Matthew Poynter

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc Serum amyloid A inhibits dendritic cell apoptosis to induce glucocorticoid resistance in CD4(+) T cells
    J L Ather
    Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Cell Death Dis 4:e786. 2013
  2. pmc Airway epithelial regulation of allergic sensitization in asthma
    Matthew E Poynter
    Department of Medicine and Vermont Lung Center, University of Vermont, Given E410A, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Pulm Pharmacol Ther 25:438-46. 2012
  3. pmc NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization
    Samantha R Hodgkins
    The Vermont Lung Center and Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Respir Res 11:102. 2010
  4. ncbi request reprint A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation
    Matthew E Poynter
    Vermont Lung Center and Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 170:6257-65. 2003
  5. pmc NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness
    Matthew E Poynter
    Vermont Lung Center and the Department of Medicine, Division of Pulmonary and Critical Care, University of Vermont, Burlington, VT 05405, USA
    J Immunol 173:7003-9. 2004
  6. pmc Acrolein inhalation suppresses lipopolysaccharide-induced inflammatory cytokine production but does not affect acute airways neutrophilia
    David Itiro Kasahara
    Department of Pathology, Vermont Lung Center, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 181:736-45. 2008
  7. pmc Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness
    Cristen Pantano
    Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Respir Crit Care Med 177:959-69. 2008
  8. pmc Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation
    John F Alcorn
    Department of Pathology, Univ of Vermont, HSRF Bldg, Rm 216A, Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 298:L57-66. 2010
  9. ncbi request reprint Airway epithelial NF-kappaB activation modulates asbestos-induced inflammation and mucin production in vivo
    Astrid Haegens
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    J Immunol 178:1800-8. 2007
  10. pmc Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products
    Jenna B Allard
    Department of Medicine, Division of Pulmonary Disease and Critical Care, Vermont Lung Center, University of Vermont, Burlington, VT, USA
    Eur J Immunol 39:776-88. 2009

Collaborators

Detail Information

Publications32

  1. pmc Serum amyloid A inhibits dendritic cell apoptosis to induce glucocorticoid resistance in CD4(+) T cells
    J L Ather
    Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Cell Death Dis 4:e786. 2013
    ..These findings reveal mechanisms through which SAA enhances the CD4(+) T-cell-stimulating capacity of antigen-presenting cells that may actively participate in the pathogenicity of glucocorticoid-resistant lung disease...
  2. pmc Airway epithelial regulation of allergic sensitization in asthma
    Matthew E Poynter
    Department of Medicine and Vermont Lung Center, University of Vermont, Given E410A, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Pulm Pharmacol Ther 25:438-46. 2012
    ....
  3. pmc NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization
    Samantha R Hodgkins
    The Vermont Lung Center and Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Respir Res 11:102. 2010
    ..As CD11c+ antigen presenting cells are considered critical for naïve T cell activation, we investigated the role of CD11c+ cells in NO2-promoted allergic sensitization...
  4. ncbi request reprint A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation
    Matthew E Poynter
    Vermont Lung Center and Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 170:6257-65. 2003
    ....
  5. pmc NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness
    Matthew E Poynter
    Vermont Lung Center and the Department of Medicine, Division of Pulmonary and Critical Care, University of Vermont, Burlington, VT 05405, USA
    J Immunol 173:7003-9. 2004
    ....
  6. pmc Acrolein inhalation suppresses lipopolysaccharide-induced inflammatory cytokine production but does not affect acute airways neutrophilia
    David Itiro Kasahara
    Department of Pathology, Vermont Lung Center, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 181:736-45. 2008
    ..Disruption of cytokine signaling by acrolein may represent a mechanism by which smoking contributes to chronic disease in chronic obstructive pulmonary disease and asthma...
  7. pmc Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness
    Cristen Pantano
    Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Respir Crit Care Med 177:959-69. 2008
    ..Previous studies demonstrated that inhibition of NF-kappaB in airway epithelium causes attenuation of allergic inflammation...
  8. pmc Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation
    John F Alcorn
    Department of Pathology, Univ of Vermont, HSRF Bldg, Rm 216A, Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 298:L57-66. 2010
    ....
  9. ncbi request reprint Airway epithelial NF-kappaB activation modulates asbestos-induced inflammation and mucin production in vivo
    Astrid Haegens
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    J Immunol 178:1800-8. 2007
    ..05) in Tg(+) vs Tg(-) mice. Our findings demonstrate that airway epithelial NF-kappaB activity plays a role in orchestrating the inflammatory response as well as cell proliferation in response to asbestos...
  10. pmc Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products
    Jenna B Allard
    Department of Medicine, Division of Pulmonary Disease and Critical Care, Vermont Lung Center, University of Vermont, Burlington, VT, USA
    Eur J Immunol 39:776-88. 2009
    ..Thus, different types of microbial products within the airway can alter the host's adaptive immune response and potentially impact the development of allergic airway disease to environmental fungal antigens...
  11. pmc Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells
    Cory Teuscher
    Department of Medicine, University of Vermont School of Medicine, Burlington, Vermont 05405, USA
    Am J Pathol 164:883-92. 2004
    ..Because MCP-1 is known to inhibit IL-12 production, the failure of H2RKO mice to generate encephalitogenic Th1 effector cell responses is consistent with inhibition of negative regulation of MCP-1 secretion by H2R signaling in APCs...
  12. pmc Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of β-receptor affinity in murine models of asthma
    Lennart K A Lundblad
    Vermont Lung Center, Department of Medicine, University of Vermont, 149 Beaumont Ave, Burlington, VT 05401, USA
    Respir Res 12:27. 2011
    ..To test this hypothesis we studied the effect of long-term inhaled albuterol stereoisomers on immediate allergic response (IAR) and airway hyperresponsiveness (AHR) in mouse models of asthma...
  13. ncbi request reprint Reactive nitrogen species and cell signaling: implications for death or survival of lung epithelium
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Respir Crit Care Med 166:S9-S16. 2002
    ..A review of these pathways, their modes of action, and their importance in executing oxidative stress responses in lung epithelial cells are discussed...
  14. pmc Distinct functions of airway epithelial nuclear factor-kappaB activity regulate nitrogen dioxide-induced acute lung injury
    Jennifer L Ather
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 43:443-51. 2010
    ....
  15. pmc Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Proc Am Thorac Soc 6:249-55. 2009
    ....
  16. pmc Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration
    Karina Ckless
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Immunol 181:4255-64. 2008
    ..These results suggest that inhibition of arginase activity enhanced a variety of parameters relevant to allergic airways disease, possibly by altering NO homeostasis...
  17. pmc Tumor necrosis factor-alpha overexpression in lung disease: a single cause behind a complex phenotype
    Lennart K A Lundblad
    Vermont Lung Center, University of Vermont College of Medicine, HSRF 230, 149 Beaumont Avenue, Burlington, VT 05405 0075, USA
    Am J Respir Crit Care Med 171:1363-70. 2005
    ..These effects are currently unclear, because a transgenic mouse overexpressing TNF-alpha in the lung has been shown in separate studies to produce elements of both emphysema and pulmonary fibrosis...
  18. pmc Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation
    Matthew E Poynter
    Vermont Lung Center and Department of Pathology, University of Vermont, Burlington 05405, USA
    Am J Pathol 160:1325-34. 2002
    ..These studies strengthen the potential importance of the bronchiolar epithelial cell as a source of production of NF-kappaB-dependent mediators that play a role in asthma...
  19. ncbi request reprint Nitrogen dioxide promotes allergic sensitization to inhaled antigen
    Mieke Bevelander
    Vermont Lung Center, University of Vermont, Burlington, VT 05405, USA
    J Immunol 179:3680-8. 2007
    ..These findings offer a mechanism whereby allergen sensitization and asthma may result under conditions of high ambient or endogenous NO2 levels...
  20. pmc The tick salivary protein, Salp15, inhibits the development of experimental asthma
    Sara A Paveglio
    Department of Medicine, Vermont Lung Center and University of Vermont, Burlington, VT 05405, USA
    J Immunol 178:7064-71. 2007
    ..These studies, and those of others, support the notion that a lack of ectoparasitism may contribute to the increasing prevalence of allergic asthma...
  21. ncbi request reprint Acute lung injury with endotoxin or NO2 does not enhance development of airway epithelium from bone marrow
    Travis Beckett
    Pulmonary and Critical Care, Vermont Lung Center, University of Vermont College of Medicine, Burlington, 05405, USA
    Mol Ther 12:680-6. 2005
    ..These results suggest that NO(2) or endotoxin lung injury does not result in significant engraftment of marrow-derived cells in lung...
  22. ncbi request reprint Eosinophil peroxidase catalyzes JNK-mediated membrane blebbing in a Rho kinase-dependent manner
    Brian McElhinney
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Leukoc Biol 74:897-907. 2003
    ..Our findings demonstrate that catalytically active EPO is capable of causing significant damage to lung epithelial cells in vitro and that this involves the activation of JNK...
  23. ncbi request reprint Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury
    Joseph M Petty
    Department of Medicine, University of Vermont College of Medicine, 149 Beaumont Avenue, Burlington, VT 05405, USA
    J Immunol 178:8148-57. 2007
    ....
  24. ncbi request reprint Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulator
    Jenna B Allard
    Vermont Lung Center, Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 177:5186-94. 2006
    ..The Th2 bias of CD4+ T cells in the absence of functional CFTR correlates with elevated nuclear levels of NFAT. Thus, CFTR is important to maintain the Th1/Th2 balance in CD4+ T cells...
  25. pmc Slam haplotypes modulate the response to lipopolysaccharide in vivo through control of NKT cell number and function
    Idil Aktan
    Department of Surgery, University of Vermont, College of Medicine, Burlington, VT 05405, USA
    J Immunol 185:144-56. 2010
    ..These data suggest that the polymorphisms that distinguish two Slam haplotypes significantly modulate the innate immune response in vivo through their effect on NKT cells...
  26. ncbi request reprint Nitrogen dioxide enhances allergic airway inflammation and hyperresponsiveness in the mouse
    Matthew E Poynter
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 290:L144-52. 2006
    ..Collectively, these observations suggest an important role for NO2 in airway pathologies associated with asthma, both in modulation of degree and duration of inflammatory response, as well as in induction of AHR...
  27. pmc Airway epithelial NF-κB activation promotes allergic sensitization to an innocuous inhaled antigen
    Jennifer L Ather
    Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, 05405, USA
    Am J Respir Cell Mol Biol 44:631-8. 2011
    ....
  28. pmc Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure
    Sara A Paveglio
    Vermont Lung Center, and Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, 149 Beaumont Ave, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 44:11-23. 2011
    ....
  29. pmc Crosstalk between CXCR4/stromal derived factor-1 and VLA-4/VCAM-1 pathways regulates neutrophil retention in the bone marrow
    Joseph M Petty
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Immunol 182:604-12. 2009
    ....
  30. pmc Widespread natural variation in murine natural killer T-cell number and function
    Stacia L Rymarchyk
    Department of Surgery, Univeristy of Vermont College of Medicine, Burlington, VT 05405, USA
    Immunology 125:331-43. 2008
    ....
  31. ncbi request reprint Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung
    Rebecca L Persinger
    Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle, USA
    Mol Cell Biochem 234:71-80. 2002
    ..Understanding the molecular mechanisms of epithelial cell death associated with the exposure to .NO2 will be important in designing therapeutics aimed at protecting the lung from persistent injury and repair...
  32. pmc Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait loci
    Ryan D McAllister
    Department of Microbiology, University of Illinois, Urbana, IL, USA
    Am J Pathol 163:1735-41. 2003
    ..Additionally, to recapitulate dominant resistance to mortality as seen in (BALB/c x DBA/2) F(1) hybrids, DBA/2 alleles are required at all three QTL...

Research Grants6

  1. Airway Epithelial NF-kB Activation by CpG DNA
    Matthew Poynter; Fiscal Year: 2005
    ..Specific aim 4) Demonstrate that intranasal CpG DNA administration augments secretary immunoglobulin levels in the airway through TLR9-mediated NF-kB activation by bronchiolar epithelial cells. ..
  2. Nitrogen Dioxide in the Sensitization to Allergic Airway Disease
    Matthew Poynter; Fiscal Year: 2007
    ....
  3. Nitrogen Dioxide in the Sensitization to Allergic Airway Disease
    Matthew Poynter; Fiscal Year: 2008
    ....
  4. Nitrogen Dioxide in the Sensitization to Allergic Airway Disease
    Matthew Poynter; Fiscal Year: 2009
    ....
  5. Nitrogen Dioxide in the Sensitization to Allergic Airway Disease
    Matthew E Poynter; Fiscal Year: 2010
    ....
  6. Nitrogen Dioxide in the Sensitization to Allergic Airway Disease
    Matthew Poynter; Fiscal Year: 2009
    ....