Research Topics
Species | Matthew PoynterSummaryAffiliation: University of Vermont Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Airway epithelial regulation of allergic sensitization in asthmaMatthew E Poynter
Department of Medicine and Vermont Lung Center, University of Vermont, Given E410A, 89 Beaumont Avenue, Burlington, VT 05405, USA
Pulm Pharmacol Ther 25:438-46. 2012....- NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarizationSamantha R Hodgkins
The Vermont Lung Center and Department of Medicine, University of Vermont, Burlington, VT 05405, USA
Respir Res 11:102. 2010..As CD11c+ antigen presenting cells are considered critical for naïve T cell activation, we investigated the role of CD11c+ cells in NO2-promoted allergic sensitization... 
A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammationMatthew E Poynter
Vermont Lung Center and Department of Medicine, University of Vermont, Burlington, VT 05405, USA
J Immunol 170:6257-65. 2003....- NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsivenessMatthew E Poynter
Vermont Lung Center and the Department of Medicine, Division of Pulmonary and Critical Care, University of Vermont, Burlington, VT 05405, USA
J Immunol 173:7003-9. 2004.... - Acrolein inhalation suppresses lipopolysaccharide-induced inflammatory cytokine production but does not affect acute airways neutrophiliaDavid Itiro Kasahara
Department of Pathology, Vermont Lung Center, College of Medicine, University of Vermont, Burlington, VT 05405, USA
J Immunol 181:736-45. 2008..Disruption of cytokine signaling by acrolein may represent a mechanism by which smoking contributes to chronic disease in chronic obstructive pulmonary disease and asthma... - Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsivenessCristen Pantano
Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
Am J Respir Crit Care Med 177:959-69. 2008..Previous studies demonstrated that inhibition of NF-kappaB in airway epithelium causes attenuation of allergic inflammation... - Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial productsJenna B Allard
Department of Medicine, Division of Pulmonary Disease and Critical Care, Vermont Lung Center, University of Vermont, Burlington, VT, USA
Eur J Immunol 39:776-88. 2009..Thus, different types of microbial products within the airway can alter the host's adaptive immune response and potentially impact the development of allergic airway disease to environmental fungal antigens... - Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammationJohn F Alcorn
Department of Pathology, Univ of Vermont, HSRF Bldg, Rm 216A, Burlington, VT 05405, USA
Am J Physiol Lung Cell Mol Physiol 298:L57-66. 2010.... - Airway epithelial NF-kappaB activation modulates asbestos-induced inflammation and mucin production in vivoAstrid Haegens
Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
J Immunol 178:1800-8. 2007..05) in Tg(+) vs Tg(-) mice. Our findings demonstrate that airway epithelial NF-kappaB activity plays a role in orchestrating the inflammatory response as well as cell proliferation in response to asbestos... - Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of β-receptor affinity in murine models of asthmaLennart K A Lundblad
Vermont Lung Center, Department of Medicine, University of Vermont, 149 Beaumont Ave, Burlington, VT 05401, USA
Respir Res 12:27. 2011..To test this hypothesis we studied the effect of long-term inhaled albuterol stereoisomers on immediate allergic response (IAR) and airway hyperresponsiveness (AHR) in mouse models of asthma... - Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitrationKarina Ckless
Department of Pathology, University of Vermont, Burlington, VT 05405, USA
J Immunol 181:4255-64. 2008..These results suggest that inhibition of arginase activity enhanced a variety of parameters relevant to allergic airways disease, possibly by altering NO homeostasis... - Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cellsCory Teuscher
Department of Medicine, University of Vermont School of Medicine, Burlington, Vermont 05405, USA
Am J Pathol 164:883-92. 2004..Because MCP-1 is known to inhibit IL-12 production, the failure of H2RKO mice to generate encephalitogenic Th1 effector cell responses is consistent with inhibition of negative regulation of MCP-1 secretion by H2R signaling in APCs... - Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox controlYvonne M W Janssen-Heininger
Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
Proc Am Thorac Soc 6:249-55. 2009.... - Reactive nitrogen species and cell signaling: implications for death or survival of lung epitheliumYvonne M W Janssen-Heininger
Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
Am J Respir Crit Care Med 166:S9-S16. 2002..A review of these pathways, their modes of action, and their importance in executing oxidative stress responses in lung epithelial cells are discussed... - Distinct functions of airway epithelial nuclear factor-kappaB activity regulate nitrogen dioxide-induced acute lung injuryJennifer L Ather
Department of Pathology, University of Vermont, Burlington, VT 05405, USA
Am J Respir Cell Mol Biol 43:443-51. 2010.... - Tumor necrosis factor-alpha overexpression in lung disease: a single cause behind a complex phenotypeLennart K A Lundblad
Vermont Lung Center, University of Vermont College of Medicine, HSRF 230, 149 Beaumont Avenue, Burlington, VT 05405 0075, USA
Am J Respir Crit Care Med 171:1363-70. 2005..These effects are currently unclear, because a transgenic mouse overexpressing TNF-alpha in the lung has been shown in separate studies to produce elements of both emphysema and pulmonary fibrosis... - Nitrogen dioxide promotes allergic sensitization to inhaled antigenMieke Bevelander
Vermont Lung Center, University of Vermont, Burlington, VT 05405, USA
J Immunol 179:3680-8. 2007..These findings offer a mechanism whereby allergen sensitization and asthma may result under conditions of high ambient or endogenous NO2 levels... - Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammationMatthew E Poynter
Vermont Lung Center and Department of Pathology, University of Vermont, Burlington 05405, USA
Am J Pathol 160:1325-34. 2002..These studies strengthen the potential importance of the bronchiolar epithelial cell as a source of production of NF-kappaB-dependent mediators that play a role in asthma... - The tick salivary protein, Salp15, inhibits the development of experimental asthmaSara A Paveglio
Department of Medicine, Vermont Lung Center and University of Vermont, Burlington, VT 05405, USA
J Immunol 178:7064-71. 2007..These studies, and those of others, support the notion that a lack of ectoparasitism may contribute to the increasing prevalence of allergic asthma... - Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injuryJoseph M Petty
Department of Medicine, University of Vermont College of Medicine, 149 Beaumont Avenue, Burlington, VT 05405, USA
J Immunol 178:8148-57. 2007.... - Eosinophil peroxidase catalyzes JNK-mediated membrane blebbing in a Rho kinase-dependent mannerBrian McElhinney
Department of Pathology, University of Vermont, Burlington, VT 05405, USA
J Leukoc Biol 74:897-907. 2003..Our findings demonstrate that catalytically active EPO is capable of causing significant damage to lung epithelial cells in vitro and that this involves the activation of JNK... - Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulatorJenna B Allard
Vermont Lung Center, Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
J Immunol 177:5186-94. 2006..The Th2 bias of CD4+ T cells in the absence of functional CFTR correlates with elevated nuclear levels of NFAT. Thus, CFTR is important to maintain the Th1/Th2 balance in CD4+ T cells... - Slam haplotypes modulate the response to lipopolysaccharide in vivo through control of NKT cell number and functionIdil Aktan
Department of Surgery, University of Vermont, College of Medicine, Burlington, VT 05405, USA
J Immunol 185:144-56. 2010..These data suggest that the polymorphisms that distinguish two Slam haplotypes significantly modulate the innate immune response in vivo through their effect on NKT cells... - Acute lung injury with endotoxin or NO2 does not enhance development of airway epithelium from bone marrowTravis Beckett
Pulmonary and Critical Care, Vermont Lung Center, University of Vermont College of Medicine, Burlington, 05405, USA
Mol Ther 12:680-6. 2005..These results suggest that NO(2) or endotoxin lung injury does not result in significant engraftment of marrow-derived cells in lung... - Nitrogen dioxide enhances allergic airway inflammation and hyperresponsiveness in the mouseMatthew E Poynter
Department of Medicine, University of Vermont, Burlington, VT 05405, USA
Am J Physiol Lung Cell Mol Physiol 290:L144-52. 2006..Collectively, these observations suggest an important role for NO2 in airway pathologies associated with asthma, both in modulation of degree and duration of inflammatory response, as well as in induction of AHR... - Airway epithelial NF-κB activation promotes allergic sensitization to an innocuous inhaled antigenJennifer L Ather
Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, 05405, USA
Am J Respir Cell Mol Biol 44:631-8. 2011.... - Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposureSara A Paveglio
Vermont Lung Center, and Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, 149 Beaumont Ave, Burlington, VT 05405, USA
Am J Respir Cell Mol Biol 44:11-23. 2011.... - Widespread natural variation in murine natural killer T-cell number and functionStacia L Rymarchyk
Department of Surgery, Univeristy of Vermont College of Medicine, Burlington, VT 05405, USA
Immunology 125:331-43. 2008.... - Crosstalk between CXCR4/stromal derived factor-1 and VLA-4/VCAM-1 pathways regulates neutrophil retention in the bone marrowJoseph M Petty
Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
J Immunol 182:604-12. 2009.... - Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait lociRyan D McAllister
Department of Microbiology, University of Illinois, Urbana, IL, USA
Am J Pathol 163:1735-41. 2003..Additionally, to recapitulate dominant resistance to mortality as seen in (BALB/c x DBA/2) F(1) hybrids, DBA/2 alleles are required at all three QTL... - Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lungRebecca L Persinger
Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle, USA
Mol Cell Biochem 234:71-80. 2002..Understanding the molecular mechanisms of epithelial cell death associated with the exposure to .NO2 will be important in designing therapeutics aimed at protecting the lung from persistent injury and repair...
Research Grants
- Airway Epithelial NF-kB Activation by CpG DNAMatthew Poynter; Fiscal Year: 2005..Specific aim 4) Demonstrate that intranasal CpG DNA administration augments secretary immunoglobulin levels in the airway through TLR9-mediated NF-kB activation by bronchiolar epithelial cells. ..
- Nitrogen Dioxide in the Sensitization to Allergic Airway DiseaseMatthew E Poynter; Fiscal Year: 2010....
- Nitrogen Dioxide in the Sensitization to Allergic Airway DiseaseMatthew Poynter; Fiscal Year: 2009....