RICHARD PRESLAND

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple beta-defensins in gingival keratinocytes
    Andrea A Kalus
    Department of Medicine Dermatology, University of Washington, Seattle, Washington 98195, USA
    BMC Oral Health 9:21. 2009
  2. ncbi request reprint Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris
    R B Presland
    Department of Oral Biology, University of Washington, Seattle, Washington 98195 7132, USA
    J Invest Dermatol 115:1072-81. 2000
  3. ncbi request reprint Making sense of the epithelial barrier: what molecular biology and genetics tell us about the functions of oral mucosal and epidermal tissues
    Richard B Presland
    Department of Oral Biology, School of Dentistry, University of Washington, Seattle 98195 7132, USA
    J Dent Educ 66:564-74. 2002
  4. ncbi request reprint Regulation of human profilaggrin promoter activity in cultured epithelial cells by retinoic acid and glucocorticoids
    R B Presland
    Department of Oral Biology, University of Washington, Box 357132, Seattle, WA 98195 7132, USA
    J Dermatol Sci 27:192-205. 2001
  5. ncbi request reprint Regulated expression of human filaggrin in keratinocytes results in cytoskeletal disruption, loss of cell-cell adhesion, and cell cycle arrest
    R B Presland
    Department of Oral Biology, University of Washington, Seattle, Washington 98195, USA
    Exp Cell Res 270:199-213. 2001
  6. ncbi request reprint Epithelial structural proteins of the skin and oral cavity: function in health and disease
    R B Presland
    Department of Oral Biology, University of Washington, Seattle 98195, USA
    Crit Rev Oral Biol Med 11:383-408. 2000
  7. ncbi request reprint Evidence that TRPC4 supports the calcium selective I(CRAC)-like current in human gingival keratinocytes
    Sahba Fatherazi
    Department of Oral Biology, University of Washington, Seattle, WA 98195 7132, USA
    Pflugers Arch 453:879-89. 2007
  8. ncbi request reprint TRPC channel expression during calcium-induced differentiation of human gingival keratinocytes
    Shiwei Cai
    Department of Oral Biology, University of Washington, Box 357132, Seattle, WA 98195 6524, USA
    J Dermatol Sci 40:21-8. 2005
  9. ncbi request reprint Functional analysis of the profilaggrin N-terminal peptide: identification of domains that regulate nuclear and cytoplasmic distribution
    David J Pearton
    Department of Oral Biology, University of Washington, Seattle, Washington 98195 7132, USA
    J Invest Dermatol 119:661-9. 2002
  10. ncbi request reprint Evidence that TRPC1 contributes to calcium-induced differentiation of human keratinocytes
    Shiwei Cai
    Department of Oral Biology, University of Washington, Box 357132, Seattle, WA 98195, USA
    Pflugers Arch 452:43-52. 2006

Research Grants

Collaborators

Detail Information

Publications16

  1. pmc Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple beta-defensins in gingival keratinocytes
    Andrea A Kalus
    Department of Medicine Dermatology, University of Washington, Seattle, Washington 98195, USA
    BMC Oral Health 9:21. 2009
    ..These results suggest a complex relationship between genetics and defensin expression that may influence periodontal health and innate immune responses...
  2. ncbi request reprint Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris
    R B Presland
    Department of Oral Biology, University of Washington, Seattle, Washington 98195 7132, USA
    J Invest Dermatol 115:1072-81. 2000
    ..J Invest Dermatol 115:1072-1081 2000..
  3. ncbi request reprint Making sense of the epithelial barrier: what molecular biology and genetics tell us about the functions of oral mucosal and epidermal tissues
    Richard B Presland
    Department of Oral Biology, School of Dentistry, University of Washington, Seattle 98195 7132, USA
    J Dent Educ 66:564-74. 2002
    ..We also highlight recent work demonstrating how loss or attenuation of certain proteases can lead to early onset periodontitis and tooth loss as well as other epithelial abnormalities...
  4. ncbi request reprint Regulation of human profilaggrin promoter activity in cultured epithelial cells by retinoic acid and glucocorticoids
    R B Presland
    Department of Oral Biology, University of Washington, Box 357132, Seattle, WA 98195 7132, USA
    J Dermatol Sci 27:192-205. 2001
    ..These studies demonstrate that RA and glucocorticoids regulate profilaggrin expression at least in part by transcriptional mechanisms, via a region of the promoter that contains both retinoid and glucocorticoid responsive elements...
  5. ncbi request reprint Regulated expression of human filaggrin in keratinocytes results in cytoskeletal disruption, loss of cell-cell adhesion, and cell cycle arrest
    R B Presland
    Department of Oral Biology, University of Washington, Seattle, Washington 98195, USA
    Exp Cell Res 270:199-213. 2001
    ....
  6. ncbi request reprint Epithelial structural proteins of the skin and oral cavity: function in health and disease
    R B Presland
    Department of Oral Biology, University of Washington, Seattle 98195, USA
    Crit Rev Oral Biol Med 11:383-408. 2000
    ..These studies have furthered our understanding of how epithelial tissue and cell integrity is maintained and provide a basis for the future treatment of skin and oral disorders by gene therapy and other novel therapeutics...
  7. ncbi request reprint Evidence that TRPC4 supports the calcium selective I(CRAC)-like current in human gingival keratinocytes
    Sahba Fatherazi
    Department of Oral Biology, University of Washington, Seattle, WA 98195 7132, USA
    Pflugers Arch 453:879-89. 2007
    ..Cells transfected with a scrambled TRPC4 oligonucleotide showed no change in either the I(CRAC)-like or nonspecific currents. The results indicate that TRPC4 is an important component of the I(CRAC)-like channel in HGKs...
  8. ncbi request reprint TRPC channel expression during calcium-induced differentiation of human gingival keratinocytes
    Shiwei Cai
    Department of Oral Biology, University of Washington, Box 357132, Seattle, WA 98195 6524, USA
    J Dermatol Sci 40:21-8. 2005
    ..However, canonical transient receptor potential (TRPC) channels have been identified as store-operated calcium channels in several tissues...
  9. ncbi request reprint Functional analysis of the profilaggrin N-terminal peptide: identification of domains that regulate nuclear and cytoplasmic distribution
    David J Pearton
    Department of Oral Biology, University of Washington, Seattle, Washington 98195 7132, USA
    J Invest Dermatol 119:661-9. 2002
    ....
  10. ncbi request reprint Evidence that TRPC1 contributes to calcium-induced differentiation of human keratinocytes
    Shiwei Cai
    Department of Oral Biology, University of Washington, Box 357132, Seattle, WA 98195, USA
    Pflugers Arch 452:43-52. 2006
    ..These results indicate that TRPC1 is involved in calcium-induced differentiation of HGKs likely by supporting a store-operated calcium ion influx...
  11. ncbi request reprint Expression and characterization of constitutively active human caspase-14
    Kyewhan Park
    Department of Oral Biology, University of Washington, Seattle, WA 98195, USA
    Biochem Biophys Res Commun 347:941-8. 2006
    ....
  12. ncbi request reprint Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation
    Andy J Chien
    Division of Dermatology, Department of Medicine, University of Washington, Box 357132, Seattle, WA 98195 7132, USA
    Biochem Biophys Res Commun 296:911-7. 2002
    ..These data provide evidence for novel processing of caspase-14 suggesting that this enzyme has unique mechanisms of regulation during epidermal differentiation...
  13. ncbi request reprint Analysis of epidermal-type transglutaminase (transglutaminase 3) in human stratified epithelia and cultured keratinocytes using monoclonal antibodies
    Kiyotaka Hitomi
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, 464 8601, Nagoya, Japan
    J Dermatol Sci 32:95-103. 2003
    ..TGase 3 is activated by limited proteolysis of a 77 kDa zymogen during keratinocyte differentiation...
  14. ncbi request reprint Caspase-14 protects against epidermal UVB photodamage and water loss
    Geertrui Denecker
    Department for Molecular Biomedical Research, VIB, Technologie Park 927, B 9052, Ghent, Belgium
    Nat Cell Biol 9:666-74. 2007
    ..Removal of the stratum corneum indicate that caspase-14 controls the UVB scavenging capacity of the stratum corneum...
  15. ncbi request reprint Tetracycline-regulated gene expression in epidermal keratinocytes
    Richard B Presland
    Department of Oral Biology and Medicine, University of Seattle, WA, USA
    Methods Mol Biol 289:273-86. 2005
    ....
  16. ncbi request reprint Barrier function in transgenic mice overexpressing K16, involucrin, and filaggrin in the suprabasal epidermis
    Richard B Presland
    J Invest Dermatol 123:603-6. 2004

Research Grants6

  1. PROFILAGGRIN IN EPIDERMAL DIFFERENTIATION AND FUNCTION
    RICHARD PRESLAND; Fiscal Year: 2002
    ....
  2. Protease-Mediated Events in Epidermal Differentiation
    RICHARD PRESLAND; Fiscal Year: 2006
    ..abstract_text> ..