Julie C Price

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Molecular brain imaging in the multimodality era
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Cereb Blood Flow Metab 32:1377-92. 2012
  2. ncbi request reprint Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 25:1528-47. 2005
  3. ncbi request reprint Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:1032-41. 2005
  4. ncbi request reprint Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:387-96. 2005
  5. ncbi request reprint Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
    Scott K Ziolko
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm B 938, PA 15213, USA
    Neuroimage 33:94-102. 2006
  6. ncbi request reprint Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, Pittsburgh, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 61:1090-9. 2007
  7. pmc Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 22:261-8. 2008
  8. pmc Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:14770-8. 2009
  9. ncbi request reprint Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis
    Brian J Lopresti
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Nucl Med 46:1959-72. 2005
  10. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008

Collaborators

Detail Information

Publications64

  1. pmc Molecular brain imaging in the multimodality era
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Cereb Blood Flow Metab 32:1377-92. 2012
    ....
  2. ncbi request reprint Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 25:1528-47. 2005
    ..This study also showed that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum...
  3. ncbi request reprint Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:1032-41. 2005
    ..Previous studies have shown that women with anorexia nervosa (AN), when ill and after recovery, have alterations of serotonin (5-HT) neuronal activity and core eating disorder symptoms, such as anxiety...
  4. ncbi request reprint Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:387-96. 2005
    ..Non-rapid eye movement sleep is associated with decreases in frontal, parietal, and temporal cortex metabolic activity compared with wakefulness...
  5. ncbi request reprint Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
    Scott K Ziolko
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm B 938, PA 15213, USA
    Neuroimage 33:94-102. 2006
    ..These results indicate that voxel-based methods will be useful for future larger longitudinal studies of amyloid deposition that could improve AD diagnosis and anti-amyloid therapy assessment...
  6. ncbi request reprint Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, Pittsburgh, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 61:1090-9. 2007
    ..Because little is known about 5-HT receptor function in AN, positron emission tomography (PET) imaging with 5-HT receptor-specific radioligands was used to characterize 5-HT1A and 5-HT2A receptors...
  7. pmc Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 22:261-8. 2008
    ..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals...
  8. pmc Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:14770-8. 2009
    ....
  9. ncbi request reprint Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis
    Brian J Lopresti
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Nucl Med 46:1959-72. 2005
    ..This work reports on simplified methods of analysis for human PIB imaging...
  10. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
    ..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden...
  11. pmc Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
    J Neurosci Methods 172:277-82. 2008
    ..02, p=0.01) and anterior ventral striatum [t(9)=2.37, p=0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1, 15)=0.15, p=0.7] or asymmetry [F (1, 15)=0.7, p=0.42]...
  12. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    ....
  13. ncbi request reprint Serotonin transporter binding after recovery from eating disorders
    Ursula F Bailer
    Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 195:315-24. 2007
    ..Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN)...
  14. pmc Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study
    Eydie L Moses-Kolko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Fertil Steril 89:685-92. 2008
    ..To measure brain serotonin-1A (5HT1A) receptor binding potential (BP) in healthy and depressed postpartum women...
  15. pmc In vivo assessment of amyloid-β deposition in nondemented very elderly subjects
    Chester A Mathis
    Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Neurol 73:751-61. 2013
    ....
  16. ncbi request reprint Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Arch Gen Psychiatry 61:695-702. 2004
    ....
  17. pmc Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET
    Bedda L Rosario
    Department of Radiology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, B 938, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Neuroimage 55:933-41. 2011
    ....
  18. ncbi request reprint Functional neuroimaging evidence for hyperarousal in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 161:2126-8. 2004
    ..The authors investigated the neurobiological basis of poor sleep and daytime fatigue in insomnia...
  19. pmc Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Neurology 80:1378-84. 2013
    ..To determine whether a high prevalence (55%) of Aβ deposition in a cohort of individuals remaining dementia-free into their 9th and 10th decades is associated with cognitive decline prior to imaging...
  20. pmc Postpartum and depression status are associated with lower [[¹¹C]raclopride BP(ND) in reproductive-age women
    Eydie L Moses-Kolko
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 37:1422-32. 2012
    ....
  21. ncbi request reprint Regional cerebral metabolic correlates of WASO during NREM sleep in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    J Clin Sleep Med 2:316-22. 2006
    ..To investigate the non-rapid eye movement (NREM) sleep-related regional cerebral metabolic correlates of wakefulness after sleep onset (WASO) in patients with primary insomnia...
  22. pmc Amyloid imaging in mild cognitive impairment subtypes
    David A Wolk
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
    Ann Neurol 65:557-68. 2009
    ....
  23. pmc Classification of amyloid-positivity in controls: comparison of visual read and quantitative approaches
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 71:207-15. 2013
    ..IO was developed using full-dynamic atrophy-corrected PiB PET data obtained from a group of control subjects with a fairly distinct separation between PiB-positive [PiB(+)] and PiB-negative [PiB(-)] subjects...
  24. pmc Age, sex, and reproductive hormone effects on brain serotonin-1A and serotonin-2A receptor binding in a healthy population
    Eydie L Moses-Kolko
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 36:2729-40. 2011
    ..Additional study in clinical populations is needed to further examine the affective role of sex-hormone-serotonin receptor relationships...
  25. pmc Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 200 Lothrop Street BST S521, Pittsburgh, PA 15213 USA
    Acta Neuropathol 123:433-47. 2012
    ..Studies in greater numbers of [C-11]PiB PET autopsy cases are needed to define the Aβ concentration and [H-3]PiB binding levels required to produce a positive [C-11]PiB PET signal...
  26. pmc Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements
    REBECCA L MCNAMEE
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Nucl Med 50:348-55. 2009
    ..In this work, regional PiB SUVRs were examined across 9 time windows to select the window that provided the best trade-offs between bias, correlation, and effective contrast...
  27. pmc Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...
  28. ncbi request reprint Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635
    Eydie L Moses-Kolko
    Departments of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Synapse 61:523-30. 2007
    ..To assess effects of chronic antidepressant drug treatment on serotonin type-1A receptor (5-HT(1A)R) binding potential (BP) in major depressive disorder...
  29. ncbi request reprint Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography
    William E Klunk
    Laboratory of Molecular Neuropharmacology, Department of Psychiatry, University of Pittsburgh School of Medicine, 705 Parran Hall, Pittsburgh, PA 15213, USA
    Neuroimaging Clin N Am 13:781-9, ix. 2003
    ..The capability to use positron emission tomography and selective markers for amyloid protein deposition promises to substantially alter the way we diagnosis and manage patients who have AD...
  30. ncbi request reprint Regional cerebral blood flow after recovery from anorexia or bulimia nervosa
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Int J Eat Disord 40:488-92. 2007
    ..Abnormalities of regional cerebral blood flow (rCBF) have been found in individuals who are ill with anorexia (AN) or bulimia nervosa (BN). Little is known about whether rCBF normalizes after recovery from AN and BN...
  31. ncbi request reprint Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studies
    Walter H Kaye
    University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, United States
    Physiol Behav 85:73-81. 2005
    ..Alterations of these circuits may affect mood and impulse control as well as the motivating and hedonic aspects of feeding behavior. Such imaging studies may offer insights into new pharmacology and psychotherapy approaches...
  32. pmc Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 34:624-33. 2009
    ....
  33. pmc Brain function, cognition, and the blood pressure response to pharmacological treatment
    J Richard Jennings
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychosom Med 72:702-11. 2010
    ..To extend evidence suggesting that essential hypertension influences neuropsychological performance and that brain function before treatment is related to the success of pharmacological lowering of blood pressure (BP)...
  34. ncbi request reprint 5HT2A receptor binding is increased in borderline personality disorder
    Paul H Soloff
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Biol Psychiatry 62:580-7. 2007
    ..We examined 5HT(2A) receptor binding potential (BP) in impulsive subjects with BPD, with positron emission tomography neuroimaging with [(18)F] altanserin...
  35. ncbi request reprint Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Ann Neurol 55:306-19. 2004
    ..This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects...
  36. ncbi request reprint Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:10598-606. 2005
    ....
  37. ncbi request reprint Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinness
    Ursula F Bailer
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 29:1143-55. 2004
    ..It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects...
  38. pmc In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, USA
    Am J Psychiatry 169:55-63. 2012
    ....
  39. pmc Medial prefrontal cortex 5-HT(2A) density is correlated with amygdala reactivity, response habituation, and functional coupling
    Patrick M Fisher
    Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cereb Cortex 19:2499-507. 2009
    ..Collectively, our results indicate that mPFC 5-HT(2A) is strongly associated with threat-related amygdala reactivity as well as its temporal habituation and functional coupling with prefrontal regulatory regions...
  40. ncbi request reprint Serotonin 1A receptor binding and treatment response in late-life depression
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2258-65. 2004
    ..Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression...
  41. pmc Gender, personality, and serotonin-2A receptor binding in healthy subjects
    Paul H Soloff
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychiatry Res 181:77-84. 2010
    ..Future studies of 5HT(2A) receptor function and its relationship to behavior should control for gender...
  42. ncbi request reprint Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies
    Chester A Mathis
    Department of Neurology, University of Pittsburgh and Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Neurol 62:196-200. 2005
    ....
  43. pmc Cognitive aging in persons with minimal amyloid-β and white matter hyperintensities
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Electronic address
    Neuropsychologia 51:2202-9. 2013
    ....
  44. ncbi request reprint Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    ....
  45. pmc Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studies
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:574-84. 2009
    ..The aim of the present study was to define the optimal analytic method to derive accurate and reliable D(2/3) receptor parameters with [(11)C]NPA...
  46. pmc Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B
    Benjamin L Handen
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Alzheimers Dement 8:496-501. 2012
    ..These results demonstrate the feasibility of conducting PiB positron emission tomography scanning in this special population, and suggest a link between Aβ overproduction and early striatal deposition of fibrillar Aβ...
  47. pmc Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity
    Patrick M Fisher
    Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Biol Mood Anxiety Disord 1:2. 2011
    ..abstract:..
  48. pmc Imaging of dopamine D2/3 agonist binding in cocaine dependence: a [11C]NPA positron emission tomography study
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:1344-9. 2011
    ....
  49. ncbi request reprint MR atlas of the baboon brain for functional neuroimaging
    Phil J Greer
    University of Pittsburgh PET Facility, Pittsburgh, PA 15213 2582, USA
    Brain Res Bull 58:429-38. 2002
    ..Overall, the digital MR-based atlas allowed for automatic co-registration, proved useful across a range of PET Studies, and is accessible electronically via the Internet...
  50. ncbi request reprint Positron emission tomography imaging of the aging brain
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh School of Medicine, CHP MT 3972, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Neuroimaging Clin N Am 13:759-67. 2003
    ..Recognition of inherent potential confounds in the use of PET in aging studies is essential to the proper interpretation of these data...
  51. ncbi request reprint Principles of tracer kinetic analysis
    Julie C Price
    Positron Emission Tomography Facility, B 938, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Neuroimaging Clin N Am 13:689-704. 2003
    ..Fig. 5 is a summary diagram that links these ideas and provides a more complete picture of the multiple components that are involved in tracer kinetic PET imaging research...
  52. ncbi request reprint Sequential H(2)(15)O PET studies in baboons: before and after amphetamine
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Nucl Med 43:1090-100. 2002
    ..A common assumption in bolus injection PET studies of this type is that cerebral blood flow (CBF) does not vary during the scan. The goal of this work was to examine the effect of AMPH administration on sequential PET measures of CBF...
  53. ncbi request reprint Glucose transport and phosphorylation in skeletal muscle in obesity: insight from a muscle-specific positron emission tomography model
    Katherine V Williams
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 88:1271-9. 2003
    ....
  54. pmc Assessment of parameter settings for SPM5 spatial normalization of structural MRI data: application to type 2 diabetes
    Bedda L Rosario
    Department of Biostatistics, University of Pittsburgh, Graduate School of Public Health, 130 DeSoto Street, 326 Parran Hall, Pittsburgh, PA 15261, USA
    Neuroimage 41:363-70. 2008
    ..These findings are relevant for studies of structural brain alterations that may occur in normal aging, chronic medical conditions, neuropsychiatric disorders, and neurodegenerative disorders...
  55. ncbi request reprint Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
    William E Klunk
    University of Pittsburgh Medical School Pittsburgh, MA, USA
    Brain 129:2805-7. 2006
  56. ncbi request reprint Identification of hemodynamic compromise by cerebrovascular reserve and oxygen extraction fraction in occlusive vascular disease
    Edwin M Nemoto
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pennsylvania, USA
    J Cereb Blood Flow Metab 24:1081-9. 2004
    ..CVR and OEF showed a significant negative linear relationship in stage II hemodynamic compromise but revealed hemispheres in hemodynamic compromise by CVR but normal OEF that were associated with subcortical white matter infarction...
  57. pmc Dynamic PET Imaging Reveals Heterogeneity of Skeletal Muscle Insulin Resistance
    Jason M Ng
    Division of Endocrinology and Metabolism Department of Medicine J M N, N L H, B H G and Departments of Radiology D S M, J C P and Health and Physical Activity P M C, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15231 Department of Information Engineering A B, C C, University of Padova, Padova, Italy and Merck, Sharp, and Dohme Corporation D E K, Rahway, New Jersey 07065
    J Clin Endocrinol Metab 99:E102-6. 2014
    ..Conclusion: Lower glucose transport rates are the major feature underlying IR preceding type 2 diabetes, although substantial heterogeneity in insulin action across muscle types highlight the complexity of skeletal muscle IR. ..
  58. ncbi request reprint Reduced 5-HT2A receptor binding after recovery from anorexia nervosa
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 52:896-906. 2002
    ..This study applied positron emission tomography (PET) to investigate the brain serotonin 2A (5HT2A) receptor, which could contribute to disturbances of appetite and behavior in AN...
  59. ncbi request reprint Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to waking
    Eric A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Brain 125:1105-15. 2002
    ....
  60. ncbi request reprint Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study
    Julie C Price
    PET Facility, Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop St, Rm B938, Pittsburgh, PA 15213, USA
    Brain Res 927:97-103. 2002
    ..02). These findings support previous studies that suggest serotonergic underpinnings to the neurobiology of diabetes and have shown diabetes-induced neurological changes in hippocampus...
  61. doi request reprint Components of a curriculum for molecular imaging scientists
    Kurt R Zinn
    Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama AL 35294 0019, USA
    J Nucl Med 52:650-6. 2011
    ....
  62. ncbi request reprint Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...
  63. ncbi request reprint Interactions between delivery, transport, and phosphorylation of glucose in governing uptake into human skeletal muscle
    Alessandra Bertoldo
    Department of Information Engineering, University of Padova, Italy
    Diabetes 55:3028-37. 2006
    ..This redistribution of control is triggered by the robust stimulation of glucose transport, which in turn unmasks a greater dependence upon delivery and glucose phosphorylation...
  64. ncbi request reprint Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]raclopride
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of California San Diego, California, USA
    Biol Psychiatry 58:908-12. 2005
    ..Several lines of evidence support the possibility that disturbances of dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and reward in anorexia nervosa (AN)...

Research Grants11

  1. Imaging Amyloid Pathology and its Functional Sequelae
    Julie Price; Fiscal Year: 2007
    ..This research has the potential to provide information that has not previously been obtainable and facilitate understanding of the impact of progressive amyloid deposition on both cognitive performance and functional brain circuitry. ..
  2. Mapping Brain Structure and Function in AD
    Julie Price; Fiscal Year: 2007
    ..g. structural MR, functional PET, behavioral measures) to provide robust outcome measures that are clinically more informative, consistent with the theme of her mentored career development award (K01) that is in its final year. ..
  3. Simple In Vivo PET Measure of Amyloid Binding in AD
    Julie Price; Fiscal Year: 2006
    ..abstract_text> ..
  4. Neuroimaging Medical Illness in Elderly Depression
    Julie Price; Fiscal Year: 2005
    ....
  5. Establishing the In Vivo Threshold for Amyloid Deposition in Normal Aging
    Julie C Price; Fiscal Year: 2010
    ....