Brian Prendergast

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Photoperiodic regulation of circulating leukocytes in juvenile Siberian hamsters: mediation by melatonin and testosterone
    Brian J Prendergast
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    J Biol Rhythms 18:473-80. 2003
  2. pmc Sex-specific social regulation of inflammatory responses and sickness behaviors
    Jason R Yee
    Department of Comparative Human Development, University of Chicago, Chicago, IL 60637, USA
    Brain Behav Immun 24:942-51. 2010
  3. pmc MT1 melatonin receptors mediate somatic, behavioral, and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters (Phodopus sungorus)
    Brian J Prendergast
    Department of Psychology and Committee on Neurobiology, Institute for Mind and Biology, University of Chicago, 940 East 57th Street, Chicago, Illinois 60637, USA
    Endocrinology 151:714-21. 2010
  4. pmc Photoperiod history differentially impacts reproduction and immune function in adult Siberian hamsters
    Brian J Prendergast
    Department of Psychology, University of Chicago, Illinois, USA
    J Biol Rhythms 24:509-22. 2009
  5. pmc Reproductive responses to photoperiod persist in olfactory bulbectomized Siberian hamsters (Phodopus sungorus)
    Brian J Prendergast
    Department of Psychology, The University of Chicago, Chicago, IL 60637, USA
    Behav Brain Res 198:159-64. 2009
  6. ncbi request reprint Influence of the olfactory bulbs on blood leukocytes and behavioral responses to infection in Siberian hamsters
    Brian J Prendergast
    Department of Psychology, Institute for Mind and Biology, The University of Chicago, Chicago, IL 60637, USA
    Brain Res 1268:48-57. 2009
  7. doi request reprint Circadian arrhythmia dysregulates emotional behaviors in aged Siberian hamsters
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA Committee on Neurobiology, University of Chicago, Chicago, IL 60637, USA Electronic address
    Behav Brain Res 261:146-57. 2014
  8. pmc Neonatal monosodium glutamate treatment counteracts circadian arrhythmicity induced by phase shifts of the light-dark cycle in female and male Siberian hamsters
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Brain Res 1521:51-8. 2013
  9. pmc Impaired leukocyte trafficking and skin inflammatory responses in hamsters lacking a functional circadian system
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Brain Behav Immun 32:94-104. 2013
  10. pmc Sex differences in Siberian hamster ultradian locomotor rhythms
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Physiol Behav 110:206-12. 2013

Research Grants

Detail Information

Publications43

  1. ncbi request reprint Photoperiodic regulation of circulating leukocytes in juvenile Siberian hamsters: mediation by melatonin and testosterone
    Brian J Prendergast
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    J Biol Rhythms 18:473-80. 2003
    ..These data indicate that juvenile Siberian hamsters are immunologically responsive to photoperiod and that the leukocyte responses to day length are the result of melatonin-mediated effects of photoperiod on testicular hormone secretion...
  2. pmc Sex-specific social regulation of inflammatory responses and sickness behaviors
    Jason R Yee
    Department of Comparative Human Development, University of Chicago, Chicago, IL 60637, USA
    Brain Behav Immun 24:942-51. 2010
    ..These sex differences are mediated in part by differential effects of the social environment on pro- and anti-inflammatory cytokine production...
  3. pmc MT1 melatonin receptors mediate somatic, behavioral, and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters (Phodopus sungorus)
    Brian J Prendergast
    Department of Psychology and Committee on Neurobiology, Institute for Mind and Biology, University of Chicago, 940 East 57th Street, Chicago, Illinois 60637, USA
    Endocrinology 151:714-21. 2010
    ..Together, the outcomes indicate that signaling at the MT1 receptor is sufficient and necessary to mediate the effects of photoperiod-driven changes in MEL on behavior and reproductive function in a reproductively photoperiodic mammal...
  4. pmc Photoperiod history differentially impacts reproduction and immune function in adult Siberian hamsters
    Brian J Prendergast
    Department of Psychology, University of Chicago, Illinois, USA
    J Biol Rhythms 24:509-22. 2009
    ..Prior photoperiod exposure has an enduring impact on the ability of the immune system to respond to subsequent changes in day length...
  5. pmc Reproductive responses to photoperiod persist in olfactory bulbectomized Siberian hamsters (Phodopus sungorus)
    Brian J Prendergast
    Department of Psychology, The University of Chicago, Chicago, IL 60637, USA
    Behav Brain Res 198:159-64. 2009
    ..In marked contrast to Syrian hamsters, the olfactory bulbs of Siberian hamsters play essentially no role in the modulation of tonic gonadotrophin production or gonadotrophin responses to photoperiod...
  6. ncbi request reprint Influence of the olfactory bulbs on blood leukocytes and behavioral responses to infection in Siberian hamsters
    Brian J Prendergast
    Department of Psychology, Institute for Mind and Biology, The University of Chicago, Chicago, IL 60637, USA
    Brain Res 1268:48-57. 2009
    ..The data indicate that photoperiod affects immune function via OB-dependent and -independent mechanisms, and that changes in cortisol production are not required for photoperiodic changes in sickness behaviors to manifest...
  7. doi request reprint Circadian arrhythmia dysregulates emotional behaviors in aged Siberian hamsters
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA Committee on Neurobiology, University of Chicago, Chicago, IL 60637, USA Electronic address
    Behav Brain Res 261:146-57. 2014
    ....
  8. pmc Neonatal monosodium glutamate treatment counteracts circadian arrhythmicity induced by phase shifts of the light-dark cycle in female and male Siberian hamsters
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Brain Res 1521:51-8. 2013
    ..The data also suggest that light thresholds for entrainment of circadian rhythms may be lower than those required to disrupt circadian organization...
  9. pmc Impaired leukocyte trafficking and skin inflammatory responses in hamsters lacking a functional circadian system
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Brain Behav Immun 32:94-104. 2013
    ..Robust entrainment of the circadian pacemaker provides a signal critical to diurnal rhythms in immunosurveilliance and optimal memory T-cell dependent immune responses...
  10. pmc Sex differences in Siberian hamster ultradian locomotor rhythms
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Physiol Behav 110:206-12. 2013
    ..Day length controls several UR characteristics via gonadal steroid and melatonin-independent mechanisms. Sex differences in ultradian timing may contribute to sex diphenisms in rhythms of sleep, food intake and exercise...
  11. pmc Pineal and gonadal influences on ultradian locomotor rhythms of male Siberian hamsters
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Horm Behav 63:54-64. 2013
    ....
  12. pmc Photoperiodic influences on ultradian rhythms of male Siberian hamsters
    Brian J Prendergast
    Department of Psychology and Committee on Neurobiology, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e41723. 2012
    ..At the UR-threshold photoperiod of 13 L, differences in gonadal status were largely without effect on most UR parameters...
  13. pmc Dissociation of ultradian and circadian phenotypes in female and male Siberian hamsters
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    J Biol Rhythms 27:287-98. 2012
    ..Considered together, the present results point to the existence of separable control mechanisms for generation of circadian and ultradian rhythms...
  14. pmc Enhancement and suppression of ultradian and circadian rhythms across the female hamster reproductive cycle
    Brian J Prendergast
    Department of Psychology and Committee on Neurobiology, University of Chicago, Chicago, IL 60637, USA
    J Biol Rhythms 27:246-56. 2012
    ..Diminution of CRs and augmentation of URs may afford greater behavioral flexibility during life stages when interactions with mates and offspring are less predictable...
  15. ncbi request reprint Gonadal hormone-dependent and -independent regulation of immune function by photoperiod in Siberian hamsters
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Regul Integr Comp Physiol 294:R384-92. 2008
    ..Thus, photoperiod affects the immune system and neural-immune interactions underlying sickness behaviors via gonadal hormone-dependent and -independent mechanisms...
  16. ncbi request reprint Affective and adrenocorticotrophic responses to photoperiod in Wistar rats
    B J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    J Neuroendocrinol 20:261-7. 2008
    ..Standard laboratory husbandry practices (exposure to a 12 : 12 h light/dark cycle) may inadvertently deliver a chronic background depressive and anxiogenic stimulus...
  17. pmc Behavioral tolerance to endotoxin is enhanced by adaptation to winter photoperiods
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Psychoneuroendocrinology 33:540-5. 2008
    ..During winter, enhancements in behavioral endotoxin tolerance may conserve energy and facilitate survival in the face of energetically challenging conditions...
  18. pmc Can photoperiod predict mortality in the 1918-1920 influenza pandemic?
    Brian J Prendergast
    Department of Psychology, Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, USA
    J Biol Rhythms 26:345-52. 2011
    ..The author proposes that some proportion of the global variance in morbidity and mortality from infectious diseases may be explained by effects of day length on the innate immune response to infection...
  19. pmc Winter day lengths enhance T lymphocyte phenotypes, inhibit cytokine responses, and attenuate behavioral symptoms of infection in laboratory rats
    Brian J Prendergast
    Department of Psychology, Institute for Mind and Biology, University of Chicago, 940 E 57th Street, Chicago, IL 60637, USA
    Brain Behav Immun 21:1096-108. 2007
    ..Seasonal changes in the host immune system, endocrine system, and behavior may contribute to the seasonal variability in disease outcomes, even in reproductively non-photoperiodic mammals...
  20. ncbi request reprint Effects of photoperiod history on immune responses to intermediate day lengths in Siberian hamsters (Phodopus sungorus)
    Brian J Prendergast
    Departments of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    J Neuroimmunol 149:31-9. 2004
    ..The data suggest that photoperiodic mechanisms that enhance and suppress several aspects of immunity in young-adult hamsters are not responsive to prenatally communicated photoperiod history information...
  21. ncbi request reprint Genetic analyses of a seasonal interval timer
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    J Biol Rhythms 19:298-311. 2004
    ..Balancing selection in environments where the onset of spring conditions varies from year to year could maintain genetic variance in interval timers and yield interval timers tuned to the local environment...
  22. ncbi request reprint Refractoriness to short day lengths augments tonic and gonadotrophin-releasing hormone-stimulated lutenising hormone secretion
    B J Prendergast
    Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, USA
    J Neuroendocrinol 18:339-48. 2006
    ....
  23. ncbi request reprint Short day lengths enhance skin immune responses in gonadectomised Siberian hamsters
    B J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    J Neuroendocrinol 17:18-21. 2005
    ..The data suggest that contemporary gonadal hormone secretion is neither necessary, nor sufficient to mediate the effects of short photoperiods on skin immune function...
  24. ncbi request reprint Internalization of seasonal time
    Brian J Prendergast
    Department of Psychology, Institute for Mind and Biology, University of Chicago, 940 E 57th St, Chicago, IL 60637, USA
    Horm Behav 48:503-11. 2005
    ....
  25. ncbi request reprint Affective responses to changes in day length in Siberian hamsters (Phodopus sungorus)
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Psychoneuroendocrinology 30:438-52. 2005
    ..Together the results indicate that adaptation to short photoperiods is associated with increased expression of anxiety- and depressive-like behaviors relative to those observed under LD photoperiod conditions...
  26. pmc Pineal-dependent and -independent effects of photoperiod on immune function in Siberian hamsters (Phodopus sungorus)
    Jarvi C Wen
    Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, USA
    Horm Behav 51:31-9. 2007
    ..The pineal gland is required for photoperiodic regulation of circulating leukocytes and neural-immune interactions that mediate select aspects of sickness behaviors...
  27. pmc Hypothalamic gene expression in reproductively photoresponsive and photorefractory Siberian hamsters
    Brian J Prendergast
    Departments of Psychology and Neuroscience, and Biochemistry and Medical Biochemistry and Neurobiotechnology Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 99:16291-6. 2002
    ....
  28. ncbi request reprint Photoperiod controls the induction, retention, and retrieval of antigen-specific immunological memory
    Brian J Prendergast
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Regul Integr Comp Physiol 286:R54-60. 2004
    ..The data suggest that short photoperiods have enduring effects on immune responsiveness and on the establishment and retention of immunological memory...
  29. pmc Photoperiodic regulation of behavioral responsiveness to proinflammatory cytokines
    Jarvi C Wen
    Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States
    Physiol Behav 90:717-25. 2007
    ....
  30. ncbi request reprint Peripubertal immune challenges attenuate reproductive development in male Siberian hamsters (Phodopus sungorus)
    Brian J Prendergast
    Departments of Psychology and Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    Biol Reprod 70:813-20. 2004
    ..The data also underscore the importance of seasonally dependent life history factors in assessing physiological tradeoffs...
  31. doi request reprint Photoperiodic regulation of behavioral responses to bacterial and viral mimetics: a test of the winter immunoenhancement hypothesis
    Scott R Baillie
    Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, USA
    J Biol Rhythms 23:81-90. 2008
    ..Energetically costly behavioral responses to several distinct classes of infectious organisms are attenuated in anticipation of winter. The data are not consistent with a pathogen-specific seasonal modulation of innate immune responses...
  32. ncbi request reprint Low amplitude entrainment of mice and the impact of circadian phase on behavior tests
    Jeff A Beeler
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA
    Physiol Behav 87:870-80. 2006
    ..In general, testing mice during their active phase is more suitable for behavioral studies; a reversed dim/bright photocycle potentially offers one practical strategy for managing rodents' circadian cycles...
  33. ncbi request reprint Photoperiodic adjustments in immune function protect Siberian hamsters from lethal endotoxemia
    Brian J Prendergast
    Department of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    J Biol Rhythms 18:51-62. 2003
    ..Adaptation to short days induces changes in immune parameters that affect survival in the face of immune challenges...
  34. pmc Mammary tumors induce select cognitive impairments
    Leah M Pyter
    Department of Psychology, Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, USA
    Brain Behav Immun 24:903-7. 2010
    ..Together the results indicate that peripheral tumors alone are sufficient to induce increases in hippocampal cytokine expression and select deficits in hippocampal-dependent memory tasks...
  35. pmc Photoperiodic regulation of the orexigenic effects of ghrelin in Siberian hamsters
    Sean P Bradley
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Horm Behav 58:647-52. 2010
    ..The data also identify photoperiod-induced changes in the ability of ghrelin to activate ARC NPY neurons as a possible mechanism by which changes in day length alter food intake...
  36. pmc Peripheral tumors induce depressive-like behaviors and cytokine production and alter hypothalamic-pituitary-adrenal axis regulation
    Leah M Pyter
    Department of Psychology, Institute for Mind and Biology, University of Chicago, 940 East 57th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:9069-74. 2009
    ..The results establish that tumors alone are sufficient to trigger changes in emotional behaviors. Dampened glucocorticoid responses to stressors may exacerbate the deleterious effects of tumor-induced cytokines on affective states...
  37. ncbi request reprint Temporal integration of melatonin infusion duration: signal averaging versus frequency dependence
    Jolanta M Piatkowska
    Department of Psychology, University of California, San Diego, CA, USA
    J Pineal Res 35:91-7. 2003
    ..In the majority (six of seven) of infusion regimes, reproductive responses to chimeric patterns of long and short melatonin signals were compatible with a simple signal-averaging mechanism...
  38. ncbi request reprint Photoperiod and stress affect wound healing in Siberian hamsters
    Steven G Kinsey
    Departments of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Physiol Behav 78:205-11. 2003
    ..In nature, enhanced wound healing coincident with the breeding season and territorial defense may be adaptive...
  39. ncbi request reprint Periodic arousal from hibernation is necessary for initiation of immune responses in ground squirrels
    Brian J Prendergast
    Department of Psychology, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1054-62. 2002
    ..Periodic arousals may activate a dormant immune system, which can then combat pathogens that may have been introduced immediately before or during hibernation...
  40. ncbi request reprint Form over function?
    Randy J Nelson
    Department of Psychology, The Ohio State University, Columbus 43210, USA
    J Biol Rhythms 17:406-9; discussion 410-2. 2002
  41. ncbi request reprint Social facilitation of wound healing
    Courtney E Detillion
    Department of Psychology, The Ohio State University, 01 Townsend Hall, 1885 Neil Avenue, Columbus, OH 43210 USA
    Psychoneuroendocrinology 29:1004-11. 2004
    ..The data imply that social isolation impairs wound healing, whereas OT treatment may ameliorate some effects of social isolation on health...
  42. ncbi request reprint Melatonin acts at the suprachiasmatic nucleus to attenuate behavioral symptoms of infection
    David A Freeman
    Department of Biology, University of Memphis, Memphis, TN, USA
    Behav Neurosci 121:689-97. 2007
    ....
  43. ncbi request reprint Exogenous T3 mimics long day lengths in Siberian hamsters
    David A Freeman
    Department of Biology, University of Memphis, Memphis, Tennessee 38152 3540, USA
    Am J Physiol Regul Integr Comp Physiol 292:R2368-72. 2007
    ..These results suggest that T3 mimics long day exposure in Siberian hamsters and may serve as an intermediate step between the Mel rhythm and the reproductive response...

Research Grants4

  1. Processing Photoperiod Information by the Immune System
    Brian Prendergast; Fiscal Year: 2005
    ....
  2. Processing Photoperiod Information by the Immune System
    Brian Prendergast; Fiscal Year: 2006
    ....
  3. Processing Photoperiod Information by the Immune System
    Brian Prendergast; Fiscal Year: 2007
    ....