D Pratico

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Vitamin E: murine studies versus clinical trials
    D Pratico
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, BRB II III, Room 812, 421, Curie Boulevard, Philadelphia, PA 19104, USA
    Ital Heart J 2:878-81. 2001
  2. ncbi Lipid peroxidation and oxidative imbalance: early functional events in Alzheimer's disease
    Domenico Pratico
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Alzheimers Dis 6:171-5. 2004
  3. ncbi In vivo measurement of the redox state
    D Pratico
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia 19104, USA
    Lipids 36:S45-7. 2001
  4. ncbi Antioxidants and endothelium protection
    Domenico Pratico
    The Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Atherosclerosis 181:215-24. 2005
  5. ncbi Local and systemic increase in lipid peroxidation after moderate experimental traumatic brain injury
    Domenico Pratico
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Neurochem 80:894-8. 2002
  6. ncbi Alzheimer's disease and oxygen radicals: new insights
    Domenico Pratico
    Department of Pharmacology, Center for Experimental Therapeutics School of Medicine, University of Pennsylvania, 421 Curie Blvd, BRB 2 3, Room 812, Philadelphia, PA 19104, USA
    Biochem Pharmacol 63:563-7. 2002
  7. ncbi Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice
    Domenico Pratico
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    FASEB J 16:1138-40. 2002
  8. ncbi Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease
    Domenico Pratico
    Center for Experimental Therapeutics, University of Pennsylvania, BRB II III, Room 812, 421 Curie Blvd, Philadelphia, PA 19104
    Arch Neurol 59:972-6. 2002
  9. ncbi Peripheral biomarkers of oxidative damage in Alzheimer's disease: the road ahead
    Domenico Pratico
    University of Pennsylvania, School of Medicine, Department of Pharmacology, 3620 Hamilton Walk, John Morgan Building, Room 124, Philadelphia, PA 19104, USA
    Neurobiol Aging 26:581-3. 2005
  10. ncbi Reduction of brain lipid peroxidation by CSF drainage in Alzheimer's disease patients
    Domenico Pratico
    Department of Pharmacology, The Center for Experimental Therapeutics, University of Pennsylvania, School of Medicine, Philadelphia 19104, USA
    J Alzheimers Dis 6:385-9; discussion 443-9. 2004

Collaborators

Detail Information

Publications65

  1. ncbi Vitamin E: murine studies versus clinical trials
    D Pratico
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, BRB II III, Room 812, 421, Curie Boulevard, Philadelphia, PA 19104, USA
    Ital Heart J 2:878-81. 2001
    ..Finally, insights into what might be the most appropriate nature of future trials in humans are given...
  2. ncbi Lipid peroxidation and oxidative imbalance: early functional events in Alzheimer's disease
    Domenico Pratico
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Alzheimers Dis 6:171-5. 2004
    ....
  3. ncbi In vivo measurement of the redox state
    D Pratico
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia 19104, USA
    Lipids 36:S45-7. 2001
    ..The task for the near future will be to try to simplify the analytical methodology and elucidate the molecular mechanisms underlying the formation, disposition, and kinetics of FR marker molecules...
  4. ncbi Antioxidants and endothelium protection
    Domenico Pratico
    The Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Atherosclerosis 181:215-24. 2005
    ..Finally, the non-antioxidant activities of some antioxidant will also be described...
  5. ncbi Local and systemic increase in lipid peroxidation after moderate experimental traumatic brain injury
    Domenico Pratico
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Neurochem 80:894-8. 2002
    ..Peripheral measurement of 8,12-iso-iPF(2alpha) -VI levels after brain injury may be a reliable marker of brain oxidative damage...
  6. ncbi Alzheimer's disease and oxygen radicals: new insights
    Domenico Pratico
    Department of Pharmacology, Center for Experimental Therapeutics School of Medicine, University of Pennsylvania, 421 Curie Blvd, BRB 2 3, Room 812, Philadelphia, PA 19104, USA
    Biochem Pharmacol 63:563-7. 2002
    ....
  7. ncbi Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice
    Domenico Pratico
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    FASEB J 16:1138-40. 2002
    ..These results indicate that dietary Al can modulate in vivo AD-like amyloidosis in Tg2576 by increasing brain oxidative stress...
  8. ncbi Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease
    Domenico Pratico
    Center for Experimental Therapeutics, University of Pennsylvania, BRB II III, Room 812, 421 Curie Blvd, Philadelphia, PA 19104
    Arch Neurol 59:972-6. 2002
    ..The pathological changes associated with AD have a long silent phase before the appearance of clinical symptoms. Several studies have shown that AD is preceded by a prodromal phase characterized by mild cognitive impairment (MCI)...
  9. ncbi Peripheral biomarkers of oxidative damage in Alzheimer's disease: the road ahead
    Domenico Pratico
    University of Pennsylvania, School of Medicine, Department of Pharmacology, 3620 Hamilton Walk, John Morgan Building, Room 124, Philadelphia, PA 19104, USA
    Neurobiol Aging 26:581-3. 2005
  10. ncbi Reduction of brain lipid peroxidation by CSF drainage in Alzheimer's disease patients
    Domenico Pratico
    Department of Pharmacology, The Center for Experimental Therapeutics, University of Pennsylvania, School of Medicine, Philadelphia 19104, USA
    J Alzheimers Dis 6:385-9; discussion 443-9. 2004
    ..This finding supports the hypothesis that improving CSF drainage enhances extra-cellular clearance of end products of oxidative reactions and lowers brain lipid peroxidation...
  11. ncbi Lipid peroxidation and the aging process
    Domenico Pratico
    Center for Experimental Therapeutics, Department of Pharmacology at the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Sci Aging Knowledge Environ 2002:re5. 2002
    ..The current evidence for the presence and importance of lipid peroxidation in the aging process is discussed in this review...
  12. pmc 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress
    Domenico Pratico
    Center for Experimental Therapeutics, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 164:1655-62. 2004
    ..These data show that the 12/15-LOX metabolic pathway is increased and correlates with an oxidative imbalance in the AD brain, implying that this enzyme might contribute to the pathogenesis of this neurodegenerative disorder...
  13. ncbi Lipid peroxidation in mouse models of atherosclerosis
    D Pratico
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Trends Cardiovasc Med 11:112-6. 2001
    ..This should finally provide the basis for the development of most effective antioxidant agents that could modulate atherogenesis...
  14. ncbi F(2)-isoprostanes: sensitive and specific non-invasive indices of lipid peroxidation in vivo
    D Pratico
    The Center for Experimental Therapeutics, 905 Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104 6100, USA
    Atherosclerosis 147:1-10. 1999
    ..Although F(2)-iPs possess biological activities in vitro and in vivo, much remains to be learned about their role and as mediators of the cellular effects of lipid peroxidation and oxidant stress...
  15. ncbi Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis
    D Pratico
    Center for Experimental Therapeutics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Blood 96:3823-6. 2000
    ..Assessment of their generation in these models may afford the basis for future studies on the functional role of these eicosanoids in the evolution and progression of atherosclerosis. (Blood. 2000;96:3823-3826)..
  16. ncbi Circulating autoantibodies to oxidized cardiolipin correlate with isoprostane F(2alpha)-VI levels and the extent of atherosclerosis in ApoE-deficient mice: modulation by vitamin E
    D Pratico
    The Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 97:459-64. 2001
    ....
  17. ncbi Selective cyclooxygenase-2 inhibitors development in cardiovascular medicine
    Domenico Pratico
    Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, USA
    Circulation 112:1073-9. 2005
  18. pmc Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice
    D Pratico
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Proc Natl Acad Sci U S A 98:3358-63. 2001
    ..Furthermore, evidence that COX-1-derived prostanoids contribute to atherogenesis suggests that controlled evaluation of the effects of nonsteroidal anti-inflammatory drugs and/or aspirin on plaque progression in humans is timely...
  19. ncbi Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
    D Pratico
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 21:4183-7. 2001
    ..Because LPO precedes amyloid plaque formation in Tg2576 mice, this suggests that brain oxidative damage contributes to AD pathogenesis before Abeta accumulation in the AD brain...
  20. ncbi The isoprostanes in biology and medicine
    D Pratico
    The Center for Experimental Therapeutics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6100, USA
    Trends Endocrinol Metab 12:243-7. 2001
    ..Finally, some F2-isoprostanes possess potent biological activities in vitro and in vivo, suggesting that they may also act as mediators of the cellular effects of oxidative stress...
  21. ncbi Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice
    T Cyrus
    Center for Experimental Therapeutics, Department of Medicine, University of Pennsylvania, Philadelphia, USA
    Circulation 103:2277-82. 2001
    ....
  22. ncbi Lipid peroxidation and platelet activation in murine atherosclerosis
    T Cyrus
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, USA
    Circulation 104:1940-5. 2001
    ..Lipid peroxidation and platelet activation are thought to be important contributors to the pathogenesis of atherosclerosis. The relevance of their interaction in vivo, however, is unknown...
  23. ncbi Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation
    D Pratico
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia 19104, USA
    J Neurochem 73:736-41. 1999
    ..Our findings indicate that disorder of lipid metabolism in the absence of apoE can induce an age-dependent increase in brain lipid peroxidation products...
  24. ncbi Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E
    R K Tangirala
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:261-6. 2001
    ..In summary, these results demonstrate that liver-derived apoE directly induced regression of advanced atherosclerosis and has anti-oxidant properties in vivo that may contribute to its anti-atherogenic effects...
  25. ncbi Enhanced brain levels of 8,12-iso-iPF2alpha-VI differentiate AD from frontotemporal dementia
    Y Yao
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia 19104, USA
    Neurology 61:475-8. 2003
    ..To quantify the isoprostane 8,12-iso-iPF2alpha-VI in brain tissues obtained from patients with AD, patients with frontotemporal dementia (FTD), and controls...
  26. ncbi Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury
    Valeria Conte
    Head Injury Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurochem 90:758-64. 2004
    ..This study suggests that the exacerbation of brain oxidative stress following RCBI plays a mechanistic role in accelerating Alphabeta accumulation and behavioral impairments in the Tg2576 mice...
  27. pmc Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor
    L Zhao
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Br J Pharmacol 156:774-85. 2009
    ..Sirolimus reduces neointimal proliferation after balloon angioplasty and chronic graft vessel disease. These studies were undertaken to investigate the effects of this anti-proliferative drug on atherogenesis...
  28. ncbi Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis
    Kunihiro Uryu
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Neurosci 22:446-54. 2002
    ....
  29. pmc Absence of 12/15 lipoxygenase reduces brain oxidative stress in apolipoprotein E-deficient mice
    Cinzia M Chinnici
    Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, John Morgan Building, Room 124, Philadelphia, PA 19104, USA
    Am J Pathol 167:1371-7. 2005
    ....
  30. ncbi Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease
    Syuan Sung
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    FASEB J 18:323-5. 2004
    ..These results support the hypothesis that oxidative stress is an important early event in AD pathogenesis, and antioxidant therapy may be beneficial only if given at this stage of the disease process...
  31. ncbi Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis
    M S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Blvd, 605B Stellar Chance Building, Philadelphia, PA 19104, USA
    Neurology 68:757-63. 2007
    ..Mild cognitive impairment, hypothesized to be prodromal Alzheimer disease (AD), shows abundant senile plaques and neurofibrillary tangles, but its biochemical correlates remain undefined...
  32. ncbi Local amplification of platelet function by 8-Epi prostaglandin F2alpha is not mediated by thromboxane receptor isoforms
    D Pratico
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 271:14916-24. 1996
    ..However, incidental activation of such a receptor by systemic concentrations of 8-epi PGF2alpha is unlikely to occur, even in syndromes of excessive free radical generation in vivo...
  33. ncbi Generation of 8-epiprostaglandin F2alpha by human monocytes. Discriminate production by reactive oxygen species and prostaglandin endoperoxide synthase-2
    D Pratico
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 271:8919-24. 1996
    ..8-Epi-PGF2alpha is a more abundant product of monocyte PG G/H S-2 than of platelet PG G/H S-1. Formation by inducible PG G/H S-2 must be considered as a source of this compound in vivo...
  34. doi Additive anti-atherogenic effect of thromboxane receptor antagonism with 12/15lipoxygenase gene disruption in apolipoprotein E-deficient mice
    Liung Tang
    Department of Pharmacology, School of Medicine, Temple University, Philadelphia, PA 19140, United States
    Atherosclerosis 199:265-70. 2008
    ..These results suggest that the 12/15LO- and TxA(2) receptor-mediated pro-atherogenic effects are two distinct pathways and represent two separate therapeutic targets for a better anti-atherogenic strategy...
  35. ncbi Increase in peripheral oxidative stress during hypercholesterolemia is not reflected in the central nervous system: evidence from two mouse models
    Tao Ding
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Room 124, John Morgan Building, Philadelphia, PA 19104, USA
    Neurochem Int 46:435-9. 2005
    ..Our findings indicate that in hypercholesterolemia the peripheral formation of oxidative products does not contribute to their levels found in the central nervous system...
  36. ncbi Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia
    Lei Zhao
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:35350-6. 2002
    ..The data provide support for a novel mechanism linking the 12/15-lipoxygenase pathway to a known immunomodulatory Th1 cytokine in atherogenesis...
  37. pmc Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet
    Jia Min Zhuo
    Temple University, School of Medicine, Department of Pharmacology, Philadelphia, PA 19140, USA
    Exp Gerontol 45:195-201. 2010
    ..They further support the concept that dietary factors can contribute to the development of AD neuropathology...
  38. ncbi FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo 
    J Chu
    Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA, USA
    Transl Psychiatry 3:e333. 2013
    ....
  39. ncbi Cyclo-oxygenase products and atherothrombosis
    G A Fitzgerald
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia 19104, USA
    Ann Med 32:21-6. 2000
    ..By contrast, the effects of TP antagonists, aspirin, and even traditional NSAIDs on atherosclerotic plaque progression merit further evaluation in humans...
  40. ncbi Longitudinal CSF isoprostane and MRI atrophy in the progression to AD
    M J de Leon
    New York University, School of Medicine, Center for Brain Health MHL 400, New York, NY 10016, USA
    J Neurol 254:1666-75. 2007
    ..These data indicate that IsoP is potentially useful for both the early detection of AD-related pathology and for monitoring the course of AD...
  41. ncbi 12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway
    Lei Zhao
    Institute of Translational Medicine and Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Prostaglandins Other Lipid Mediat 78:185-93. 2005
    ..These results suggest that early 12/15-LO-mediated lipid peroxidation triggers ensuing non-enzymatic peroxidation that is susceptible to Vitamin E antioxidant action in a common pathway of atherogenesis...
  42. ncbi Involvement of thromboxane receptor in the proatherogenic effect of isoprostane F2alpha-III: evidence from apolipoprotein E- and LDL receptor-deficient mice
    Myan Tang
    Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Circulation 112:2867-74. 2005
    ..Several proatherogenic biological effects have been attributed to this isoprostane, suggesting that it could be an active factor in the pathogenesis of the disease...
  43. pmc Severe In vivo hyper-homocysteinemia is not associatedwith elevation of amyloid-beta peptides in the Tg2576 mice
    Jia Min Zhuo
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Alzheimers Dis 21:133-40. 2010
    ..These results demonstrate that this combination diet-induced severe HHcy does not influence amyloidogenesis in vivo...
  44. ncbi Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment
    Yuemang Yao
    Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Ann Neurol 58:623-6. 2005
    ..These results suggest that the activation of this enzyme occurs early in the course of AD, before the onset of overt dementia, thereby implicating 12/15LOX-mediated lipid peroxidation in the pathogenesis of AD...
  45. pmc Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease
    Syaun Sung
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Pathol 165:2197-206. 2004
    ....
  46. ncbi Vitamin E reduces progression of atherosclerosis in low-density lipoprotein receptor-deficient mice with established vascular lesions
    Tillmann Cyrus
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Circulation 107:521-3. 2003
    ..In contrast, clinical trials with antioxidant vitamins have not produced consistent results in humans with established atherosclerosis...
  47. pmc Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease
    J M Zhuo
    Department of Pharmacology, Neuroscience Program Temple University School of Medicine, Philadelphia, PA 19140, USA
    Curr Alzheimer Res 7:140-9. 2010
    ..Overall, these data support a potential link between GSK3 and the pro-amyloidotic effect of HHcy in vivo and in vitro...
  48. doi Oxidative stress hypothesis in Alzheimer's disease: a reappraisal
    Domenico Pratico
    Department of Pharmacology, Temple University, School of Medicine, Philadelphia, PA 19140, USA
    Trends Pharmacol Sci 29:609-15. 2008
    ..These conflicting results have created a wave of criticism towards the oxidative stress hypothesis of AD. Here, I review the available data and discuss the necessary paths for a fair reappraisal of the hypothesis...
  49. ncbi A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism
    Francesca Succol
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurochem 103:380-7. 2007
    ..We conclude that specific pharmacologic inhibition of 12/15LO could represent a novel therapeutic target for treating or preventing AD pathology in humans...
  50. doi The neurobiology of isoprostanes and Alzheimer's disease
    Domenico Pratico
    Department of Pharmacology, Temple University, School of Medicine, Philadelphia, PA 19140, USA
    Biochim Biophys Acta 1801:930-3. 2010
    ....
  51. pmc Normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of Alzheimer's disease
    Jia Min Zhuo
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    FASEB J 24:3895-902. 2010
    ..Our findings provide new biological insights for future clinical trials aimed at lowering this modifiable risk factor in human AD...
  52. pmc The Herp protein pathway is not involved in the pro-amyloidogenic effect of hyperhomocysteinemia
    Jia Min Zhuo
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA
    J Alzheimers Dis 20:569-76. 2010
    ..Finally, over-expression of Herp did not result in any significant modification of Abeta levels. We conclude that the Herp protein pathway is unlikely to be directly involved in the pro-amyloidotic effect of HHcy...
  53. ncbi Altered vascular phenotype in autism: correlation with oxidative stress
    Yuemang Yao
    Department of Pharmacology, School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Arch Neurol 63:1161-4. 2006
    ..Autism is a neurologic disorder characterized by impaired communication and social interaction. Results of previous studies showed biochemical evidence for abnormal platelet reactivity and altered blood flow in children with autism...
  54. pmc 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease
    Omidreza Firuzi
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    FASEB J 22:1169-78. 2008
    ..Our work suggests that pharmacological inhibition of 5LO could provide a novel therapeutic tool for AD...
  55. ncbi F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases
    Domenico Pratico
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Chem Phys Lipids 128:165-71. 2004
    ..Moreover, measurement of F2-isoprostanes might provide a sensitive biochemical basis of dose-selection in studies of natural and synthetic antioxidants...
  56. ncbi Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs
    Kirk P Townsend
    Center for Experimental Therapeutics and Department of Pharmacology University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    FASEB J 19:1592-601. 2005
    ....
  57. ncbi COX-2-dependent cardiac failure in Gh/tTG transgenic mice
    Zhibing Zhang
    Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Circ Res 92:1153-61. 2003
    ..Gh/tTG activation regulates expression of COX-2 and its products may differentially modulate cardiomyocyte commitment to cell death or survival...
  58. doi Prostanoid and isoprostanoid pathways in atherogenesis
    Domenico Pratico
    Department of Pharmacology, Temple University School of Medicine, 3420 North, Broad Street, MRB, room 706A, Philadelphia, PA 19140, USA
    Atherosclerosis 201:8-16. 2008
    ....
  59. ncbi The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old
    Cinzia M Chinnici
    Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Neurobiol Aging 28:1457-62. 2007
    ..This observation supports the hypothesis that 5-LO may be involved in diseases of the brain associated with aging...
  60. ncbi Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows
    Domenico Pratico
    Department of Pharmacology, Temple University, School of Medicine, Philadelphia, PA 19140, USA
    Ann N Y Acad Sci 1147:70-8. 2008
    ..This article will review both promises and caveats of the available data and propose future directions to be taken for addressing them...
  61. doi Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease
    P F Giannopoulos
    1 Center for Translational Medicine and Temple University School of Medicine, Philadelphia, PA, USA 2 Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA
    Mol Psychiatry 19:511-8. 2014
    ..They establish this protein as a pleiotropic contributor to the development of the full spectrum of the AD phenotype, making it a valid therapeutic target for the treatment of AD. ..
  62. ncbi Coxibs and Alzheimer's disease: should they stay or should they go?
    Omidreza Firuzi
    Department of Pharmacology, University of Pennsylvania, School of Medicine Philadelphia, PA 19014, USA
    Ann Neurol 59:219-28. 2006
    ....
  63. ncbi Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice
    Tillmann Cyrus
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia 19104, USA
    Circulation 106:1282-7. 2002
    ..We wished to determine the effect of low-dose aspirin on vascular inflammation, plaque composition, and atherogenesis in LDL receptor-deficient mice fed a high fat diet...
  64. doi Vascular biology of eicosanoids and atherogenesis
    Domenico Pratico
    Temple University, Department of Pharmacology, Philadelphia, PA 19140, USA
    Expert Rev Cardiovasc Ther 7:1079-89. 2009
    ....
  65. pmc Thromboxane receptor blockade improves the antiatherogenic effect of thromboxane A2 suppression in LDLR KO mice
    Tillmann Cyrus
    Department of Pharmacology, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Blood 109:3291-6. 2007
    ..These results show for the first time that the addition of a TP antagonist increases the antiatherogenic effect of COX-1-dependent TxA(2) suppression...