CRAIG POWELL

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
    Pascal S Kaeser
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:14680-5. 2008
  2. pmc RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia
    Jacqueline Blundell
    Departments of Neurology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8813, USA
    J Neurosci 30:5326-33. 2010
  3. pmc Region-specific deletions of RIM1 reproduce a subset of global RIM1α(-/-) phenotypes
    M E Haws
    Department of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Genes Brain Behav 11:201-13. 2012
  4. ncbi request reprint The presynaptic active zone protein RIM1alpha is critical for normal learning and memory
    Craig M Powell
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 42:143-53. 2004
  5. ncbi request reprint Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder?
    Craig M Powell
    Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    Biol Psychiatry 59:1198-207. 2006
  6. ncbi request reprint Gene targeting of presynaptic proteins in synaptic plasticity and memory: across the great divide
    Craig M Powell
    Department of Neurology, The University of Texas, Southwestern Medical Center, Dallas, TX 75225, USA
    Neurobiol Learn Mem 85:2-15. 2006
  7. pmc A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
    Katsuhiko Tabuchi
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 318:71-6. 2007
  8. pmc Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior
    Jacqueline Blundell
    Departments of Neurology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8813, USA
    J Neurosci 30:2115-29. 2010
  9. ncbi request reprint Pten regulates neuronal arborization and social interaction in mice
    Chang Hyuk Kwon
    Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 50:377-88. 2006
  10. pmc Motor coordination deficits in mice lacking RGS9
    Jacqueline Blundell
    Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX, 75390 8813, USA
    Brain Res 1190:78-85. 2008

Collaborators

Detail Information

Publications17

  1. pmc RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
    Pascal S Kaeser
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:14680-5. 2008
    ....
  2. pmc RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia
    Jacqueline Blundell
    Departments of Neurology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8813, USA
    J Neurosci 30:5326-33. 2010
    ....
  3. pmc Region-specific deletions of RIM1 reproduce a subset of global RIM1α(-/-) phenotypes
    M E Haws
    Department of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Genes Brain Behav 11:201-13. 2012
    ....
  4. ncbi request reprint The presynaptic active zone protein RIM1alpha is critical for normal learning and memory
    Craig M Powell
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 42:143-53. 2004
    ....
  5. ncbi request reprint Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder?
    Craig M Powell
    Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    Biol Psychiatry 59:1198-207. 2006
    ..The development of such models will provide critical tools to understand the pathogenesis of schizophrenia and novel insights into therapeutic approaches to this complex disorder...
  6. ncbi request reprint Gene targeting of presynaptic proteins in synaptic plasticity and memory: across the great divide
    Craig M Powell
    Department of Neurology, The University of Texas, Southwestern Medical Center, Dallas, TX 75225, USA
    Neurobiol Learn Mem 85:2-15. 2006
    ..This review article briefly surveys current knowledge on the role of presynaptic proteins in learning and memory in mammals and suggests future directions in learning and memory research on the presynaptic rim of the "great divide."..
  7. pmc A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
    Katsuhiko Tabuchi
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 318:71-6. 2007
    ..These data suggest that increased inhibitory synaptic transmission may contribute to human ASDs and that the R451C knockin mice may be a useful model for studying autism-related behaviors...
  8. pmc Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior
    Jacqueline Blundell
    Departments of Neurology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8813, USA
    J Neurosci 30:2115-29. 2010
    ....
  9. ncbi request reprint Pten regulates neuronal arborization and social interaction in mice
    Chang Hyuk Kwon
    Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 50:377-88. 2006
    ..Thus, our data suggest that abnormal activation of the PI3K/AKT pathway in specific neuronal populations can underlie macrocephaly and behavioral abnormalities reminiscent of certain features of human ASD...
  10. pmc Motor coordination deficits in mice lacking RGS9
    Jacqueline Blundell
    Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX, 75390 8813, USA
    Brain Res 1190:78-85. 2008
    ..These studies are the first to describe a role for RGS9-2 in motor coordination and working memory and implicate RGS9-2 as a potential therapeutic target for motor and cognitive dysfunction...
  11. pmc Essential role of brain-derived neurotrophic factor in adult hippocampal function
    Lisa M Monteggia
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 101:10827-32. 2004
    ..These results establish roles for BDNF in the adult, and demonstrate the strength of this inducible knockout system in studying gene function in the adult brain...
  12. ncbi request reprint Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation
    Ammar H Hawasli
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Nat Neurosci 10:880-6. 2007
    ..These findings reveal a previously unknown mechanism by which Cdk5 facilitates calpain-mediated proteolysis of NR2B and may control synaptic plasticity and learning...
  13. pmc Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5
    Ammar H Hawasli
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e5808. 2009
    ..These findings indicate that Cdk5 regulates synaptic plasticity, controls neuronal and behavioral stimulus-induced excitability and may be a novel pharmacological target for cognitive and anticonvulsant therapies...
  14. ncbi request reprint Learning-induced glutamate receptor phosphorylation resembles that induced by long term potentiation
    Kajal Shukla
    Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    J Biol Chem 282:18100-7. 2007
    ....
  15. ncbi request reprint Postreactivation glucocorticoids impair recall of established fear memory
    Wen Hui Cai
    Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 26:9560-6. 2006
    ..These findings provide a rodent model for a potential treatment of established acquired anxiety disorders in humans, as suggested by others (Aerni et al., 2004; Schelling et al., 2004), based on a mechanism of enhanced extinction...
  16. pmc Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation
    Jacqueline Blundell
    Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8813, USA
    Neurobiol Learn Mem 90:28-35. 2008
    ..We have examined the role of mTOR in traumatic memory reconsolidation...
  17. ncbi request reprint Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
    Jing Zhou
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, and University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 29:1773-83. 2009
    ....

Research Grants4

  1. BDNF in depression, antidepressant action, and memory
    CRAIG POWELL; Fiscal Year: 2007
    ..We also propose to make use of focal injection of Cre-expressing AAV vectors into flox-BDNF mice to assess the specific brain subregions involved with greater temporal specificity. ..
  2. Neuroligin Function in vivo: Implications for Autism and Mental Retardation
    CRAIG POWELL; Fiscal Year: 2009
    ..Mice with genetic alterations of Neuroligin will be characterized as potential animal models of autism and mental retardation in an effort to better understand the cause and treatment of these debilitating disorders. ..
  3. Neuroligin Function in vivo: Implications for Autism and Mental Retardation
    Craig M Powell; Fiscal Year: 2010
    ..Mice with genetic alterations of Neuroligin will be characterized as potential animal models of autism and mental retardation in an effort to better understand the cause and treatment of these debilitating disorders. ..
  4. Neuroligin Function in vivo: Implications for Autism and Mental Retardation
    Craig M Powell; Fiscal Year: 2011
    ..Mice with genetic alterations of Neuroligin will be characterized as potential animal models of autism and mental retardation in an effort to better understand the cause and treatment of these debilitating disorders. ..