Research Topics
| Kimberly A PowersSummaryAffiliation: University of North Carolina Country: USA Publications
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Detail Information
Publications
Sexual partnership patterns in malawi: implications for HIV/STI transmissionKimberly A Powers
Department s of Epidemiology, The University of North Carolina, Chapel Hill, NC 27599 7030, USA
Sex Transm Dis 38:657-66. 2011..To contribute to the understanding of sexual partnership patterns in this region, we estimated partnership lengths, temporal gaps between partners, and periods of overlap across partners at an STI clinic in Lilongwe, Malawi...- Rethinking the heterosexual infectivity of HIV-1: a systematic review and meta-analysisKimberly A Powers
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Lancet Infect Dis 8:553-63. 2008..001 was estimated among stable couples with low prevalences of high-risk cofactors, and represents a lower bound. Cofactor effects are important to include in epidemic models, policy considerations, and prevention messages... - Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithmKimberly A Powers
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
AIDS 21:2237-42. 2007..To facilitate the efficient use of these tests, we sought to develop a risk score algorithm for identifying likely AHI cases and targeting the tests towards those individuals... - The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling studyKimberly A Powers
Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7030, USA
Lancet 378:256-68. 2011..We estimated the contribution of early infection to HIV incidence in Lilongwe, Malawi, and predict the future effect of hypothetical prevention interventions targeted at early infection only, chronic infection only, or both stages... - Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infectionChristopher D Pilcher
Center for Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
AIDS 21:1723-30. 2007..This study was conducted to compare viral dynamics in blood and semen between subjects with antibody negative, acute HIV-1 infection and other subjects with later stages of infection... 
Rapid, real-time detection of acute HIV infection in patients in AfricaSusan A Fiscus
Department of Microbiology and Immunology, University of North Carolina UNC at Chapel Hill, Chapel Hill, NC 27599 7290, USA
J Infect Dis 195:416-24. 2007..We conducted a prospective study to evaluate methods of detecting clients with sexually transmitted diseases (STDs) who were acutely coinfected with human immunodeficiency virus (HIV) in Lilongwe, Malawi...
The year-long effect of HIV-positive test results on pregnancy intentions, contraceptive use, and pregnancy incidence among Malawian womenIrving F Hoffman
Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA
J Acquir Immune Defic Syndr 47:477-83. 2008....- HIV treatment as prevention: debate and commentary--will early infection compromise treatment-as-prevention strategies?Myron S Cohen
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America
PLoS Med 9:e1001232. 2012..This article presents two opposing viewpoints by Powers, Miller, and Cohen, and Williams and Dye, followed by a commentary by Fraser... - Antiviral agents and HIV prevention: controversies, conflicts, and consensusMyron S Cohen
aDepartment of Medicine bDepartment of Epidemiology cDepartment of Microbiology and Immunology dSchool of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA
AIDS 26:1585-98. 2012..Most importantly, the best strategy for use of antiretroviral agents to reduce the spread of HIV at either the individual level or the population level has not been developed, and remains the ultimate goal of this area of investigation... - Role of acute and early HIV infection in the sexual transmission of HIVWilliam C Miller
Division of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7030, USA
Curr Opin HIV AIDS 5:277-82. 2010..Although a substantial role of AHI in the sexual transmission of HIV is biologically plausible, the significance of AHI in the epidemiological spread of HIV remains uncertain... - Community viral load as a measure for assessment of HIV treatment as preventionWilliam C Miller
Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA School of Medicine, and Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Electronic address
Lancet Infect Dis 13:459-64. 2013..These issues need careful assessment as community viral load is being considered as a public health measurement to assess the effect of HIV care on prevention... - Does ART prevent HIV transmission among MSM?Kathryn E Muessig
Department of Medicine, University of North Carolina, Chapel Hill, USA
AIDS 26:2267-73. 2012..To review the evidence for antiretroviral 'treatment as prevention' for HIV transmission among MSM... - HIV treatment as prevention: the utility and limitations of ecological observationM Kumi Smith
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
PLoS Med 9:e1001260. 2012..By examining the strengths and weaknesses of ecological analyses, we aim to aid understanding of the findings from these studies to inform future policy decisions regarding the use of ART for HIV prevention... - HIV-1 treatment as prevention: the good, the bad, and the challengesKumi Smith
Department of Epidemiology, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599 7030, USA
Curr Opin HIV AIDS 6:315-25. 2011..This work focuses on the use of antiretroviral agents to prevent the sexual transmission of HIV-1... - Pharmacodynamics of PEG-IFN alpha differentiate HIV/HCV coinfected sustained virological responders from nonrespondersAndrew H Talal
Department of Medicine and the Center for the Study of Hepatitis C, Weill Medical College of Cornell University, New York, NY 10021, USA
Hepatology 43:943-53. 2006..In contrast, pharmacodynamic measurements-namely EC50, the therapeutic quotient, and C(7)/EC50--are different in coinfected SVRs and NRs. These parameters might be useful predictors of treatment outcome during the first month of therapy... - Kinetics of hepatitis C virus reinfection after liver transplantationKimberly A Powers
Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Liver Transpl 12:207-16. 2006..In conclusion, we have quantified liver reinfection dynamics in the absence of posttransplantation antiviral therapy. Our findings support the notion that early antiviral therapy may delay or prevent reinfection... - Modeling viral and drug kinetics: hepatitis C virus treatment with pegylated interferon alfa-2bKimberly A Powers
Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
Semin Liver Dis 23:13-8. 2003..Models incorporating pharmacokinetics are needed to correctly interpret viral load changes and estimate drug effectiveness in treatment protocols using peginterferon alfa-2b... - Dynamics of alanine aminotransferase during hepatitis C virus treatmentRuy M Ribeiro
Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Hepatology 38:509-17. 2003..02). The week-4 ALT decline correlated with the HCV log drop (P =.006) and the efficacy of therapy (P =.025). In conclusion, our results suggest the use of ALT as a surrogate marker for treatment effect in patients with elevated ALT...