Research Topics
Species | Julie C PriceSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Molecular brain imaging in the multimodality eraJulie C Price
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Cereb Blood Flow Metab 32:1377-92. 2012....
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-BJulie C Price
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Cereb Blood Flow Metab 25:1528-47. 2005..This study also showed that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum...- Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635Ursula F Bailer
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 62:1032-41. 2005..These psychobiological alterations may be trait related and may contribute to the pathogenesis of AN... - Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's diseaseScott K Ziolko
Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm. B-938, PA 15213, USA
Neuroimage 33:94-102. 2006..These results indicate that voxel-based methods will be useful for future larger longitudinal studies of amyloid deposition that could improve AD diagnosis and anti-amyloid therapy assessment... - Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depressionEric A Nofzinger
Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 62:387-96. 2005..Non-rapid eye movement sleep is associated with decreases in frontal, parietal, and temporal cortex metabolic activity compared with wakefulness... - Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-BMeryl A Butters
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Alzheimer Dis Assoc Disord 22:261-8. 2008..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals... - Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosaUrsula F Bailer
Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, Pittsburgh, University of Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 61:1090-9. 2007..Because little is known about 5-HT receptor function in AN, positron emission tomography (PET) imaging with 5-HT receptor-specific radioligands was used to characterize 5-HT1A and 5-HT2A receptors... - Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysisBrian J Lopresti
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Nucl Med 46:1959-72. 2005..This work reports on simplified methods of analysis for human PIB imaging... - Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound BCyrus A Raji
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
J Neurosci Methods 172:277-82. 2008..02, p=0.01) and anterior ventral striatum [t(9)=2.37, p=0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1, 15)=0.15, p=0.7] or asymmetry [F (1, 15)=0.7, p=0.42]... - Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserveAnn D Cohen
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 29:14770-8. 2009.... - Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's diseaseMilos D Ikonomovic
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Brain 131:1630-45. 2008..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden... - Frequent amyloid deposition without significant cognitive impairment among the elderlyHoward Jay Aizenstein
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Neurol 65:1509-17. 2008.... - Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography studyEydie L Moses-Kolko
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Fertil Steril 89:685-92. 2008..To measure brain serotonin-1A (5HT1A) receptor binding potential (BP) in healthy and depressed postpartum women... - Serotonin transporter binding after recovery from eating disordersUrsula F Bailer
Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 195:315-24. 2007..Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN)... - Functional neuroimaging evidence for hyperarousal in insomniaEric A Nofzinger
Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
Am J Psychiatry 161:2126-8. 2004..The authors investigated the neurobiological basis of poor sleep and daytime fatigue in insomnia... - Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depressionEric A Nofzinger
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
Arch Gen Psychiatry 61:695-702. 2004.... - Inter-rater reliability of manual and automated region-of-interest delineation for PiB PETBedda L Rosario
Department of Radiology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, B 938, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Neuroimage 55:933-41. 2011.... - Postpartum and depression status are associated with lower [[¹¹C]raclopride BP(ND) in reproductive-age womenEydie L Moses-Kolko
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 37:1422-32. 2012.... - Regional cerebral metabolic correlates of WASO during NREM sleep in insomniaEric A Nofzinger
Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
J Clin Sleep Med 2:316-22. 2006..To investigate the non-rapid eye movement (NREM) sleep-related regional cerebral metabolic correlates of wakefulness after sleep onset (WASO) in patients with primary insomnia... - Amyloid imaging in mild cognitive impairment subtypesDavid A Wolk
Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
Ann Neurol 65:557-68. 2009.... - Age, sex, and reproductive hormone effects on brain serotonin-1A and serotonin-2A receptor binding in a healthy populationEydie L Moses-Kolko
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 36:2729-40. 2011..Additional study in clinical populations is needed to further examine the affective role of sex-hormone-serotonin receptor relationships... - Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical studyMilos D Ikonomovic
Department of Neurology, University of Pittsburgh School of Medicine, 200 Lothrop Street BST S521, Pittsburgh, PA 15213 USA
Acta Neuropathol 123:433-47. 2012..Studies in greater numbers of [C-11]PiB PET autopsy cases are needed to define the Aβ concentration and [H-3]PiB binding levels required to produce a positive [C-11]PiB PET signal... - Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigreesWilliam E Klunk
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 27:6174-84. 2007..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms... - Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-BWilliam E Klunk
Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA
Ann Neurol 55:306-19. 2004..This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects... - Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurementsREBECCA L MCNAMEE
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Nucl Med 50:348-55. 2009..In this work, regional PiB SUVRs were examined across 9 time windows to select the window that provided the best trade-offs between bias, correlation, and effective contrast... - Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635Eydie L Moses-Kolko
Departments of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Synapse 61:523-30. 2007..To assess effects of chronic antidepressant drug treatment on serotonin type-1A receptor (5-HT(1A)R) binding potential (BP) in major depressive disorder... - Regional cerebral blood flow after recovery from anorexia or bulimia nervosaGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 40:488-92. 2007..Abnormalities of regional cerebral blood flow (rCBF) have been found in individuals who are ill with anorexia (AN) or bulimia nervosa (BN). Little is known about whether rCBF normalizes after recovery from AN and BN... - Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studiesWalter H Kaye
University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, United States
Physiol Behav 85:73-81. 2005..Alterations of these circuits may affect mood and impulse control as well as the motivating and hedonic aspects of feeding behavior. Such imaging studies may offer insights into new pharmacology and psychotherapy approaches... - Brain function, cognition, and the blood pressure response to pharmacological treatmentJ Richard Jennings
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychosom Med 72:702-11. 2010..To extend evidence suggesting that essential hypertension influences neuropsychological performance and that brain function before treatment is related to the success of pharmacological lowering of blood pressure (BP)... - 5HT2A receptor binding is increased in borderline personality disorderPaul H Soloff
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Biol Psychiatry 62:580-7. 2007..We examined 5HT(2A) receptor binding potential (BP) in impulsive subjects with BPD, with positron emission tomography neuroimaging with [(18)F] altanserin... - Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjectsW Gordon Frankle
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 34:624-33. 2009.... - Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinnessUrsula F Bailer
Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 29:1143-55. 2004..It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects... - In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusersRajesh Narendran
Department of Radiology, University of Pittsburgh, USA
Am J Psychiatry 169:55-63. 2012.... - Gender, personality, and serotonin-2A receptor binding in healthy subjectsPaul H Soloff
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Psychiatry Res 181:77-84. 2010..Future studies of 5HT(2A) receptor function and its relationship to behavior should control for gender... - Serotonin 1A receptor binding and treatment response in late-life depressionCarolyn Cidis Meltzer
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
Neuropsychopharmacology 29:2258-65. 2004..Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression... - Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologiesChester A Mathis
Department of Neurology, University of Pittsburgh and Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Neurol 62:196-200. 2005.... - Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomographyWilliam E Klunk
Laboratory of Molecular Neuropharmacology, Department of Psychiatry, University of Pittsburgh School of Medicine, 705 Parran Hall, Pittsburgh, PA 15213, USA
Neuroimaging Clin N Am 13:781-9, ix. 2003..The capability to use positron emission tomography and selective markers for amyloid protein deposition promises to substantially alter the way we diagnosis and manage patients who have AD... - Medial prefrontal cortex 5-HT(2A) density is correlated with amygdala reactivity, response habituation, and functional couplingPatrick M Fisher
Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
Cereb Cortex 19:2499-507. 2009..Collectively, our results indicate that mPFC 5-HT(2A) is strongly associated with threat-related amygdala reactivity as well as its temporal habituation and functional coupling with prefrontal regulatory regions... - Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studiesRajesh Narendran
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Synapse 63:574-84. 2009..The aim of the present study was to define the optimal analytic method to derive accurate and reliable D(2/3) receptor parameters with [(11)C]NPA... - Imaging of amyloid burden and distribution in cerebral amyloid angiopathyKeith A Johnson
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
Ann Neurol 62:229-34. 2007.... - Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brainWilliam E Klunk
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 25:10598-606. 2005.... - Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound BBenjamin L Handen
Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Alzheimers Dement 8:496-501. 2012..These results demonstrate the feasibility of conducting PiB positron emission tomography scanning in this special population, and suggest a link between Aβ overproduction and early striatal deposition of fibrillar Aβ... - Classification of amyloid-positivity in controls: comparison of visual read and quantitative approachesAnn D Cohen
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Neuroimage 71:207-15. 2013..IO was developed using full-dynamic atrophy-corrected PiB PET data obtained from a group of control subjects with a fairly distinct separation between PiB-positive [PiB(+)] and PiB-negative [PiB(-)] subjects... - Imaging of dopamine D2/3 agonist binding in cocaine dependence: a [11C]NPA positron emission tomography studyRajesh Narendran
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Synapse 65:1344-9. 2011.... - Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivityPatrick M Fisher
Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Biol Mood Anxiety Disord 1:2. 2011..abstract:.. - Positron emission tomography imaging of the aging brainCarolyn Cidis Meltzer
Department of Radiology, University of Pittsburgh School of Medicine, CHP MT 3972, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
Neuroimaging Clin N Am 13:759-67. 2003..Recognition of inherent potential confounds in the use of PET in aging studies is essential to the proper interpretation of these data... - MR atlas of the baboon brain for functional neuroimagingPhil J Greer
University of Pittsburgh PET Facility, Pittsburgh, PA 15213-2582, USA
Brain Res Bull 58:429-38. 2002..Overall, the digital MR-based atlas allowed for automatic co-registration, proved useful across a range of PET Studies, and is accessible electronically via the Internet... - Principles of tracer kinetic analysisJulie C Price
Positron Emission Tomography Facility, B 938, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Neuroimaging Clin N Am 13:689-704. 2003..Fig. 5 is a summary diagram that links these ideas and provides a more complete picture of the multiple components that are involved in tracer kinetic PET imaging research... - Assessment of parameter settings for SPM5 spatial normalization of structural MRI data: application to type 2 diabetesBedda L Rosario
Department of Biostatistics, University of Pittsburgh, Graduate School of Public Health, 130 DeSoto Street, 326 Parran Hall, Pittsburgh, PA 15261, USA
Neuroimage 41:363-70. 2008..These findings are relevant for studies of structural brain alterations that may occur in normal aging, chronic medical conditions, neuropsychiatric disorders, and neurodegenerative disorders... - Glucose transport and phosphorylation in skeletal muscle in obesity: insight from a muscle-specific positron emission tomography modelKatherine V Williams
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Clin Endocrinol Metab 88:1271-9. 2003.... - Sequential H(2)(15)O PET studies in baboons: before and after amphetamineJulie C Price
Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
J Nucl Med 43:1090-100. 2002..A common assumption in bolus injection PET studies of this type is that cerebral blood flow (CBF) does not vary during the scan. The goal of this work was to examine the effect of AMPH administration on sequential PET measures of CBF... - Two-year follow-up of amyloid deposition in patients with Alzheimer's diseaseWilliam E Klunk
University of Pittsburgh Medical School Pittsburgh, MA, USA
Brain 129:2805-7. 2006 - Identification of hemodynamic compromise by cerebrovascular reserve and oxygen extraction fraction in occlusive vascular diseaseEdwin M Nemoto
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pennsylvania, USA
J Cereb Blood Flow Metab 24:1081-9. 2004..CVR and OEF showed a significant negative linear relationship in stage II hemodynamic compromise but revealed hemispheres in hemodynamic compromise by CVR but normal OEF that were associated with subcortical white matter infarction... - Reduced 5-HT2A receptor binding after recovery from anorexia nervosaGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 52:896-906. 2002..Altered 5-HT neurotransmission after recovery also supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of AN... - Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to wakingEric A Nofzinger
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
Brain 125:1105-15. 2002.... - Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography studyJulie C Price
PET Facility, Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop St, Rm B938, Pittsburgh, PA 15213, USA
Brain Res 927:97-103. 2002..02). These findings support previous studies that suggest serotonergic underpinnings to the neurobiology of diabetes and have shown diabetes-induced neurological changes in hippocampus... 
Components of a curriculum for molecular imaging scientistsKurt R Zinn
Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama AL 35294 0019, USA
J Nucl Med 52:650-6. 2011....- Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]racloprideGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of California San Diego, California, USA
Biol Psychiatry 58:908-12. 2005..Most intriguing is the possibility that individuals with AN might have a DA related disturbance of reward mechanisms contributing to altered hedonics of feeding behavior and their ascetic, anhedonic temperament... - Consensus nomenclature for in vivo imaging of reversibly binding radioligandsRobert B Innis
National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
J Cereb Blood Flow Metab 27:1533-9. 2007..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands... - Interactions between delivery, transport, and phosphorylation of glucose in governing uptake into human skeletal muscleAlessandra Bertoldo
Department of Information Engineering, University of Padova, Italy
Diabetes 55:3028-37. 2006..This redistribution of control is triggered by the robust stimulation of glucose transport, which in turn unmasks a greater dependence upon delivery and glucose phosphorylation...
Research Grants
- Imaging Amyloid Pathology and its Functional SequelaeJulie Price; Fiscal Year: 2007..This research has the potential to provide information that has not previously been obtainable and facilitate understanding of the impact of progressive amyloid deposition on both cognitive performance and functional brain circuitry. ..
- Mapping Brain Structure and Function in ADJulie Price; Fiscal Year: 2007..g. structural MR, functional PET, behavioral measures) to provide robust outcome measures that are clinically more informative, consistent with the theme of her mentored career development award (K01) that is in its final year. ..
- Simple In Vivo PET Measure of Amyloid Binding in ADJulie Price; Fiscal Year: 2006..abstract_text> ..
- Neuroimaging Medical Illness in Elderly DepressionJulie Price; Fiscal Year: 2005....
- Establishing the In Vivo Threshold for Amyloid Deposition in Normal AgingJulie C Price; Fiscal Year: 2010....