Affiliation: University of California
- Co-translational protein targeting catalyzed by the Escherichia coli signal recognition particle and its receptorT Powers
Department of Biochemistry and Biophysics, University of California, School of Medicine, San Francisco 94143, USA
EMBO J 16:4880-6. 1997..Our data illustrate the extreme functional conservation between prokaryotic and eukaryotic SRP and SRP receptors and suggest that the basic mechanism of co-translational protein targeting is conserved between bacteria and mammals...
- Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiaeT Powers
Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California, School of Medicine, San Francisco, California 94143 0448, USA
Mol Biol Cell 10:987-1000. 1999..This induction has been shown previously to involve both the Ras-adenylate cyclase as well as the fermentable growth medium-induced pathways, and our results therefore suggest that these three pathways may be intimately linked...
- Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPasesT Powers
Department of Biochemistry and Biophysics, University of California Medical School, San Francisco 94143 0448, USA
Science 269:1422-4. 1995..5S ribonucleoprotein and GTP. Thus, nucleotide triphosphate hydrolysis by Ffh and FtsY is likely to occur in reciprocally coupled reactions in which the two interacting guanosine triphosphatases act as regulatory proteins for each other...
- Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factorsA Komeili
Howard Hughes Medical Institute, University of California School of Medicine, San Francisco, California 94143, USA
J Cell Biol 151:863-78. 2000..Taken together, these results demonstrate that target of rapamycin signaling regulates specific anaplerotic reactions by coupling nitrogen quality to the activity and subcellular localization of distinct transcription factors...
- Hydroxyl radical footprinting of ribosomal proteins on 16S rRNAT Powers
Sinsheimer Laboratories, University of California, Santa Cruz 95064, USA
RNA 1:194-209. 1995..These results reinforce and extend previous data on the localization of ribosomal proteins with respect to structural features of 16S rRNA, and offer many new constraints for three-dimensional modeling of the 30S ribosomal subunit...
- Yeast TOR signaling: a mechanism for metabolic regulationT Powers
Section of Molecular and Cellular Biology, Center for Genetics and Development, Division of Biological Sciences, University of California Davis, Davis, CA 95616, USA
Curr Top Microbiol Immunol 279:39-51. 2004..These studies have raised the important issue as to how diverse nutritional cues can pass through a common signaling pathway and yet ultimately generate distinct transcriptional responses...