SCOTT KLINE POWERS

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Loss of exercise-induced cardioprotection after cessation of exercise
    Shannon L Lennon
    Department of Exercise and Sport Sciences, University of Florida, Gainesville, Florida 32611, USA
    J Appl Physiol 96:1299-305. 2004
  2. pmc Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Physiol Rev 88:1243-76. 2008
  3. doi request reprint Reactive oxygen species: impact on skeletal muscle
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA
    Compr Physiol 1:941-69. 2011
  4. pmc Mitochondrial signaling contributes to disuse muscle atrophy
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Endocrinol Metab 303:E31-9. 2012
  5. doi request reprint Oxidative stress and disuse muscle atrophy: cause or consequence?
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Curr Opin Clin Nutr Metab Care 15:240-5. 2012
  6. pmc Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered
    Karen Maes
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Respir Res 11:178. 2010
  7. doi request reprint Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Crit Care Med 39:1749-59. 2011
  8. ncbi request reprint Oxidative stress and disuse muscle atrophy
    Scott K Powers
    Department of Applied Physiology and Kinesiology, PO Box 118205, University of Florida, Gainesville, FL 32611, USA
    J Appl Physiol 102:2389-97. 2007
  9. pmc Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32608, USA
    Crit Care 12:191. 2008
  10. ncbi request reprint Dietary antioxidants and exercise
    Scott K Powers
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    J Sports Sci 22:81-94. 2004

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Loss of exercise-induced cardioprotection after cessation of exercise
    Shannon L Lennon
    Department of Exercise and Sport Sciences, University of Florida, Gainesville, Florida 32611, USA
    J Appl Physiol 96:1299-305. 2004
    ..Therefore, other cytoprotective molecules are responsible for providing protection during I/R...
  2. pmc Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Physiol Rev 88:1243-76. 2008
    ..Ongoing research continues to probe the mechanisms by which oxidants influence skeletal muscle contractile properties and to explore interventions capable of protecting muscle from oxidant-mediated dysfunction...
  3. doi request reprint Reactive oxygen species: impact on skeletal muscle
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA
    Compr Physiol 1:941-69. 2011
    ..Ongoing research continues to explore the redox-sensitive targets in muscle that are responsible for both redox regulation of muscle adaptation and oxidant-mediated muscle fatigue...
  4. pmc Mitochondrial signaling contributes to disuse muscle atrophy
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Endocrinol Metab 303:E31-9. 2012
    ....
  5. doi request reprint Oxidative stress and disuse muscle atrophy: cause or consequence?
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Curr Opin Clin Nutr Metab Care 15:240-5. 2012
    ..This review will discuss the evidence both for and against the concept that reactive oxygen species (ROS) play an important role in the regulation of inactivity-induced skeletal muscle atrophy...
  6. pmc Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered
    Karen Maes
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Respir Res 11:178. 2010
    ..This may be important for patients undergoing mechanical ventilation and receiving corticosteroids...
  7. doi request reprint Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Crit Care Med 39:1749-59. 2011
    ..Therefore, identifying the site(s) of mechanical ventilation- induced reactive oxygen species production in the diaphragm is important...
  8. ncbi request reprint Oxidative stress and disuse muscle atrophy
    Scott K Powers
    Department of Applied Physiology and Kinesiology, PO Box 118205, University of Florida, Gainesville, FL 32611, USA
    J Appl Physiol 102:2389-97. 2007
    ..By presenting unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field...
  9. pmc Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32608, USA
    Crit Care 12:191. 2008
    ..Therefore, developing methods to protect against mechanical ventilation-induced diaphragmatic weakness is important...
  10. ncbi request reprint Dietary antioxidants and exercise
    Scott K Powers
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    J Sports Sci 22:81-94. 2004
    ..Furthermore, it is currently unclear whether regular vigorous exercise increases the need for dietary intake of antioxidants. Clearly, additional research that analyses the antioxidant requirements of individual athletes is needed...
  11. ncbi request reprint Aging, exercise, and cardioprotection
    Scott K Powers
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    Ann N Y Acad Sci 1019:462-70. 2004
    ..Understanding the molecular basis for exercise-induced cardioprotection is important in developing exercise paradigms to protect the heart during an I-R insult...
  12. pmc Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy
    Kisuk Min
    Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
    J Appl Physiol 111:1459-66. 2011
    ....
  13. pmc Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    J Physiol 589:2129-38. 2011
    ..We will conclude with a discussion of unanswered questions in redox signalling in skeletal muscle in the hope of promoting additional research interest in this field...
  14. ncbi request reprint Ischemia-reperfusion-induced cardiac injury: a brief review
    Scott K Powers
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    Med Sci Sports Exerc 39:1529-36. 2007
    ..Finally, in hopes of stimulating future research, this review will also identify important gaps in our knowledge of IR-induced myocardial injury...
  15. doi request reprint Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 44:193-201. 2008
    ..Understanding the molecular basis for exercise-induced cardioprotection will provide the required knowledge base to develop therapeutic approaches to protect the heart during an IR insult...
  16. doi request reprint Antioxidant and Vitamin D supplements for athletes: sense or nonsense?
    Scott Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611 8208, USA
    J Sports Sci 29:S47-55. 2011
    ....
  17. pmc Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle
    Ashley J Smuder
    Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
    J Appl Physiol 110:935-42. 2011
    ..Together, these novel results demonstrate that muscular exercise is a useful countermeasure that can protect skeletal muscle against Dox treatment-induced oxidative stress and protease activation in skeletal muscles...
  18. pmc Mechanistic links between oxidative stress and disuse muscle atrophy
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, 32611, USA
    Antioxid Redox Signal 15:2519-28. 2011
    ..Finally, by presenting unresolved issues related to oxidative stress and muscle atrophy, we hope that this review will serve as a stimulus for new research in this exciting field...
  19. ncbi request reprint Mechanisms of disuse muscle atrophy: role of oxidative stress
    Scott K Powers
    Department of Applied Physiology and Kinesiology, PO Box 118225, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Regul Integr Comp Physiol 288:R337-44. 2005
    ..By discussing unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field...
  20. ncbi request reprint Exercise-induced changes in diaphragmatic bioenergetic and antioxidant capacity
    Scott K Powers
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville 32611, USA
    Exerc Sport Sci Rev 30:69-74. 2002
    ..These exercise-induced changes in oxidative and antioxidant capacity occur rapidly after the onset of training and are associated with reduced oxidative injury and improved diaphragmatic endurance...
  21. doi request reprint Exercise-induced oxidative stress in humans: cause and consequences
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 51:942-50. 2011
    ....
  22. ncbi request reprint Mechanical ventilation results in progressive contractile dysfunction in the diaphragm
    Scott K Powers
    Department of Exercise and Sport Sciences, University of Florida, Gainesville 32611, USA
    J Appl Physiol 92:1851-8. 2002
    ..These data support the hypothesis that relatively short-term MV impairs diaphragmatic contractile function and that the magnitude of MV-induced force deficit increases with time on the ventilator...
  23. ncbi request reprint Myosin phenotype and bioenergetic characteristics of rat respiratory muscles
    S K Powers
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville 32611, USA
    Med Sci Sports Exerc 29:1573-9. 1997
    ..These differences in biochemical properties provide the muscles of the respiratory pump with great versatility in functional properties...
  24. ncbi request reprint Exercise and cardioprotection
    Scott K Powers
    Department of Exercise and Sport Sciences and Physiology, Center for Exercise Science, University of Florida, Gainesville, 32611, USA
    Curr Opin Cardiol 17:495-502. 2002
    ..Improving our understanding of the molecular basis for exercise-induced cardioprotection will play an important role in developing optimal exercise interventions to protect the heart from ischemic injury...
  25. ncbi request reprint Exercise, heat shock proteins, and myocardial protection from I-R injury
    S K Powers
    Department of Exercise and Sport Sciences and Physiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    Med Sci Sports Exerc 33:386-92. 2001
    ..This is an important area for future research...
  26. ncbi request reprint Analysis of cellular responses to free radicals: focus on exercise and skeletal muscle
    S K Powers
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville 32611, USA
    Proc Nutr Soc 58:1025-33. 1999
    ..Also, training-induced upregulation of antioxidant enzymes is limited to highly-oxidative skeletal muscles. The effects of endurance training on non-enzymic antioxidants remain a relatively uninvestigated area...
  27. ncbi request reprint Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review
    S K Powers
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville 32611, USA
    Med Sci Sports Exerc 31:987-97. 1999
    ..It seems plausible that increased cellular concentrations of these antioxidants will reduce the risk of cellular injury, improve performance, and delay muscle fatigue...
  28. pmc Prolonged mechanical ventilation alters diaphragmatic structure and function
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Crit Care Med 37:S347-53. 2009
    ..To review current knowledge about the impact of prolonged mechanical ventilation on diaphragmatic function and biology...
  29. ncbi request reprint Antioxidants and exercise
    S K Powers
    Department of Exercise and Sport Sciences, University of Florida, Gainesville, USA
    Clin Sports Med 18:525-36. 1999
    ..This is an important area for future research...
  30. pmc Reactive oxygen species are signalling molecules for skeletal muscle adaptation
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, FL 32611, USA
    Exp Physiol 95:1-9. 2010
    ..e. exercise training) and during prolonged periods of muscular inactivity (i.e. immobilization). In an effort to stimulate further research, we conclude with a discussion of unanswered questions about redox signalling in skeletal muscle...
  31. ncbi request reprint Mechanical ventilation-induced oxidative stress in the diaphragm
    Murat A Zergeroglu
    Department of Execise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32601, USA
    J Appl Physiol 95:1116-24. 2003
    ..We conclude that MV results in a rapid onset of oxidative injury in the diaphragm and that insoluble proteins are primary targets of MV-induced protein oxidation...
  32. ncbi request reprint Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity
    R Andrew Shanely
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA
    Am J Respir Crit Care Med 166:1369-74. 2002
    ..These data support the hypothesis that MV is associated with atrophy of all diaphragmatic fiber types, increased diaphragmatic protease activity, and augmented diaphragmatic oxidative stress...
  33. ncbi request reprint Increased temperature, not cardiac load, activates heat shock transcription factor 1 and heat shock protein 72 expression in the heart
    Jessica L Staib
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Regul Integr Comp Physiol 292:R432-9. 2007
    ..Collectively, these data suggest that HSF1 activation and HSP72 gene transcriptional competence during simulated exercise are linked to elevated heart temperature and are not a direct function of increased cardiac workload...
  34. ncbi request reprint Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuli
    Andreas N Kavazis
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Heart Circ Physiol 294:H928-35. 2008
    ..Furthermore, these results are consistent with the concept that exercise-induced mitochondrial adaptations contribute to exercise-induced cardioprotection...
  35. ncbi request reprint Mechanical ventilation depresses protein synthesis in the rat diaphragm
    R Andrew Shanely
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville 32611, USA
    Am J Respir Crit Care Med 170:994-9. 2004
    ..Further, the decline in myosin heavy chain protein synthesis does not appear to be associated with a decrease in myosin heavy chain messenger ribonucleic acid...
  36. ncbi request reprint Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusion
    Karyn L Hamilton
    Department of Exercise and Sport Science, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 34:800-9. 2003
    ....
  37. pmc Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction
    Melissa A Whidden
    Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
    J Appl Physiol 106:385-94. 2009
    ..Nonetheless, the failure of XO inhibition to completely prevent MV-induced diaphragmatic oxidative damage suggests that other sources of oxidant production are active in the diaphragm during prolonged MV...
  38. ncbi request reprint Reloading the diaphragm following mechanical ventilation does not promote injury
    Darin Van Gammeren
    Department of Applied Psychology, Center for Exercise Science, University of Florida, Room 25 FLG, Gainesville, FL 32611, USA
    Chest 127:2204-10. 2005
    ..Therefore, these experiments tested the hypothesis that reloading the diaphragm following MV exacerbates MV-induced diaphragmatic contractile dysfunction, while causing muscle fiber membrane damage and inflammation...
  39. pmc Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm
    Melissa A Whidden
    Department of Applied Physiology and Kinesiology, University of Florida, PO Box 118205, Gainesville, FL 32611, USA
    J Appl Physiol 108:1376-82. 2010
    ....
  40. ncbi request reprint Selective downregulation of ubiquitin conjugation cascade mRNA occurs in the senescent rat soleus muscle
    Keith C DeRuisseau
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Exp Gerontol 40:526-31. 2005
    ..Furthermore, the decline in E2(14k) and MuRF1 mRNA levels may contribute to altered substrate degradation by the UCC in the soleus muscle of senescent rats...
  41. pmc Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72
    Andreas N Kavazis
    Applied Physiology and Kinesiology, University of Florida, USA
    Am J Physiol Heart Circ Physiol 299:H1515-24. 2010
    ..Finally, our data are consistent with the concept that increases in cardiac mitochondrial antioxidant enzymes may contribute to exercise-induced cardioprotection...
  42. ncbi request reprint Diaphragmatic proteasome function is maintained in the ageing Fisher 344 rat
    Andreas N Kavazis
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Exp Physiol 92:895-901. 2007
    ....
  43. ncbi request reprint Elevated MnSOD is not required for exercise-induced cardioprotection against myocardial stunning
    Shannon L Lennon
    Department of Exercise and Sport Science, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Heart Circ Physiol 287:H975-80. 2004
    ..Therefore, we conclude that different mediators are responsible for exercise-induced cardioprotection against myocardial stunning and infarction...
  44. ncbi request reprint Trolox attenuates mechanical ventilation-induced diaphragmatic dysfunction and proteolysis
    Jenna L Betters
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    Am J Respir Crit Care Med 170:1179-84. 2004
    ..Our findings suggest that antioxidant therapy could be beneficial during prolonged mechanical ventilation...
  45. ncbi request reprint Cumulative effects of aging and mechanical ventilation on in vitro diaphragm function
    David S Criswell
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    Chest 124:2302-8. 2003
    ..Since aging increases skeletal muscle susceptibility to atrophy and injury, we tested the hypothesis that MV-induced diaphragmatic contractile dysfunction would be exacerbated in aging rats...
  46. pmc Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation
    Joseph M McClung
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL, USA
    Crit Care Med 37:1373-9. 2009
    ..To investigate whether apocynin protects the diaphragm from wasting and oxidative stress during mechanical ventilation (MV)...
  47. pmc Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production
    Andreas N Kavazis
    Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 46:842-50. 2009
    ..In conclusion, these results are consistent with the concept that diaphragmatic inactivity promotes an increase in mitochondrial ROS emission, mitochondrial oxidative damage, and mitochondrial respiratory dysfunction...
  48. pmc Exercise training induces a cardioprotective phenotype and alterations in cardiac subsarcolemmal and intermyofibrillar mitochondrial proteins
    Andreas N Kavazis
    Applied Physiology and Kinesiology, Proteomics Division, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Heart Circ Physiol 297:H144-52. 2009
    ..Importantly, based on our findings, pharmacological or other interventions could be used to develop a strategy of protecting the myocardium during an ischemic attack...
  49. pmc Experimental guidelines for studies designed to investigate the impact of antioxidant supplementation on exercise performance
    Scott K Powers
    Dept of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Int J Sport Nutr Exerc Metab 20:2-14. 2010
    ....
  50. ncbi request reprint Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm
    Keith C DeRuisseau
    Center for Exercise Science, Univ of Florida, Rm 25 FLG, Gainesville, FL 32611, USA
    J Appl Physiol 98:1314-21. 2005
    ....
  51. ncbi request reprint Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition
    Joel P French
    Dept of Applied Physiology and Kinesiology, Center for Exercise Science, Univ of Florida, Gainesville, FL 32611, USA
    Am J Physiol Heart Circ Physiol 290:H128-36. 2006
    ....
  52. ncbi request reprint Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise
    Keith C DeRuisseau
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Antioxid Redox Signal 8:539-47. 2006
    ..085). In summary, although CR elevated the mRNA of key antioxidant enzymes in the diaphragm, lifelong CR alone or in combination with voluntary exercise did not alter diaphragm CS activity, antioxidant protein quantity, or GSH levels...
  53. ncbi request reprint Adaptation of upper airway muscles to chronic endurance exercise
    Heather K Vincent
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    Am J Respir Crit Care Med 166:287-93. 2002
    ..It seems possible that this exercise-mediated adaptation is related to the recruitment of these muscles as stabilizers of the upper airway...
  54. ncbi request reprint Alteration of contractile force and mass in the senescent diaphragm with beta(2)-agonist treatment
    Wesley N Smith
    Department of Exercise and Sport Sciences, University of Florida, Gainesville, Florida 32611, USA
    J Appl Physiol 92:941-8. 2002
    ..05) in type IIb MHC and a decrease in type I, IIa, and IIx MHC in both young and old animals. These data support the hypothesis that CB treatment can restore the age-associated decline in both diaphragmatic-specific P(o) and muscle mass...
  55. ncbi request reprint Short-term exercise does not increase ER stress protein expression in cardiac muscle
    Zsolt Murlasits
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    Med Sci Sports Exerc 39:1522-8. 2007
    ..Hence, these experiments tested the hypothesis that exercise training is associated with an increase in ER stress proteins in the heart...
  56. pmc Diaphragm unloading via controlled mechanical ventilation alters the gene expression profile
    Keith C DeRuisseau
    Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, Florida 32611, USA
    Am J Respir Crit Care Med 172:1267-75. 2005
    ..However, the impact of controlled mechanical ventilation on global mRNA alterations in the diaphragm remains unknown...
  57. pmc Overexpression of antioxidant enzymes in diaphragm muscle does not alter contraction-induced fatigue or recovery
    Joseph M McClung
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Exp Physiol 95:222-31. 2010
    ..Finally, the transgenic overexpression of independent endogenous antioxidants alters diaphragm skeletal muscle morphology, and these changes may also contribute to the diminished specific force production observed in these animals...
  58. ncbi request reprint Diaphragm contractile dysfunction in MyoD gene-inactivated mice
    Jessica L Staib
    Department of Exercise and Sport Sciences, University of Florida, Gainesville, Florida 32611, USA
    Am J Physiol Regul Integr Comp Physiol 283:R583-90. 2002
    ..Hence, MyoD plays an important role in determining diaphragmatic contractile properties...
  59. ncbi request reprint Correction of the enzymatic and functional deficits in a model of Pompe disease using adeno-associated virus vectors
    Thomas J Fraites
    Powell Gene Therapy Center, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Mol Ther 5:571-8. 2002
    ....
  60. pmc Exercise-induced protection against myocardial apoptosis and necrosis: MnSOD, calcium-handling proteins, and calpain
    Joel P French
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida, USA
    FASEB J 22:2862-71. 2008
    ..These results suggest that MnSOD provides cardioprotection by attenuating IR-induced oxidation and calpain-mediated degradation of myocardial Ca(2+)-handling proteins, thereby preventing myocardial apoptosis and necrosis...
  61. ncbi request reprint MnSOD antisense treatment and exercise-induced protection against arrhythmias
    Karyn L Hamilton
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida Gainesville, FL 32611, USA
    Free Radic Biol Med 37:1360-8. 2004
    ..The mechanism by which MnSOD provides protection does not appear to be linked to protein nitrosylation or oxidation...
  62. ncbi request reprint Diaphragmatic nitric oxide synthase is not induced during mechanical ventilation
    Darin Van Gammeren
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA
    J Appl Physiol 102:157-62. 2007
    ..Collectively, these data reveal that MV-induced oxidative stress in the diaphragm is not due to increases in nitric oxide production by NOS...
  63. ncbi request reprint Short-duration mechanical ventilation enhances diaphragmatic fatigue resistance but impairs force production
    R Andrew Shanely
    Department of Exercise and Sport Sciences, University of Florida, Gainesville, FL 32601, USA
    Chest 123:195-201. 2003
    ..We tested the hypothesis that 18 h of controlled MV will diminish diaphragmatic maximal tetanic specific tension (force per cross-sectional area of muscle) without impairing diaphragmatic fatigue resistance...
  64. pmc Increased temperature and protein oxidation lead to HSP72 mRNA and protein accumulation in the in vivo exercised rat heart
    Jessica L Staib
    Department of Applied Physiology and Kinesiology, University of Florida, PO Box 118225, Gainesville, FL 32611, USA
    Exp Physiol 94:71-80. 2009
    ....
  65. ncbi request reprint Exercise-induced HSP-72 elevation and cardioprotection against infarct and apoptosis
    John C Quindry
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida, USA
    J Appl Physiol 103:1056-62. 2007
    ....
  66. pmc Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophy
    Joseph M McClung
    Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, FL 32611, USA
    Am J Respir Crit Care Med 175:150-9. 2007
    ..Unloading the diaphragm via mechanical ventilation (MV) results in rapid diaphragmatic fiber atrophy. It is unknown whether the myonuclear domain (cytoplasmic myofiber volume/myonucleus) of diaphragm myofibers is altered during MV...
  67. pmc Mechanical ventilation-induced oxidative stress in the diaphragm: role of heme oxygenase-1
    Darin J Falk
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Chest 139:816-24. 2011
    ..We tested the hypothesis that HO-1 acts as a pro-oxidant in the diaphragm during prolonged MV...
  68. ncbi request reprint Effects of vitamin E deficiency on fatigue and muscle contractile properties
    Jeff S Coombes
    School of Human Movement Studies, Rm 520, Connell Building, University of Queensland, St Lucia, QLD 4072, Australia
    Eur J Appl Physiol 87:272-7. 2002
    ..05). These data support the hypothesis that VE deficiency impairs muscular endurance and alters muscle contractile properties following a prolonged series of contractions...
  69. doi request reprint Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans
    Sanford Levine
    Department of Surgery, University of Pennsylvania, USA
    N Engl J Med 358:1327-35. 2008
    ..The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the same may also occur in the human diaphragm...
  70. doi request reprint Elevation of body temperature is an essential factor for exercise-increased extracellular heat shock protein 72 level in rat plasma
    Yuji Ogura
    Institute of Health and Sports Science and Medicine, Juntendo University, Inba, Chiba, Japan
    Am J Physiol Regul Integr Comp Physiol 294:R1600-7. 2008
    ..In addition, the possible role of body temperature elevation is displayed when the exercise stressor is combined with it...
  71. ncbi request reprint Changes in PKB/Akt and calcineurin signaling during recovery in atrophied soleus muscle induced by unloading
    Takao Sugiura
    Department of Exercise and Health Sciences, Faculty of Education, Yamaguchi University, Japan
    Am J Physiol Regul Integr Comp Physiol 288:R1273-8. 2005
    ..Our data support the concept that CaN is involved in muscle remodeling during the later phases of recovery from disuse muscle atrophy...
  72. ncbi request reprint Infusions of rocuronium and cisatracurium exert different effects on rat diaphragm function
    Dries Testelmans
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, O and N 1, bus 706, Herestraat 49, 3000, Leuven, Belgium
    Intensive Care Med 33:872-9. 2007
    ..The aim of our study was to compare the effects of 24 h infusion of rocuronium or cisatracurium on the diaphragm in mechanically ventilated rats...
  73. ncbi request reprint Estrogen administration attenuates immobilization-induced skeletal muscle atrophy in male rats
    Takao Sugiura
    Department of Exercise and Health Sciences, Yamaguchi University, Yamaguchi, 753 8513 Japan
    J Physiol Sci 56:393-9. 2006
    ..These results support the postulate that estrogen attenuates the rate of disuse muscle atrophy, partly because of reductions in immobilization-induced calcium-activated protease levels...
  74. ncbi request reprint High intensity exercise increases expression of matrix metalloproteinases in fast skeletal muscle fibres
    Eli Carmeli
    Department of Physical Therapy, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Exp Physiol 90:613-9. 2005
    ....
  75. ncbi request reprint Age and attenuation of exercise-induced myocardial HSP72 accumulation
    Haydar A Demirel
    Department of Sports Medicine, School of Medicine, Hacettepe University, Ankara, Turkey
    Am J Physiol Heart Circ Physiol 285:H1609-15. 2003
    ..These data demonstrate that aging is associated with diminished exercise-induced myocardial HSP72 expression. Mechanisms other than HSF-1 activation and transcription of HSP72 mRNA are responsible for this age-related impairment...
  76. ncbi request reprint Use of anabolic steroids to attenuate the effects of glucocorticoids on the rat diaphragm
    Jane M Eason
    Louisiana State University Health Sciences Center, Department of Physical Therapy, 1900 Gravier St, New Orleans, LA 70112, USA
    Phys Ther 83:29-36. 2003
    ..The purpose of this study was to assess the effects of simultaneous administration of testosterone and glucocorticoids on morphological and contractile properties of the rat diaphragm...

Research Grants13

  1. Mechanical ventilation, oxidative stress, and diaphragmatic atrophy
    Scott Powers; Fiscal Year: 2009
    ..Our long-term goal is to develop methods for the prevention of MV-induced diaphragmatic weakness based on an understanding of the cellular mechanisms responsible for MV-induced diaphragmatic atrophy and contractile dysfunction. ..
  2. Mechanical Ventilation and Diaphragmatic Oxidant Injury
    Scott Powers; Fiscal Year: 2007
    ..abstract_text> ..
  3. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2006
    ..abstract_text> ..
  4. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
  5. Mechanical ventilation, oxidative stress, and diaphragmatic atrophy
    SCOTT KLINE POWERS; Fiscal Year: 2010
    ..Our long-term goal is to develop methods for the prevention of MV-induced diaphragmatic weakness based on an understanding of the cellular mechanisms responsible for MV-induced diaphragmatic atrophy and contractile dysfunction. ..