Konasale M Prasad

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Antiherpes virus-specific treatment and cognition in schizophrenia: a test-of-concept randomized double-blind placebo-controlled trial
    Konasale M Prasad
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Schizophr Bull 39:857-66. 2013
  2. ncbi request reprint Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia
    K M R Prasad
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Mol Psychiatry 12:105-13, 1. 2007
  3. pmc Grey matter changes associated with host genetic variation and exposure to Herpes Simplex Virus 1 (HSV1) in first episode schizophrenia
    Konasale M Prasad
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    Schizophr Res 118:232-9. 2010
  4. pmc Neurological abnormalities among offspring of persons with schizophrenia: relation to premorbid psychopathology
    Konasale M Prasad
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Schizophr Res 108:163-9. 2009
  5. pmc Cortical surface characteristics among offspring of schizophrenia subjects
    Konasale M Prasad
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Schizophr Res 116:143-51. 2010
  6. pmc Genetic associations between neuregulin-1 SNPs and neurocognitive function in multigenerational, multiplex schizophrenia families
    Jessica L Yokley
    Department of Psychology, University of Pittsburgh, 210 S Bouquet St, Pittsburgh, PA 15260, USA
    Psychiatr Genet 22:70-81. 2012
  7. pmc Progressive alterations of the auditory association areas in young non-psychotic offspring of schizophrenia patients
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Psychiatr Res 45:205-12. 2011
  8. pmc Gray matter loss in young relatives at risk for schizophrenia: relation with prodromal psychopathology
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA
    Neuroimage 54:S272-9. 2011
  9. pmc Longitudinal alterations of executive function in non-psychotic adolescents at familial risk for schizophrenia
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:469-74. 2010
  10. pmc Do inter-regional gray-matter volumetric correlations reflect altered functional connectivity in high-risk offspring of schizophrenia patients?
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 118:62-8. 2010

Collaborators

Detail Information

Publications22

  1. pmc Antiherpes virus-specific treatment and cognition in schizophrenia: a test-of-concept randomized double-blind placebo-controlled trial
    Konasale M Prasad
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Schizophr Bull 39:857-66. 2013
    ....
  2. ncbi request reprint Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia
    K M R Prasad
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Mol Psychiatry 12:105-13, 1. 2007
    ..This study provides suggestive evidence for a link between HSV1 exposure and some of the cerebral morphological changes often reported in schizophrenia...
  3. pmc Grey matter changes associated with host genetic variation and exposure to Herpes Simplex Virus 1 (HSV1) in first episode schizophrenia
    Konasale M Prasad
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    Schizophr Res 118:232-9. 2010
    ..In this study, we examined whether PFC grey matter changes associated with HSV1 exposure varied against the background of MICB genotypes...
  4. pmc Neurological abnormalities among offspring of persons with schizophrenia: relation to premorbid psychopathology
    Konasale M Prasad
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Schizophr Res 108:163-9. 2009
    ..We investigated the prevalence, and neurocognitive and psychopathological correlates of NEA among offspring of schizophrenia patients who are at increased genetic risk for this illness...
  5. pmc Cortical surface characteristics among offspring of schizophrenia subjects
    Konasale M Prasad
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Schizophr Res 116:143-51. 2010
    ..We examined these measures obtained on structural magnetic resonance imaging (MRI) scans at baseline and one year on a series of offspring of schizophrenia parents and healthy subjects...
  6. pmc Genetic associations between neuregulin-1 SNPs and neurocognitive function in multigenerational, multiplex schizophrenia families
    Jessica L Yokley
    Department of Psychology, University of Pittsburgh, 210 S Bouquet St, Pittsburgh, PA 15260, USA
    Psychiatr Genet 22:70-81. 2012
    ..Given the role of NRG1 in glutamate regulation and glutamate's effect on cognition, we hypothesized that cognitive deficits may be related to variation within NRG1, providing a possible mechanism to increase risk for schizophrenia...
  7. pmc Progressive alterations of the auditory association areas in young non-psychotic offspring of schizophrenia patients
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Psychiatr Res 45:205-12. 2011
    ..These alterations may be greater in male patients. It is unclear if these deficits are state-dependent or whether they predate illness onset and reflect familial diathesis...
  8. pmc Gray matter loss in young relatives at risk for schizophrenia: relation with prodromal psychopathology
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA
    Neuroimage 54:S272-9. 2011
    ....
  9. pmc Longitudinal alterations of executive function in non-psychotic adolescents at familial risk for schizophrenia
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:469-74. 2010
    ..Our results suggest an altered maturational trajectory of executive function during adolescence in individuals at familial risk for schizophrenia...
  10. pmc Do inter-regional gray-matter volumetric correlations reflect altered functional connectivity in high-risk offspring of schizophrenia patients?
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 118:62-8. 2010
    ..Gray-matter volumetric alterations may be related to these functional connectivity deficits. Also, gray-matter volume inter-regional correlations may reflect altered inter-regional functional connectivity...
  11. pmc Antibodies to cytomegalovirus and Herpes Simplex Virus 1 associated with cognitive function in schizophrenia
    Brian H Shirts
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States
    Schizophr Res 106:268-74. 2008
    ..Neurotropic viruses have been associated with focal gray matter deficits in patients with schizophrenia. We evaluated whether such agents alter cognitive function in schizophrenia...
  12. pmc Abnormalities of the corpus callosum in non-psychotic high-risk offspring of schizophrenia patients
    Alan N Francis
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Psychiatry Res 191:9-15. 2011
    ..The absence of an age-related volume increase suggests an abnormal developmental trajectory that may underlie susceptibility to schizophrenia...
  13. pmc Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?
    Konasale M Prasad
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Schizophr Bull 34:774-90. 2008
    ..Further work is needed to examine how specific genes and their interactions with the environment may produce alterations in brain structure and function that accompany psychotic disorders...
  14. doi request reprint Fine-mapping reveals novel alternative splicing of the dopamine transporter
    Michael E Talkowski
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1434-47. 2010
    ..These studies do not provide a compelling link to schizophrenia. However, the impact of the alternative splicing on other neuropsychiatric disorders should be investigated. © 2010 Wiley-Liss, Inc...
  15. doi request reprint Striatal metabolic alterations in non-psychotic adolescent offspring at risk for schizophrenia: a (1)H spectroscopy study
    Matcheri S Keshavan
    Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Schizophr Res 115:88-93. 2009
    ....
  16. doi request reprint Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophrenia
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 115:202-8. 2009
    ..Volumetric deficits and altered asymmetry in inferior parietal and Heschl's gyrii may accompany genetic liability to schizophrenia...
  17. pmc RGS4 polymorphisms associated with variability of cognitive performance in a family-based schizophrenia sample
    Konasale M Prasad
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Schizophr Bull 36:983-90. 2010
    ..02) and face memory speed (P = .03). RGS4 polymorphisms are associated with variations in cognitive functions and contribute a small but statistically significant proportion of variance in a family-based sample...
  18. pmc Exposure to herpes simplex virus type 1 and cognitive impairments in individuals with schizophrenia
    Konasale M Prasad
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Bull 38:1137-48. 2012
    ..These studies are reviewed critically and further lines of enquiry recommended. The results are important from a public health perspective, as HSV1 exposure is highly prevalent in many populations...
  19. ncbi request reprint Are brain structural abnormalities useful as endophenotypes in schizophrenia?
    Matcheri S Keshavan
    Department of Psychiatry, Wayne State University School of Medicine, 4201 St Antoine Boulevard, Detroit, MA 48201, USA
    Int Rev Psychiatry 19:397-406. 2007
    ..Further work is needed to examine how specific genes and their interactions with the environment may produce alterations in brain structure and function that accompany psychotic disorders...
  20. doi request reprint HLA associations in schizophrenia: are we re-discovering the wheel?
    Chowdari V Kodavali
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
    Am J Med Genet B Neuropsychiatr Genet 165:19-27. 2014
    ..Suggestions for future research are discussed. We favor, in particular; efforts to evaluate local population sub-structure as well as further evaluation of immune-related variables in future studies...
  21. pmc Approaches for adolescents with an affected family member with schizophrenia
    Vaibhav A Diwadkar
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room 441, Pittsburgh, PA 15213, USA
    Curr Psychiatry Rep 6:296-302. 2004
    ..The authors review the relevant literature in this promising field of inquiry and summarize recent findings from high-risk studies...
  22. ncbi request reprint Genetic polymorphisms of the RGS4 and dorsolateral prefrontal cortex morphometry among first episode schizophrenia patients
    K M R Prasad
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Mol Psychiatry 10:213-9. 2005
    ..The findings suggest that RGS4 polymorphisms may contribute to structural alterations in the DLPFC...