LINCOLN POTTER

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc A functional screen provides evidence for a conserved, regulatory, juxtamembrane phosphorylation site in guanylyl cyclase a and B
    Andrea R Yoder
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e36747. 2012
  2. ncbi request reprint Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions
    Lincoln R Potter
    Department of Biochemistry, Molecular Biology, and Biophysics, 6 155 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Endocr Rev 27:47-72. 2006
  3. ncbi request reprint Domain analysis of human transmembrane guanylyl cyclase receptors: implications for regulation
    Lincoln Ross Potter
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson Hall, 321 Church Street, S E, Minneapolis, USA
    Front Biosci 10:1205-20. 2005
  4. doi request reprint Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases
    Lincoln R Potter
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, 6 155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Pharmacol Ther 130:71-82. 2011
  5. doi request reprint Natriuretic peptide metabolism, clearance and degradation
    Lincoln R Potter
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
    FEBS J 278:1808-17. 2011
  6. doi request reprint Guanylyl cyclase structure, function and regulation
    Lincoln R Potter
    Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Cell Signal 23:1921-6. 2011
  7. ncbi request reprint Reduced ability of C-type natriuretic peptide (CNP) to activate natriuretic peptide receptor B (NPR-B) causes dwarfism in lbab -/- mice
    Andrea R Yoder
    Department of Pharmacology, University of Minnesota, Twin Cities, 321 Church St SE, Minneapolis, MN 55455, USA
    Peptides 29:1575-81. 2008
  8. ncbi request reprint Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B
    Regine Potthast
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, 55405, USA
    J Biol Chem 279:48513-9. 2004
  9. pmc Arg13 of B-type natriuretic Peptide reciprocally modulates binding to guanylyl cyclase but not clearance receptors
    Deborah M Dickey
    Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Pharmacol 78:431-5. 2010
  10. pmc Novel bifunctional natriuretic peptides as potential therapeutics
    Deborah M Dickey
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 283:35003-9. 2008

Research Grants

Collaborators

  • Andrea R Yoder
  • M Kuhn
  • Robert Feil
  • Deborah M Dickey
  • Paula M Bryan
  • Laura K Antos
  • Darcy R Flora
  • Sarah E Abbey-Hosch
  • Regine Potthast
  • Sarah E Abbey
  • Yingjie Chen
  • Xin Xu
  • Dmitri Smirnov
  • Danhua Fan
  • Kathryn A Barbieri
  • Christopher M McGuirk
  • John C Burnett
  • Franz Hofmann
  • Suzanne Lohmann
  • Susanne Feil
  • Albert Smolenski
  • Regine J Potthast
  • Jonathan S Marchant
  • Alyssa N Cody

Detail Information

Publications27

  1. pmc A functional screen provides evidence for a conserved, regulatory, juxtamembrane phosphorylation site in guanylyl cyclase a and B
    Andrea R Yoder
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e36747. 2012
    ..We conclude that Ser-473 and Ser-489 are Km-regulating phosphorylation sites that are difficult to detect using current methods...
  2. ncbi request reprint Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions
    Lincoln R Potter
    Department of Biochemistry, Molecular Biology, and Biophysics, 6 155 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Endocr Rev 27:47-72. 2006
    ..In this comprehensive review, the structure, function, regulation, and biological consequences of natriuretic peptides and their associated signaling proteins are described...
  3. ncbi request reprint Domain analysis of human transmembrane guanylyl cyclase receptors: implications for regulation
    Lincoln Ross Potter
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson Hall, 321 Church Street, S E, Minneapolis, USA
    Front Biosci 10:1205-20. 2005
    ..In the second part, regulation by ATP, calcium, protein kinase C and phosphorylation is discussed...
  4. doi request reprint Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases
    Lincoln R Potter
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, 6 155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Pharmacol Ther 130:71-82. 2011
    ..This review discusses the discovery of cGMP, guanylyl cyclases, the general characteristics and therapeutic applications of GC-A, GC-B and GC-C, and emphasizes the regulation of transmembrane guanylyl cyclases by phosphorylation and ATP...
  5. doi request reprint Natriuretic peptide metabolism, clearance and degradation
    Lincoln R Potter
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
    FEBS J 278:1808-17. 2011
    ....
  6. doi request reprint Guanylyl cyclase structure, function and regulation
    Lincoln R Potter
    Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Cell Signal 23:1921-6. 2011
    ....
  7. ncbi request reprint Reduced ability of C-type natriuretic peptide (CNP) to activate natriuretic peptide receptor B (NPR-B) causes dwarfism in lbab -/- mice
    Andrea R Yoder
    Department of Pharmacology, University of Minnesota, Twin Cities, 321 Church St SE, Minneapolis, MN 55455, USA
    Peptides 29:1575-81. 2008
    ..Molecular modeling suggested that the conserved arginine is critical for binding to an equally conserved acidic pocket in NPR-B. These results indicate that reduced binding to and activation of NPR-B causes dwarfism in lbab(-/-) mice...
  8. ncbi request reprint Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B
    Regine Potthast
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, 55405, USA
    J Biol Chem 279:48513-9. 2004
    ..This is the first study to measure the phosphorylation state of an endogenous guanylyl cyclase and to link intracellular calcium elevations with its dephosphorylation...
  9. pmc Arg13 of B-type natriuretic Peptide reciprocally modulates binding to guanylyl cyclase but not clearance receptors
    Deborah M Dickey
    Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Pharmacol 78:431-5. 2010
    ....
  10. pmc Novel bifunctional natriuretic peptides as potential therapeutics
    Deborah M Dickey
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 283:35003-9. 2008
    ..However, none of the chimeric peptides bound NPR-C with significantly higher affinity than endogenous ligands. We suggest that bifunctional chimeric peptides represent a new generation of natriuretic peptide therapeutics...
  11. ncbi request reprint Adenine nucleotides decrease the apparent Km of endogenous natriuretic peptide receptors for GTP
    Laura K Antos
    Dept of Biochemistry, Molecular Biology and Biophysics, Univ of Minnesota, 6 155 Jackson, 321 Church St SE, Minneapolis, MN 55455, USA
    Am J Physiol Endocrinol Metab 293:E1756-63. 2007
    ..We conclude that ATP is not required for the initial activation of NPRs but does increase activity over time by reducing the apparent K(m) for GTP...
  12. ncbi request reprint Differential regulation of membrane guanylyl cyclases in congestive heart failure: natriuretic peptide receptor (NPR)-B, Not NPR-A, is the predominant natriuretic peptide receptor in the failing heart
    Deborah M Dickey
    University of Minnesota, Department of Biochemistry, Molecular Biology, and Biophysics, 6 155 Jackson Hall, 321 Church Street Southeast, Minneapolis, Minnesota 55455, USA
    Endocrinology 148:3518-22. 2007
    ..Based on these findings, we suggest that drugs that target both NPRs may be more beneficial than drugs like nesiritide (Natrecor) that target NPR-A alone...
  13. ncbi request reprint Lysophosphatidic acid inhibits C-type natriuretic peptide activation of guanylyl cyclase-B
    Sarah E Abbey
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Endocrinology 144:240-6. 2003
    ..We hypothesize that cross-talk between the LPA and CNP signaling pathway maximizes the response of fibroblasts in the wound-healing process...
  14. ncbi request reprint ATP-independent activation of natriuretic peptide receptors
    Laura K Antos
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 280:26928-32. 2005
    ..Instead, ATP increases activity primarily by maintaining proper receptor phosphorylation status but also serves a previously unappreciated enzyme stabilizing function...
  15. ncbi request reprint The atrial natriuretic peptide receptor (NPR-A/GC-A) is dephosphorylated by distinct microcystin-sensitive and magnesium-dependent protein phosphatases
    Paula M Bryan
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, St Paul, Minnesota 55108, USA
    J Biol Chem 277:16041-7. 2002
    ..Finally, we observed that the desensitization of NPR-A in membranes from mouse kidneys and NIH3T3 cells was increased by prior exposure to atrial natriuretic peptide, suggesting that hormone binding enhances receptor dephosphorylation...
  16. ncbi request reprint Vasopressin-dependent inhibition of the C-type natriuretic peptide receptor, NPR-B/GC-B, requires elevated intracellular calcium concentrations
    Sarah E Abbey
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 277:42423-30. 2002
    ..Together, these data reveal a dominant role for intracellular calcium in the reciprocal regulation of these two important vasoactive signaling systems...
  17. pmc A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation
    Deborah M Dickey
    Departments of Biochemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 284:19196-202. 2009
    ..These data indicate that the familial ANP mutation associated with atrial fibrillation has only minor effects on natriuretic peptide receptor interactions but markedly modifies peptide proteolysis...
  18. ncbi request reprint Phosphorylation-dependent regulation of the guanylyl cyclase-linked natriuretic peptide receptors
    Regine Potthast
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Twin Cities, 6 155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Peptides 26:1001-8. 2005
    ..Here, we provide a brief review of how various desensitizing agents and/or conditions inhibit NPR-A and NPR-B by decreasing their phosphorylation state...
  19. ncbi request reprint Differential regulation of NPR-B/GC-B by protein kinase c and calcium
    Sarah E Abbey-Hosch
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson, 321 Church Street SE, Minneapolis, MN 55455, USA
    Biochem Pharmacol 70:686-94. 2005
    ..The latter is associated with reductions in maximal velocities by a mechanism that does not involve inhibition of NPR-B phosphorylation and requires a process in addition to the dephosphorylation of the known sites...
  20. ncbi request reprint A sensitive method for determining the phosphorylation status of natriuretic peptide receptors: cGK-Ialpha does not regulate NPR-A
    Paula M Bryan
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota 55455, USA
    Biochemistry 45:1295-303. 2006
    ..Furthermore, we find that Pro-Q Diamond staining is a sensitive method for measuring the phosphate levels of natriuretic peptide receptors, but protein levels are best detected by Western blot analysis, not SYPRO Ruby staining...
  21. ncbi request reprint Sphingosine-1-phosphate inhibits C-type natriuretic peptide activation of guanylyl cyclase B (GC-B/NPR-B)
    Sarah E Abbey-Hosch
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Hypertension 43:1103-9. 2004
    ..These are the first data demonstrating cross-talk between the natriuretic peptide and S1P signaling systems. They suggest that the effects of S1P on vascular disease and wound healing may be mediated in part through inhibition of NPR-B...
  22. doi request reprint Antibody tracking demonstrates cell type-specific and ligand-independent internalization of guanylyl cyclase a and natriuretic peptide receptor C
    Deborah M Dickey
    Department of Biochemistry, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA
    Mol Pharmacol 80:155-62. 2011
    ..We further deduce that NPR-C is internalized faster than GC-A and that increased internalization is not required for GC-A down-regulation...
  23. doi request reprint Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B
    Andrea R Yoder
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, United States
    Biochemistry 49:10137-45. 2010
    ..In conclusion, we identified and characterized new phosphorylation sites in GC-A and GC-B and provide the first evidence of phosphorylation sites within human guanylyl cyclases...
  24. ncbi request reprint Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize
    Danhua Fan
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson, 321 Church Street S E, Minneapolis, MN 55455, USA
    Mol Pharmacol 67:174-83. 2005
    ..We suggest that mechanisms other than receptor down-regulation account for the desensitization of NPR-A and NPR-B that occurs in response to various physiological and pathological stimuli...
  25. doi request reprint Prolonged atrial natriuretic peptide exposure stimulates guanylyl cyclase-a degradation
    Darcy R Flora
    University of Minnesota Twin Cities, Department of Biochemistry, Molecular Biology, and Biophysics, 6 155 Jackson Hall, 321 Church Street, South East Minneapolis, Minnesota 55455, USA
    Endocrinology 151:2769-76. 2010
    ..We conclude that down-regulation is a universal property of NPR-A but is relatively slow and varies with receptor expression levels and cell type...
  26. ncbi request reprint Renal hyporesponsiveness to atrial natriuretic peptide in congestive heart failure results from reduced atrial natriuretic peptide receptor concentrations
    Paula M Bryan
    Departments of Biochemistry, Molecular Biology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Physiol Renal Physiol 292:F1636-44. 2007
    ..We conclude that reduced NPR-A protein levels, not receptor dephosphorylation, explain the renal hyporesponsiveness to natriuretic peptides in CHF...

Research Grants5

  1. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2002
    ..dependent regulation of natriuretic peptide receptors and to use this knowledge as a stepping stone towards the development of effective therapeutic agents for the treatment of cardiovascular diseases. ..
  2. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2003
    ..dependent regulation of natriuretic peptide receptors and to use this knowledge as a stepping stone towards the development of effective therapeutic agents for the treatment of cardiovascular diseases. ..
  3. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2004
    ..dependent regulation of natriuretic peptide receptors and to use this knowledge as a stepping stone towards the development of effective therapeutic agents for the treatment of cardiovascular diseases. ..
  4. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2005
    ..dependent regulation of natriuretic peptide receptors and to use this knowledge as a stepping stone towards the development of effective therapeutic agents for the treatment of cardiovascular diseases. ..