Kedar N Prasad

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review
    Kedar N Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, Campus Box C 278, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    J Am Coll Nutr 22:108-17. 2003
  2. ncbi request reprint Prostaglandins as putative neurotoxins in Alzheimer's disease
    K N Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, School of Medicine, Denver 80262 0228, USA
    Proc Soc Exp Biol Med 219:120-5. 1998
  3. ncbi request reprint Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicity
    Kedar N Prasad
    Center for Vitamin and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver 80262 0278, USA
    Integr Cancer Ther 3:310-22. 2004
  4. ncbi request reprint Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy
    Kedar N Prasad
    Center for Vitamin and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 134:3182S-3S. 2004
  5. ncbi request reprint Health risks of low dose ionizing radiation in humans: a review
    Kedar N Prasad
    Center for Vitamins and Cancer Research, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Exp Biol Med (Maywood) 229:378-82. 2004
  6. ncbi request reprint Can we prevent Parkinson's and Alzheimer's disease?
    N P Kedar
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Postgrad Med 49:236-45. 2003
  7. ncbi request reprint Defects in cAMP-pathway may initiate carcinogenesis in dividing nerve cells: a review
    K N Prasad
    Department of Radiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Apoptosis 8:579-86. 2003
  8. ncbi request reprint Risk factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment
    Kedar N Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Am Coll Nutr 21:506-22. 2002
  9. ncbi request reprint Differentiation genes: are they primary targets for human carcinogenesis?
    K N Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Exp Biol Med (Maywood) 226:805-13. 2001
  10. ncbi request reprint Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationale
    K N Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Curr Opin Neurol 12:761-70. 1999

Research Grants

Collaborators

  • Piruz Nahreini
  • Bhushan Kumar
  • Curt Freed
  • BRADFORD WAYNE GIBSON
  • Julie Kay Andersen
  • Atul Sharma
  • Amy J Hanson
  • Xiang Dong Yan
  • Judith E Prasad
  • Cynthia Andreatta
  • Ashutosh K Pathak
  • Gerald M Haase
  • Birgit Schilling
  • Cynthia P Andreatta
  • Vinod Kochupillai
  • N P Kedar
  • A Rudie Hovland
  • Suzanne E Wyatt
  • Jewell M Baggett-Strehlau
  • William C Cole
  • Roderick A Capaldi
  • Manisha Bhutani
  • Srinivas Bharath M M
  • Raminder Pathak
  • Michael P Cusack
  • Richard H Row
  • Sabyasachi Bal
  • Anant Mohan
  • Randeep Guleria
  • Bidhu K Mohanti
  • James Murray
  • Narendra K Bhardwaj
  • Neeta Singh
  • Neeru Khanna
  • Vijay G Reddy
  • William T Koustas
  • J Edwards-Prasad
  • C P Andreatta

Detail Information

Publications36

  1. ncbi request reprint Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review
    Kedar N Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, Campus Box C 278, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    J Am Coll Nutr 22:108-17. 2003
    ..Thus, alpha-TS alone or in combination with dietary micronutrients can be useful as an adjunct to standard cancer therapy by increasing tumor response and possibly decreasing some of the toxicities to normal cells...
  2. ncbi request reprint Prostaglandins as putative neurotoxins in Alzheimer's disease
    K N Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, School of Medicine, Denver 80262 0228, USA
    Proc Soc Exp Biol Med 219:120-5. 1998
    ....
  3. ncbi request reprint Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicity
    Kedar N Prasad
    Center for Vitamin and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver 80262 0278, USA
    Integr Cancer Ther 3:310-22. 2004
    ..This review also discusses the reasons for the current debates regarding the use of antioxidants during radiation or chemotherapy...
  4. ncbi request reprint Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy
    Kedar N Prasad
    Center for Vitamin and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Nutr 134:3182S-3S. 2004
  5. ncbi request reprint Health risks of low dose ionizing radiation in humans: a review
    Kedar N Prasad
    Center for Vitamins and Cancer Research, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Exp Biol Med (Maywood) 229:378-82. 2004
    ..Low doses of ionizing radiation should not be considered insignificant for risks of somatic and heritable mutations and neoplastic and nonneoplastic diseases in humans...
  6. ncbi request reprint Can we prevent Parkinson's and Alzheimer's disease?
    N P Kedar
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Postgrad Med 49:236-45. 2003
    ..This review provides a brief description of the epidemiology and pathogenesis of PD and AD, and the scientific rationale for the use of multiple antioxidants in the prevention of these neurological diseases...
  7. ncbi request reprint Defects in cAMP-pathway may initiate carcinogenesis in dividing nerve cells: a review
    K N Prasad
    Department of Radiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Apoptosis 8:579-86. 2003
    ....
  8. ncbi request reprint Risk factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment
    Kedar N Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Am Coll Nutr 21:506-22. 2002
    ..In addition, agents, which can prevent formation of plaques or dissolve these plaques may further enhance the efficacy of our proposed treatment strategy...
  9. ncbi request reprint Differentiation genes: are they primary targets for human carcinogenesis?
    K N Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Exp Biol Med (Maywood) 226:805-13. 2001
    ..Our proposed hypothesis of carcinogenesis can also be applied to other human tumors such as melanoma, pheochromocytoma, medulloblastoma, glioma, sarcoma, and colon cancer...
  10. ncbi request reprint Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationale
    K N Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Curr Opin Neurol 12:761-70. 1999
    ....
  11. ncbi request reprint Identifying genes involved in regulating differentiation of neuroblastoma cells
    A Rudie Hovland
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Neurosci Res 64:302-10. 2001
    ..The transcript size and expression level of N-myc, cyclin B1, protease nexin 1, c-fes, and c-fos were verified by Northern blotting. These genes may represent key mediators involved in the regulation of NB cell differentiation...
  12. ncbi request reprint Scientific rationale for using high-dose multiple micronutrients as an adjunct to standard and experimental cancer therapies
    K N Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    J Am Coll Nutr 20:450S-463S; discussion 473S-475S. 2001
    ..Scientific rationale in support of a micronutrient protocol to be used as an adjunct to standard or experimental cancer therapy is presented...
  13. ncbi request reprint Pros and cons of antioxidant use during radiation therapy
    K N Prasad
    Center for Vitamin and Cancer Research, Department of Radiology, Health Sciences Center, University of Colorado, Denver, CO 80262, USA
    Cancer Treat Rev 28:79-91. 2002
    ....
  14. doi request reprint VP16CREB-induced differentiation of neuroblastoma
    Piruz Nahreini
    Department of Gastroenterology and Hepatology, University of Colorado Health Sciences Center UCHSC and Denver Health Medical Center DHMC, Denver, CO 80204, USA
    Indian J Pediatr 75:1009-13. 2008
    ..Objective was to test whether cAMP-induced differentiation in a murine neuroblastoma cell line (NBP2) is partly mediated by CREB...
  15. ncbi request reprint Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability
    Bipin Kumar
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Cancer Lett 204:53-9. 2004
    ..Thus, the strategy of using low doses of a proteasome inhibitor in combination with a cAMP-stimulating agent may be useful in pre-clinical and clinical studies on NB tumor because of the selectivity of the effect on cancer cells...
  16. ncbi request reprint Concomitant differentiation and partial proteasome inhibition trigger apoptosis in neuroblastoma cells
    Piruz Nahreini
    Department of Radiology, Center for Vitamins and Cancer Research, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Neurooncol 63:15-23. 2003
    ..Thus, differentiating drugs combined with partial proteasome inhibition may impart higher therapeutic efficacy than differentiating agents alone for the treatment of neuroblastoma tumors...
  17. ncbi request reprint Overexpression of amyloid precursor protein is associated with degeneration, decreased viability, and increased damage caused by neurotoxins (prostaglandins A1 and E2, hydrogen peroxide, and nitric oxide) in differentiated neuroblastoma cells
    Amy J Hanson
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Neurosci Res 74:148-59. 2003
    ..These results suggest that the mechanisms of action of PGs on neurodegeneration are different from those of H2O2 and SIN-1 and that the mechanisms of neurotoxicity of H2O2 and SIN-1 are, at least in part, different from each other...
  18. ncbi request reprint Overexpression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E(2), hydrogen peroxide, and a nitric oxide donor in differentiated neuroblastoma cells
    Judith E Prasad
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    J Neurosci Res 76:415-22. 2004
    ..These results suggest that overexpression of alpha-synuclein not only participates directly in degeneration of neurons, but it also increases the vulnerability of neurons to other potential neurotoxins...
  19. ncbi request reprint Prostaglandin-induced neurodegeneration is associated with increased levels of oxidative markers and reduced by a mixture of antioxidants
    Xiang Dong Yan
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Neurosci Res 81:85-90. 2005
    ..The addition of a single antioxidant at two or four times the concentration used in the mixture was toxic...
  20. ncbi request reprint Selenomethionine prevents degeneration induced by overexpression of wild-type human alpha-synuclein during differentiation of neuroblastoma cells
    Bipin Kumar
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    J Am Coll Nutr 24:516-23. 2005
    ..We have also studied whether selenomethionine can modify the effect of overexpression of alpha-synuclein during differentiation of NB cells...
  21. ncbi request reprint Role of the adenosine 3',5'-cyclic monophosphate (cAMP) in enhancing the efficacy of siRNA-mediated gene silencing in neuroblastoma cells
    Amy J Hanson
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Oncogene 24:4149-54. 2005
    ..Our data suggest a role for the cAMP pathway in affecting the efficacy of siRNA system during differentiation of NB cells...
  22. ncbi request reprint Altered expression of genes regulating cell growth, proliferation, and apoptosis during adenosine 3',5'-cyclic monophosphate-induced differentiation of neuroblastoma cells in culture
    Xiang Dong Yan
    Center for Vitamins and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    In Vitro Cell Dev Biol Anim 38:529-37. 2002
    ....
  23. ncbi request reprint Regulated expression of VP16CREB in neuroblastoma cells: analysis of differentiation and apoptosis
    Cynthia P Andreatta
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci Res 78:570-9. 2004
    ....
  24. ncbi request reprint Identifying altered gene expression in neuroblastoma cells preceding apoptosis
    Piruz Nahreini
    Department of Gastroenterology and Hepatology, School of Medicine, University of Colorado Health Sciences Center UCHSC, Denver Health Medical Center DHMC, Unit 7, Room 208, 777 Bannock St, Box 4000, Denver, CO 80204, USA
    J Cancer Res Clin Oncol 134:411-9. 2008
    ..Neither induction of differentiation nor partial inhibition of proteasome alone affects the viability of NBP2 cells. We wanted to identify genes whose expression alters under concomitant conditions and may account for cell death...
  25. ncbi request reprint Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects
    Bipin Kumar
    Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Neurosci Res 68:627-35. 2002
    ..Our results suggest that mevastatin could act as a neurotoxic agent or neuroprotective agent, depending upon the extent of its hydrolysis to an open-ring structure and the level of mevalonic acid...
  26. ncbi request reprint Altering cellular signaling pathways enhance gene silencing activity of shRNA, shRNA.ribozyme, and shRNA.antisense in neuroblastoma cells
    Piruz Nahreini
    Department of Radiology, School of Medicine, Center for Vitamins and Cancer Research, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Cell Mol Neurobiol 24:781-92. 2004
    ..5. This report describes novel strategies of modifying shRNA and altering signaling pathways to affect siRNA-mediated gene silencing in a neuronal cell line...
  27. ncbi request reprint Antioxidants in cancer care: when and how to use them as an adjunct to standard and experimental therapies
    Kedar N Prasad
    Center for Vitamin and Cancer Research, Department of Radiology, University of Colorado, Health Sciences Center, Denver 80262 80278, USA
    Expert Rev Anticancer Ther 3:903-15. 2003
    ..This review discusses these issues and provides a biological and clinical rationale for the use of active and maintenance nutritional protocols as an adjunct to standard therapy and after therapy, respectively...
  28. ncbi request reprint Distinct patterns of gene expression induced by viral oncogenes in human embryonic brain cells
    Piruz Nahreini
    Department of Radiology, Center for Vitamins and Cancer Research, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Cell Mol Neurobiol 23:27-42. 2003
    ..7. This suggests that the mechanisms for inducing neuronal differentiation are still intact in HEB-E6E7 and HEB-LTA cells. More importantly, differentiation signals can override the effects of viral oncogenes in HEB cells...
  29. ncbi request reprint Enrichment of cells exhibiting tetracycline regulated gene expression
    Piruz Nahreini
    UCHSC, School of Medicine, Dept of Radiology, Box C 278, 4200 East Ninth Ave, SOM 0630, Denver, CO 80262, USA
    Biotechniques 34:958-62, 964, 966 passim. 2003
    ..e., VP16CREB) is achieved in HG cells. Therefore, we have developed a simple method to enrich for a population of tetracycline-responsive cells with no need for screening for tetracycline-responsive clonal cell lines...
  30. ncbi request reprint Chemotherapy alone vs. chemotherapy plus high dose multiple antioxidants in patients with advanced non small cell lung cancer
    Ashutosh K Pathak
    Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110 029, India
    J Am Coll Nutr 24:16-21. 2005
    ..Therefore, we initiated a clinical study to test the efficacy of high-dose multiple antioxidants (vitamins C, E and beta carotene) as an adjunct to chemotherapy (paclitaxel and carboplatin) in non-small-cell lung cancer...
  31. ncbi request reprint Potentiation of the effect of paclitaxel and carboplatin by antioxidant mixture on human lung cancer h520 cells
    Ashutosh K Pathak
    Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India
    J Am Coll Nutr 21:416-21. 2002
    ..In this study, the objective was to see whether pretreatment with antioxidant mixture could enhance the cytotoxic and apoptotic effect of commonly used chemotherapeutic agents, paclitaxel and carboplatin for the treatment of NSCLC...
  32. ncbi request reprint D-alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells
    Bipin Kumar
    Center for Vitamins and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver 80262 0278, USA
    J Am Coll Nutr 21:339-43. 2002
    ..The purpose of this study was to measure and compare the effect of d-alpha-tocopheryl succinate (alpha-TS) in modifying radiation-induced chromosomal damage in human normal cells and cancer cells in culture...
  33. ncbi request reprint Antioxidants in cancer therapy
    Kedar N Prasad
    J Clin Oncol 24:e8-9; author reply e10. 2006
  34. doi request reprint Antioxidant micronutrient impact on hearing disorders: concept, rationale, and evidence
    Gerald M Haase
    University of Colorado, School of Medicine, Premier Micronutrient Corporation, Clinical Programs Center, Denver, Colorado, USA
    Am J Otolaryngol 32:55-61. 2011
    ..Therefore, considering appropriate biologic therapy as an adjunct to standard care against these damaging factors may provide rational expansion of treatment options for otolaryngologists and audiologists...
  35. ncbi request reprint Low-level radiation risk
    Kedar N Prasad
    AJR Am J Roentgenol 181:278-9; author reply 279. 2003
  36. ncbi request reprint Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line
    Birgit Schilling
    Buck Institute for Age Research, Novato, CA 94945, USA
    Mol Cell Proteomics 4:84-96. 2005
    ....

Research Grants10

  1. POTENTIAL CLINICAL IMPLICATIONS OF CAMP IN NEURAL TUMORS
    KEDAR PRASAD; Fiscal Year: 2003
    ..We have the experience with all the proposed techniques. Future studies will focus on the regulatory mechanisms for each of the differentiation and cancer genes. ..
  2. NEURODEGENERATIVE MECHANISMS IN ALZHEIMER'S DISEASE
    KEDAR PRASAD; Fiscal Year: 2003
    ....
  3. INTERNATIONAL CONFERENCE ON NUTRITION AND CANCER
    KEDAR PRASAD; Fiscal Year: 2004
    ..The proceedings of these conferences were published. The 9th International Conference on Nutrition and Cancer will be held in San Francisco on March 8-10, 2007. ..