Matthew R Pratt

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Small-molecule reprogramming of cancer metabolism
    Matthew R Pratt
    Departments of Chemistry and Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA Electronic address
    Chem Biol 19:1084-5. 2012
  2. pmc Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe
    Matthew R Pratt
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, NY 10065, USA
    Chem Biol 16:1001-12. 2009
  3. doi request reprint N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation
    Leslie A Bateman
    Department of Chemistry, University of Southern California, Los Angeles, USA
    Chem Commun (Camb) 49:4328-30. 2013
  4. doi request reprint O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation
    Nicholas P Marotta
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089 0744, USA
    Chembiochem 13:2665-70. 2012
  5. pmc Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent
    Kathleen M Averette
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 4:e7913. 2009
  6. pmc Site-specific differences in proteasome-dependent degradation of monoubiquitinated α-synuclein
    Tharindumala Abeywardana
    Department of Chemistry, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA
    Chem Biol 20:1207-13. 2013
  7. ncbi request reprint Robust in-gel fluorescence detection of mucin-type O-linked glycosylation
    Balyn W Zaro
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA
    Bioorg Med Chem Lett 21:5062-6. 2011
  8. doi request reprint An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells
    Leslie A Bateman
    Department of Chemistry and Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States
    J Am Chem Soc 135:14568-73. 2013
  9. pmc A dual small-molecule rheostat for precise control of protein concentration in Mammalian cells
    Yu Hsuan Lin
    Department of Chemistry, University of Southern California, 840 Downey Way, Los Angeles, CA 90089 USA
    Chembiochem 15:805-9. 2014
  10. doi request reprint Incorporation of unnatural sugars for the identification of glycoproteins
    Balyn W Zaro
    Department of Chemistry, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 951:57-67. 2013

Collaborators

  • Tom W Muir
  • Joseph A Loo
  • Howard C Hang
  • Maja Köhn
  • Simone Engelender
  • Balyn W Zaro
  • Leslie A Bateman
  • Tharindumala Abeywardana
  • Yu Hsuan Lin
  • Nicholas P Marotta
  • Franziska Meier
  • Champak Chatterjee
  • Robert K McGinty
  • Kathleen M Averette
  • Ruth Rott
  • Stephanie M Miller
  • Kelly N Chuh
  • Ralf Langen
  • Jobin Varkey
  • Carli A Cherwien
  • Abhinav Dhall
  • Yu Ying Yang
  • Julian P Whitelegge
  • Kenneth A Bradley
  • Kyle P Chiang
  • Sara Bassilian
  • Yanan Yang

Detail Information

Publications13

  1. ncbi request reprint Small-molecule reprogramming of cancer metabolism
    Matthew R Pratt
    Departments of Chemistry and Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA Electronic address
    Chem Biol 19:1084-5. 2012
    ..In this issue of Chemistry & Biology, Kung et al. report the characterization of a small molecule activator of the enzyme pyruvate kinase M2, which reprograms cancer cell metabolism resulting in dependence on the amino acid serine...
  2. pmc Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe
    Matthew R Pratt
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, NY 10065, USA
    Chem Biol 16:1001-12. 2009
    ..Our data further supports a role for cathepsin B in the cytosol as a positive regulator of a cell death feed-forward loop and provides a chemical tool for future investigations...
  3. doi request reprint N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation
    Leslie A Bateman
    Department of Chemistry, University of Southern California, Los Angeles, USA
    Chem Commun (Camb) 49:4328-30. 2013
    ..Here we describe the synthesis and characterization of metabolic chemical reporters bearing an N-propargyloxycarbamate (Poc) group that creates discrimination between glycosylation pathways...
  4. doi request reprint O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation
    Nicholas P Marotta
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089 0744, USA
    Chembiochem 13:2665-70. 2012
    ..Here we show that an O-GlcNAc-modified peptide does not participate in α-synuclein aggregation, thus suggesting that O-GlcNAc might directly inhibit aggregation in cells...
  5. pmc Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent
    Kathleen M Averette
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 4:e7913. 2009
    ..These data reveal a role for lysosomal membrane permeabilization in the cellular response to bacterial pathogens and demonstrate a shared requirement for cytosolic relocalization of cathepsins in pyroptosis and pyronecrosis...
  6. pmc Site-specific differences in proteasome-dependent degradation of monoubiquitinated α-synuclein
    Tharindumala Abeywardana
    Department of Chemistry, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA
    Chem Biol 20:1207-13. 2013
    ..The data suggest that the site-specific effects of monoubiquitination support different levels of α-synuclein degradation...
  7. ncbi request reprint Robust in-gel fluorescence detection of mucin-type O-linked glycosylation
    Balyn W Zaro
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA
    Bioorg Med Chem Lett 21:5062-6. 2011
    ..We report here the use of the metabolic chemical reporter GalNAz along with Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition conditions for the robust, in-gel fluorescent visualization of mucin-type O-linked glycoproteins...
  8. doi request reprint An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells
    Leslie A Bateman
    Department of Chemistry and Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States
    J Am Chem Soc 135:14568-73. 2013
    ..Finally, AspAlk was shown to modify the core histone proteins, implicating aspirin as a potential chemical-regulator of transcription. ..
  9. pmc A dual small-molecule rheostat for precise control of protein concentration in Mammalian cells
    Yu Hsuan Lin
    Department of Chemistry, University of Southern California, 840 Downey Way, Los Angeles, CA 90089 USA
    Chembiochem 15:805-9. 2014
    ..The TTShld system has a greatly improved dynamic range compared to our previously reported system, and the traceless feature is attractive for elucidation of the consequences of protein concentration in cell biology. ..
  10. doi request reprint Incorporation of unnatural sugars for the identification of glycoproteins
    Balyn W Zaro
    Department of Chemistry, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 951:57-67. 2013
    ....
  11. pmc Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1
    Balyn W Zaro
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 108:8146-51. 2011
    ..Finally we confirmed the O-GlcNAc modification of the ubiquitin ligase NEDD4-1, the first reported glycosylation of this protein...
  12. pmc Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation
    Franziska Meier
    Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States
    J Am Chem Soc 134:5468-71. 2012
    ..We have used protein semisynthesis to generate nine site-specifically ubiquitin modified α-synuclein derivatives and have demonstrated that different ubiquitination sites have differential effects on α-synuclein aggregation...
  13. pmc Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B
    Robert K McGinty
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    ACS Chem Biol 4:958-68. 2009
    ..Furthermore, titration of the level of uH2B within the nucleosome revealed a 1:1 stoichiometry of Dot1L activation...