Joseph G Pressey
Affiliation: University of Alabama at Birmingham
- Sirolimus therapy for fibromatosis and multifocal renal cell carcinoma in a child with tuberous sclerosis complexJoseph G Pressey
Division of Hematology Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
Pediatr Blood Cancer 54:1035-7. 2010..In an attempt to avoid bilateral nephrectomies, the patient was treated with the mTOR inhibitor sirolimus. Within 6 months of therapy, the fibromatosis and remaining RCC tumors responded substantially with minimal adverse effects...
- Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology GroupJoseph G Pressey
Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Pediatr Blood Cancer 57:930-8. 2011..A previous report utilizing in situ hybridization has provided initial evidence for the expression of Hh targets GLI1 and PTCH in RMS tumors...
- 2D-difference gel electrophoretic proteomic analysis of a cell culture model of alveolar rhabdomyosarcomaJoseph G Pressey
Department of Pediatrics, Division of Hematology Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
J Proteome Res 10:624-36. 2011..Thus, the 2D-DIGE proteomics methodology described here provided an important discovery approach to the study of RMS biology and complements the findings of previous mRNA expression studies...
- Embryonal rhabdomyosarcoma with a novel t(2;6)(p23;p21.1)Joseph G Pressey
Department of Pediatrics, Division of Hematology Oncology, University of Alabama at Birmingham, 1600 7th Avenue South, ACC 512, Birmingham, AL 35233, USA
Cancer Genet Cytogenet 187:39-42. 2008..Despite the involvement of the 2p23 locus in the translocation, the tumor did not express ALK. The t(2;6)(p23;p21.1) is a novel finding in E-RMS that may provide insight into the pathogenesis of this relatively frequent childhood tumor...
- Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine modelSamer Z Kaylani
Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Avenue South, ACC 414, Birmingham, AL 35233, USA
Biochem Biophys Res Commun 435:557-61. 2013..Our data provide bases for using rapamycin either alone or in combination with traditional chemotherapeutic drugs to block the pathogenesis of high risk RMS...
- CD133 marks a myogenically primitive subpopulation in rhabdomyosarcoma cell lines that are relatively chemoresistant but sensitive to mutant HSVJoseph G Pressey
Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Pediatr Blood Cancer 60:45-52. 2013..Cancer stem cells or cancer-initiating cells (CIC) represent a theorized population of cells that give rise to tumors and are responsible for treatment resistance...
- Current concepts on the surgical and medical management of osteosarcomaHerrick J Siegel
University of Alabama at Birmingham, Orthopedic Specialties Building, 1313 13th St South, Suite 211, Birmingham, AL 35205, USA
Expert Rev Anticancer Ther 8:1257-69. 2008..Biologic targets that will enable new therapies to have maximum effect on tumor cells while minimizing toxicity to the host tissues need to be identified...
- Herpes simplex virus oncolytic therapy for pediatric malignanciesGregory K Friedman
Department of Pediatrics, Children s Hospital of Alabama, University of Alabama at Birmingham, USA
Mol Ther 17:1125-35. 2009....
- Molecular pathogenesis of rhabdomyosarcomaShujuan J Xia
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th Street and Hamilton Walk, Philadelphia, Pennsylvania 19104 6082, USA
Cancer Biol Ther 1:97-104. 2002..Therefore, despite similarities in the downstream targets of these genetic alterations, the striking cytogenetic and molecular differences between ARMS and ERMS indicate distinct molecular etiologies in these two subtypes...
- Primary Ewing sarcoma of the brain: a case report and literature reviewSyed Ali Jaffar Kazmi
Division of Neuropathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Diagn Mol Pathol 16:108-11. 2007..Demonstration of characteristic translocations by molecular studies differentiates CNS-EES from cPNET and help clinicians make informed decisions regarding therapy...
- Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosisJianmin Xu
Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
Cancer Res 70:6566-76. 2010..Our findings indicate that the ability of CP-31398 to modulate wild-type and mutant p53 results in the inhibition of RMS growth and invasiveness...
- Myelofibrosis in a patient with familial hemophagocytic lymphohistiocytosisGregory K Friedman
Division of Pediatric Hematology Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
Pediatr Blood Cancer 50:1260-2. 2008..We report a unique case of primary hemophagocytic lymphohistiocytosis (HLH) detected in an infant who had bone marrow biopsies demonstrating myelofibrosis, a finding not previously reported in primary HLH...