JOHN HARVEY POSTLETHWAIT

Summary

Affiliation: University of Oregon
Country: USA

Publications

  1. doi request reprint The zebrafish genome: a review and msx gene case study
    J H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    Genome Dyn 2:183-97. 2006
  2. ncbi request reprint The zebrafish genome in context: ohnologs gone missing
    John H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    J Exp Zool B Mol Dev Evol 308:563-77. 2007
  3. pmc Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes
    Cristian Canestro
    Institute of Neuroscience, University of Oregon, Eugene, OR, USA
    PLoS Genet 5:e1000496. 2009
  4. pmc Retinoic acid metabolic genes, meiosis, and gonadal sex differentiation in zebrafish
    Adriana Rodriguez-Mari
    Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America Departament de Genètica, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e73951. 2013
  5. pmc Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish
    Fanwei Meng
    Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Mol Biol Evol 30:1527-43. 2013
  6. pmc Dynamic Evolution of the LPS-Detoxifying Enzyme Intestinal Alkaline Phosphatase in Zebrafish and Other Vertebrates
    Ye Yang
    Institute of Molecular Biology, University of Oregon Eugene, OR, USA
    Front Immunol 3:314. 2012
  7. pmc Multiple sex-associated regions and a putative sex chromosome in zebrafish revealed by RAD mapping and population genomics
    Jennifer L Anderson
    Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America
    PLoS ONE 7:e40701. 2012
  8. pmc Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish
    Adriana Rodriguez-Mari
    Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America
    PLoS Genet 7:e1001357. 2011
  9. pmc Seeing chordate evolution through the Ciona genome sequence
    Cristian Canestro
    Institute of Neuroscience, 1254 University of Oregon, 1425 E, 13th Avenue, Eugene, OR 97403, USA
    Genome Biol 4:208. 2003
  10. pmc Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton
    April DeLaurier
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 12:16. 2012

Research Grants

  1. Resources for Teleost Gene Duplicates and Human Disease
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010
  2. Resources for Teleost Gene Duplicates and Human Disease
    John Postlethwait; Fiscal Year: 2009
  3. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010
  4. Developmental Mechanisms for the Evolution of Bone Loss
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010
  5. Developmental Mechanisms for the Evolution of Bone Loss
    John Postlethwait; Fiscal Year: 2009
  6. Resources for Teleost Gene Duplicates and Human Disease
    John Postlethwait; Fiscal Year: 2006
  7. Genomic Analysis in Zebrafish Development
    John Postlethwait; Fiscal Year: 2006
  8. Genomic Analysis in Zebrafish Development
    John Postlethwait; Fiscal Year: 2005
  9. Genomic Analysis in Zebrafish Development
    John Postlethwait; Fiscal Year: 2004
  10. Genomic Analysis in Zebrafish Development
    John Postlethwait; Fiscal Year: 2003

Collaborators

Detail Information

Publications64

  1. doi request reprint The zebrafish genome: a review and msx gene case study
    J H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    Genome Dyn 2:183-97. 2006
    ..Genomic analysis suggests orthologs for this difficult to understand group of paralogs...
  2. ncbi request reprint The zebrafish genome in context: ohnologs gone missing
    John H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    J Exp Zool B Mol Dev Evol 308:563-77. 2007
    ....
  3. pmc Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes
    Cristian Canestro
    Institute of Neuroscience, University of Oregon, Eugene, OR, USA
    PLoS Genet 5:e1000496. 2009
    ....
  4. pmc Retinoic acid metabolic genes, meiosis, and gonadal sex differentiation in zebrafish
    Adriana Rodriguez-Mari
    Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America Departament de Genètica, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e73951. 2013
    ....
  5. pmc Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish
    Fanwei Meng
    Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Mol Biol Evol 30:1527-43. 2013
    ..These results show that the independent evolution of retinal degeneration in cavefish can occur by different developmental genetic mechanisms...
  6. pmc Dynamic Evolution of the LPS-Detoxifying Enzyme Intestinal Alkaline Phosphatase in Zebrafish and Other Vertebrates
    Ye Yang
    Institute of Molecular Biology, University of Oregon Eugene, OR, USA
    Front Immunol 3:314. 2012
    ....
  7. pmc Multiple sex-associated regions and a putative sex chromosome in zebrafish revealed by RAD mapping and population genomics
    Jennifer L Anderson
    Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America
    PLoS ONE 7:e40701. 2012
    ..Our results reveal that chr-4 has functional and structural properties expected of a sex chromosome...
  8. pmc Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish
    Adriana Rodriguez-Mari
    Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America
    PLoS Genet 7:e1001357. 2011
    ..Overall, this work verified zebrafish as a model for the role of Brca2 in human disease and uncovered a novel function of Brca2 in vertebrate oocyte nuclear architecture...
  9. pmc Seeing chordate evolution through the Ciona genome sequence
    Cristian Canestro
    Institute of Neuroscience, 1254 University of Oregon, 1425 E, 13th Avenue, Eugene, OR 97403, USA
    Genome Biol 4:208. 2003
    ....
  10. pmc Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton
    April DeLaurier
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 12:16. 2012
    ..In humans, HDAC4 deficiency is associated with non-syndromic oral clefts and brachydactyly mental retardation syndrome (BDMR) with craniofacial abnormalities...
  11. pmc Evolution of the osteoblast: skeletogenesis in gar and zebrafish
    B Frank Eames
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
    BMC Evol Biol 12:27. 2012
    ....
  12. pmc RAD marker microarrays enable rapid mapping of zebrafish mutations
    Michael R Miller
    Institute of Molecular Biology, University of Oregon, 1370 Franklin Blvd, Eugene, Oregon 97403, USA
    Genome Biol 8:R105. 2007
    ..The RAD approach is highly effective for genetic mapping in zebrafish and is an attractive option for mapping in other organisms...
  13. pmc Molecular pedomorphism underlies craniofacial skeletal evolution in Antarctic notothenioid fishes
    R Craig Albertson
    Department of Biology, Syracuse University, 130 College Place, Syracuse, NY 13244, USA
    BMC Evol Biol 10:4. 2010
    ....
  14. pmc Evolution of developmental roles of Pax2/5/8 paralogs after independent duplication in urochordate and vertebrate lineages
    Susan Bassham
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403, USA
    BMC Biol 6:35. 2008
    ..Separate from the vertebrate genome expansions, a duplication also created two Pax2/5/8 genes in the common ancestor of ascidian and larvacean urochordates...
  15. ncbi request reprint Subfunction partitioning, the teleost radiation and the annotation of the human genome
    John Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Trends Genet 20:481-90. 2004
    ..Applying these principles on a genomic scale can accelerate the functional annotation of the human genome and understanding of the roles of human genes in health and disease...
  16. ncbi request reprint A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 132:1069-83. 2005
    ..By contrast, subfunction partitioning between zebrafish co-orthologs of tetrapod genes, such as sox9a and sox9b, can relax pleiotropy and reveal both early and late developmental gene functions...
  17. pmc Evolution of developmental regulation in the vertebrate FgfD subfamily
    Richard Jovelin
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, USA
    J Exp Zool B Mol Dev Evol 314:33-56. 2010
    ....
  18. ncbi request reprint Genome duplication, subfunction partitioning, and lineage divergence: Sox9 in stickleback and zebrafish
    William A Cresko
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403 1254, USA
    Dev Dyn 228:480-9. 2003
    ..We conclude that some gene subfunctions, as represented by lineage-specific expression domains, may have assorted differently in separate lineages and that these may have contributed to lineage diversification during teleost evolution...
  19. ncbi request reprint Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development
    Adriana Rodriguez-Mari
    Institute of Neuroscience, University of Oregon, Eugene, 97403, USA
    Gene Expr Patterns 5:655-67. 2005
    ..The finding that zebrafish sox9b and sox8 were not co-expressed with amh in oocytes excludes the possibility that amh expression in zebrafish granulosa cells is directly regulated by either of these two genes...
  20. pmc Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation
    Hayato Yokoi
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Dev Biol 329:1-15. 2009
    ..These roles in eye development were previously unrecognized and reinforce the multiple functions that Sox9 plays in vertebrate development...
  21. ncbi request reprint Hox cluster organization in the jawless vertebrate Petromyzon marinus
    Allan Force
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    J Exp Zool 294:30-46. 2002
    ..If Hox clusters were duplicated in whole-genome duplication events, then these data suggest that, at most, one whole genome duplication occurred before the evolution of vertebrate developmental innovations...
  22. ncbi request reprint The evolutionary history of placodes: a molecular genetic investigation of the larvacean urochordate Oikopleura dioica
    Susan Bassham
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 132:4259-72. 2005
    ....
  23. ncbi request reprint A zebrafish sox9 gene required for cartilage morphogenesis
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Development 129:5065-79. 2002
    ..Likewise, calcein labeling revealed that early bone formation was largely unaffected in jef (sox9a) mutants. These studies show that jef (sox9a) is essential for both morphogenesis of condensations and overt cartilage differentiation...
  24. ncbi request reprint Inferring ancestral gene order
    Julian M Catchen
    Department of Computer and Information Science and Institute of Neuroscience, University of Oregon, Eugene, OR, USA
    Methods Mol Biol 452:365-83. 2008
    ..We apply this method here to reconstruct the ancestors of a specific chromosome in the zebrafish Danio rerio...
  25. ncbi request reprint Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification
    Dong Liu
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA Gene Tools, LLC, 1 Summerton Way, Philomath, OR 97370, USA
    Development 130:2213-24. 2003
    ....
  26. pmc MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
    Johann K Eberhart
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Nat Genet 40:290-8. 2008
    ..These results suggest that the conserved regulatory interactions of mirn140 and pdgfra define an ancient mechanism of palatogenesis, and they provide candidate genes for cleft palate...
  27. ncbi request reprint Duplication and divergence of fgf8 functions in teleost development and evolution
    Richard Jovelin
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, USA
    J Exp Zool B Mol Dev Evol 308:730-43. 2007
    ....
  28. pmc Automated identification of conserved synteny after whole-genome duplication
    Julian M Catchen
    Department of Computer and Information Science, University of Oregon, Eugene, Oregon 97403, USA
    Genome Res 19:1497-505. 2009
    ..To demonstrate the utility of the system, we present a case study of gene family evolution, investigating the ARNTL gene family in the genomes of Ciona intestinalis, amphioxus, zebrafish, and human...
  29. pmc UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton
    B Frank Eames
    Institute of Neuroscience, 1254 University of Oregon, Eugene OR 97403 1254, USA
    Dev Biol 341:400-15. 2010
    ....
  30. ncbi request reprint Studies of threespine stickleback developmental evolution: progress and promise
    William A Cresko
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403 5289, USA
    Genetica 129:105-26. 2007
    ....
  31. ncbi request reprint Developmental genetic basis for the evolution of pelvic fin loss in the pufferfish Takifugu rubripes
    Mikiko Tanaka
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Dev Biol 281:227-39. 2005
    ..This mechanism appears to be different from the mechanism for pelvic loss in stickleback, showing that different taxa can evolve similar phenotypes by different mechanisms...
  32. pmc Developmental roles of pufferfish Hox clusters and genome evolution in ray-fin fish
    Angel Amores
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97402, USA
    Genome Res 14:1-10. 2004
    ....
  33. ncbi request reprint Evolution of sarcomeric myosin heavy chain genes: evidence from fish
    Katrina McGuigan
    Institute of Neurosciences, University of Oregon, USA
    Mol Biol Evol 21:1042-56. 2004
    ..One outcome of this high level of concerted evolution is that different fish taxa have different suites of MYH genes, i.e., true orthologs do not exist...
  34. pmc Evolution and development of facial bone morphology in threespine sticklebacks
    Charles B Kimmel
    Institute of Neuroscience and Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403, USA
    Proc Natl Acad Sci U S A 102:5791-6. 2005
    ..A quantitative trait locus is present on linkage group 19 that contributes in a major way to this phenotype...
  35. pmc The Fanconi anemia/BRCA gene network in zebrafish: embryonic expression and comparative genomics
    Tom A Titus
    Institute of Neuroscience, University of Oregon, 1425 E 13th Avenue, Eugene, OR 97403, USA
    Mutat Res 668:117-32. 2009
    ....
  36. doi request reprint Oikopleura dioica alcohol dehydrogenase class 3 provides new insights into the evolution of retinoic acid synthesis in chordates
    Cristian Canestro
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Zoolog Sci 27:128-33. 2010
    ..Thereby, if Adh3 plays a role in RA synthesis in vertebrates, it might be a lineage-specific neofunctionalization...
  37. ncbi request reprint Is retinoic acid genetic machinery a chordate innovation?
    Cristian Canestro
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Evol Dev 8:394-406. 2006
    ..We propose a new hypothesis in which lineage-specific duplication and loss of RA machinery genes could be related to the morphological radiation of deuterostomes...
  38. pmc MicroRNAs and micromanaging the skeleton in disease, development and evolution
    Xinjun He
    Institute of Neuroscience, University of Oregon, Eugene, USA
    J Cell Mol Med 13:606-18. 2009
    ....
  39. ncbi request reprint Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development
    Alexandra Tallafuss
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Gene Expr Patterns 6:556-65. 2006
    ..Understanding phylogenetic relationships among Rxr genes and their expression patterns during development provides a foundation for future studies of Rxr functions...
  40. ncbi request reprint Evolutionary developmental biology and genomics
    Cristian Canestro
    Institute of Neuroscience, 1425 East 13th Avenue, University of Oregon, Eugene, Oregon 97403, USA
    Nat Rev Genet 8:932-42. 2007
    ..Finally, comparative genomics helps us to identify conserved non-coding elements and their relationship to genome architecture and development...
  41. ncbi request reprint Characterization of the retinoic acid receptor genes raraa, rarab and rarg during zebrafish development
    Laura A Hale
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Gene Expr Patterns 6:546-55. 2006
    ..Thus, these three genes have largely overlapping expression patterns and a few gene-specific expression domains. Knowledge of these expression patterns will guide the interpretation of the roles these genes play in development...
  42. doi request reprint Evolution of the thyroid: anterior-posterior regionalization of the Oikopleura endostyle revealed by Otx, Pax2/5/8, and Hox1 expression
    Cristian Canestro
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    Dev Dyn 237:1490-9. 2008
    ....
  43. ncbi request reprint The Fanconi anemia gene network is conserved from zebrafish to human
    Tom A Titus
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Gene 371:211-23. 2006
    ..The application of powerful genetic, cellular, and embryological methodologies make zebrafish a useful model for discovering FA gene functions, identifying new genes in the network, and identifying therapeutic compounds...
  44. pmc Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations
    William A Cresko
    Institute of Neuroscience and Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403 1254, USA
    Proc Natl Acad Sci U S A 101:6050-5. 2004
    ..Thus, rapid and repeated armor loss in Alaskan stickleback populations appears to be occurring through the fixation of large-effect variants in the same genes...
  45. ncbi request reprint Development of a chordate anterior-posterior axis without classical retinoic acid signaling
    Cristian Canestro
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Dev Biol 305:522-38. 2007
    ..We discuss possible relationships of altered roles of RA in urochordate development to genomic events, such as rupture of the Hox-cluster, in the context of a new understanding of chordate phylogeny...
  46. pmc Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis
    Adriana Rodriguez-Mari
    Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America
    PLoS Genet 6:e1001034. 2010
    ....
  47. ncbi request reprint Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis
    Maggie L Kalev-Zylinska
    Division of Molecular Medicine, The University of Auckland, Auckland, New Zealand
    Development 129:2015-30. 2002
    ..The phenotype obtained with transient expression of RUNX1-CBF2T1 validates the zebrafish as a model system to study t(8;21)-mediated leukemogenesis...
  48. pmc Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor
    Torun Dunér
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, P O Box 593, SE 751 24 Uppsala, Sweden
    Biochem J 364:817-24. 2002
    ..The B1-selective analogue [Arg0,Trp5,Leu8,des-Arg9]-BK was inactive at nanomolar concentrations. Taken together, these results strongly support the gene's identity as a piscine orthologue of the mammalian B2 receptor...
  49. ncbi request reprint One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology
    Aneta Ringholm
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, BMC, 75 124 Uppsala, Sweden
    J Neurochem 82:6-18. 2002
    ....
  50. ncbi request reprint Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development
    Junya Masumoto
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor 48109, USA
    J Biol Chem 278:4268-76. 2003
    ..These studies suggest that zAsc mediates the activation of Caspy, a caspase that plays an important role in the morphogenesis of the jaw and gill-bearing arches...
  51. pmc The zebrafish gene map defines ancestral vertebrate chromosomes
    Ian G Woods
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5329, USA
    Genome Res 15:1307-14. 2005
    ..In a three-way comparison between the genomes of zebrafish, Tetraodon, and human, our analysis delineates the gene content for 11 of these 12 proposed ancestral chromosomes...
  52. ncbi request reprint Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates
    Con Sullivan
    Department of Biochemistry, Microbiology, and Molecular Biology, University of Maine, Orono, ME 04469, USA
    J Immunol 178:4517-27. 2007
    ..These studies provide evidence, for the first time, of the evolving function of a vertebrate TLR pathway...
  53. ncbi request reprint The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish
    David E I Gloriam
    Department of Neuroscience, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden
    Mol Phylogenet Evol 35:470-82. 2005
    ..The evolutionary history of the TA-receptors is more complex than for most other GPCR families and here we suggest a mechanism by which they may have arisen...
  54. ncbi request reprint Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency
    Barry H Paw
    Department of Medicine, Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts, USA
    Nat Genet 34:59-64. 2003
    ..1R-binding domains. Our report establishes an evolutionarily conserved role for band 3 in erythroid-specific cell division and illustrates the concept of cell-specific adaptation for mitosis...
  55. ncbi request reprint Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish
    Jori O Ruuskanen
    Department of Pharmacology and Clinical Pharmacology, Turku Graduate School of Biomedical Sciences, University of Turku, Finland
    Mol Biol Evol 21:14-28. 2004
    ....
  56. ncbi request reprint Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39
    Madhusudhan R Papasani
    Department of Biological Sciences, Illinois State University, Normal, Illinois 61790, USA
    Endocrinology 145:5294-304. 2004
    ..Because the mammalian PTH2R was also most abundantly expressed in these tissues, the TIP39-PTH2R system may serve conserved physiological roles in mammals and fishes...
  57. pmc Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear
    Josep Rotllant
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Matrix Biol 27:561-72. 2008
    ..A comparison of the phenotypes of Sparc knockdown and known zebrafish mutants with similar defects places Sparc downstream of sox9 in the genetic network that regulates development of the pharyngeal skeleton and inner ear of vertebrates...
  58. ncbi request reprint Two Na,K-ATPase beta 2 subunit isoforms are differentially expressed within the central nervous system and sensory organs during zebrafish embryogenesis
    Johannes R Rajarao
    Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
    Dev Dyn 223:254-61. 2002
    ....
  59. ncbi request reprint Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution
    Malin C Lagerström
    Department of Neuroscience, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden
    Genomics 85:688-703. 2005
    ..This report suggests how gene duplication events can lead to novel peptide ligand/receptor interactions and hence spur the evolution of new physiological functions...
  60. pmc Conserved function of caspase-8 in apoptosis during bony fish evolution
    Shin ichi Sakata
    Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Gene 396:134-48. 2007
    ....
  61. ncbi request reprint Runx3 is required for hematopoietic development in zebrafish
    Maggie L Kalev-Zylinska
    Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
    Dev Dyn 228:323-36. 2003
    ..We propose a role for Runx3 in the regulation of blood cell numbers...
  62. ncbi request reprint Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signaling
    Muriel Rhinn
    Department of Genetics, Max Planck Institute for Molecular Cell Biology and Genetics, University of Dresden, Pfotenhauer Strasse 108, 01307 Dresden, Germany
    Mech Dev 120:919-36. 2003
    ..Moreover, our results provide an example for switching of a specific gene function of gbx1 versus gbx2 between orthologous genes in zebrafish and mammals...
  63. ncbi request reprint Female-specific increase in primordial germ cells marks sex differentiation in threespine stickleback (Gasterosteus aculeatus)
    Zachary R Lewis
    Department of Biology, Reed College, Portland, Oregon 97202, USA
    J Morphol 269:909-21. 2008
    ..The data suggest that an increase in PGC number may direct the undifferentiated gonad toward ovarian differentiation...
  64. ncbi request reprint Na,K-ATPase alpha and beta subunit genes exhibit unique expression patterns during zebrafish embryogenesis
    Victor A Canfield
    Department of Pharmacology, Penn State College of Medicine, Hershey 17033, USA
    Mech Dev 116:51-9. 2002
    ..Based on these expression patterns, we predict that at least 14 alpha/beta subunit pairs are likely to be formed in different tissues...

Research Grants21

  1. Resources for Teleost Gene Duplicates and Human Disease
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010
    ..Proposed work will provide genomic resources for an unduplicated fish genome that will better link model fish and human genomes and thus will more effectively translate research on fish biomedical models to human health and disease. ..
  2. Resources for Teleost Gene Duplicates and Human Disease
    John Postlethwait; Fiscal Year: 2009
    ..Analysis of duplicated teleost genes can ease discoveryof candidate tissue-specific regulatory elements and protein structural motifs that may be targets for drugs withfewer side effects. ..
  3. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010
    ....
  4. Developmental Mechanisms for the Evolution of Bone Loss
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010
    ....
  5. Developmental Mechanisms for the Evolution of Bone Loss
    John Postlethwait; Fiscal Year: 2009
    ....
  6. Resources for Teleost Gene Duplicates and Human Disease
    John Postlethwait; Fiscal Year: 2006
    ..Analysis of duplicated teleost genes can ease discovery of candidate tissue-specific regulatory elements and protein structural motifs that may be targets for drugs with fewer side effects. ..
  7. Genomic Analysis in Zebrafish Development
    John Postlethwait; Fiscal Year: 2006
    ..Furthermore, the coordinated and simultaneous functional investigation of both copies of human disease genes will reveal conserved gene functions that may be obscured by analysis of the single gene in tetrapods. ..
  8. Genomic Analysis in Zebrafish Development
    John Postlethwait; Fiscal Year: 2005
    ..Furthermore, the coordinated and simultaneous functional investigation of both copies of human disease genes will reveal conserved gene functions that may be obscured by analysis of the single gene in tetrapods. ..
  9. Genomic Analysis in Zebrafish Development
    John Postlethwait; Fiscal Year: 2004
    ..Furthermore, the coordinated and simultaneous functional investigation of both copies of human disease genes will reveal conserved gene functions that may be obscured by analysis of the single gene in tetrapods. ..
  10. Genomic Analysis in Zebrafish Development
    John Postlethwait; Fiscal Year: 2003
    ..Furthermore, the coordinated and simultaneous functional investigation of both copies of human disease genes will reveal conserved gene functions that may be obscured by analysis of the single gene in tetrapods. ..
  11. GENOMIC ANALYSIS OF ZEBRAFISH DEVELOPMENT
    John Postlethwait; Fiscal Year: 2001
    ....
  12. GENOMIC ANALYSIS OF ZEBRAFISH DEVELOPMENT
    John Postlethwait; Fiscal Year: 2000
    ....
  13. GENOMIC ANALYSIS OF ZEBRAFISH DEVELOPMENT
    John Postlethwait; Fiscal Year: 1999
    ....
  14. Resources for Teleost Gene Duplicates and Human Disease
    John Postlethwait; Fiscal Year: 2007
    ..Analysis of duplicated teleost genes can ease discoveryof candidate tissue-specific regulatory elements and protein structural motifs that may be targets for drugs withfewer side effects. ..
  15. GENOMIC ANALYSIS OF ZEBRAFISH DEVELOPMENT
    John Postlethwait; Fiscal Year: 2002
    ....