DON WATSON POWELL

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi Myofibroblasts. I. Paracrine cells important in health and disease
    D W Powell
    University of Texas Medical Branch at Galveston, Departments of Internal Medicine, Physiology, and Biophysics and Pathology, Galveston, Texas 77555, USA
    Am J Physiol 277:C1-9. 1999
  2. ncbi Mesenchymal cells of the intestinal lamina propria
    D W Powell
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, 77555 0764, USA
    Annu Rev Physiol 73:213-37. 2011
  3. ncbi Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer
    D W Powell
    Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 0133, USA
    Am J Physiol Gastrointest Liver Physiol 289:G2-7. 2005
  4. ncbi Myofibroblasts. II. Intestinal subepithelial myofibroblasts
    D W Powell
    University of Texas Medical Branch at Galveston, Department of Internal Medicine, Galveston, Texas 77555 0567, USA
    Am J Physiol 277:C183-201. 1999
  5. ncbi Regulation of COX-2 expression in human intestinal myofibroblasts: mechanisms of IL-1-mediated induction
    Randy C Mifflin
    Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Am J Physiol Cell Physiol 282:C824-34. 2002
  6. ncbi Subepithelial myofibroblasts are novel nonprofessional APCs in the human colonic mucosa
    Jamal I Saada
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 177:5968-79. 2006
  7. ncbi Pathophysiology of motility dysfunction in bowel obstruction: role of stretch-induced COX-2
    Xuan Zheng Shi
    Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
    Am J Physiol Gastrointest Liver Physiol 300:G99-G108. 2011
  8. ncbi Immunohistochemical study of myofibroblasts in normal colonic mucosa, hyperplastic polyps, and adenomatous colorectal polyps
    Patrick A Adegboyega
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Arch Pathol Lab Med 126:829-36. 2002
  9. ncbi The role of protein kinase C in gastrointestinal function and disease
    John F Di Mari
    Department of Internal Medicine, University of Texas Medical Branch, Galveston 77555-1064, USA
    Gastroenterology 128:2131-46. 2005
  10. ncbi Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas
    Patrick A Adegboyega
    Department of Pathology, 2190 John Sealy Annex, Mail Route 0588, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0588, USA
    Clin Cancer Res 10:5870-9. 2004

Research Grants

  1. COX GENE REGULATION IN INTESTINAL MYOFIBROBLASTS
    Don Powell; Fiscal Year: 2009
  2. COX GENE REGULATION IN INTESTINAL MYOFIBROBLASTS
    Don Powell; Fiscal Year: 2003
  3. Targeting COX-2 Expressing Myofibroblasts in Colorectal Cancer (CRC)
    DON WATSON POWELL; Fiscal Year: 2010

Collaborators

Detail Information

Publications17

  1. ncbi Myofibroblasts. I. Paracrine cells important in health and disease
    D W Powell
    University of Texas Medical Branch at Galveston, Departments of Internal Medicine, Physiology, and Biophysics and Pathology, Galveston, Texas 77555, USA
    Am J Physiol 277:C1-9. 1999
    ..Because of their ubiquitous presence in all tissues, myofibroblasts play important roles in various organ diseases and perhaps in multisystem diseases as well...
  2. ncbi Mesenchymal cells of the intestinal lamina propria
    D W Powell
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, 77555 0764, USA
    Annu Rev Physiol 73:213-37. 2011
    ..Lastly, we review emerging information about myofibroblasts as nonprofessional immune cells that may be important as an alarm system for the gut and as a participant in peripheral immune tolerance...
  3. ncbi Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer
    D W Powell
    Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 0133, USA
    Am J Physiol Gastrointest Liver Physiol 289:G2-7. 2005
    ..Intestinal neoplasms enlist and conscript myofibroblast factors and matrix molecules to promote neoplastic growth, carcinoma invasion, and distant metastases...
  4. ncbi Myofibroblasts. II. Intestinal subepithelial myofibroblasts
    D W Powell
    University of Texas Medical Branch at Galveston, Department of Internal Medicine, Galveston, Texas 77555 0567, USA
    Am J Physiol 277:C183-201. 1999
    ..More investigation is needed to clarify the functions of these pleiotropic cells...
  5. ncbi Regulation of COX-2 expression in human intestinal myofibroblasts: mechanisms of IL-1-mediated induction
    Randy C Mifflin
    Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Am J Physiol Cell Physiol 282:C824-34. 2002
    ..Each parallel pathway acts in relative autonomy, the sum of their actions culminating in a dramatic increase in COX-2 transcription and message stability...
  6. ncbi Subepithelial myofibroblasts are novel nonprofessional APCs in the human colonic mucosa
    Jamal I Saada
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 177:5968-79. 2006
    ..Thus, human CMFs may be important in regulating local immunity in the colon...
  7. ncbi Pathophysiology of motility dysfunction in bowel obstruction: role of stretch-induced COX-2
    Xuan Zheng Shi
    Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
    Am J Physiol Gastrointest Liver Physiol 300:G99-G108. 2011
    ..In conclusion, mechanical stretch in obstruction induces marked expression of COX-2 in the colonic SMC, and stretch-induced COX-2 plays a critical role in the suppression of smooth muscle contractility in bowel obstruction...
  8. ncbi Immunohistochemical study of myofibroblasts in normal colonic mucosa, hyperplastic polyps, and adenomatous colorectal polyps
    Patrick A Adegboyega
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Arch Pathol Lab Med 126:829-36. 2002
    ..Through their ability to secrete cytokines, chemokines, prostaglandins, growth factors, and matrix components, they are thought to play critical roles in inflammation, growth, repair, and neoplasia...
  9. ncbi The role of protein kinase C in gastrointestinal function and disease
    John F Di Mari
    Department of Internal Medicine, University of Texas Medical Branch, Galveston 77555-1064, USA
    Gastroenterology 128:2131-46. 2005
  10. ncbi Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas
    Patrick A Adegboyega
    Department of Pathology, 2190 John Sealy Annex, Mail Route 0588, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0588, USA
    Clin Cancer Res 10:5870-9. 2004
    ..However, the cell types responsible for producing COX-2 in colorectal adenomas remain a subject of controversy...
  11. ncbi Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts
    Randy C Mifflin
    Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas 77555 1058, USA
    Mol Pharmacol 65:470-8. 2004
    ..Aspirin also enhanced steady-state mRNA levels of other IL-1 modulated genes (IL-1beta, IL-6, groalpha, and TNFalpha) that are likewise regulated at the level of message stability via p38 activation...
  12. ncbi IL-1alpha-induced COX-2 expression in human intestinal myofibroblasts is dependent on a PKCzeta-ROS pathway
    John F Di Mari
    Department of Internal Medicine, 9 138 MRB, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1064, USA
    Gastroenterology 124:1855-65. 2003
    ..Because NF-kappaB activity can be mediated by PKC activation and reactive oxygen species (ROS) generation, we examined the relationship of these pathways to IL-1alpha-induced COX-2 expression...
  13. ncbi PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity
    Irina V Pinchuk
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0366, USA
    Gastroenterology 135:1228-1237, 1237.e1-2. 2008
    ..In the normal human colon, CMFs represent a distinct population of major histocompatibility complex class II(+) cells involved in the regulation of mucosal CD4(+) T-cell responses...
  14. ncbi Monocyte chemoattractant protein-1 production by intestinal myofibroblasts in response to staphylococcal enterotoxin a: relevance to staphylococcal enterotoxigenic disease
    Irina V Pinchuk
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 178:8097-106. 2007
    ..Thus, MCP-1 may play a leading role in initiation of inflammatory injury associated with staphylococcal enterotoxigenic disease...
  15. ncbi Intestinal myofibroblasts: targets for stem cell therapy
    R C Mifflin
    Depts of Internal Medicine, University of Texas Medical Branch, Galveston, USA
    Am J Physiol Gastrointest Liver Physiol 300:G684-96. 2011
    ..Information about the stem cell origin of intestinal stromal cells may inform future stem cell therapies to treat human inflammatory bowel disease (IBD)...
  16. ncbi Roles of myofibroblasts in prostaglandin E2-stimulated intestinal epithelial proliferation and angiogenesis
    Jinyi Shao
    Department of Surgery and Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cancer Res 66:846-55. 2006
    ....
  17. ncbi Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors
    Cynthia Kosinski
    Department of Biopharmaceutical Sciences, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:15418-23. 2007
    ..Our study also suggests that BMP antagonists are candidate signaling components that make up the intestinal epithelial stem cell niche...

Research Grants13

  1. COX GENE REGULATION IN INTESTINAL MYOFIBROBLASTS
    Don Powell; Fiscal Year: 2009
    ..abstract_text> ..
  2. COX GENE REGULATION IN INTESTINAL MYOFIBROBLASTS
    Don Powell; Fiscal Year: 2003
    ..abstract_text> ..
  3. Targeting COX-2 Expressing Myofibroblasts in Colorectal Cancer (CRC)
    DON WATSON POWELL; Fiscal Year: 2010
    ..We hypothesize that CMF-derived PGE2 regulates Wnt/f3-catenin/TCF signaling within the malignant epit helium by regulating the stability, nuclear translocation and transcriptional activity of /3- catenin. ..