Research Topics
| Sampath PrahaladSummaryAffiliation: University of Utah Country: USA Publications
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Detail Information
Publications
Negative association between the chemokine receptor CCR5-Delta32 polymorphism and rheumatoid arthritis: a meta-analysisS Prahalad
Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84132 2206, USA
Genes Immun 7:264-8. 2006..0001), suggesting that CCR5-Delta32 is protective against the development of RA. CCR5 blockade in animal models of RA results in amelioration of arthritis, suggesting that CCR5 blockade could also modify disease in patients with RA...- A comprehensive review of the genetics of juvenile idiopathic arthritisSampath Prahalad
Assistant Professor of Pediatrics, Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah School of Medicine, P, O Box 581289 Salt Lake City, UT 84158 1289, USA
Pediatr Rheumatol Online J 6:11. 2008..Finally we discuss several genetic variants underlying multiple clinically distinct autoimmune phenotypes... - Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritisSampath Prahalad
Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158 1289, USA
Arthritis Rheum 58:2147-52. 2008..Single-nucleotide polymorphisms (SNPs) in CTLA4 have been implicated in susceptibility to several autoimmune disorders, including JIA. This study was undertaken to test 3 functional CTLA4 variants for association with JIA... - Elevated serum levels of soluble CD154 in children with juvenile idiopathic arthritisSampath Prahalad
Department of Pediatrics, University of Utah, Salt Lake City, UT, USA
Pediatr Rheumatol Online J 6:8. 2008..Our objectives were to determine if sCD154 is elevated in JIA, and to examine correlations between sCD154 and other inflammatory cytokines... - Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritisS Prahalad
Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, UT 84132 2206, USA
Genes Immun 7:468-75. 2006..05). Both variants are in regions under natural selection, and result in functional consequences. Our results suggest these CCR5 variants are protective against early-onset JRA... - Familial autoimmunity: maternal parent-of-origin effect in juvenile idiopathic arthritisAndrew Zeft
Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158 1289, USA
Clin Rheumatol 27:241-4. 2008.... 
Familial aggregation of juvenile idiopathic arthritisSampath Prahalad
University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Arthritis Rheum 50:4022-7. 2004..To estimate the degree of familial aggregation of juvenile idiopathic arthritis (JIA), determine whether the aggregation of JIA and the aggregation of type 1 diabetes mellitus (type 1 DM) overlap, and identify multiplex JIA pedigrees...
The genetics of juvenile idiopathic arthritis: what is new in 2010?Sheila Angeles-Han
Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA
Curr Rheumatol Rep 12:87-93. 2010..This review highlights recent genetic investigations of JIA...- Genetic analysis of juvenile rheumatoid arthritis: approaches to complex traitsSampath Prahalad
Department of Pediatrics, Division of Immunology and Rheumatology, University of Utah School of Medicine, 30 North, 1900 East, Salt Lake City, UT 84132-2206, USA
Curr Probl Pediatr Adolesc Health Care 36:83-90. 2006 - Increased prevalence of familial autoimmunity in simplex and multiplex families with juvenile rheumatoid arthritisSampath Prahalad
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132, USA
Arthritis Rheum 46:1851-6. 2002..To determine if the prevalence of autoimmunity among relatives of patients with juvenile rheumatoid arthritis (JRA) is greater than that among relatives of healthy volunteer control subjects... - Lack of association between birth order and juvenile idiopathic arthritisSampath Prahalad
University of Utah, Salt Lake City, UT, USA
Arthritis Rheum 48:2989-90. 2003 - Genetics of juvenile idiopathic arthritis: an updateSampath Prahalad
Department of Pediatrics, Division of Immunology and Rheumatology, University of Utah School of Medicine, Salt Lake City, Utah 84132 2206, USA
Curr Opin Rheumatol 16:588-94. 2004..This review outlines the principles behind genetic studies and summarizes recent studies on the genetics of JIA... - Fatal acute fibrinous and organizing pneumonia in a child with juvenile dermatomyositisSampath Prahalad
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
J Pediatr 146:289-92. 2005..We describe a child with juvenile dermatomyositis who had development of acute fibrinous and organizing pneumonia. There does not appear to be a successful method of treatment, particularly in severe cases with respiratory failure... - Musculoskeletal abnormalities of the tibia in juvenile rheumatoid arthritisElena M O Felin
University of Utah, Salt Lake City, UT 84158, USA
Arthritis Rheum 56:984-94. 2007.... - Lack of association between beta 2-adrenergic receptor polymorphisms and juvenile idiopathic arthritisG Pont-Kingdon
ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
Scand J Rheumatol 38:91-5. 2009..Associations between variants in the gene encoding the beta 2-adrenergic receptor (ADRB2) and autoimmune disorders such as rheumatoid arthritis (RA) have been demonstrated. We aimed to investigate ADRB2 variants for association with JIA... - Etanercept in the treatment of macrophage activation syndromeS Prahalad
Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio 45229-3039, USA
J Rheumatol 28:2120-4. 2001..We describe a patient with MAS and sJRA successfully treated with the anti-TNF agent etanercept. The outcome in this patient suggests etanercept might be an effective therapeutic agent in MAS... - Juvenile idiopathic arthritis and exposure to fine particulate air pollutionA S Zeft
Department of Pediatrics, University of Utah, Salt Lake City, 84158 1289, USA
Clin Exp Rheumatol 27:877-84. 2009..This study evaluated potential associations between JIA symptom onset and temporal changes in regional air pollution measured by stagnant air conditions and PM2.5 concentrations... - Long-term outcome among patients with juvenile rheumatoid arthritisS Prahalad
Division of Rheumatology, Department of Pediatrics, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Front Biosci 3:e13-22. 1998..Several of the instruments that are available for assessing outcome among patients are described. The role of laboratory and radiological evaluation in predicting outcome is also addressed... - A genome-wide scan for juvenile rheumatoid arthritis in affected sibpair families provides evidence of linkageSusan D Thompson
Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
Arthritis Rheum 50:2920-30. 2004..These findings for JRA are consistent with findings for other autoimmune diseases and support the notion that common genetic regions contribute to an autoimmune phenotype...