R W Powers

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery
    Robert W Powers
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Am J Obstet Gynecol 194:160. 2006
  2. ncbi request reprint Maternal plasma homocysteine concentrations are not increased in twin pregnancies
    Robert W Powers
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, 204 Craft Ave, Room 620, 15213, Pittsburgh, Pennsylvania 15213, USA
    Hypertens Pregnancy 24:49-58. 2005
  3. ncbi request reprint Maternal serum soluble fms-like tyrosine kinase 1 concentrations are not increased in early pregnancy and decrease more slowly postpartum in women who develop preeclampsia
    R W Powers
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, PA 15213, USA
    Am J Obstet Gynecol 193:185-91. 2005
  4. pmc Evidence of endothelial dysfunction in preeclampsia and risk of adverse pregnancy outcome
    Robert W Powers
    Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Reprod Sci 15:374-81. 2008
  5. ncbi request reprint Moderate hyperhomocysteinemia decreases endothelial-dependent vasorelaxation in pregnant but not nonpregnant mice
    Robert W Powers
    Magee Women s Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
    Hypertension 44:327-33. 2004
  6. pmc Novel soluble Flt-1 isoforms in plasma and cultured placental explants from normotensive pregnant and preeclamptic women
    A Rajakumar
    Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Placenta 30:25-34. 2009
  7. pmc Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants
    Paul D Speer
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 198:112.e1-7. 2008
  8. ncbi request reprint Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor
    Eiji Shibata
    Magee Womens Research Institute, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 90:4895-903. 2005
  9. ncbi request reprint Homocysteine and cellular fibronectin are increased in preeclampsia, not transient hypertension of pregnancy
    R W Powers
    Magee Womens Research Institute Department of Ob Gyn and Reproductive Sciences, Pittsburgh, Pennsylvania, USA
    Hypertens Pregnancy 20:69-77. 2001
  10. ncbi request reprint Maternal and fetal amino acid concentrations and fetal outcomes during pre-eclampsia
    R W Evans
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Reproduction 125:785-90. 2003

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery
    Robert W Powers
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Am J Obstet Gynecol 194:160. 2006
    ..We investigated changes in serum uric acid across pregnancy in women with gestational hyperuricemia at delivery, with and without preeclampsia, compared with normal pregnant and women with preeclampsia without gestational hyperuricemia...
  2. ncbi request reprint Maternal plasma homocysteine concentrations are not increased in twin pregnancies
    Robert W Powers
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, 204 Craft Ave, Room 620, 15213, Pittsburgh, Pennsylvania 15213, USA
    Hypertens Pregnancy 24:49-58. 2005
    ..We further hypothesized that twin pregnancies complicated by preeclampsia would have increased plasma homocysteine compared to twin pregnancies without preeclampsia and normal singleton pregnancies...
  3. ncbi request reprint Maternal serum soluble fms-like tyrosine kinase 1 concentrations are not increased in early pregnancy and decrease more slowly postpartum in women who develop preeclampsia
    R W Powers
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, PA 15213, USA
    Am J Obstet Gynecol 193:185-91. 2005
    ..We measured maternal serum soluble fms-like tyrosine kinase 1 concentrations across pregnancy and immediately postpartum in women who developed preeclampsia and normal pregnant women...
  4. pmc Evidence of endothelial dysfunction in preeclampsia and risk of adverse pregnancy outcome
    Robert W Powers
    Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Reprod Sci 15:374-81. 2008
    ..5-13.1) in women with preeclampsia, hyperuricemia, and elevated cFN compared with normotensive women. Elevated cFN is prevalent among women with preeclampsia and identifies women at increased risk of preterm delivery and SGA...
  5. ncbi request reprint Moderate hyperhomocysteinemia decreases endothelial-dependent vasorelaxation in pregnant but not nonpregnant mice
    Robert W Powers
    Magee Women s Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
    Hypertension 44:327-33. 2004
    ..This effect appears to result from a loss in NO-mediated relaxation that may be mediated by the oxidative inactivation of the NO synthase cofactor tetrahydrobiopterin...
  6. pmc Novel soluble Flt-1 isoforms in plasma and cultured placental explants from normotensive pregnant and preeclamptic women
    A Rajakumar
    Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Placenta 30:25-34. 2009
    ..Placental hypoxia may contribute to sFlt-1 over expression but other regulatory mechanisms cannot be ruled out...
  7. pmc Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants
    Paul D Speer
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 198:112.e1-7. 2008
    ....
  8. ncbi request reprint Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor
    Eiji Shibata
    Magee Womens Research Institute, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 90:4895-903. 2005
    ..However, the latter condition occurs without maternal vascular disease...
  9. ncbi request reprint Homocysteine and cellular fibronectin are increased in preeclampsia, not transient hypertension of pregnancy
    R W Powers
    Magee Womens Research Institute Department of Ob Gyn and Reproductive Sciences, Pittsburgh, Pennsylvania, USA
    Hypertens Pregnancy 20:69-77. 2001
    ....
  10. ncbi request reprint Maternal and fetal amino acid concentrations and fetal outcomes during pre-eclampsia
    R W Evans
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Reproduction 125:785-90. 2003
    ..Furthermore, the data are consistent with the hypothesis that pre-eclampsia is a heterogeneous disease associated with the metabolic syndrome...
  11. pmc Placental system A amino acid transport is reduced in pregnancies with small for gestational age (SGA) infants but not in preeclampsia with SGA infants
    E Shibata
    Magee Womens Research Institute, University of Pittsburgh School of Medicine, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Placenta 29:879-82. 2008
    ....
  12. pmc Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor
    F von Versen-Höynck
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Placenta 30:434-42. 2009
    ..These data are consistent with the hypothesis that differences in placental adenosine receptors may contribute to alterations in placental function in preeclampsia...
  13. pmc Leptin affects system A amino acid transport activity in the human placenta: evidence for STAT3 dependent mechanisms
    F von Versen-Höynck
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Placenta 30:361-7. 2009
    ..However, the role of leptin in placental function has not been fully elucidated. We hypothesize that leptin plays a role in the regulation of placental amino acid transport by activation of the JAK-STAT pathway...
  14. ncbi request reprint Maternal vitamin D deficiency increases the risk of preeclampsia
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, A742 Crabtree Hall, 130 DeSoto Street, Pittsburgh, Pennsylvania, 15261, USA
    J Clin Endocrinol Metab 92:3517-22. 2007
    ..Vitamin D has direct influence on molecular pathways proposed to be important in the pathogenesis of preeclampsia, yet the vitamin D-preeclampsia relation has not been studied...
  15. ncbi request reprint Changes in markers of vascular injury in response to transient hyperhomocysteinemia
    Robert W Powers
    Magee Womens Research Institute and the Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh, PA 15213, USA
    Metabolism 52:501-7. 2003
    ..These data suggest that very high homocysteine concentrations can promote endothelial injury; however, this effect is likely mediated by secondary effects that include a factor(s) present in plasma that affects endothelial cells...
  16. ncbi request reprint Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia
    H Laivuori
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Hum Reprod 12:551-6. 2006
    ..This study suggests that despite similar failed placental bed vascular remodelling in pre-eclampsia and intrauterine growth restriction (IUGR), leptin gene expression is higher only in preterm pre-eclampsia...
  17. pmc Cigarette smoke exposure and angiogenic factors in pregnancy and preeclampsia
    Arun Jeyabalan
    Magee Womens Research Institute and Foundation, Pittsburgh, Pennsylvania, USA
    Am J Hypertens 21:943-7. 2008
    ....
  18. ncbi request reprint Citrulline is not the major product using the standard "NOS activity" assay on renal cortical homogenates
    Kirk P Conrad
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Regul Integr Comp Physiol 282:R303-10. 2002
    ..These enzyme characteristics contrasted markedly with those simultaneously obtained for NOS activity in placental homogenates. Thus results from the conventional NOS activity assay should be viewed cautiously...
  19. ncbi request reprint Uric acid is as important as proteinuria in identifying fetal risk in women with gestational hypertension
    James M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Hypertension 46:1263-9. 2005
    ..Hyperuricemia is at least as effective as proteinuria at identifying gestational hypertensive pregnancies at increased risk. Uric acid should be reexamined for clinical and research utility...
  20. pmc Effect of smoking on circulating angiogenic factors in high risk pregnancies
    Arun Jeyabalan
    Department of Obstetrics, Gynecology and Women s Health, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13270. 2010
    ..The objective of this study was to investigate whether smoking affects concentrations of angiogenic factors (sFlt1, PlGF, and sEng) in women at high risk for developing preeclampsia...
  21. ncbi request reprint The 677 C-T methylenetetrahydrofolate reductase mutation does not predict increased maternal homocysteine during pregnancy
    Robert W Powers
    Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Obstet Gynecol 101:762-6. 2003
    ....
  22. ncbi request reprint Renal handling of homocysteine during normal pregnancy and preeclampsia
    Robert W Powers
    Magee Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Soc Gynecol Investig 11:45-50. 2004
    ..The goal of this study was to investigate the role of the maternal kidney in the changes of plasma homocysteine during normal pregnancy and preeclampsia...
  23. ncbi request reprint Homocysteine and folic acid are inversely related in black women with preeclampsia
    Thelma E Patrick
    Magee Womens Research Institute, Pittsburgh, PA, USA
    Hypertension 43:1279-82. 2004
    ..Racial differences in diet, adherence to folic acid supplementation, or interactions of nutritional and maternal factors warrant further study by race and pregnancy status...
  24. ncbi request reprint Plasma homocysteine and malondialdehyde are correlated in an age- and gender-specific manner
    Robert W Powers
    Magee Womens Research Institute and Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh, PA 15213, USA
    Metabolism 51:1433-8. 2002
    ..Since oxidative stress correlates with basal homocysteine only in young men and does not increase with acutely increased homocysteine, it is unlikely to be the result of a direct effect of homocysteine...
  25. pmc Plasma levels of inflammatory markers neopterin, sialic acid, and C-reactive protein in pregnancy and preeclampsia
    Frauke M von Versen-Hoeynck
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Hypertens 22:687-92. 2009
    ....
  26. ncbi request reprint Maternal leptin concentrations are similar in African Americans and Caucasians in normal pregnancy, preeclampsia and small-for-gestational-age infants
    Laura D Jenkins
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Hypertens Pregnancy 26:101-9. 2007
    ..Differences in the frequency and severity of preeclampsia in African Americans cannot be explained by higher leptin concentrations...
  27. pmc Preeclampsia risk and angiotensinogen polymorphisms M235T and AGT -217 in African American and Caucasian women
    Laura D Jenkins
    Magee Women s Research Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Reprod Sci 15:696-701. 2008
    ..The authors investigated the frequency of M235T and AGT -217 in Caucasian and African American women with and without preeclampsia...
  28. pmc A comparison of circulating TNF-alpha in obese and lean women with and without preeclampsia
    Sandra A Founds
    University of Pittsburgh School of Nursing, Pittsburgh, PA 15261, USA
    Hypertens Pregnancy 27:39-48. 2008
    ..We hypothesized that TNF-alpha would be higher in obese versus lean women with preeclampsia...
  29. ncbi request reprint Angiotensin II decreases system A amino acid transporter activity in human placental villous fragments through AT1 receptor activation
    Eiji Shibata
    Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Endocrinol Metab 291:E1009-16. 2006
    ..These data suggest that angiotensin II, via AT1-R signaling, decreases system A activity by suppressing Na(+)-K(+)-ATPase in human placental villi, consistent with possible adverse effects of enhanced placental RAS on fetal growth...
  30. ncbi request reprint Maternal leptin across pregnancy in women with small-for-gestational-age infants
    Janet M Catov
    Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Obstet Gynecol 196:558.e1-8. 2007
    ..We hypothesized that women with small-for-gestational-age (SGA) neonates would have lower concentrations of leptin compared to women with appropriately grown infants (AGA)...
  31. pmc C-reactive protein is elevated 30 years after eclamptic pregnancy
    Carl A Hubel
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, PA, USA
    Hypertension 51:1499-505. 2008
    ..The triad of inflammation, low HDL, and insulin resistance may elevate risk for both preeclampsia/eclampsia and cardiovascular disease in later life...
  32. pmc Simple and rapid quantitative high-performance liquid chromatographic analysis of plasma amino acids
    Michael P Frank
    Magee Womens Research Institute, University of Pittsburgh School of Medicine, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 852:646-9. 2007
    ..The simple sample preparation and minimal sample volume make the method useful for the quantitation of amino acids in both patient and experimental animal samples...

Research Grants4