Jeevan Kumar Prasain

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Mass spectrometric methods for the determination of flavonoids in biological samples
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 37:1324-50. 2004
  2. ncbi request reprint Metabolism and bioavailability of flavonoids in chemoprevention: current analytical strategies and future prospectus
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, Purdue UAB Botanicals Center for Age Related Disease, UAB Center for Nutrient Gene Interaction in Cancer Prevention, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Pharm 4:846-64. 2007
  3. pmc Simultaneous quantification of F2-isoprostanes and prostaglandins in human urine by liquid chromatography tandem-mass spectrometry
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 913:161-8. 2013
  4. ncbi request reprint Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometry
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biomed Chromatogr 21:410-4. 2007
  5. ncbi request reprint Identification of isoflavone glycosides in Pueraria lobata cultures by tandem mass spectrometry
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Phytochem Anal 18:50-9. 2007
  6. ncbi request reprint Electrospray tandem mass spectrometric analysis of zeaxanthin and its oxidation products
    Jeevan Kumar Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Mass Spectrom 40:916-23. 2005
  7. ncbi request reprint Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Agric Food Chem 52:3708-12. 2004
  8. pmc A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serum
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 876:219-24. 2008
  9. doi request reprint Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometry
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Phytomedicine 16:65-71. 2009
  10. doi request reprint Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract
    Jeevan K Prasain
    Department of Pharmacology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Phytomedicine 16:233-43. 2009

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Mass spectrometric methods for the determination of flavonoids in biological samples
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 37:1324-50. 2004
    ..Emphasis is placed on the description and value of existing methods, followed by an examination of emerging technologies...
  2. ncbi request reprint Metabolism and bioavailability of flavonoids in chemoprevention: current analytical strategies and future prospectus
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, Purdue UAB Botanicals Center for Age Related Disease, UAB Center for Nutrient Gene Interaction in Cancer Prevention, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Pharm 4:846-64. 2007
    ..This review describes the chemistry of polyphenols and flavonoids, their ADME, and the various mass spectrometry-based strategies used in the analysis of flavonoids, including future trends in this field...
  3. pmc Simultaneous quantification of F2-isoprostanes and prostaglandins in human urine by liquid chromatography tandem-mass spectrometry
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 913:161-8. 2013
    ..298±0.062 vs. post-surgery 0.383±0.117ng/mg creatinine, NS). Therefore, the method is suitable for the analysis of individual F(2)-IsoPs and PGF(2α)'s in both clinical and research studies...
  4. ncbi request reprint Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometry
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biomed Chromatogr 21:410-4. 2007
    ..54 +/- 2.03 mg/L), T(max) (0.68 +/- 0.37 h), AUC(0-t) (7.29 +/- 3.79 mg h/L), AUC(0-infinity) (9.17 +/- 4.87 mg h/L), T(1/2) (1.7 +/- 0.6 h), CL/F (7.24 +/- 4.27 L/h/kg) and V/F (17.88 +/- 13.55 L/h/kg)...
  5. ncbi request reprint Identification of isoflavone glycosides in Pueraria lobata cultures by tandem mass spectrometry
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Phytochem Anal 18:50-9. 2007
    ..The molecular weights, interpretation of characteristic fragment ions obtained from HPLC-MS/MS and comparison with reported data allowed the putative identification of the isoflavone metabolites...
  6. ncbi request reprint Electrospray tandem mass spectrometric analysis of zeaxanthin and its oxidation products
    Jeevan Kumar Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Mass Spectrom 40:916-23. 2005
    ..Through the application of the LC/MS/MS method, we identified two oxime derivatives of 3-hydroxy-beta-ionone and 3-hydroxy-14'-apocarotenal with protonated molecules at m/z 252 and m/z 370 respectively, in a human eye sample...
  7. ncbi request reprint Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Agric Food Chem 52:3708-12. 2004
    ..Study of these metabolites may provide further understanding of the health beneficial effects of puerarin in kudzu dietary supplements...
  8. pmc A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serum
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 876:219-24. 2008
    ..The validated method can be used in most or all stages of the screening and optimizing process for future method validation of pharmacokinetic studies...
  9. doi request reprint Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometry
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Phytomedicine 16:65-71. 2009
    ..This report identifying puerarin in several organs including kidney and pancreas may explain its beneficial effects in diabetes...
  10. doi request reprint Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract
    Jeevan K Prasain
    Department of Pharmacology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Phytomedicine 16:233-43. 2009
    ..Using LC-MS/MS, (+)-catechin and (-)-epicatechin were identified in the brain conclusively. These data suggested that GSE catechins cross the blood brain barrier and may be responsible for the neuroprotective effects of GSE...
  11. pmc Effects of botanical dietary supplements on cardiovascular, cognitive, and metabolic function in males and females
    Scott Carlson
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Gend Med 5:S76-90. 2008
    ..After menopause, the rates of these diseases in women eventually approximate those in men. The loss of endogenous estrogen at menopause has been traditionally believed to be the primary factor involved in these changes...
  12. ncbi request reprint Differential biliary excretion of genistein metabolites following intraduodenal and intravenous infusion of genistin in female rats
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham Botanicals Center for Age Related Disease, Birmingham, AL 35294, USA
    J Nutr 136:2975-9. 2006
    ..There was no evidence for any biliary secretion of the unreacted genistin, thereby excluding its uptake in the intact form from the small intestine in this animal model...
  13. ncbi request reprint Applications of LC-MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplements
    Stephen Barnes
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Life Sci 78:2054-9. 2006
    ..In this paper, applications of these methods are described for the analysis of isoflavones, salvinorin A, synephrine isomers and their metabolites in serum, urine and aqueous humor...
  14. ncbi request reprint Review of the methods used in the determination of phytoestrogens
    Chao Cheng Wang
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 777:3-28. 2002
    ..These methods are compared with other methods of phytoestrogen analysis utilizing immunoassay approaches. The advantages and disadvantages of each of these methods are highlighted and potential areas for further development identified...
  15. ncbi request reprint Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent
    Helen Kim
    Departments of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Nutr 134:3445S-3452S. 2004
    ....
  16. pmc Chronic dietary kudzu isoflavones improve components of metabolic syndrome in stroke-prone spontaneously hypertensive rats
    Ning Peng
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    J Agric Food Chem 57:7268-73. 2009
    ..These results indicate that long-term dietary kudzu root extract supplementation can improve glucose, lipid, and blood pressure control in intact and ovariectomized SP-SHR...
  17. ncbi request reprint Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Agric Food Chem 51:4213-8. 2003
    ..Puerarin, rather than daidzin, was the most abundant component (8.44-30.60 mg/capsule) in commercially available KDS...
  18. ncbi request reprint Metabolism of phytoestrogen conjugates
    Tracy L D'Alessandro
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, USA
    Methods Enzymol 400:316-42. 2005
    ..This chapter describes the methods of analysis of all these compounds, the sources of or methods to manufacture suitable standards, and the procedures for examining the enzymes that catalyze these reactions...
  19. ncbi request reprint Contrasting effects of puerarin and daidzin on glucose homeostasis in mice
    Elias Meezan
    Department of Pharmacology and Toxicology, Comprehensive Cancer Center Mass Spectrometry Shared Facility, and Purdue UAB Botanicals Center for Age Related Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Agric Food Chem 53:8760-7. 2005
    ..The opposing effects of puerarin and daidzin on glucose homeostasis may have implications for the activity of dietary supplements that contain both of these isoflavonoids...
  20. pmc Effect of cranberry juice concentrate on chemically-induced urinary bladder cancers
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama, Birmingham, AL 35294 0019, USA
    Oncol Rep 19:1565-70. 2008
    ..However, no quercetin was detected in the serum samples, indicating its poor bioavailability. These data suggest that components of cranberries may be effective in preventing urinary bladder carcinogenesis...
  21. ncbi request reprint Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: a novel class of biological metabolites
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Mass Spectrom 38:764-71. 2003
    ..This work provides a suitable analytical basis to aid the characterization of chlorinated and nitrated metabolites in studies in vivo and in vitro...
  22. doi request reprint Simultaneous determination of 11 phytoestrogens in human serum using a 2 min liquid chromatography/tandem mass spectrometry method
    Jeevan K Prasain
    Departments of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 878:994-1002. 2010
    ..75 mL/min. This LC-MS/MS method is very useful for high-throughput analysis of phytoestrogens and proved to be simple, sensitive, reproducible, and reliable...
  23. ncbi request reprint Novel diarylheptanoids of Alpinia blepharocalyx
    Shigetoshi Kadota
    Department of Natural Products Chemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Curr Top Med Chem 3:203-25. 2003
    ..Moreover, in vitro NO inhibitory and antiproliferative activities of the isolated compounds were also tested and the active constituents identified...
  24. ncbi request reprint Rapid screening and identification of cytochalasins by electrospray tandem mass spectrometry
    Jeevan Kumar Prasain
    Antibiotics Laboratory, RIKEN, 2 1 Hirosawa Wako, Saitama 351 0198, Japan
    J Mass Spectrom 37:283-91. 2002
    ..This finding was further validated by LC/MS and LC/MS/MS experiments...