Matthew R Pratt

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Small-molecule reprogramming of cancer metabolism
    Matthew R Pratt
    Departments of Chemistry and Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA Electronic address
    Chem Biol 19:1084-5. 2012
  2. pmc Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe
    Matthew R Pratt
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, NY 10065, USA
    Chem Biol 16:1001-12. 2009
  3. doi request reprint N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation
    Leslie A Bateman
    Department of Chemistry, University of Southern California, Los Angeles, USA
    Chem Commun (Camb) 49:4328-30. 2013
  4. doi request reprint O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation
    Nicholas P Marotta
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089 0744, USA
    Chembiochem 13:2665-70. 2012
  5. pmc Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent
    Kathleen M Averette
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 4:e7913. 2009
  6. doi request reprint Robust in-gel fluorescence detection of mucin-type O-linked glycosylation
    Balyn W Zaro
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA
    Bioorg Med Chem Lett 21:5062-6. 2011
  7. doi request reprint An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells
    Leslie A Bateman
    Department of Chemistry and Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States
    J Am Chem Soc 135:14568-73. 2013
  8. pmc Site-specific differences in proteasome-dependent degradation of monoubiquitinated α-synuclein
    Tharindumala Abeywardana
    Department of Chemistry, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA
    Chem Biol 20:1207-13. 2013
  9. doi request reprint Incorporation of unnatural sugars for the identification of glycoproteins
    Balyn W Zaro
    Department of Chemistry, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 951:57-67. 2013
  10. pmc Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1
    Balyn W Zaro
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 108:8146-51. 2011

Collaborators

  • Tom W Muir
  • Howard C Hang
  • Simone Engelender
  • Balyn W Zaro
  • Leslie A Bateman
  • Tharindumala Abeywardana
  • Nicholas P Marotta
  • Franziska Meier
  • Champak Chatterjee
  • Kathleen M Averette
  • Robert K McGinty
  • Yu Hsuan Lin
  • Kelly N Chuh
  • Stephanie M Miller
  • Ruth Rott
  • Abhinav Dhall
  • Jobin Varkey
  • Carli A Cherwien
  • Ralf Langen
  • Yu Ying Yang
  • Kyle P Chiang
  • Yanan Yang
  • Maja Köhn
  • Julian P Whitelegge
  • Kenneth A Bradley
  • Sara Bassilian
  • Joseph A Loo

Detail Information

Publications12

  1. ncbi request reprint Small-molecule reprogramming of cancer metabolism
    Matthew R Pratt
    Departments of Chemistry and Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA Electronic address
    Chem Biol 19:1084-5. 2012
    ..In this issue of Chemistry & Biology, Kung et al. report the characterization of a small molecule activator of the enzyme pyruvate kinase M2, which reprograms cancer cell metabolism resulting in dependence on the amino acid serine...
  2. pmc Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe
    Matthew R Pratt
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, NY 10065, USA
    Chem Biol 16:1001-12. 2009
    ..Our data further supports a role for cathepsin B in the cytosol as a positive regulator of a cell death feed-forward loop and provides a chemical tool for future investigations...
  3. doi request reprint N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation
    Leslie A Bateman
    Department of Chemistry, University of Southern California, Los Angeles, USA
    Chem Commun (Camb) 49:4328-30. 2013
    ..Here we describe the synthesis and characterization of metabolic chemical reporters bearing an N-propargyloxycarbamate (Poc) group that creates discrimination between glycosylation pathways...
  4. doi request reprint O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation
    Nicholas P Marotta
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089 0744, USA
    Chembiochem 13:2665-70. 2012
    ..Here we show that an O-GlcNAc-modified peptide does not participate in α-synuclein aggregation, thus suggesting that O-GlcNAc might directly inhibit aggregation in cells...
  5. pmc Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent
    Kathleen M Averette
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 4:e7913. 2009
    ..These data reveal a role for lysosomal membrane permeabilization in the cellular response to bacterial pathogens and demonstrate a shared requirement for cytosolic relocalization of cathepsins in pyroptosis and pyronecrosis...
  6. doi request reprint Robust in-gel fluorescence detection of mucin-type O-linked glycosylation
    Balyn W Zaro
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA
    Bioorg Med Chem Lett 21:5062-6. 2011
    ..We report here the use of the metabolic chemical reporter GalNAz along with Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition conditions for the robust, in-gel fluorescent visualization of mucin-type O-linked glycoproteins...
  7. doi request reprint An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells
    Leslie A Bateman
    Department of Chemistry and Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States
    J Am Chem Soc 135:14568-73. 2013
    ..Finally, AspAlk was shown to modify the core histone proteins, implicating aspirin as a potential chemical-regulator of transcription. ..
  8. pmc Site-specific differences in proteasome-dependent degradation of monoubiquitinated α-synuclein
    Tharindumala Abeywardana
    Department of Chemistry, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA
    Chem Biol 20:1207-13. 2013
    ..The data suggest that the site-specific effects of monoubiquitination support different levels of α-synuclein degradation...
  9. doi request reprint Incorporation of unnatural sugars for the identification of glycoproteins
    Balyn W Zaro
    Department of Chemistry, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 951:57-67. 2013
    ....
  10. pmc Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1
    Balyn W Zaro
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 108:8146-51. 2011
    ..Finally we confirmed the O-GlcNAc modification of the ubiquitin ligase NEDD4-1, the first reported glycosylation of this protein...
  11. pmc Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation
    Franziska Meier
    Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States
    J Am Chem Soc 134:5468-71. 2012
    ..We have used protein semisynthesis to generate nine site-specifically ubiquitin modified α-synuclein derivatives and have demonstrated that different ubiquitination sites have differential effects on α-synuclein aggregation...
  12. pmc Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B
    Robert K McGinty
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    ACS Chem Biol 4:958-68. 2009
    ..Furthermore, titration of the level of uH2B within the nucleosome revealed a 1:1 stoichiometry of Dot1L activation...