Nanduri R Prabhakar

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint ROS signaling in systemic and cellular responses to chronic intermittent hypoxia
    Nanduri R Prabhakar
    Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 9:1397-403. 2007
  2. pmc Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia
    Ying Jie Peng
    N R Prabhakar Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, MC 5068, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Exp Physiol 98:1620-30. 2013
  3. pmc Sensing hypoxia: physiology, genetics and epigenetics
    Nanduri R Prabhakar
    Institute for Integrative Physiology, Center for Systems Biology of O 2 Sensing, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA
    J Physiol 591:2245-57. 2013
  4. pmc Sympatho-adrenal activation by chronic intermittent hypoxia
    Nanduri R Prabhakar
    Institute for Integrative Physiology and The Center for Systems Biology of Oxygen Sensing, Biological Sciences Division, Dept of Medicine, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    J Appl Physiol (1985) 113:1304-10. 2012
  5. pmc Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body
    Nanduri R Prabhakar
    Institute for Integrative Physiology and Center for Systems Biology of O 2 Sensing, Biological Sciences Division, University of Chicago, IL 60637, USA
    Respir Physiol Neurobiol 184:165-9. 2012
  6. pmc Endogenous H2S is required for hypoxic sensing by carotid body glomus cells
    Vladislav V Makarenko
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Cell Physiol 303:C916-23. 2012
  7. doi request reprint Hydrogen sulfide (H(2)S): a physiologic mediator of carotid body response to hypoxia
    Nanduri R Prabhakar
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Adv Exp Med Biol 758:109-13. 2012
  8. pmc Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
    Nanduri R Prabhakar
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, USA
    Physiol Rev 92:967-1003. 2012
  9. pmc Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis
    Jayasri Nanduri
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, Department of Medicine University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 109:2515-20. 2012
  10. doi request reprint Gaseous messengers in oxygen sensing
    Nanduri R Prabhakar
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, The University of Chicago, Chicago, IL 60637, USA
    J Mol Med (Berl) 90:265-72. 2012

Research Grants

  1. GENE REGULATION DURING INTERMITTENT HYPOXIA
    Nanduri Prabhakar; Fiscal Year: 2000
  2. Transmitters in Altered Carotid Body Function
    Nanduri Prabhakar; Fiscal Year: 2009
  3. Consequences of Neonatal Hypoxia
    Nanduri Prabhakar; Fiscal Year: 2009
  4. Consequences of Neonatal Hypoxia
    Nanduri Prabhakar; Fiscal Year: 2007
  5. Consequences of Neonatal Hypoxia
    Nanduri Prabhakar; Fiscal Year: 2006
  6. GENE REGULATION DURING INTERMITTENT HYPOXIA
    Nanduri Prabhakar; Fiscal Year: 2003
  7. GENE REGULATION DURING INTERMITTENT HYPOXIA
    Nanduri Prabhakar; Fiscal Year: 2002
  8. GENE REGULATION DURING INTERMITTENT HYPOXIA
    Nanduri Prabhakar; Fiscal Year: 2001
  9. Transmitters in Altered Carotid Body Function
    Nanduri R Prabhakar; Fiscal Year: 2010

Collaborators

Detail Information

Publications50

  1. ncbi request reprint ROS signaling in systemic and cellular responses to chronic intermittent hypoxia
    Nanduri R Prabhakar
    Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 9:1397-403. 2007
    ....
  2. pmc Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia
    Ying Jie Peng
    N R Prabhakar Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, MC 5068, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Exp Physiol 98:1620-30. 2013
    ....
  3. pmc Sensing hypoxia: physiology, genetics and epigenetics
    Nanduri R Prabhakar
    Institute for Integrative Physiology, Center for Systems Biology of O 2 Sensing, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA
    J Physiol 591:2245-57. 2013
    ....
  4. pmc Sympatho-adrenal activation by chronic intermittent hypoxia
    Nanduri R Prabhakar
    Institute for Integrative Physiology and The Center for Systems Biology of Oxygen Sensing, Biological Sciences Division, Dept of Medicine, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    J Appl Physiol (1985) 113:1304-10. 2012
    ..Molecular mechanisms underlying increased ROS generation by CIH seem to involve transcriptional dysregulation of genes encoding pro-and antioxidant enzymes by hypoxia-inducible factor-1 and -2, respectively...
  5. pmc Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body
    Nanduri R Prabhakar
    Institute for Integrative Physiology and Center for Systems Biology of O 2 Sensing, Biological Sciences Division, University of Chicago, IL 60637, USA
    Respir Physiol Neurobiol 184:165-9. 2012
    ..HO inhibitor increased and CO donor inhibited H(2)S generation. It is proposed that carotid body response to hypoxia requires interactions between HO-2-CO and CSE-H(2)S systems...
  6. pmc Endogenous H2S is required for hypoxic sensing by carotid body glomus cells
    Vladislav V Makarenko
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Cell Physiol 303:C916-23. 2012
    ..These results demonstrate that H(2)S generated by CSE is a physiologic mediator of the glomus cell's response to hypoxia...
  7. doi request reprint Hydrogen sulfide (H(2)S): a physiologic mediator of carotid body response to hypoxia
    Nanduri R Prabhakar
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Adv Exp Med Biol 758:109-13. 2012
    ..Evidence is emerging implicating Ca2+ activated K+ channels in glomus cells as potential targets of H2S...
  8. pmc Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
    Nanduri R Prabhakar
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, USA
    Physiol Rev 92:967-1003. 2012
    ..In contrast, intermittent hypoxia, which occurs in association with sleep-disordered breathing, results in an imbalance between HIF-1α and HIF-2α that causes oxidative stress, leading to cardiorespiratory pathology...
  9. pmc Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis
    Jayasri Nanduri
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, Department of Medicine University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 109:2515-20. 2012
    ..These findings implicate a hitherto uncharacterized role for DNA methylation in mediating neonatal programming of hypoxic sensitivity and the ensuing autonomic dysfunction in adulthood...
  10. doi request reprint Gaseous messengers in oxygen sensing
    Nanduri R Prabhakar
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, The University of Chicago, Chicago, IL 60637, USA
    J Mol Med (Berl) 90:265-72. 2012
    ..The enzymes that generate gas messengers and redox regulation by HIFs represent potential therapeutic targets for normalizing carotid body function and downstream autonomic output in these disease states...
  11. doi request reprint Redox Pioneer: Professor Gregg L. Semenza
    Nanduri R Prabhakar
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Antioxid Redox Signal 13:559-64. 2010
    ..He has received several honors for his scientific contributions, including the 2010 Gairdner Foundation International Award and election to the National Academy of Sciences of the United States of America...
  12. pmc Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS
    Nanduri R Prabhakar
    Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, IL 60637, USA
    Respir Physiol Neurobiol 174:230-4. 2010
    ..Transcriptional regulation of pro- and anti-oxidant enzymes by hypoxia-inducible factors 1 and 2 appears to be a major molecular mechanism regulating ROS generation by IH...
  13. ncbi request reprint Cellular mechanisms associated with intermittent hypoxia
    Jayasri Nanduri
    Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Essays Biochem 43:91-104. 2007
    ..Cellular mechanisms associated with IH (other than recurrent apneas) such as repetitive, brief ascents to altitude, however, remain to be studied...
  14. pmc Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia
    Nanduri R Prabhakar
    Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, IL 60637, USA
    Respir Physiol Neurobiol 174:156-61. 2010
    ....
  15. pmc Sensory plasticity of the carotid body: role of reactive oxygen species and physiological significance
    Nanduri R Prabhakar
    Institute for Integrative Physiology and Center for Systems Biology of O 2 Sensing, Biological Sciences Division, University of Chicago, 5841 S Maryland Avenue, MC 5068, Room N 711, Chicago, IL 60637, USA
    Respir Physiol Neurobiol 178:375-80. 2011
    ..The signaling pathways mediating the sensory LTF are summarized in the second figure. It is suggested that sensory LTF contributes to the persistent sympathetic excitation under chronic IH...
  16. ncbi request reprint Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2
    Nanduri R Prabhakar
    Center for Systems Biology of O Sensing, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Ann N Y Acad Sci 1177:162-8. 2009
    ..Thus, the studies with chronic IH suggest novel, hitherto uncharacterized, roles for HIF-1 and HIF-2 in regulating red-ox status leading to plasticity of O2 sensing in CBs and AMCs...
  17. pmc Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis
    Guoxiang Yuan
    Biological Sciences Division, Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 110:E1788-96. 2013
    ....
  18. pmc Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema
    Ying Jie Peng
    Institute for Integrative Physiology and Center for Systems Biology for O2 Sensing, Biological Sciences Division, University of Chicago, IL 60637
    Proc Natl Acad Sci U S A 111:1174-9. 2014
    ..Increasing CO levels in SH carotid bodies reduced H2S generation, preventing hypersensitivity to hypoxia and controlling hypertension in SH rats. ..
  19. doi request reprint NADPH oxidase-dependent regulation of T-type Ca2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells
    Dangjai Souvannakitti
    The Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 30:10763-72. 2010
    ..These results demonstrate that neonatal IH treatment leads to NOX/ROS-dependent recruitment of T-type Ca2+ channels and RyRs, resulting in augmented [Ca2+]i mobilization and catecholamine secretion...
  20. pmc Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities
    Jayasri Nanduri
    Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:1199-204. 2009
    ..These observations demonstrate that, unlike continuous hypoxia, IH leads to down-regulation of HIF-2alpha via a calpain-dependent signaling pathway and results in oxidative stress as well as autonomic morbidities...
  21. pmc Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
    Ying Jie Peng
    Biological Sciences Division, Institute for Integrated Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 108:3065-70. 2011
    ..Thus, HIF-2α-dependent redox regulation is required for maintenance of carotid body function and cardiorespiratory homeostasis...
  22. pmc Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation
    Vladislav V Makarenko
    University of Chicago, Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Chicago, Illinois and
    Am J Physiol Cell Physiol 306:C745-52. 2014
    ..These results demonstrate that IH via ROS-dependent activation of MAP kinases leads to reorganization of cytoskeleton and junction proteins resulting in endothelial barrier dysfunction. ..
  23. pmc H2S mediates O2 sensing in the carotid body
    Ying Jie Peng
    Department of Medicine, University of Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:10719-24. 2010
    ..CSE is also expressed in neonatal adrenal medullary chromaffin cells of rats and mice whose hypoxia-evoked catecholamine secretion is greatly attenuated by CSE inhibitors and in CSE knockout mice...
  24. pmc Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells
    Dangjai Souvannakitti
    Department of Medicine, The Center for Systems Biology of O 2 Sensing, University of Chicago, Chicago, Illinois, USA
    Am J Physiol Cell Physiol 299:C381-8. 2010
    ....
  25. doi request reprint Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia
    Guoxiang Yuan
    Institute for Integrative Physiology and The Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, Illinois 60637, USA
    J Cell Physiol 226:2925-33. 2011
    ..These results establish a pathogenic mechanism linking HIF-1, ROS generation, and cardiovascular pathology in response to IH...
  26. pmc Neonatal intermittent hypoxia leads to long-lasting facilitation of acute hypoxia-evoked catecholamine secretion from rat chromaffin cells
    Dangjai Souvannakitti
    Department of Medicine, The Center for Systems Biology of O2Sensing, University of Chicago, MC 5068, Chicago, IL 60637, USA
    J Neurophysiol 101:2837-46. 2009
    ....
  27. pmc Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia
    Anita Pawar
    Center for Systems Biology of O2 Sensing, Dept of Medicine, The Univ of Chicago, IL 60637, USA
    Am J Physiol Regul Integr Comp Physiol 296:R735-42. 2009
    ..These results demonstrate that IH-evoked increase in HSR involve a ROS-mediated increase in basal ET-1 release and upregulation of ET(A) receptor mRNA...
  28. pmc Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing
    Gayatri Raghuraman
    The Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Antioxid Redox Signal 14:1179-90. 2011
    ....
  29. pmc Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase
    Ying Jie Peng
    Institute for Integrative Physiology and Center for Systems Biology of O Sensing, Biological Science Division, University of Chicago, Chicago, Illinois 60637, USA
    J Appl Physiol (1985) 111:964-70. 2011
    ..These results demonstrate that repetitive application of ANG II induces sLTF of the carotid body via activation of Nox2 by AT(1) receptors...
  30. pmc Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia
    Ying Jie Peng
    Institute for Integrative Physiology and Center for Systems Biology for O 2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, USA
    J Appl Physiol (1985) 112:187-96. 2012
    ....
  31. pmc NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats
    Shakil A Khan
    Department of Medicine, Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 14:533-42. 2011
    ..Systemic administration of mito-tempol prevented the sustained but not the acute elevations of blood pressure in IH-treated rats, suggesting that mitochondrial-derived ROS contribute to sustained elevation of blood pressure...
  32. pmc Pattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases
    Gayatri Raghuraman
    Center for Systems Biology of Oxygen Sensing, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 11:1777-89. 2009
    ..These findings demonstrate that IH in a pattern-specific manner activates TH involving ROS-mediated sustained increase in TH phosphorylation via downregulation of PP2A and upregulation of protein kinases...
  33. pmc Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR
    Guoxiang Yuan
    The Center for Systems Biology, Department of Medicine, University of Chicago, Illinois 60637, USA
    J Cell Physiol 217:674-85. 2008
    ..Rapamycin or cycloheximide, blocked increased HIF-1alpha levels during re-oxygenation indicating that mTOR-dependent protein synthesis is required for the persistent elevation of HIF-1alpha levels during re-oxygenation...
  34. pmc NADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells
    Senthilkumar B Rajamohan
    Department of Medicine, Institute for Integrative Physiology, University of Chicago, Chicago, IL 60637 1470, USA
    Antioxid Redox Signal 17:445-59. 2012
    ..Angiotensin II (Ang II) is a major regulator of aldosterone synthesis and secretion, and it is known to facilitate reactive oxygen species (ROS) generation in many cell types...
  35. pmc Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing
    Suresh D Sharma
    Dept of Medicine, Univ of Chicago, Chicago, IL 60637, USA
    J Appl Physiol (1985) 106:12-9. 2009
    ....
  36. doi request reprint Contrasting effects of intermittent and continuous hypoxia on low O(2) evoked catecholamine secretion from neonatal rat chromaffin cells
    Dangjai Souvannakitti
    The Center for Systems Biology, Departments of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Adv Exp Med Biol 648:345-9. 2009
    ..These results demonstrate that neonatal exposures IH and SH exert diametrically opposed effects on acute hypoxia-evoked CA secretion from chromaffin cells and CA contents...
  37. pmc Impairment of pancreatic β-cell function by chronic intermittent hypoxia
    Ning Wang
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, Chicago, IL 60637, USA
    Exp Physiol 98:1376-85. 2013
    ....
  38. pmc Hypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS
    Jayasri Nanduri
    Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 388:212-6. 2009
    ..These results demonstrate that ROS generated during hypoxia prevents maturation of the hERG protein by inhibiting Hsp90 interaction resulting in decreased protein expression and currents...
  39. pmc Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia
    Jayasri Nanduri
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 8:e75838. 2013
    ..These results demonstrate that ROS generated by XO activation mediates IH-induced HIF-2α degradation via activation of calpains. ..
  40. doi request reprint Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein
    Jayasri Nanduri
    Center for Systems Biology, Department of Medicine, University of Chicago, 5841S Maryland Avenue, N603, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 373:309-14. 2008
    ..These results demonstrate that hypoxia enhances the production of ROS in the mitochondria, resulting in down-regulation of hERG translation and decreased hERG-mediated K+ conductance...
  41. pmc Transcriptional responses to intermittent hypoxia
    Jayasri Nanduri
    The Center for Systems Biology, Department of Medicine, University of Chicago, MC 5068, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Respir Physiol Neurobiol 164:277-81. 2008
    ..These studies indicate that cardiorespiratory responses to chronic IH depend on complex interactions between various transcription factors resulting in alterations in several down stream genes and their protein products...
  42. doi request reprint Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression
    Naoharu Takano
    Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, IL 60637, U S A
    Biochem J 458:203-11. 2014
    ..Thus HIFs mediate tissue-specific CBS expression, which may augment cerebral vasodilation as an adaptive response to chronic hypoxia...
  43. pmc Developmental programming of O(2) sensing by neonatal intermittent hypoxia via epigenetic mechanisms
    Jayasri Nanduri
    Institute for Integrative Physiology and Center for Systems Biology of O 2 Sensing, Biological Science Division, University of Chicago, Chicago, USA
    Respir Physiol Neurobiol 185:105-9. 2013
    ....
  44. doi request reprint Differential regulation of tyrosine hydroxylase by continuous and intermittent hypoxia
    Gayatri Raghuraman
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Adv Exp Med Biol 758:381-5. 2012
    ..In this article, we present a brief overview of the impact of chronic CH and IH on TH expression, activity and the associated cellular mechanism(s)...
  45. pmc Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia
    Anita Pawar
    Center for Systems Biology, Department of Medicine, The University of Chicago, 5841 S Maryland MC, Chicago, IL 60637, USA
    J Appl Physiol (1985) 104:1287-94. 2008
    ....
  46. pmc Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling
    Gayatri Raghuraman
    Department of Medicine, Center for Systems Biology of Oxygen Sensing, University of Chicago, Chicago, Illinois 60637 1470, USA
    J Neurochem 115:1568-78. 2010
    ..These results provide evidence for the role of D1R-cAMP-PKA signaling in IH-mediated inhibition of GAD67 via protein phosphorylation resulting in down-regulation of GABA synthesis...
  47. pmc Post-translational modification of proteins during intermittent hypoxia
    Ganesh K Kumar
    The Center for Systems Biology, Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Respir Physiol Neurobiol 164:272-6. 2008
    ....
  48. doi request reprint Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels
    Ting Wang
    Section of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 46:524-31. 2012
    ..Our results suggest a multiorgan pathobiology inherent to the CHF phenotype that is exaggerated by PM exposure via heightened carotid body sensitivity and cardiac Na(+) channel dysfunction...
  49. ncbi request reprint Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia
    Guoxiang Yuan
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 280:4321-8. 2005
    ..These observations suggest that IH induces HIF-1 transcriptional activity via a novel signaling pathway involving CaM kinase...
  50. ncbi request reprint Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44109, USA
    Exp Physiol 92:39-44. 2007
    ....

Research Grants12

  1. GENE REGULATION DURING INTERMITTENT HYPOXIA
    Nanduri Prabhakar; Fiscal Year: 2000
    ....
  2. Transmitters in Altered Carotid Body Function
    Nanduri Prabhakar; Fiscal Year: 2009
    ....
  3. Consequences of Neonatal Hypoxia
    Nanduri Prabhakar; Fiscal Year: 2009
    ..Understanding the consequences of neonatal IH provide insights into how neonatal intermittent hypoxia caused by recurrent apneas affects the ventilation in premature infants. Experimental Animal Model: Rat Pups. ..
  4. Consequences of Neonatal Hypoxia
    Nanduri Prabhakar; Fiscal Year: 2007
    ..Understanding the consequences of neonatal IH provide insights into how neonatal intermittent hypoxia caused by recurrent apneas affects the ventilation in premature infants. Experimental Animal Model: Rat Pups. ..
  5. Consequences of Neonatal Hypoxia
    Nanduri Prabhakar; Fiscal Year: 2006
    ..Understanding the consequences of neonatal IH provide insights into how neonatal intermittent hypoxia caused by recurrent apneas affects the ventilation in premature infants. Experimental Animal Model: Rat Pups. ..
  6. GENE REGULATION DURING INTERMITTENT HYPOXIA
    Nanduri Prabhakar; Fiscal Year: 2003
    ....
  7. GENE REGULATION DURING INTERMITTENT HYPOXIA
    Nanduri Prabhakar; Fiscal Year: 2002
    ....
  8. GENE REGULATION DURING INTERMITTENT HYPOXIA
    Nanduri Prabhakar; Fiscal Year: 2001
    ....
  9. Transmitters in Altered Carotid Body Function
    Nanduri R Prabhakar; Fiscal Year: 2010
    ....