Research Topics
Genomes and Genes | Paul PriceSummaryAffiliation: University of California Country: USA Publications
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Publications
Minerals form a continuum phase in mature cancellous bonePo Yu Chen
Materials Science and Engineering Program, Department of Mechanical and Aerospace Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0411, USA
Calcif Tissue Int 88:351-61. 2011..Results were compared with commercially available heat-deproteinized bone (Bio-Oss(®)), and evidence showed consistency in bone mineral structure. A two-phase interpenetrating composite model of mature bone is proposed and discussed...- YKL-40 tissue expression and plasma levels in patients with ovarian cancerEstrid V S Høgdall
Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
BMC Cancer 9:8. 2009..The aim of the study was to determine the expression of YKL-40 in tumor tissue and plasma in patients with borderline ovarian tumor or epithelial ovarian cancer (OC), and investigate prognostic value of this marker... 
Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valvesP A Price
Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
Arterioscler Thromb Vasc Biol 18:1400-7. 1998..The results indicate that the improved warfarin plus vitamin K treatment protocol developed in this study should provide a useful model to investigate the role of MGP in preventing calcification of arteries and heart valves...- Evidence for a serum factor that initiates the re-calcification of demineralized bonePaul A Price
Division of Biology, University of California, San Diego, La Jolla, California 92093 0368, USA
J Biol Chem 279:19169-80. 2004..The speed, matrix-type specificity, and extent of the serum-induced re-calcification of demineralized bone suggest that the serum calcification factor identified in these studies may participate in the normal calcification of bone... - The elastic lamellae of devitalized arteries calcify when incubated in serum: evidence for a serum calcification factorPaul A Price
Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0368, USA
Arterioscler Thromb Vasc Biol 26:1079-85. 2006..To determine whether serum contains an activity that induces artery calcification... - Artery calcification in uremic rats is increased by a low protein diet and prevented by treatment with ibandronateP A Price
Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0368, USA
Kidney Int 70:1577-83. 2006..5% protein diet containing 0.75% adenine produces consistent and dramatic medial calcification in adult rats within just 4 weeks... - The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complexPaul A Price
Division of Biology, University of California San Diego, La Jolla, CA 92093 0368, USA
J Biol Chem 278:22144-52. 2003..The complex found at 24 h to 14 days is identical to the fetuin-mineral complex found in the serum of etidronate-treated rats, whereas the complex found between 1 and 20 h is less stable... - Biochemical characterization of the serum fetuin-mineral complexPaul A Price
Division of Biology 0368, University of California San Diego, La Jolla, CA 92093 0368, USA
J Biol Chem 278:22153-60. 2003..Exogenous spp24 associated strongly with the FMC when added to serum containing it. These observations suggest that spp24 may, like fetuin and MGP, play a role in inhibiting calcification... 
Tissue-nonspecific alkaline phosphatase is required for the calcification of collagen in serum: a possible mechanism for biomineralizationPaul A Price
Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0368, USA
J Biol Chem 284:4594-604. 2009..4) A large protein (fetuin) that selectively inhibits growth of crystals remaining in solution, thereby ensuring that only crystals within fibrils grow ( Toroian, D. T., and Price, P. A. (2008) Calcif. Tissue Int. 82, 116-126 )...- The amino bisphosphonate ibandronate prevents calciphylaxis in the rat at doses that inhibit bone resorptionP A Price
Division of Biology, 0368, University of California, San Diego, La Jolla, CA 92093 0368, USA
Calcif Tissue Int 71:356-63. 2002.... - Mineralization by inhibitor exclusion: the calcification of collagen with fetuinPaul A Price
Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0368, USA
J Biol Chem 284:17092-101. 2009..Future studies will be needed to evaluate the possible role of this mechanism in bone mineralization... - SB 242784, a selective inhibitor of the osteoclastic V-H+ATPase, inhibits arterial calcification in the ratPaul A Price
Department of Biology, University of California, San Diego, La Jolla, Calif 92093 0368, USA
Circ Res 91:547-52. 2002.... - The amino bisphosphonate ibandronate prevents vitamin D toxicity and inhibits vitamin D-induced calcification of arteries, cartilage, lungs and kidneys in ratsP A Price
Division of Biology, University of California, San Diego, La Jolla, CA 92093 0368, USA
J Nutr 131:2910-5. 2001.... - Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin DP A Price
Division of Biology, University of California, San Diego, La Jolla, USA
Arterioscler Thromb Vasc Biol 21:1610-6. 2001..These results support the hypothesis that arterial calcification is linked to bone resorption... - Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorptionP A Price
Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
Arterioscler Thromb Vasc Biol 21:817-24. 2001..These results support the hypothesis that artery calcification is linked to bone resorption. The mechanism of this linkage remains to be established, however, and an alternative explanation for the present results is also considered... - Warfarin-induced artery calcification is accelerated by growth and vitamin DP A Price
Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
Arterioscler Thromb Vasc Biol 20:317-27. 2000..These observations indicate that although the gamma-carboxyglutamate residues of matrix Gla protein are apparently required for its function as a calcification inhibitor, they are not required for its accumulation at calcification sites... - Serum levels of the fetuin-mineral complex correlate with artery calcification in the ratPaul A Price
Division of Biology, University of California, La Jolla, CA 92093 0368, USA
J Biol Chem 279:1594-600. 2004.... - Bone origin of the serum complex of calcium, phosphate, fetuin, and matrix Gla protein: biochemical evidence for the cancellous bone-remodeling compartmentPaul A Price
Division of Biology, University of California, San Diego, La Jolla 92093-0368, USA
J Bone Miner Res 17:1171-9. 2002.... - The size exclusion characteristics of type I collagen: implications for the role of noncollagenous bone constituents in mineralizationDamon Toroian
Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0368, USA
J Biol Chem 282:22437-47. 2007.... - Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated ratsPaul A Price
Division of Biology, University of California, San Diego, La Jolla, California 92093-0368, USA
J Biol Chem 277:3926-34. 2002.... - Fetuin-A and BMD in older persons: the Health Aging and Body Composition (Health ABC) studyJoachim H Ix
Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
J Bone Miner Res 24:514-21. 2009..Future studies should evaluate whether fetuin-A may refine fracture risk assessment in older women... - The essential role of fetuin in the serum-induced calcification of collagenDamon Toroian
Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0368, USA
Calcif Tissue Int 82:116-26. 2008.... - Structural evidence of a fourth Gla residue in fish osteocalcin: biological implicationsCarlos Frazao
ITQB UNL, Av da Republica, 2784 505 Oeiras, Portugal
Biochemistry 44:1234-42. 2005..This further suggests that the known high affinity of osteocalcin for bone mineral may be derived from the clustering of calcium binding sites on this surface of the molecules... - Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebratesVincent Laizé
Centro de Ciências do Mar CCMar, Universidade do Algarve, 8005 139 Faro, Portugal
J Biol Chem 280:26659-68. 2005..We also propose a highly specific pattern definition for the Gla domain of BGP and MGP... - Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcificationChristopher J O'Donnell
Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
Arterioscler Thromb Vasc Biol 26:2769-74. 2006..Matrix Gla protein (MGP) is an inhibitor of calcification in vivo. However, little is known regarding the distribution of circulating MGP and its associations with CHD risk factors or with CAC in humans... - High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancerBenny Vittrup Jensen
Department of Oncology, Herlev Hospital, Hvidovre Hospital, University of Copenhagen, DK 2750 Herlev Denmark
Clin Cancer Res 9:4423-34. 2003.... - YKL-40 protein expression in the early developing human musculoskeletal systemJulia S Johansen
Department of Rheumatology, Q 107, Herlev Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
J Histochem Cytochem 55:1213-28. 2007..This indicates that YKL-40 is associated with cell proliferation, differentiation, and tissue morphogenesis during development of the human musculoskeletal system... - High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survivalAnne Roslind
Department of Oncology, Herlev Hospital, University of Copenhagen, Denmark
Int J Cancer 122:857-63. 2008..Immunohistochemical analysis showed YKL-40 expression in the malignant tumor cells. In conclusion, serum YKL-40 was demonstrated to be an independent prognostic biomarker of recurrence-free and overall survival in patients with HNSCC... - YKL-40 expression in benign and malignant lesions of the breast: a methodologic studyAnne Roslind
Department of Oncology, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Copenhagen, Denmark
Appl Immunohistochem Mol Morphol 15:371-81. 2007..No nuclear and membrane staining was found. A subpopulation of cells of macrophage morphology in normal breast tissue and in malignant lesions showed strong YKL-40 immunoreactivity... - Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity?Julia S Johansen
Department of Rheumatology, Herlev Hospital, University of Copenhagen, Denmark
Respir Med 99:396-402. 2005.... - High serum YKL-40 level after surgery for colorectal carcinoma is related to short survivalChristina Cintin
Department of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Denmark
Cancer 95:267-74. 2002..In the current study the authors evaluated the value of serum YKL-40 in monitoring patients with colorectal carcinoma... - Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the diseaseGitte Kronborg
Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
Scand J Infect Dis 34:323-6. 2002..002). In conclusion, high serum levels of YKL40 indicated a poorer prognosis for patients with S. pneumoniae bacteremia... - Plasma YKL-40, as a prognostic tumor marker in recurrent ovarian cancerHannah Dehn
Gynecologic Clinic, The Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark
Acta Obstet Gynecol Scand 82:287-93. 2003..27) (p = 0.006), including serum CA-125 and clinical/histological parameters. CONCLUSION: High plasma YKL-40 is related to short survival in patients with recurrent ovarian cancer... - Changes of biochemical markers of bone turnover and YKL-40 following hormonal treatment for metastatic prostate cancer are related to survivalJulia S Johansen
Department of Rheumatology, Herlev Hospital, Denmark
Clin Cancer Res 13:3244-9. 2007..In this study, we evaluated the value of these biomarkers in monitoring the patients during hormonal treatment... - High serum YKL-40 level in patients with small cell lung cancer is related to early deathJulia S Johansen
Department of Medicine, Division of Rheumatology Q, Herlev Hospital, Herlev Ringvej 75, Herlev DK 2730, Denmark
Lung Cancer 46:333-40. 2004..02) is independent of prognostic variables for survival within the first 6 months. Studies are needed to determine the function of YKL-40 in SCLC... - High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survivalJulia S Johansen
Connective Tissue Laboratory, Department of Rheumatology, H S Hvidovre Hospital, Denmark
Breast Cancer Res Treat 80:15-21. 2003..Further studies are required to determine the biological function of YKL-40 in breast cancer... - Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinomaKlaus Brasso
Department of Urology, H S Rigshospitalet, University of Copenhagen, Cophenhagen, Denmark
Prostate 66:503-13. 2006..To examine the prognostic value of markers of bone metabolism (serum PINP, BAP, and CTX-I) and serum YKL-40 in metastatic prostate carcinoma (PC)... - Serum YKL-40, a new prognostic biomarker in cancer patients?Julia S Johansen
Department of Rheumatology Q107, Herlev Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
Cancer Epidemiol Biomarkers Prev 15:194-202. 2006.... - High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survivalEstrid V S Høgdall
Institute of Cancer Epidemiology, Danish Cancer Society, DK 2100 Copenhagen Ø, Denmark
Oncol Rep 10:1535-8. 2003..In conclusion, plasma levels of YKL-40 proved of prognostic value in stage III OC patients... - Identification of an osteocalcin isoform in fish with a large acidic prodomainVincent Laizé
Centro de Ciencias do Mar, Universidade do Algarve, 8005 139 Faro, Portugal
J Biol Chem 281:15037-43. 2006.... - Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver diseaseCamilla Nøjgaard
Department of Gastroenterology and Alcohol Unit, Hvidovre Hospital, Hvidovre, Denmark
J Hepatol 39:179-86. 2003..The aim was to evaluate the prognostic value of serum YKL-40 and PIIINP levels in patients with alcoholic liver disease... - Is YKL-40 a new therapeutic target in cancer?Julia S Johansen
Herlev Hospital, University of Copenhagen, Department of Rheumatology Q107, Herlev Ringvej 75, DK 2730 Herlev, Denmark
Expert Opin Ther Targets 11:219-34. 2007..Drugs inhibiting YKL-40 should be explored as new cancer therapeutics... - YKL-40 protein expression in normal adult human tissues--an immunohistochemical studyMerete Ringsholt
Department of Pathology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
J Mol Histol 38:33-43. 2007..In conclusion, all cells with a functioning nucleus appeared to be capable of expressing YKL-40 in their cytoplasm, the intensity of which was dependent on cellular activity... - Serum levels of YKL-40 increases in patients with acute myocardial infarctionCamilla Nøjgaard
Department of Gastroenterology, Hvidovre Hospital, Denmark
Coron Artery Dis 19:257-63. 2008..The aim was to examine the sequential changes in serum YKL-40 in patients with acute myocardial infarction (AMI), with and without thrombolytic therapy, as compared with patients with stable coronary artery disease (CAD)...
Research Grants
- MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATIONPaul Price; Fiscal Year: 2001..The investigators will further study the demonstrated ability of MGP to inhibit calcification in supersaturated solutions, and will investigate the ability of MGP to inhibit matrix vesicle -initiated calcification. ..
- MATRIX GLA PROTEIN AND ARTERY CALCIFICATIONPaul Price; Fiscal Year: 2002..These experiments are being done to establish the importance of vitamin K deficiency and of warfarin treatment as risk factors for the calcification of human arteries. ..
- Initiation and Inhibition of Medial Artery CalcificationPaul Price; Fiscal Year: 2007..abstract_text> ..
- REGULATION OF VITAMIN K-DEPENDENT BONE PROTEINSPaul Price; Fiscal Year: 1993....
- REGULATION AND BIOSYNTHESIS OF K-DEPENDENT BONE PROTEINSPaul Price; Fiscal Year: 1990..These studies should help to define the clinical and biological significance of the Gla protein of bone and may provide a useful and unique biochemical marker for the assessment of bone turnover and skeletal status...