Research Topics
| Kedar N PrasadSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a reviewKedar N Prasad
Center for Vitamins and Cancer Research, Department of Radiology, Campus Box C 278, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
J Am Coll Nutr 22:108-17. 2003..Thus, alpha-TS alone or in combination with dietary micronutrients can be useful as an adjunct to standard cancer therapy by increasing tumor response and possibly decreasing some of the toxicities to normal cells...- Prostaglandins as putative neurotoxins in Alzheimer's diseaseK N Prasad
Center for Vitamins and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, School of Medicine, Denver 80262 0228, USA
Proc Soc Exp Biol Med 219:120-5. 1998.... - Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicityKedar N Prasad
Center for Vitamin and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver 80262 0278, USA
Integr Cancer Ther 3:310-22. 2004..This review also discusses the reasons for the current debates regarding the use of antioxidants during radiation or chemotherapy... - Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapyKedar N Prasad
Center for Vitamin and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Nutr 134:3182S-3S. 2004 - Health risks of low dose ionizing radiation in humans: a reviewKedar N Prasad
Center for Vitamins and Cancer Research, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Exp Biol Med (Maywood) 229:378-82. 2004..Low doses of ionizing radiation should not be considered insignificant for risks of somatic and heritable mutations and neoplastic and nonneoplastic diseases in humans... - Can we prevent Parkinson's and Alzheimer's disease?N P Kedar
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Postgrad Med 49:236-45. 2003..This review provides a brief description of the epidemiology and pathogenesis of PD and AD, and the scientific rationale for the use of multiple antioxidants in the prevention of these neurological diseases... - Defects in cAMP-pathway may initiate carcinogenesis in dividing nerve cells: a reviewK N Prasad
Department of Radiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Apoptosis 8:579-86. 2003.... - Risk factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatmentKedar N Prasad
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Am Coll Nutr 21:506-22. 2002..In addition, agents, which can prevent formation of plaques or dissolve these plaques may further enhance the efficacy of our proposed treatment strategy... - Differentiation genes: are they primary targets for human carcinogenesis?K N Prasad
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Exp Biol Med (Maywood) 226:805-13. 2001..Our proposed hypothesis of carcinogenesis can also be applied to other human tumors such as melanoma, pheochromocytoma, medulloblastoma, glioma, sarcoma, and colon cancer... - Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationaleK N Prasad
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
Curr Opin Neurol 12:761-70. 1999.... - Identifying genes involved in regulating differentiation of neuroblastoma cellsA Rudie Hovland
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Neurosci Res 64:302-10. 2001..The transcript size and expression level of N-myc, cyclin B1, protease nexin 1, c-fes, and c-fos were verified by Northern blotting. These genes may represent key mediators involved in the regulation of NB cell differentiation... - Scientific rationale for using high-dose multiple micronutrients as an adjunct to standard and experimental cancer therapiesK N Prasad
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
J Am Coll Nutr 20:450S-463S; discussion 473S-475S. 2001..Scientific rationale in support of a micronutrient protocol to be used as an adjunct to standard or experimental cancer therapy is presented... - Pros and cons of antioxidant use during radiation therapyK N Prasad
Center for Vitamin and Cancer Research, Department of Radiology, Health Sciences Center, University of Colorado, Denver, CO 80262, USA
Cancer Treat Rev 28:79-91. 2002.... - VP16CREB-induced differentiation of neuroblastomaPiruz Nahreini
Department of Gastroenterology and Hepatology, University of Colorado Health Sciences Center UCHSC and Denver Health Medical Center DHMC, Denver, CO 80204, USA
Indian J Pediatr 75:1009-13. 2008..Objective was to test whether cAMP-induced differentiation in a murine neuroblastoma cell line (NBP2) is partly mediated by CREB... - Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viabilityBipin Kumar
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Cancer Lett 204:53-9. 2004..Thus, the strategy of using low doses of a proteasome inhibitor in combination with a cAMP-stimulating agent may be useful in pre-clinical and clinical studies on NB tumor because of the selectivity of the effect on cancer cells... - Concomitant differentiation and partial proteasome inhibition trigger apoptosis in neuroblastoma cellsPiruz Nahreini
Department of Radiology, Center for Vitamins and Cancer Research, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Neurooncol 63:15-23. 2003..Thus, differentiating drugs combined with partial proteasome inhibition may impart higher therapeutic efficacy than differentiating agents alone for the treatment of neuroblastoma tumors... - Overexpression of amyloid precursor protein is associated with degeneration, decreased viability, and increased damage caused by neurotoxins (prostaglandins A1 and E2, hydrogen peroxide, and nitric oxide) in differentiated neuroblastoma cellsAmy J Hanson
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Neurosci Res 74:148-59. 2003..These results suggest that the mechanisms of action of PGs on neurodegeneration are different from those of H2O2 and SIN-1 and that the mechanisms of neurotoxicity of H2O2 and SIN-1 are, at least in part, different from each other... - Overexpression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E(2), hydrogen peroxide, and a nitric oxide donor in differentiated neuroblastoma cellsJudith E Prasad
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
J Neurosci Res 76:415-22. 2004..These results suggest that overexpression of alpha-synuclein not only participates directly in degeneration of neurons, but it also increases the vulnerability of neurons to other potential neurotoxins... - Prostaglandin-induced neurodegeneration is associated with increased levels of oxidative markers and reduced by a mixture of antioxidantsXiang-Dong Yan
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Neurosci Res 81:85-90. 2005..The addition of a single antioxidant at two or four times the concentration used in the mixture was toxic... - Selenomethionine prevents degeneration induced by overexpression of wild-type human alpha-synuclein during differentiation of neuroblastoma cellsBipin Kumar
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
J Am Coll Nutr 24:516-23. 2005..This suggest that one of mechanisms of action alpha-synuclein may involve increased oxidative stress... - Role of the adenosine 3',5'-cyclic monophosphate (cAMP) in enhancing the efficacy of siRNA-mediated gene silencing in neuroblastoma cellsAmy J Hanson
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Oncogene 24:4149-54. 2005..Our data suggest a role for the cAMP pathway in affecting the efficacy of siRNA system during differentiation of NB cells... - Altered expression of genes regulating cell growth, proliferation, and apoptosis during adenosine 3',5'-cyclic monophosphate-induced differentiation of neuroblastoma cells in cultureXiang-Dong Yan
Center for Vitamins and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
In Vitro Cell Dev Biol Anim 38:529-37. 2002.... - Regulated expression of VP16CREB in neuroblastoma cells: analysis of differentiation and apoptosisCynthia P Andreatta
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci Res 78:570-9. 2004.... - Identifying altered gene expression in neuroblastoma cells preceding apoptosisPiruz Nahreini
Department of Gastroenterology and Hepatology, School of Medicine, University of Colorado Health Sciences Center UCHSC, Denver Health Medical Center DHMC, Unit 7, Room 208, 777 Bannock St, Box 4000, Denver, CO 80204, USA
J Cancer Res Clin Oncol 134:411-9. 2008..Neither induction of differentiation nor partial inhibition of proteasome alone affects the viability of NBP2 cells. We wanted to identify genes whose expression alters under concomitant conditions and may account for cell death... - Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effectsBipin Kumar
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Neurosci Res 68:627-35. 2002..Our results suggest that mevastatin could act as a neurotoxic agent or neuroprotective agent, depending upon the extent of its hydrolysis to an open-ring structure and the level of mevalonic acid... - Altering cellular signaling pathways enhance gene silencing activity of shRNA, shRNA.ribozyme, and shRNA.antisense in neuroblastoma cellsPiruz Nahreini
Department of Radiology, School of Medicine, Center for Vitamins and Cancer Research, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Cell Mol Neurobiol 24:781-92. 2004..5. This report describes novel strategies of modifying shRNA and altering signaling pathways to affect siRNA-mediated gene silencing in a neuronal cell line... - Antioxidants in cancer care: when and how to use them as an adjunct to standard and experimental therapiesKedar N Prasad
Center for Vitamin and Cancer Research, Department of Radiology, University of Colorado, Health Sciences Center, Denver 80262 80278, USA
Expert Rev Anticancer Ther 3:903-15. 2003..This review discusses these issues and provides a biological and clinical rationale for the use of active and maintenance nutritional protocols as an adjunct to standard therapy and after therapy, respectively... - Distinct patterns of gene expression induced by viral oncogenes in human embryonic brain cellsPiruz Nahreini
Department of Radiology, Center for Vitamins and Cancer Research, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Cell Mol Neurobiol 23:27-42. 2003..7. This suggests that the mechanisms for inducing neuronal differentiation are still intact in HEB-E6E7 and HEB-LTA cells. More importantly, differentiation signals can override the effects of viral oncogenes in HEB cells... - Enrichment of cells exhibiting tetracycline regulated gene expressionPiruz Nahreini
UCHSC, School of Medicine, Dept of Radiology, Box C 278, 4200 East Ninth Ave, SOM 0630, Denver, CO 80262, USA
Biotechniques 34:958-62, 964, 966 passim. 2003..e., VP16CREB) is achieved in HG cells. Therefore, we have developed a simple method to enrich for a population of tetracycline-responsive cells with no need for screening for tetracycline-responsive clonal cell lines... - Chemotherapy alone vs. chemotherapy plus high dose multiple antioxidants in patients with advanced non small cell lung cancerAshutosh K Pathak
Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110 029, India
J Am Coll Nutr 24:16-21. 2005..Larger trials are needed to demonstrate whether high-dose multiple antioxidants in conjunction with chemotherapy increase the response rates and/or survival time in advanced lung cancer... - Potentiation of the effect of paclitaxel and carboplatin by antioxidant mixture on human lung cancer h520 cellsAshutosh K Pathak
Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India
J Am Coll Nutr 21:416-21. 2002..Thus, the most promising sequence of these agents, which emerged in this study, was pretreatment with antioxidant mixture for 24 hours followed by paclitaxel treatment for 24 hours followed by carboplatin exposure for 24 hours... - Antioxidants in cancer therapyKedar N Prasad
J Clin Oncol 24:e8-9; author reply e10. 2006 - D-alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cellsBipin Kumar
Center for Vitamins and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver 80262-0278, USA
J Am Coll Nutr 21:339-43. 2002..CONCLUSION: The use of alpha-TS during radiation therapy may improve the efficacy of radiation therapy by enhancing tumor response and decreasing some of the toxicities on normal cells... - Antioxidant micronutrient impact on hearing disorders: concept, rationale, and evidenceGerald M Haase
University of Colorado, School of Medicine, Premier Micronutrient Corporation, Clinical Programs Center, Denver, Colorado, USA
Am J Otolaryngol 32:55-61. 2011..Therefore, considering appropriate biologic therapy as an adjunct to standard care against these damaging factors may provide rational expansion of treatment options for otolaryngologists and audiologists... - Low-level radiation riskKedar N Prasad
AJR Am J Roentgenol 181:278-9; author reply 279. 2003 - Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell lineBirgit Schilling
Buck Institute for Age Research, Novato, CA 94945, USA
Mol Cell Proteomics 4:84-96. 2005....
Research Grants
- POTENTIAL CLINICAL IMPLICATIONS OF CAMP IN NEURAL TUMORSKEDAR PRASAD; Fiscal Year: 2003..We have the experience with all the proposed techniques. Future studies will focus on the regulatory mechanisms for each of the differentiation and cancer genes. ..
- NEURODEGENERATIVE MECHANISMS IN ALZHEIMER'S DISEASEKEDAR PRASAD; Fiscal Year: 2003....
- INTERNATIONAL CONFERENCE ON NUTRITION AND CANCERKEDAR PRASAD; Fiscal Year: 2004..The proceedings of these conferences were published. The 9th International Conference on Nutrition and Cancer will be held in San Francisco on March 8-10, 2007. ..