William Powers

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint Perfusion-diffusion mismatch: does it identify who will benefit from reperfusion therapy?
    William J Powers
    Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, Box 7025, Room 2131, 170 Manning Drive, Chapel Hill, NC, 27599, USA
    Transl Stroke Res 3:182-7. 2012
  2. doi request reprint Thromobolysis for acute ischemic stroke: is intra-arterial better than intravenous? A treatment effects model
    William J Powers
    Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Stroke Cerebrovasc Dis 21:401-3. 2012
  3. doi request reprint Imaging preventable infarction in patients with acute ischemic stroke
    W J Powers
    Department of Neurology, University of North Carolina School of Medicine, 170 Manning Dr, Rm 2131, CB 7025, Chapel Hill, NC 27599 7025, USA
    AJNR Am J Neuroradiol 29:1823-5. 2008
  4. pmc Autoregulation after ischaemic stroke
    William J Powers
    Department of Neurology, University of North Carolina School of Medicine, North Carolina 27599 7025, USA
    J Hypertens 27:2218-22. 2009
  5. doi request reprint PET studies of cerebral metabolism in Parkinson disease
    William J Powers
    Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Rm 2131, CB 7025, Chapel Hill, NC 27599 7025, USA
    J Bioenerg Biomembr 41:505-8. 2009
  6. pmc Intracerebral hemorrhage and head trauma: common effects and common mechanisms of injury
    William J Powers
    Department of Neurology, University of North Carolina, Chapel Hill, NC 27599 7025, USA
    Stroke 41:S107-10. 2010
  7. pmc Platelet mitochondrial complex I and I+III activities do not correlate with cerebral mitochondrial oxidative metabolism
    William J Powers
    Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7025, USA
    J Cereb Blood Flow Metab 31:e1-5. 2011
  8. pmc Metabolic control of resting hemispheric cerebral blood flow is oxidative, not glycolytic
    William J Powers
    Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    J Cereb Blood Flow Metab 31:1223-8. 2011
  9. ncbi request reprint Management of patients with atherosclerotic carotid occlusion
    William J Powers
    Department of Neurology, University of North Carolina at Chapel Hill, Box 7025, Room 2131, 170 Manning Drive, Chapel Hill, NC, 27599, USA
    Curr Treat Options Neurol 13:608-15. 2011
  10. pmc Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial
    William J Powers
    Department of Neurology, Box 7025, Room 2131, 170 Manning Dr, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    JAMA 306:1983-92. 2011

Detail Information

Publications27

  1. doi request reprint Perfusion-diffusion mismatch: does it identify who will benefit from reperfusion therapy?
    William J Powers
    Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, Box 7025, Room 2131, 170 Manning Drive, Chapel Hill, NC, 27599, USA
    Transl Stroke Res 3:182-7. 2012
    ..Unless RCT data are forthcoming to demonstrate that MRI perfusion-diffusion mismatch improves clinical outcome, it should not be used to guide delayed reperfusion therapy. ..
  2. doi request reprint Thromobolysis for acute ischemic stroke: is intra-arterial better than intravenous? A treatment effects model
    William J Powers
    Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Stroke Cerebrovasc Dis 21:401-3. 2012
    ..Three randomized trials of intra-arterial thrombolysis (IAT) for acute ischemic stroke ≤ 6 hours were conducted without intravenous tissue plasminogen activator (IV-tPA) treatment of patients in the control groups now known to benefit...
  3. doi request reprint Imaging preventable infarction in patients with acute ischemic stroke
    W J Powers
    Department of Neurology, University of North Carolina School of Medicine, 170 Manning Dr, Rm 2131, CB 7025, Chapel Hill, NC 27599 7025, USA
    AJNR Am J Neuroradiol 29:1823-5. 2008
    ..This article will discuss the design, analysis, and interpretation of clinical research studies carried out to establish the accuracy and clinical value of neuroimaging to select such patients...
  4. pmc Autoregulation after ischaemic stroke
    William J Powers
    Department of Neurology, University of North Carolina School of Medicine, North Carolina 27599 7025, USA
    J Hypertens 27:2218-22. 2009
    ..Data from human participants have failed to resolve the question whether cerebral blood flow (CBF) in the peri-infarct region will decrease due to impaired autoregulation when systemic mean arterial pressure (MAP) is rapidly reduced...
  5. doi request reprint PET studies of cerebral metabolism in Parkinson disease
    William J Powers
    Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Rm 2131, CB 7025, Chapel Hill, NC 27599 7025, USA
    J Bioenerg Biomembr 41:505-8. 2009
    ..Which is the case in early PD and whether these metabolic abnormalities are important in the pathogenesis of PD will require further study...
  6. pmc Intracerebral hemorrhage and head trauma: common effects and common mechanisms of injury
    William J Powers
    Department of Neurology, University of North Carolina, Chapel Hill, NC 27599 7025, USA
    Stroke 41:S107-10. 2010
    ..Recent data demonstrating contralateral hemispheric damage in patients with acute ICH provide further support for this theory of common injury mechanisms...
  7. pmc Platelet mitochondrial complex I and I+III activities do not correlate with cerebral mitochondrial oxidative metabolism
    William J Powers
    Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7025, USA
    J Cereb Blood Flow Metab 31:e1-5. 2011
    ..On the basis of these data, we conclude that measures of mitochondrial complex I and I+III activity in platelets within the ranges we have studied do not correlate with oxidative function of cerebral mitochondria...
  8. pmc Metabolic control of resting hemispheric cerebral blood flow is oxidative, not glycolytic
    William J Powers
    Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    J Cereb Blood Flow Metab 31:1223-8. 2011
    ..Our findings provide evidence for compartmentalization of brain metabolism into a basal component in which CBF is coupled to oxygen metabolism and an activation component in which CBF is controlled by another mechanism...
  9. ncbi request reprint Management of patients with atherosclerotic carotid occlusion
    William J Powers
    Department of Neurology, University of North Carolina at Chapel Hill, Box 7025, Room 2131, 170 Manning Drive, Chapel Hill, NC, 27599, USA
    Curr Treat Options Neurol 13:608-15. 2011
    ..Asymptomatic carotid occlusion has a benign prognosis and requires no specific treatment other than lifestyle modification and risk factor intervention...
  10. pmc Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial
    William J Powers
    Department of Neurology, Box 7025, Room 2131, 170 Manning Dr, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    JAMA 306:1983-92. 2011
    ..Patients with symptomatic atherosclerotic internal carotid artery occlusion (AICAO) and hemodynamic cerebral ischemia are at high risk for subsequent stroke when treated medically...
  11. pmc Cerebral mitochondrial metabolism in early Parkinson's disease
    William J Powers
    Department of Neurology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7025, USA
    J Cereb Blood Flow Metab 28:1754-60. 2008
    ..Whether this is the case in early PD and whether it is important in the pathogenesis of PD will require further study...
  12. pmc Signal evolution and infarction risk for apparent diffusion coefficient lesions in acute ischemic stroke are both time- and perfusion-dependent
    Hongyu An
    Department of Radiology and Biomedical Research Imaging Center, CB 7513, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Stroke 42:1276-81. 2011
    ....
  13. ncbi request reprint The use of positron emission tomography in cerebrovascular disease
    William J Powers
    Department of Neurology, Neurological Surgery, and Radiology, East Building Imaging Center, Room 2218F, Campus Box 8225, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuroimaging Clin N Am 13:741-58. 2003
    ..Whether the role of PET expands to impact the management of individual patients will depend on the results of investigations like the Carotid Occlusion Surgery Study that directly assess the ability of PET to influence patient outcome...
  14. doi request reprint Transient focal increase in perihematomal glucose metabolism after acute human intracerebral hemorrhage
    Allyson R Zazulia
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 40:1638-43. 2009
    ....
  15. pmc Selective defect of in vivo glycolysis in early Huntington's disease striatum
    William J Powers
    Department of Neurology, Program in Physical Therapy, and Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 4525 Scott Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:2945-9. 2007
    ..Because glycolytic metabolism is predominantly astrocytic, the selective reduction in striatal CMRglc raises the possibility that astrocyte dysfunction may be involved in the pathogenesis of HD...
  16. ncbi request reprint Effect of normal saline bolus on cerebral blood flow in regions with low baseline flow in patients with vasospasm following subarachnoid hemorrhage
    Sarah C Jost
    Department of Neurology, Neurological Surgery, and Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 103:25-30. 2005
    ..The purpose of this study was to examine the effects of volume expansion on regional (r)CBF in patients with DIND following SAH...
  17. ncbi request reprint Regional cerebrovascular and metabolic effects of hyperventilation after severe traumatic brain injury
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 96:103-8. 2002
    ..In the present study they sought to determine if hyperventilation lowers CBF below the ischemic threshold of 18 to 20 ml/100 g/ min in any brain region and if those reductions cause energy failure (defined as a fall in CMRO2)...
  18. ncbi request reprint Effect of hyperoxia on cerebral metabolic rate for oxygen measured using positron emission tomography in patients with acute severe head injury
    Michael N Diringer
    Department of Neurology, Neurology Neurosurgery Intensive Care Unit, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 106:526-9. 2007
    ....
  19. pmc No effect of low-dose statins treatment on cerebral blood flow in humans with atherosclerotic cerebrovascular disease
    Colin P Derdeyn
    Department of Neurology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cereb Blood Flow Metab 27:1643-8. 2007
    ..9+/-13.5 and 44.2+/-13.3 mL/100 g min for the statin and nonstatin groups, respectively. We conclude that the stroke risk reduction observed with statin therapy in humans likely involves mechanisms other than an increased basal CBF...
  20. pmc Autoregulation of cerebral blood flow to changes in arterial pressure in mild Alzheimer's disease
    Allyson R Zazulia
    Department of Neurology, Washington University, St Louis, Missouri 63110, USA
    J Cereb Blood Flow Metab 30:1883-9. 2010
    ..30, 95% CI=-7.7 to 2.7). The absence of significant change in CBF with a 10 to 15 mm Hg reduction in MAP within the normal autoregulatory range demonstrates that there is neither a generalized nor local defect of autoregulation in AD...
  21. ncbi request reprint Symptomatic autoregulatory failure in acute ischemic stroke
    Allyson R Zazulia
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 68:389-90. 2007
  22. pmc Normal platelet mitochondrial complex I activity in Huntington's disease
    William J Powers
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 27:99-101. 2007
    ..Reductions > 10% were excluded with 80% confidence. A systemic defect in complex I activity is not present in early HD when striatal neuronal degeneration is already present...
  23. ncbi request reprint The Carotid Occlusion Surgery Study
    Robert L Grubb
    Department of Neurological Surgery, Washington University School of Medicine, Washington University Medical Center, St Louis, Missouri 63110 1093, USA
    Neurosurg Focus 14:e9. 2003
    ..It is estimated that 186 patients will be required in each group. Assuming that 40% of PET scans will demonstrate increased OEF, this will require enrolling 930 clinically eligible individuals...
  24. ncbi request reprint Patterns of infarction in hemodynamic failure
    Colin P Derdeyn
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cerebrovasc Dis 24:11-9. 2007
    ..The purpose of this study was to investigate the clinical and imaging features of stroke in these patients...
  25. pmc Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failure
    Ana Maria Arbelaez
    Campus Box 8127, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Diabetes 57:470-5. 2008
    ..We investigated the role of cerebral mechanisms in HAAF by measuring regional brain activation during recurrent hypoglycemia with attenuated counterregulatory responses and comparing it with initial hypoglycemia in healthy individuals...
  26. ncbi request reprint Re: Stages and thresholds of hemodynamic failure
    Colin P Derdeyn
    Stroke 34:589. 2003
  27. ncbi request reprint Variability of cerebral blood volume and oxygen extraction: stages of cerebral haemodynamic impairment revisited
    Colin P Derdeyn
    Neuroradiology Section, Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    Brain 125:595-607. 2002
    ..The physiological explanation for the measurement of normal CBV in patients with increased OEF is less certain and may reflect preserved autoregulatory capacity...

Research Grants7

  1. CEREBRAL MITOCHONDRIAL METABOLISM IN NEURODEGENERATION
    William Powers; Fiscal Year: 2001
    ..If such studies yield consistent results, they will establish the basis for the utilization of platelet rnitochondrial function assays to monitor cerebral mitochondrial metabolism. ..
  2. CEREBRAL MITOCHONDRIAL METABOLISM IN NEURODEGENERATION
    William Powers; Fiscal Year: 2002
    ..If such studies yield consistent results, they will establish the basis for the utilization of platelet rnitochondrial function assays to monitor cerebral mitochondrial metabolism. ..
  3. CEREBRAL MITOCHONDRIAL METABOLISM IN NEURODEGENERATION
    William Powers; Fiscal Year: 2003
    ..If such studies yield consistent results, they will establish the basis for the utilization of platelet rnitochondrial function assays to monitor cerebral mitochondrial metabolism. ..
  4. CEREBRAL MITOCHONDRIAL METABOLISM IN NEURODEGENERATION
    William Powers; Fiscal Year: 2004
    ..If such studies yield consistent results, they will establish the basis for the utilization of platelet rnitochondrial function assays to monitor cerebral mitochondrial metabolism. ..
  5. Vascular and Metabolic Mechanisms in Alzheimer's Disease
    William Powers; Fiscal Year: 2005
    ..Through the use of the unique resources and personnel at Washington University Medical Center, we have the opportunity to provide answers to important clinical and mechanistic questions in AD. ..