S G Potkin

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Efficacy and tolerability of asenapine in acute schizophrenia: a placebo- and risperidone-controlled trial
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, Brain Imaging Center, CA 92697 3960, USA
    J Clin Psychiatry 68:1492-500. 2007
  2. doi request reprint Patient and prescriber perspectives on long-acting injectable (LAI) antipsychotics and analysis of in-office discussion regarding LAI treatment for schizophrenia
    Steven Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, School of Medicine, Irvine, California, 5251 California Avenue, Suite 240, Irvine, CA 92697 3960, USA
    BMC Psychiatry 13:261. 2013
  3. doi request reprint Long-term effects of asenapine or olanzapine in patients with persistent negative symptoms of schizophrenia: a pooled analysis
    Steven G Potkin
    University of California, 5251 California Ave, Irvine, CA, 92617, USA Electronic address
    Schizophr Res 150:442-9. 2013
  4. doi request reprint A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine Irvine, CA 92697 3960, USA
    J Clin Psychopharmacol 33:3-10. 2013
  5. pmc Nicotine-induced brain metabolism associated with anger provocation
    JEAN G GEHRICKE
    Department of Psychiatry and Human Behavior, University of California, Irvine, 19722 MacArthur Blvd, Irvine, California 92612, USA
    Behav Brain Funct 5:19. 2009
  6. pmc SNP-based pathway enrichment analysis for genome-wide association studies
    Lingjie Weng
    Department of Computer Science, University of California, Irvine, USA
    BMC Bioinformatics 12:99. 2011
  7. pmc Widespread cortical dysfunction in schizophrenia: the FBIRN imaging consortium
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92617, USA
    Schizophr Bull 35:15-8. 2009
  8. doi request reprint Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697 3960, USA
    J Clin Psychopharmacol 28:S4-11. 2008
  9. doi request reprint New advances in the treatment of schizophrenia. Introduction
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine and UCI Medical Center Brain Imaging Center, Orange, CA 92868 3298, USA
    J Clin Psychopharmacol 28:S1-3. 2008
  10. ncbi request reprint A double-blind comparison of risperidone, quetiapine and placebo in patients with schizophrenia experiencing an acute exacerbation requiring hospitalization
    Steven G Potkin
    University of California, Irvine, Orange, 92696, USA
    Schizophr Res 85:254-65. 2006

Research Grants

  1. Function BIRN
    Steven Potkin; Fiscal Year: 2007
  2. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
  3. PET IMAGING & MAPPING
    Steven Potkin; Fiscal Year: 2002

Collaborators

Detail Information

Publications82

  1. ncbi request reprint Efficacy and tolerability of asenapine in acute schizophrenia: a placebo- and risperidone-controlled trial
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, Brain Imaging Center, CA 92697 3960, USA
    J Clin Psychiatry 68:1492-500. 2007
    ..This 6-week trial assessed the efficacy, tolerability, and safety of the investigational psychopharmacologic agent asenapine versus placebo and risperidone in patients with acute schizophrenia (DSM-IV criteria)...
  2. doi request reprint Patient and prescriber perspectives on long-acting injectable (LAI) antipsychotics and analysis of in-office discussion regarding LAI treatment for schizophrenia
    Steven Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, School of Medicine, Irvine, California, 5251 California Avenue, Suite 240, Irvine, CA 92697 3960, USA
    BMC Psychiatry 13:261. 2013
    ..Addressing these perspectives in the clinic may lead to greater success in achieving therapeutic goals for the patient with schizophrenia...
  3. doi request reprint Long-term effects of asenapine or olanzapine in patients with persistent negative symptoms of schizophrenia: a pooled analysis
    Steven G Potkin
    University of California, 5251 California Ave, Irvine, CA, 92617, USA Electronic address
    Schizophr Res 150:442-9. 2013
    ..While neither study met the primary endpoint of superiority of ASE over OLA, ASE was statistically superior to OLA in one extension study. This prompted a pooled analysis of the treatment effects of both drugs...
  4. doi request reprint A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine Irvine, CA 92697 3960, USA
    J Clin Psychopharmacol 33:3-10. 2013
    ..The only cardiovascular adverse events with iloperidone were non-concentration-dependent tachycardia that was mild in most patients and did not lead to further sequelae. Pharmacogenetics and recommendations are discussed...
  5. pmc Nicotine-induced brain metabolism associated with anger provocation
    JEAN G GEHRICKE
    Department of Psychiatry and Human Behavior, University of California, Irvine, 19722 MacArthur Blvd, Irvine, California 92612, USA
    Behav Brain Funct 5:19. 2009
    ..These findings reveal the underlying brain circuitry targeted by nicotine during anger provocation...
  6. pmc SNP-based pathway enrichment analysis for genome-wide association studies
    Lingjie Weng
    Department of Computer Science, University of California, Irvine, USA
    BMC Bioinformatics 12:99. 2011
    ..Most current methods choose the most significant SNP from each gene as a representative, ignoring the joint action of multiple SNPs within a gene. This approach leads to preferential identification of genes with a greater number of SNPs...
  7. pmc Widespread cortical dysfunction in schizophrenia: the FBIRN imaging consortium
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92617, USA
    Schizophr Bull 35:15-8. 2009
    ..identified six genes that influence DLPFC activation and have functions related to forebrain development and stress responses in schizophrenia. These related publications indicate the power of multisite neuroimaging...
  8. doi request reprint Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697 3960, USA
    J Clin Psychopharmacol 28:S4-11. 2008
    ..These trials indicate that iloperidone is effective for the treatment of schizophrenia...
  9. doi request reprint New advances in the treatment of schizophrenia. Introduction
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine and UCI Medical Center Brain Imaging Center, Orange, CA 92868 3298, USA
    J Clin Psychopharmacol 28:S1-3. 2008
  10. ncbi request reprint A double-blind comparison of risperidone, quetiapine and placebo in patients with schizophrenia experiencing an acute exacerbation requiring hospitalization
    Steven G Potkin
    University of California, Irvine, Orange, 92696, USA
    Schizophr Res 85:254-65. 2006
    ..This study compared the effects of atypical antipsychotics (risperidone or quetiapine) with placebo and with each other in recently exacerbated patients with schizophrenia requiring hospitalization...
  11. ncbi request reprint Psychometric evaluation of the Readiness for Discharge Questionnaire
    Steven G Potkin
    University of California, Irvine, Department of Psychiatry and Human Behavior, Brain Imaging Center, Irvine Hall, Room 166, Orange, CA, USA
    Schizophr Res 80:203-12. 2005
    ..The psychometric properties of the RDQ are described...
  12. ncbi request reprint Ziprasidone in acute bipolar mania: a 21-day randomized, double-blind, placebo-controlled replication trial
    Steven G Potkin
    Neuropsychiatric Center, University of California Irvine, 101 City Drive South, Bldg 3, Orange, CA 92868 3298, USA
    J Clin Psychopharmacol 25:301-10. 2005
    ..In an earlier 21-day, placebo-controlled trial, ziprasidone was efficacious in improving symptoms of mania and was well tolerated. To confirm these results, a similarly designed 21-day trial was conducted...
  13. pmc A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92617, USA
    Schizophr Bull 35:96-108. 2009
    ..We present an alternative strategy with increased statistical power over a case-control study that uses brain imaging as a quantitative trait (QT) in the context of a GWAS in schizophrenia...
  14. pmc Working memory and DLPFC inefficiency in schizophrenia: the FBIRN study
    S G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA 92617, USA
    Schizophr Bull 35:19-31. 2009
    ..Both prefrontal hyper- or hypoactivity in chronic schizophrenia have been found in previous studies of working memory...
  15. doi request reprint Asenapine: a clinical overview
    Steven G Potkin
    Department of Psychiatry, UCI Brain Imaging Center, University of California Irvine, 5251 California Avenue, Irvine, CA, USA
    J Clin Psychiatry 72:14-8. 2011
    ..Asenapine may be a helpful treatment option for patients with schizophrenia when weight gain, dyslipidemia, and endocrine abnormalities are a concern...
  16. doi request reprint Double-blind comparison of the safety and efficacy of lurasidone and ziprasidone in clinically stable outpatients with schizophrenia or schizoaffective disorder
    Steven G Potkin
    Department of Psychiatry, Human Behavior, University of California at Irvine, Irvine, CA 92617, United States
    Schizophr Res 132:101-7. 2011
    ..The current study evaluated the safety and efficacy of lurasidone and ziprasidone in stable outpatients diagnosed with schizophrenia or schizoaffective disorder...
  17. doi request reprint Placebo response trajectories in short-term and long-term antipsychotic trials in schizophrenia
    Steven Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA 92617, USA
    Schizophr Res 132:108-13. 2011
    ..Further research is warranted to examine the trajectory patterns of placebo responses in independent patient populations...
  18. pmc Identifying gene regulatory networks in schizophrenia
    Steven G Potkin
    Department of Psychiatry and Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA
    Neuroimage 53:839-47. 2010
    ..The model demonstrates epistatic interactions between FGF and glypican on brain development and may be a useful model of negative symptom schizophrenia...
  19. pmc Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA
    PLoS ONE 4:e6501. 2009
    ..With the exception of APOE epsilon4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown...
  20. pmc Genome-wide strategies for discovering genetic influences on cognition and cognitive disorders: methodological considerations
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University California of Irvine, Irvine, CA, USA
    Cogn Neuropsychiatry 14:391-418. 2009
    ..GWASs make it possible to survey the entire genome to discover important but unanticipated genetic influences...
  21. doi request reprint Remission in schizophrenia: 196-week, double-blind treatment with ziprasidone vs. haloperidol
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
    Int J Neuropsychopharmacol 12:1233-48. 2009
    ..In this long-term, double-blind study, ziprasidone treatment was more likely to result in remission than haloperidol treatment, and was associated with greater improvement in quality-of-life...
  22. pmc Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia
    S G Potkin
    Department of Psychiatry and Human Behavior, Brain Imaging Center, University of California, Irvine, CA 92617, USA
    Mol Psychiatry 14:416-28. 2009
    ..We introduce the use of functional magnetic resonance imaging activation as a quantitative phenotype in conjunction with genome-wide association as a gene discovery tool...
  23. ncbi request reprint Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder
    Steven G Potkin
    Brain Imaging Center, University of California, Irvine, 92697, USA
    Arch Gen Psychiatry 60:681-90. 2003
    ..This multicenter trial examined the efficacy, safety, and tolerability of aripiprazole in patients with acute exacerbation of schizophrenia or schizoaffective disorder...
  24. ncbi request reprint Brain metabolic effects of Neotrofin in patients with Alzheimer's disease
    Steven G Potkin
    Department of Psychiatry and Human Behavior, Brain Imaging Center, Irvine Hall, Room 166, University of California, Irvine, Irvine, CA 92697 3960, USA
    Brain Res 951:87-95. 2002
    ..Thus, Neotrofin appears to induce metabolic changes in brain regions involved in circuits underlying memory, attention, and executive functioning...
  25. ncbi request reprint Impact of Alzheimer's disease and rivastigmine treatment on activities of daily living over the course of mild to moderately severe disease
    Steven G Potki
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine 92697, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:713-20. 2002
    ..To investigate the relationship between activities of daily living (ADL) impairment and Alzheimer's disease (AD) severity in mild to moderately severe AD patients receiving the cholinesterase (ChE) inhibitor rivastigmine...
  26. ncbi request reprint Effect of fluoxetine and imipramine on the pharmacokinetics and tolerability of the antipsychotic quetiapine
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, Medical Center, Orange, USA
    J Clin Psychopharmacol 22:174-82. 2002
    ..No unexpected side effects were reported. In conclusion, combination therapy with quetiapine and fluoxetine or imipramine had a minimal effect on quetiapine pharmacokinetics and was well tolerated...
  27. ncbi request reprint The safety and pharmacokinetics of quetiapine when coadministered with haloperidol, risperidone, or thioridazine
    Steven G Potkin
    UC Irvine Medical Center, Department of Psychiatry and Human Behavior, Orange, California, USA
    J Clin Psychopharmacol 22:121-30. 2002
    ..Thioridazine significantly increased the oral clearance of quetiapine. Increased doses of quetiapine may be necessary to control psychotic symptoms when thioridazine is coadministered with quetiapine...
  28. ncbi request reprint Neurocognitive performance does not correlate with suicidality in schizophrenic and schizoaffective patients at risk for suicide
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Room 166, Irvine Hall, Irvine, CA 92697 3960, USA
    Schizophr Res 59:59-66. 2003
    ....
  29. ncbi request reprint Open-label study of the effect of combination quetiapine/lithium therapy on lithium pharmacokinetics and tolerability
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine Medical Center, Orange, California, USA
    Clin Ther 24:1809-23. 2002
    ..The aim of this study was to assess the effect of oral quetiapine on the steady-state pharmacokinetics of lithium...
  30. ncbi request reprint A PET study of the pathophysiology of negative symptoms in schizophrenia. Positron emission tomography
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine 92697 3960, USA
    Am J Psychiatry 159:227-37. 2002
    ....
  31. ncbi request reprint Brain metabolic and clinical effects of rivastigmine in Alzheimer's disease
    S G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92627 3960, USA
    Int J Neuropsychopharmacol 4:223-30. 2001
    ..Rivastigmine prevented the expected deterioration in clinical status and dramatically increased brain metabolic activity in a majority of patients...
  32. ncbi request reprint The ABC of Alzheimer's disease: ADL and improving day-to-day functioning of patients
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California at Irvine Medical Center, Orange, California 92668, USA
    Int Psychogeriatr 14:7-26. 2002
    ..Rivastigmine robustly inhibits butyrylcholinesterase in addition to AChE and therefore acts as a dual ChE inhibitor. Comparative studies evaluating the differential effects of these ChE inhibitors on ADL are awaited...
  33. ncbi request reprint D1 receptor alleles predict PET metabolic correlates of clinical response to clozapine
    S G Potkin
    Department of Psychiatry and Human Behavior, University of Caliornia, Irvine 92697 3960, USA
    Mol Psychiatry 8:109-13. 2003
    ..05). In this preliminary study, brain metabolic and clinical response to clozapine are related to the D1 receptor genotype...
  34. ncbi request reprint Clozapine enhances neurocognition and clinical symptomatology more than standard neuroleptics
    S G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, UCI Medical Center, Orange 92686, USA
    J Clin Psychopharmacol 21:479-83. 2001
    ..The superiority of clozapine over haloperidol may be related to clozapine's unique psychopharmacologic profile...
  35. ncbi request reprint Structured Interview for Assessing Perceptual Anomalies (SIAPA)
    W E Bunney
    Department of Psychiatry and Human Behavior, University of California, Irvine 92717, USA
    Schizophr Bull 25:577-92. 1999
    ..The data indicate that the putative phenomenological correlates of sensory gating may be reliably measured and tested with the Structured Interview for Assessing Perceptual Anomalies...
  36. ncbi request reprint Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics
    S Akbarian
    Department of Anatomy and Neurobiology, University of California, Irvine 92717, USA
    J Neurosci 16:19-30. 1996
    ..In schizophrenics, the alterations in expression of NR2 subunit mRNA in prefrontal cortex are potential indicators of deficits in NMDA receptor-mediated neurotransmission accompanying functional hypoactivity of the frontal lobes...
  37. ncbi request reprint Gender: a major determinant of brain response to nicotine
    James H Fallon
    Department of Anatomy and Neurobiology, BIRN RP, University of California, Irvine, CA 92697 3960, USA
    Int J Neuropsychopharmacol 8:17-26. 2005
    ..The overall effect of nicotine was to decrease these gender differences in brain metabolism...
  38. doi request reprint A post hoc analysis of negative symptoms and psychosocial function in patients with schizophrenia: a 40-week randomized, double-blind study of ziprasidone versus haloperidol followed by a 3-year double-blind extension trial
    Stephen M Stahl
    Department of Psychiatry, University of California, San Diego, CA 92093 9116 A, USA
    J Clin Psychopharmacol 30:425-30. 2010
    ....
  39. pmc Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    E C Mormino
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Brain 132:1310-23. 2009
    ..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy...
  40. pmc fMRI activity correlated with auditory hallucinations during performance of a working memory task: data from the FBIRN consortium study
    C G Wible
    Department of Psychiatry, Harvard Medical School and Brockton VAMC, Boston, MA 02115, USA
    Schizophr Bull 35:47-57. 2009
    ..We hypothesized that regions involved in verbal working memory and language processing would show activity that was associated with levels of hallucinations during a condition where subjects were rehearsing the stimuli...
  41. ncbi request reprint Effects of clozapine and thiothixene on glucose metabolic rate in schizophrenia
    M S Buchsbaum
    Department of Psychiatry, University of California, Irvine 92717
    Neuropsychopharmacology 6:155-63. 1992
    ..Larger sample studies are needed to replicate and extend these initial findings...
  42. ncbi request reprint Imaging phenotypes and genotypes in schizophrenia
    Jessica A Turner
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA
    Neuroinformatics 4:21-49. 2006
    ....
  43. ncbi request reprint Synthesis and evaluation of nicotine alpha4beta2 receptor radioligand, 5-(3'-18F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine, in rodents and PET in nonhuman primate
    Sankha Chattopadhyay
    Department of Psychiatry and Human Behavior Brain Imaging Center, University of California, Irvine, CA 92697, USA
    J Nucl Med 46:130-40. 2005
    ..We report the development and evaluation of a putative antagonist, 5-(3'-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine (nifrolidine) as a PET agent for nicotine alpha(4)beta(2) receptors...
  44. ncbi request reprint Three-month change in cerebral glucose metabolism in patients with nonarteritic ischemic optic neuropathy
    S Bose
    Department of Ophthalmology, University of California, Irvine, 118 Med Surge I, Irvine, CA 92697, USA
    Graefes Arch Clin Exp Ophthalmol 244:1052-5. 2006
    ..Positron emission tomography (PET) to determine the change in glucose metabolic rate in the visual cortex of patients with NAION versus age-matched controls was performed after 3 months' administration of pentoxifylline...
  45. ncbi request reprint Sex-related difference in amygdala activity during emotionally influenced memory storage
    L Cahill
    Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, CA 92697 3800, USA
    Neurobiol Learn Mem 75:1-9. 2001
    ....
  46. pmc Therapeutic effects of individualized alpha frequency transcranial magnetic stimulation (alphaTMS) on the negative symptoms of schizophrenia
    Yi Jin
    Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, USA
    Schizophr Bull 32:556-61. 2006
    ..These results affirm that the resonant features of alpha frequency EEG play an important role in the pathophysiology of schizophrenia and merit further investigation as a particularly efficacious frequency for rTMS treatments...
  47. doi request reprint Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in bipolar disorder
    Joseph C Wu
    Department of Psychiatry and Human Behavior, University of California at Irvine School of Medicine, Room 109, Irvine Hall, Irvine, CA 92697 3960, USA
    Biol Psychiatry 66:298-301. 2009
    ..This study evaluates the combined efficacy of three established circadian-related treatments (SD, bright light [BL]), sleep phase advance [SPA]) as adjunctive treatment to lithium and antidepressants...
  48. pmc Brain-performance correlates of working memory retrieval in schizophrenia: a cognitive modeling approach
    Gregory G Brown
    Department of Psychiatry, University of California, San Diego, CA, USA
    Schizophr Bull 35:32-46. 2009
    ..The results show at both cognitive and neural levels that disordered memory scanning contributes to deficient SIRP performance among schizophrenia patients...
  49. pmc Working memory circuitry in schizophrenia shows widespread cortical inefficiency and compensation
    Miyoung A Kim
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92617, USA
    Schizophr Res 117:42-51. 2010
    ..g. neural inefficiencies). We employed a data-driven, multivariate analysis to identify the patterns of brain-behavior relationships in SZ during working memory...
  50. pmc What is causing the reduced drug-placebo difference in recent schizophrenia clinical trials and what can be done about it?
    Aaron S Kemp
    UCI Neuropsychiatric Center, 101 The City Drive South, Orange, CA 92868, USA
    Schizophr Bull 36:504-9. 2010
    ..The session closed with a roundtable discussion and recommendations for data sharing to further explore potential causes and viable solutions to be applied in future trials...
  51. pmc Multivariate analyses suggest genetic impacts on neurocircuitry in schizophrenia
    Emanuela Tura
    Departments of Psychiatry and Human Behavior, University of California, Irvine, California 92617, USA
    Neuroreport 19:603-7. 2008
    ..Two groups of schizophrenic patients with similar symptomatology and performance on a working memory task, but with distinct dopamine receptor genotypes, may use distinct neural systems to retrieve information...
  52. pmc Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort
    Anita Lakatos
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92617, USA
    Neurobiol Aging 31:1355-63. 2010
    ..Our results indicate that the mitochondrial haplogroup UK may confer genetic susceptibility to AD independently of the apolipoprotein E4 (APOE4) allele...
  53. doi request reprint Smoking to self-medicate attentional and emotional dysfunctions
    JEAN G GEHRICKE
    Department of Psychiatry and Human Behavior, D402 Medical Sciences I, Irvine, California 92697 1674, USA
    Nicotine Tob Res 9:S523-36. 2007
    ....
  54. ncbi request reprint Predicting suicidal risk in schizophrenic and schizoaffective patients in a prospective two-year trial
    Steven G Potkin
    Brain Imaging Center, University of California, Irvine, California 92697 3960, USA
    Biol Psychiatry 54:444-52. 2003
    ..Enhanced ability to reliably identify risk factors for suicidal behavior permits more focused decisions concerning treatment interventions and support services, with potential reduction in lives lost to suicide...
  55. ncbi request reprint Alzheimer disease and other dementias
    Gustavo Alva
    Department of Psychiatry and Human Behavior, University of California, Irvine, 101 The City Drive, Orange, CA 92868, USA
    Clin Geriatr Med 19:763-76. 2003
    ..Palliative ways of slowing progressive decline are available primarily by way of ChEIs, although no cures yet exist for the dementias. Optimizing current treatments makes sense in improving the quality of life of sufferers...
  56. ncbi request reprint Alpha EEG predicts visual reaction time
    Yi Jin
    Department of Psychiatry and Human Behavior, University of California Irvine College of Medicine, Irvine, California 2868 3298, USA
    Int J Neurosci 116:1035-44. 2006
    ..These findings are consistent with previous reports and support the hypothesis that alpha EEG represents excitability cycles and may serves as a brain clock for spatial synchronization...
  57. ncbi request reprint Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate
    Neil Saigal
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California 92697 3960, USA
    J Nucl Med 47:1697-706. 2006
    ..We have synthesized N-{2-[4-(2-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4-18F-fluoromethylcyclohexane)carboxamide (18F-mefway), which contains a 18F on a primary carbon to make the compound more stable to defluorination...
  58. ncbi request reprint Hostility differentiates the brain metabolic effects of nicotine
    James H Fallon
    Department of Anatomy and Neurobiology, University of California, Irvine, BIRN RP, 5251 California, Suite 240, Irvine, CA 92697 3960, USA
    Brain Res Cogn Brain Res 18:142-8. 2004
    ..This biological difference in brain metabolic response to nicotine between high and low hostility trait subjects may explain differences in susceptibility to nicotine dependence...
  59. ncbi request reprint EEG resonant responses in schizophrenia: a photic driving study with improved harmonic resolution
    Y Jin
    From the Department of Psychiatry and Human Behavior, University of California, Irvine Medical Center, Orange CA 92868, USA
    Schizophr Res 44:213-20. 2000
    ....
  60. ncbi request reprint Fluvoxamine in the treatment of panic disorder: a multi-center, double-blind, placebo-controlled study in outpatients
    G M Asnis
    Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, 111 E 210th Street, Bronx, New York, NY 10467 2490, USA
    Psychiatry Res 103:1-14. 2001
    ..Significant improvement was evident as early as week 1 for some panic variables. Fluvoxamine is a potent anti-panic agent with a relatively rapid onset of action...
  61. ncbi request reprint Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer, (18)F-nifene: A measure of acetylcholine competition
    Balasubramaniam Easwaramoorthy
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, California 92697, USA
    Synapse 61:29-36. 2007
    ..The effect is AChEI-concentration dependent and is greater for PHY than GAL. Thus (18)F-nifene has promise for assessing ACh levels and AChEI effects in vivo...
  62. ncbi request reprint Nicotinic alpha4beta2 receptor imaging agents: part II. Synthesis and biological evaluation of 2-[18F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine (18F-nifene) in rodents and imaging by PET in nonhuman primate
    Rama Pichika
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697 3960, USA
    Nucl Med Biol 33:295-304. 2006
    ..Thalamus-to-cerebellum ratio peaked at 30-35 min postinjection to a value of 2.2 and subsequently reduced. The faster binding profile of 18F-nifene indicates promise as a PET imaging agent and thus needs further evaluation...
  63. ncbi request reprint GABAA receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controls
    S Akbarian
    Department of Anatomy and Neurobiology, University of California, Irvine 92717, USA
    Cereb Cortex 5:550-60. 1995
    ....
  64. doi request reprint Circadian abnormalities, molecular clock genes and chronobiological treatments in depression
    Jennifer N Bunney
    University of Southern California, Los Angeles, CA, USA
    Br Med Bull 86:23-32. 2008
    ..It is hypothesized that fast-acting treatments for depression may alter circadian rhythms through chronobiological mechanisms relevant to clock gene function...
  65. ncbi request reprint Memory for emotional stimuli in patients with Alzheimer's disease
    Kirsten Fleming
    Department of Psychiatry and Human Behavior, University of California, Irvine, California, USA
    Am J Alzheimers Dis Other Demen 18:340-2. 2003
    ..These findings of improved immediate memory for emotional material in AD lends support to the notion that mnemonic functions are differentially affected in the disease...
  66. ncbi request reprint A pilot study evaluating the efficacy and safety of rivastigmine in patients with mixed dementia
    Steven G Potkin
    University of California, Irvine, California, USA
    Drugs Aging 23:241-9. 2006
    ..The object of this study was to assess the efficacy and safety of rivastigmine in patients with mixed dementia (AD with VaD)...
  67. ncbi request reprint Language in dreaming and regional EEG alpha power
    C C Hong
    Department of Psychiatry and Behavioral Medicine, University of California, Irvine, USA
    Sleep 19:232-5. 1996
    ..Our finding suggests lateralized and localized cortical activation in relation to language in dreaming...
  68. ncbi request reprint MRNA expression patterns and distribution of white matter neurons in dorsolateral prefrontal cortex of depressed patients differ from those in schizophrenia patients
    Margherita Molnar
    Center for Neuroscience, University of California, Davis, California 95616, USA
    Biol Psychiatry 53:39-47. 2003
    ..Schizophrenia, bipolar illness, and major depressive disorder have distinct presentations, but share some common symptoms. Hence, some common cellular and molecular abnormalities may be identifiable in these disorders...
  69. ncbi request reprint A general XML schema and SPM toolbox for storage of neuro-imaging results and anatomical labels
    David Bryant Keator
    University of California, Irvine, CA
    Neuroinformatics 4:199-212. 2006
    ..htm). Support for anatomical labeling is available via the Talairach Daemon (http://ric.uthscsa. edu/projects/talairachdaemon.html) and Automated Anatomical Labeling (http://www. cyceron.fr/freeware/)...
  70. ncbi request reprint Improvement in cognitive function following a switch to ziprasidone from conventional antipsychotics, olanzapine, or risperidone in outpatients with schizophrenia
    Philip D Harvey
    Mt Sinai School of Medicine, New York University, 1425 Madison Avenue, Fourth Floor, New York, NY 10029, USA
    Schizophr Res 66:101-13. 2004
    ....
  71. ncbi request reprint Strategies for continued successful treatment of Alzheimer's disease: switching cholinesterase inhibitors
    Serge Gauthier
    McGill Centre for Studies in Aging, Verdun, Quebec, Canada
    Curr Med Res Opin 19:707-14. 2003
    ..The panel also aimed to reach consensus on 'whom to switch', 'when to switch' and 'how to switch'. The key findings from that meeting are reported in this review...
  72. ncbi request reprint A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences, University of California at San Diego, La Jolla 92093, USA
    Nat Med 11:551-5. 2005
    ..05) increases in cortical 18-fluorodeoxyglucose after treatment. Brain autopsy from one subject suggested robust growth responses to NGF. Additional clinical trials of NGF for Alzheimer disease are warranted...
  73. ncbi request reprint Association study between a functional glutathione S-transferase (GSTP1) gene polymorphism (Ile105Val) and tardive dyskinesia
    Takahiro Shinkai
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ont, Canada M5T 1R8
    Neurosci Lett 388:116-20. 2005
    ..1, p=1.00) were observed between subjects with and without TD. Our results suggest that the GSTP1 gene polymorphism does not confer increased susceptibility to TD, although further studies are warranted before a conclusion can be drawn...
  74. ncbi request reprint Pharmacogenomics in schizophrenia: the quest for individualized therapy
    Vincenzo S Basile
    Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Toronto, Canada
    Hum Mol Genet 11:2517-30. 2002
    ..To the extent that the above data become more widely verified and replicated, the field of psychiatry will move closer to clinically meaningful tests that will be useful in deciding the best drug for each individual patient...
  75. ncbi request reprint Ziprasidone in treatment-resistant schizophrenia: a 52-week, open-label continuation study
    Antony D Loebel
    Pfizer Inc, New York, NY 10018, USA
    J Clin Psychiatry 68:1333-8. 2007
    ..To evaluate the efficacy, safety, and tolerability of long-term ziprasidone therapy in treatment-resistant schizophrenia...
  76. ncbi request reprint Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response
    Rudi Hwang
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    J Psychopharmacol 21:718-27. 2007
    ..2003), a trend in the same direction was observed as well. Our findings suggest that the rs4532 SNP may have a small effect if any. Further studies in larger, independent samples are required to validate these findings...
  77. ncbi request reprint Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial
    Elaine R Peskind
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Am J Geriatr Psychiatry 14:704-15. 2006
    ..The objective of this study was to compare the efficacy and safety of the moderate-affinity, uncompetitive N-methyl-d-aspartate receptor antagonist, memantine, versus placebo in patients with mild to moderate Alzheimer disease (AD)...
  78. ncbi request reprint Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia
    Katherine A Albert
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY, USA
    Arch Gen Psychiatry 59:705-12. 2002
    ..Thus, DARPP-32 occupies a key regulatory position, and may play an important role in the pathophysiological changes in dopamine and glutamate function reported in patients with schizophrenia...
  79. ncbi request reprint Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patients
    Clement C Zai
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Int J Neuropsychopharmacol 10:639-51. 2007
    ..047). Taken together, the present study suggests that DRD2 may be involved in TD in the Caucasian population, although further studies are warranted...
  80. ncbi request reprint Effectiveness of switching to ziprasidone for stable but symptomatic outpatients with schizophrenia
    Peter J Weiden
    Department of Psychiatry, SUNY Downstate Medical Center State, Brooklyn, NY 11203, USA
    J Clin Psychiatry 64:580-8. 2003
    ....
  81. ncbi request reprint Targeting acetylcholinesterase and butyrylcholinesterase in dementia
    Roger M Lane
    Novartis Neuroscience, Novartis Pharmaceuticals Corporation, NJ, USA
    Int J Neuropsychopharmacol 9:101-24. 2006
    ....
  82. pmc Chronic smoking and the BOLD response to a visual activation task and a breath hold task in patients with schizophrenia and healthy controls
    Lee Friedman
    PO Box 51, Newbury, OH 44065, USA
    Neuroimage 40:1181-94. 2008
    ....

Research Grants14

  1. Function BIRN
    Steven Potkin; Fiscal Year: 2007
    ..When completed, researchers in different fields and physical locations will be able to draw on a common set of tools and database systems not possible at a single site. ..
  2. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..These goals could not be achieved without a unifying Center focused on a single integrative theme. The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. ..
  3. PET IMAGING & MAPPING
    Steven Potkin; Fiscal Year: 2002
    ..3. Retrospect ively evaluate the fMRI structural and neuropsychological data, comparing the performance of those who did and did not show cognitive declines beyond normal age-associated memory impairment (AAMI). ..