit matrix vesicle -initiated calcification. ..
  2. MATRIX GLA PROTEIN AND ARTERY CALCIFICATION
    Paul Price; Fiscal Year: 2002
    ..These experiments are being done to establish the importance of vitamin K deficiency and of warfarin treatment as risk factors for the calcification of human arteries. ..
  3. Initiation and Inhibition of Medial Artery Calcification
    Paul Price; Fiscal Year: 2007
    ..abstract_text> ..
  4. REGULATION OF VITAMIN K-DEPENDENT BONE PROTEINS
    Paul Price; Fiscal Year: 1993
    ....
  5. REGULATION AND BIOSYNTHESIS OF K-DEPENDENT BONE PROTEINS
    Paul Price; Fiscal Year: 1990
    ..These studies should help to define the clinical and biological significance of the Gla protein of bone and may provide a useful and unique biochemical marker for the assessment of bone turnover and skeletal status...