M Pravetoni

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens
    Marco Pravetoni
    Minneapolis Medical Research Foundation, 701 Park Avenue, Minneapolis, Minnesota 55404, USA
    J Med Chem 56:915-23. 2013
  2. pmc Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats
    M Pravetoni
    Minneapolis Medical Research Foundation, 600 Shapiro Building, 914 8th Street, Minneapolis, MN 55404, USA
    Vaccine 30:4617-24. 2012
  3. pmc Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities
    M Pravetoni
    Minneapolis Medical Research Foundation, 600 Shapiro Bldg, 914 S 8th Street, Minneapolis, MN 55404, USA
    Biochem Pharmacol 83:543-50. 2012
  4. pmc An oxycodone conjugate vaccine elicits drug-specific antibodies that reduce oxycodone distribution to brain and hot-plate analgesia
    M Pravetoni
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    J Pharmacol Exp Ther 341:225-32. 2012
  5. pmc Selective effects of a morphine conjugate vaccine on heroin and metabolite distribution and heroin-induced behaviors in rats
    M D Raleigh
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
    J Pharmacol Exp Ther 344:397-406. 2013
  6. ncbi request reprint Hapten-specific naïve B cells are biomarkers of vaccine efficacy against drugs of abuse
    J J Taylor
    University of Minnesota, Department of Microbiology, Center for Immunology, 2101 6th Street SE, 2 142 MBB, Minneapolis, MN 55455, USA
    J Immunol Methods 405:74-86. 2014
  7. pmc Vaccination against nicotine alters the distribution of nicotine delivered via cigarette smoke inhalation to rats
    M Pravetoni
    Minneapolis Medical Research Foundation, Minneapolis, MN, USA
    Biochem Pharmacol 81:1164-70. 2011

Collaborators

  • J J Taylor
  • M D Raleigh
  • A M Tucker
  • M K Jenkins
  • M Laudenbach
  • A C Harris
  • A K Birnbaum
  • P R Pentel

Detail Information

Publications7

  1. pmc Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens
    Marco Pravetoni
    Minneapolis Medical Research Foundation, 701 Park Avenue, Minneapolis, Minnesota 55404, USA
    J Med Chem 56:915-23. 2013
    ..Amide conjugation showed higher haptenation ratios and greater efficacy than thioether conjugation to maleimide activated KLH (mKLH). The 6OXY(Gly)(4)-KLH vaccine may be used for treatment of prescription opioid abuse...
  2. pmc Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats
    M Pravetoni
    Minneapolis Medical Research Foundation, 600 Shapiro Building, 914 8th Street, Minneapolis, MN 55404, USA
    Vaccine 30:4617-24. 2012
    ..These data support the possibility of co-administering two or more opioid vaccines concurrently to target multiple abusable opioids without compromising the immunogenicity or efficacy of the individual components...
  3. pmc Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities
    M Pravetoni
    Minneapolis Medical Research Foundation, 600 Shapiro Bldg, 914 S 8th Street, Minneapolis, MN 55404, USA
    Biochem Pharmacol 83:543-50. 2012
    ..This approach could be applicable to other addiction vaccines or small molecule targets as well...
  4. pmc An oxycodone conjugate vaccine elicits drug-specific antibodies that reduce oxycodone distribution to brain and hot-plate analgesia
    M Pravetoni
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    J Pharmacol Exp Ther 341:225-32. 2012
    ..Immunization with OXY(Gly)(4)-KLH also reduced OXY analgesia in a thermal nociception test. These data support further study of vaccination with the OXY(Gly)(4)-KLH immunogen as a potential treatment option for OXY abuse or addiction...
  5. pmc Selective effects of a morphine conjugate vaccine on heroin and metabolite distribution and heroin-induced behaviors in rats
    M D Raleigh
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
    J Pharmacol Exp Ther 344:397-406. 2013
    ..These data support a critical role for 6-MAM in mediating the early effects of i.v. heroin and suggest that reducing 6-MAM concentration in brain is essential to the efficacy of morphine conjugate vaccines...
  6. ncbi request reprint Hapten-specific naïve B cells are biomarkers of vaccine efficacy against drugs of abuse
    J J Taylor
    University of Minnesota, Department of Microbiology, Center for Immunology, 2101 6th Street SE, 2 142 MBB, Minneapolis, MN 55455, USA
    J Immunol Methods 405:74-86. 2014
    ..Analysis of hapten-specific naïve and activated B cells may aid rational vaccine design and provide screening tools to predict vaccine clinical efficacy against drugs of abuse or other small molecules. ..
  7. pmc Vaccination against nicotine alters the distribution of nicotine delivered via cigarette smoke inhalation to rats
    M Pravetoni
    Minneapolis Medical Research Foundation, Minneapolis, MN, USA
    Biochem Pharmacol 81:1164-70. 2011
    ..v. or s.c. nicotine dosing and provide a quantitative method for studying aspects of nicotine exposure which are unique to cigarette smoke inhalation...