Huntington Potter

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation
    H Potter
    Suncoast Gerontology Center, Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Neurobiol Aging 22:923-30. 2001
  2. pmc Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice
    Chuanhai Cao
    The Byrd Alzheimer s Center and Research Institute, Tampa, FL, USA
    J Alzheimers Dis 17:681-97. 2009
  3. doi request reprint GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice
    Tim D Boyd
    USF Health Byrd Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
    J Alzheimers Dis 21:507-18. 2010
  4. doi request reprint Cross-validation of the Florida Cognitive Activities Scale (FCAS) in an Alzheimer's disease research center sample
    John A Schinka
    James A Haley VA Medical Center, Tampa, Florida, USA
    J Geriatr Psychiatry Neurol 23:9-14. 2010
  5. ncbi request reprint Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms
    David A Costa
    Johnnie B Byrd Sr Alzheimer s Center and Research Institute, Tampa, FL 33647, USA
    Neurobiol Aging 28:831-44. 2007
  6. doi request reprint Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice
    Gary W Arendash
    Department of Cell Biology, Florida Alzheimer s Disease Research Center, University of South Florida, Tampa, FL 33620, USA
    J Alzheimers Dis 17:661-80. 2009
  7. pmc Defining mild cognitive impairment: impact of varying decision criteria on neuropsychological diagnostic frequencies and correlates
    John A Schinka
    James A Haley VA Medical Center, Tampa, FL 33612, USA
    Am J Geriatr Psychiatry 18:684-91. 2010
  8. doi request reprint High Blood caffeine levels in MCI linked to lack of progression to dementia
    Chuanhai Cao
    Department of Pharmaceutical Science, University of South Florida College of Pharmacy, Tampa, FL 33620, USA
    J Alzheimers Dis 30:559-72. 2012
  9. pmc Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity
    Jennifer R Cracchiolo
    The Johnnie B Byrd Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
    Neurobiol Learn Mem 88:277-94. 2007
  10. doi request reprint A novel technique for simultaneous bilateral brain infusions in a mouse model of neurodegenerative disease
    Steven P Bennett
    USF Byrd Alzheimer s Institute, Tampa, FL 33613, USA
    J Neurosci Methods 184:320-6. 2009

Research Grants

  1. PROMOTERS AN INHIBITORS OF ALZEIMER AMYLOID FORMATION
    Huntington Potter; Fiscal Year: 2000
  2. PROMOTERS AN INHIBITORS OF ALZEIMER AMYLOID FORMATION
    Huntington Potter; Fiscal Year: 2001
  3. PROMOTERS AN INHIBITORS OF ALZEIMER AMYLOID FORMATION
    Huntington Potter; Fiscal Year: 2002
  4. PROMOTERS AN INHIBITORS OF ALZEIMER AMYLOID FORMATION
    Huntington Potter; Fiscal Year: 2003
  5. Promoters and Inhibitors of Alzheimer Amyloid Formation
    Huntington Potter; Fiscal Year: 2003
  6. PROMOTERS AN INHIBITORS OF ALZEIMER AMYLOID FORMATION
    Huntington Potter; Fiscal Year: 2004

Collaborators

Detail Information

Publications29

  1. ncbi request reprint The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation
    H Potter
    Suncoast Gerontology Center, Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Neurobiol Aging 22:923-30. 2001
    ..The importance of these findings is that they help to place inflammation at the center of the pathogenic pathway to Alzheimer's disease and identify specific steps in the pathway that may be amenable to therapeutic intervention...
  2. pmc Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice
    Chuanhai Cao
    The Byrd Alzheimer s Center and Research Institute, Tampa, FL, USA
    J Alzheimers Dis 17:681-97. 2009
    ....
  3. doi request reprint GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice
    Tim D Boyd
    USF Health Byrd Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
    J Alzheimers Dis 21:507-18. 2010
    ....
  4. doi request reprint Cross-validation of the Florida Cognitive Activities Scale (FCAS) in an Alzheimer's disease research center sample
    John A Schinka
    James A Haley VA Medical Center, Tampa, Florida, USA
    J Geriatr Psychiatry Neurol 23:9-14. 2010
    ....
  5. ncbi request reprint Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms
    David A Costa
    Johnnie B Byrd Sr Alzheimer s Center and Research Institute, Tampa, FL 33647, USA
    Neurobiol Aging 28:831-44. 2007
    ..These results indicate that EE protects against cognitive impairment in AD transgenic mice through a dual mechanism, including both amyloid dependent and independent mechanisms...
  6. doi request reprint Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice
    Gary W Arendash
    Department of Cell Biology, Florida Alzheimer s Disease Research Center, University of South Florida, Tampa, FL 33620, USA
    J Alzheimers Dis 17:661-80. 2009
    ..Even with pre-existing and substantial Abeta burden, aged APPsw mice exhibited memory restoration and reversal of AD pathology, suggesting a treatment potential of caffeine in cases of established AD...
  7. pmc Defining mild cognitive impairment: impact of varying decision criteria on neuropsychological diagnostic frequencies and correlates
    John A Schinka
    James A Haley VA Medical Center, Tampa, FL 33612, USA
    Am J Geriatr Psychiatry 18:684-91. 2010
    ..To examine the impact of varying decision criteria on neuropsychological diagnostic frequencies and on their correlates...
  8. doi request reprint High Blood caffeine levels in MCI linked to lack of progression to dementia
    Chuanhai Cao
    Department of Pharmaceutical Science, University of South Florida College of Pharmacy, Tampa, FL 33620, USA
    J Alzheimers Dis 30:559-72. 2012
    ..This case-control study provides the first direct evidence that caffeine/coffee intake is associated with a reduced risk of dementia or delayed onset, particularly for those who already have MCI...
  9. pmc Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity
    Jennifer R Cracchiolo
    The Johnnie B Byrd Alzheimer s Center and Research Institute, Tampa, FL 33613, USA
    Neurobiol Learn Mem 88:277-94. 2007
    ..Thus, our data suggest that humans who emphasize a high lifelong level of cognitive activity (over and above social and physical activities) will attain the maximal environmental protection against AD...
  10. doi request reprint A novel technique for simultaneous bilateral brain infusions in a mouse model of neurodegenerative disease
    Steven P Bennett
    USF Byrd Alzheimer s Institute, Tampa, FL 33613, USA
    J Neurosci Methods 184:320-6. 2009
    ..Utilizing the ACT/Abeta interaction, details of this procedure are discussed here in detail...
  11. ncbi request reprint Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease
    David A Costa
    Department of Biochemistry and Molecular Biology and Suncoast Gerontology Center, University of South Florida, Tampa, FL 33620, USA
    J Alzheimers Dis 6:509-14. 2004
    ..Thus, preventing apoE from binding to Abeta may prove to be an effective means of therapeutic intervention...
  12. ncbi request reprint Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition
    Ralph E Leighty
    Memory and Aging Research Laboratory, SCA 110, University of South Florida, Tampa, FL 33620, USA
    Behav Brain Res 153:107-21. 2004
    ..Analyses such as these will be very beneficial for the functional evaluation of therapeutic interventions against AD and for finding behavioral measures that can serve as predictors of pathology...
  13. doi request reprint Transfection by electroporation
    Huntington Potter
    Byrd Alzheimer s Institute, University of South Florida College of Medicine, Tampa, Florida, USA
    Curr Protoc Cell Biol . 2011
    ..Protocols are described for the use of electroporation in vivo to perform gene therapy for cancer therapy and DNA vaccination. Also described are modifications for preparation and transfection of plant protoplasts...
  14. pmc Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes
    Monique Judge
    Department of Molecular Medicine, University of South Florida, 12901 Bruce B, Downs Blvd, Tampa, FL 33612, USA
    Mol Neurodegener 6:80. 2011
    ....
  15. pmc Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors
    Sergiy I Borysov
    Eric Pfeiffer Suncoast Alzheimer s Center, College of Medicine, University of South Florida, Tampa, FL, USA
    Cell Cycle 10:1397-410. 2011
    ..The finding of mitotic motors including Eg5 in mature post-mitotic neurons implies that their inhibition by Ab may also disrupt neuronal function and plasticity...
  16. pmc Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 2:e1205. 2007
    ..However, the effect of these alterations upon barrier function in ALS is still unclear. The aim of this study was to determine the functional competence of the BSCB in G93A mice at different stages of disease...
  17. ncbi request reprint Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons
    Jaya Padmanabhan
    The Johnnie B Byrd Sr Alzheimer s Center and Research Institute Jacksonville, FL, USA
    Brain 129:3020-34. 2006
    ....
  18. ncbi request reprint A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer's transgenic mice
    G W Arendash
    The Florida Alzheimer s Disease Research Center and The Byrd Alzheimer s Institute, Tampa, FL 33613, USA
    Neuroscience 149:286-302. 2007
    ..Alternatively, dietary fish may contain nutrients, other than DHA and EPA, that could provide some protection against AD...
  19. ncbi request reprint Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition
    Gary W Arendash
    The Johnnie B Byrd Alzheimer s Center and Research Institute, Tampa, FL 33620, USA
    Neuroreport 15:1751-4. 2004
    ..The results suggest that long-term EE/cognitive stimulation could provide cognitive stabilization or improvement to AD patients through mechanisms independent of A beta deposition and clearance...
  20. ncbi request reprint Effect of cytokines, dexamethasone and the A/T-signal peptide polymorphism on the expression of alpha(1)-antichymotrypsin in astrocytes: significance for Alzheimer's disease
    L N Nilsson
    Suncoast Gerontology Center, Department of Biochemistry and Molecular Biology and Moffitt Cancer Center, College of Medicine, MDC07, University of South Florida, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    Neurochem Int 39:361-70. 2001
    ....
  21. ncbi request reprint Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease
    L N Nilsson
    Suncoast Gerontology Center, Department of Biochemistry and Molecular Biology, Moffitt Cancer Center, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 21:1444-51. 2001
    ..Our data demonstrate that ACT promotes amyloid deposition and provide a specific mechanism by which inflammation and the subsequent upregulation of astrocytic ACT expression in AD brain contributes to AD pathogenesis...
  22. doi request reprint Transfection by electroporation
    Huntington Potter
    Byrd Alzheimer s Institute, University of South Florida College of Medicine, Tampa, Florida, USA
    Curr Protoc Neurosci . 2011
    ..Protocols are described for the use of electroporation in vivo to perform gene therapy for cancer therapy and DNA vaccination. Also described are modifications for preparation and transfection of plant protoplasts...
  23. pmc Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy
    Debrah I Boeras
    Department of Molecular Medicine and Suncoast Gerontology Center, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Neurobiol Aging 29:319-28. 2008
    ..Several mechanisms by which chromosome missegregation induced by presenilin may contribute to Alzheimer's disease are discussed...
  24. doi request reprint Transfection by electroporation
    Huntington Potter
    Byrd Alzheimer s Institute, University of South Florida College of Medicine, Tampa, Florida, USA
    Curr Protoc Mol Biol . 2010
    ..Protocols are described for the use of electroporation in vivo to perform gene therapy for cancer therapy and DNA vaccination. Also described are modifications for preparation and transfection of plant protoplasts...
  25. pmc Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function
    Csilla Ari
    USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, FL, USA Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL, USA
    Neurobiol Aging 35:1839-49. 2014
    ..Preventing inhibition of Eg5 or other motors by Aβ may represent a novel approach to AD therapy. ..
  26. doi request reprint The cognitive change checklist (3CL): cross-validation of a measure of change in everyday cognition
    John A Schinka
    James A Haley VA Medical Center, Tampa, FL, USA
    Int J Geriatr Psychiatry 25:266-74. 2010
    ....
  27. ncbi request reprint Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation
    Lars N G Nilsson
    Department of Biochemistry and Molecular Biology, Suncoast Gerontology Center, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Neurobiol Aging 25:1153-67. 2004
    ....
  28. pmc Successful adjuvant-free vaccination of BALB/c mice with mutated amyloid beta peptides
    Chuanhai Cao
    Johnnie B, Byrd Alzheimer s Center and Research Institute, 4001 E, Fletcher Ave, Third Floor, Tampa, FL 33613, USA
    BMC Neurosci 9:25. 2008
    ..The development of a vaccine with mutant Abeta peptides that avoids the use of an adjuvant may result in an effective and safer human vaccine...
  29. ncbi request reprint Use of artificial neural networks to determine cognitive impairment and therapeutic effectiveness in Alzheimer's transgenic mice
    Ralph E Leighty
    The Byrd Alzheimer s Institute and The Florida Alzheimer s Disease Research Center, Tampa, FL 33647, United States
    J Neurosci Methods 167:358-66. 2008
    ..These results indicate that ANNs have an excellent capacity to discriminate cognitive impairment in AD transgenic mice and thus designate ANNs as a novel, sensitive method for cognitive assessment in Alzheimer's research...

Research Grants8

  1. PROMOTERS AN INHIBITORS OF ALZEIMER AMYLOID FORMATION
    Huntington Potter; Fiscal Year: 2000
    ..Such blocking peptides will be introduced by several means into the transgenic mice to determine their ability to reduce the level of amyloid formation. ..
  2. PROMOTERS AN INHIBITORS OF ALZEIMER AMYLOID FORMATION
    Huntington Potter; Fiscal Year: 2001
    ..Such blocking peptides will be introduced by several means into the transgenic mice to determine their ability to reduce the level of amyloid formation. ..
  3. PROMOTERS AN INHIBITORS OF ALZEIMER AMYLOID FORMATION
    Huntington Potter; Fiscal Year: 2002
    ..Such blocking peptides will be introduced by several means into the transgenic mice to determine their ability to reduce the level of amyloid formation. ..
  4. PROMOTERS AN INHIBITORS OF ALZEIMER AMYLOID FORMATION
    Huntington Potter; Fiscal Year: 2003
    ..Such blocking peptides will be introduced by several means into the transgenic mice to determine their ability to reduce the level of amyloid formation. ..
  5. Promoters and Inhibitors of Alzheimer Amyloid Formation
    Huntington Potter; Fiscal Year: 2003
    ..Such a conclusion will be important for the design of Alzheimer therapies. ..
  6. PROMOTERS AN INHIBITORS OF ALZEIMER AMYLOID FORMATION
    Huntington Potter; Fiscal Year: 2004
    ..Such blocking peptides will be introduced by several means into the transgenic mice to determine their ability to reduce the level of amyloid formation. ..