Ted Powers

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae
    Brad J Niles
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, CA, USA
    Cell Cycle 11:3745-9. 2012
  2. ncbi request reprint TOR signaling and S6 kinase 1: Yeast catches up
    Ted Powers
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Cell Metab 6:1-2. 2007
  3. ncbi request reprint Yeast TOR signaling: a mechanism for metabolic regulation
    T Powers
    Section of Molecular and Cellular Biology, Center for Genetics and Development, Division of Biological Sciences, University of California Davis, Davis, CA 95616, USA
    Curr Top Microbiol Immunol 279:39-51. 2004
  4. ncbi request reprint Cell growth control: mTOR takes on fat
    Ted Powers
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Mol Cell 31:775-6. 2008
  5. ncbi request reprint TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae
    Aaron Reinke
    Section of Molecular and Cellular Biology and Center for Genetics and Development, Division of Biological Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 279:14752-62. 2004
  6. pmc Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
    Brad J Niles
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 109:1536-41. 2012
  7. ncbi request reprint Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes
    Ivanka Dilova
    Section of Molecular and Cellular Biology and Center for Genetics and Development, Division of Biological Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 279:46527-35. 2004
  8. ncbi request reprint Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p
    Aaron Reinke
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 281:31616-26. 2006
  9. pmc Probing the membrane environment of the TOR kinases reveals functional interactions between TORC1, actin, and membrane trafficking in Saccharomyces cerevisiae
    Sofia Aronova
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, CA 95616, USA
    Mol Biol Cell 18:2779-94. 2007
  10. ncbi request reprint Accounting for strain-specific differences during RTG target gene regulation in Saccharomyces cerevisiae
    Ivanka Dilova
    Section of Molecular and Cellular Biology and Center for Genetics and Development, College of Biological Sciences, University of California, Davis, CA 95616, USA
    FEMS Yeast Res 6:112-9. 2006

Research Grants

Collaborators

  • Andrew Hill
  • C Y Chen
  • Brad J Niles
  • Sofia Aronova
  • Ivanka Dilova
  • Aaron Reinke
  • Ariadne Vlahakis
  • Jenny C Y Chen
  • John Yates
  • Scott Anderson
  • Karen P Wedaman
  • Karen Wedaman
  • Dietmar E Martin
  • Michael N Hall
  • J Michael McCaffery
  • Tara Fresques
  • Martin Graef
  • Jodi Nunnari
  • Jose L Crespo
  • Amelia C Joslin
  • Huzefa Mogri
  • Pavel A Aronov
  • Kristin Fontes
  • Karmela Ramos
  • Bruce D Hammock
  • Cory Iverson
  • Stephen Fairclough
  • Stephanie Chu
  • Brian Fowler

Detail Information

Publications20

  1. pmc Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae
    Brad J Niles
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, CA, USA
    Cell Cycle 11:3745-9. 2012
    ..Together, these studies reveal the existence of an intricate homeostatic feedback mechanism, whereby the activity of these signaling components is linked to the biosynthesis of PM lipids according to cellular need...
  2. ncbi request reprint TOR signaling and S6 kinase 1: Yeast catches up
    Ted Powers
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Cell Metab 6:1-2. 2007
    ..cerevisiae, which appears to be the long sought after yeast ortholog of mammalian S6 kinase 1 (S6K1) and a direct target for the rapamycin-sensitive TOR complex I...
  3. ncbi request reprint Yeast TOR signaling: a mechanism for metabolic regulation
    T Powers
    Section of Molecular and Cellular Biology, Center for Genetics and Development, Division of Biological Sciences, University of California Davis, Davis, CA 95616, USA
    Curr Top Microbiol Immunol 279:39-51. 2004
    ..These studies have raised the important issue as to how diverse nutritional cues can pass through a common signaling pathway and yet ultimately generate distinct transcriptional responses...
  4. ncbi request reprint Cell growth control: mTOR takes on fat
    Ted Powers
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Mol Cell 31:775-6. 2008
    ..2008) demonstrate that fatty acid biosynthesis, under the transcriptional control of SREBP1, is regulated by the rapamycin-sensitive mTOR signaling network, thus expanding the scope of biosynthetic processes integrated by mTOR...
  5. ncbi request reprint TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae
    Aaron Reinke
    Section of Molecular and Cellular Biology and Center for Genetics and Development, Division of Biological Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 279:14752-62. 2004
    ..Together, these results define a novel connection between TORC1 and Ssd1p-mediated maintenance of cellular integrity...
  6. pmc Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
    Brad J Niles
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 109:1536-41. 2012
    ..These findings both extend the scope of cellular processes regulated by Ypk1/2 to include negative regulation of calcineurin and broaden the repertoire of mechanisms for membrane recruitment and activation of a protein kinase...
  7. ncbi request reprint Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes
    Ivanka Dilova
    Section of Molecular and Cellular Biology and Center for Genetics and Development, Division of Biological Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 279:46527-35. 2004
    ..Finally, we find that Tor- and glutamine-mediated RTG-target gene repression can be experimentally uncoupled, indicating that glutamine and Tor act, at least in part, independently to inhibit this pathway...
  8. ncbi request reprint Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p
    Aaron Reinke
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 281:31616-26. 2006
    ....
  9. pmc Probing the membrane environment of the TOR kinases reveals functional interactions between TORC1, actin, and membrane trafficking in Saccharomyces cerevisiae
    Sofia Aronova
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, CA 95616, USA
    Mol Biol Cell 18:2779-94. 2007
    ..Together, these results reveal the broad scope of cellular processes influenced by TORC1, and they underscore the functional overlap between TORC1 and TORC2...
  10. ncbi request reprint Accounting for strain-specific differences during RTG target gene regulation in Saccharomyces cerevisiae
    Ivanka Dilova
    Section of Molecular and Cellular Biology and Center for Genetics and Development, College of Biological Sciences, University of California, Davis, CA 95616, USA
    FEMS Yeast Res 6:112-9. 2006
    ..That hyper-phosphorylation of Rtg3p is also caused by heat shock suggests that it may reflect a more generalized response to cell stress. Together these results contribute toward a uniform view of RTG target gene regulation...
  11. pmc Regulation of ceramide biosynthesis by TOR complex 2
    Sofia Aronova
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, CA 95616, USA
    Cell Metab 7:148-58. 2008
    ..Because Ypk2 is activated independently by LCBs, the direct precursors to ceramides, our data suggest a model wherein TORC2 signaling is coupled with LCB levels to control Ypk2 activity and, ultimately, regulate ceramide formation...
  12. ncbi request reprint Ribosome biogenesis: giant steps for a giant problem
    Ted Powers
    Section of Molecular and Cellular Biology and Center for Genetics and Development, Division of Biological Sciences, University of California, Davis, CA 95616, USA
    Cell 119:901-2. 2004
    ..2004). These findings represent a crucial advance in our understanding of the mechanism by which TOR regulates ribosome biogenesis in response to environmental cues...
  13. pmc Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae
    Karen P Wedaman
    Section of Molecular and Cellular Biology and Center for Genetics and Development, Division of Biological Sciences, University of California, Davis, Davis, California 95616, USA
    Mol Biol Cell 14:1204-20. 2003
    ..That these complexes colocalize to a membrane-bound compartment suggests an intimate relationship between membrane-mediated signaling and Tor activity...
  14. ncbi request reprint Coordinate regulation of multiple and distinct biosynthetic pathways by TOR and PKA kinases in S. cerevisiae
    Jenny C Y Chen
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Curr Genet 49:281-93. 2006
    ..Our results underscore how multiple signaling pathways, general growth conditions, as well as the availability of specific nutrients contribute to the maintenance of appropriate patterns of gene activity in yeast...
  15. pmc TOR complex 2-Ypk1 signaling maintains sphingolipid homeostasis by sensing and regulating ROS accumulation
    Brad J Niles
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, CA 95616, USA
    Cell Rep 6:541-52. 2014
    ..Thus, ROS sensing and signaling by TORC2/Ypk1 play a central physiological role in sphingolipid biosynthesis and in the maintenance of cell growth and viability...
  16. pmc Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae
    T Powers
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California, School of Medicine, San Francisco, California 94143 0448, USA
    Mol Biol Cell 10:987-1000. 1999
    ..This induction has been shown previously to involve both the Ras-adenylate cyclase as well as the fermentable growth medium-induced pathways, and our results therefore suggest that these three pathways may be intimately linked...
  17. ncbi request reprint Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae
    Ivanka Dilova
    Section of Molecular and Cellular Biology and Center for Genetics and Development, Division of Biological Sciences, University of California, Davis 95616, USA
    Curr Biol 12:389-95. 2002
    ..This latter result provides a molecular explanation for the previous identification of MKS1 as LYS80, a negative regulator of lysine biosynthesis [8]...
  18. pmc TOR complex 2-Ypk1 signaling is an essential positive regulator of the general amino acid control response and autophagy
    Ariadne Vlahakis
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616
    Proc Natl Acad Sci U S A 111:10586-91. 2014
    ..Our work reveals that the TORC2 pathway regulates autophagy in an opposing manner to TORC1 to provide a tunable response to cellular metabolic status. ..
  19. ncbi request reprint Regulation of ribosome biogenesis: where is TOR?
    Dietmar E Martin
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Cell Metab 4:259-60. 2006
    ..This is an important advance in the understanding of how ribosome biogenesis is regulated in response to environmental conditions...
  20. pmc The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine
    Jose L Crespo
    Division of Biochemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 99:6784-9. 2002
    ..Furthermore, as glutamine starvation affects only a subset of TOR-controlled transcription factors, TOR appears to discriminate between different nutrient conditions to elicit a response appropriate to a given condition...

Research Grants3

  1. TOR Complex 2 and sphingolipid biosynthesis.
    Ted Powers; Fiscal Year: 2010
    ..Thus, our work brings together these two areas of investigation that are very important for understanding human health and disease and we expect to gain novel insights into these processes through our studies. ..
  2. TOR Complex 2 and sphingolipid biosynthesis.
    Ted Powers; Fiscal Year: 2009
    ..Thus, our work brings together these two areas of investigation that are very important for understanding human health and disease and we expect to gain novel insights into these processes through our studies. ..
  3. TOR Complex 2 and sphingolipid biosynthesis.
    Ted Powers; Fiscal Year: 2010
    ..Thus, our work brings together these two areas of investigation that are very important for understanding human health and disease and we expect to gain novel insights into these processes through our studies. ..