J H Postlethwait

Summary

Affiliation: University of Oregon
Country: USA

Publications

  1. ncbi request reprint Vertebrate genome evolution and the zebrafish gene map
    J H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Nat Genet 18:345-9. 1998
  2. ncbi request reprint Zebrafish comparative genomics and the origins of vertebrate chromosomes
    J H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    Genome Res 10:1890-902. 2000
  3. ncbi request reprint Zebrafish genomics: from mutants to genes
    J H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Trends Genet 13:183-90. 1997
  4. ncbi request reprint Genetic interactions in zebrafish midline development
    M E Halpern
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Dev Biol 187:154-70. 1997
  5. ncbi request reprint Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants
    M E Halpern
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Development 121:4257-64. 1995
  6. ncbi request reprint A homeobox gene essential for zebrafish notochord development
    W S Talbot
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Nature 378:150-7. 1995
  7. ncbi request reprint Zebrafish hox clusters and vertebrate genome evolution
    A Amores
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Science 282:1711-4. 1998
  8. ncbi request reprint Ectopic expression of hoxb2 after retinoic acid treatment or mRNA injection: disruption of hindbrain and craniofacial morphogenesis in zebrafish embryos
    Y L Yan
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Dev Dyn 213:370-85. 1998
  9. ncbi request reprint Mutant rescue by BAC clone injection in zebrafish
    Y L Yan
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Genomics 50:287-9. 1998
  10. ncbi request reprint Expression of a type II collagen gene in the zebrafish embryonic axis
    Y L Yan
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Dev Dyn 203:363-76. 1995

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Vertebrate genome evolution and the zebrafish gene map
    J H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Nat Genet 18:345-9. 1998
    ..This zebrafish gene map will facilitate molecular identification of mutated zebrafish genes, which can suggest functions for human genes known only by sequence...
  2. ncbi request reprint Zebrafish comparative genomics and the origins of vertebrate chromosomes
    J H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    Genome Res 10:1890-902. 2000
    ....
  3. ncbi request reprint Zebrafish genomics: from mutants to genes
    J H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Trends Genet 13:183-90. 1997
    ..This review discusses the state of the zebrafish genome project and the genetic trickery that can expedite molecular isolation of genes disrupted by these mutations...
  4. ncbi request reprint Genetic interactions in zebrafish midline development
    M E Halpern
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Dev Biol 187:154-70. 1997
    ..From these findings we propose that ntl+ plays an early role in cell fate choice at the dorsal midline, mediated by the Ntl protein acting to antagonize floor plate development as well as to promote notochord development...
  5. ncbi request reprint Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants
    M E Halpern
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Development 121:4257-64. 1995
    ..Our results suggest that wild-type floating head provides an essential step in maintaining, rather than initiating, development of notochord-forming axial mesoderm...
  6. ncbi request reprint A homeobox gene essential for zebrafish notochord development
    W S Talbot
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Nature 378:150-7. 1995
    ..We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate...
  7. ncbi request reprint Zebrafish hox clusters and vertebrate genome evolution
    A Amores
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Science 282:1711-4. 1998
    ..Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis...
  8. ncbi request reprint Ectopic expression of hoxb2 after retinoic acid treatment or mRNA injection: disruption of hindbrain and craniofacial morphogenesis in zebrafish embryos
    Y L Yan
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Dev Dyn 213:370-85. 1998
    ..The results suggest that hoxb2 plays an important role in the patterning of hindbrain and pharyngeal arches in the zebrafish...
  9. ncbi request reprint Mutant rescue by BAC clone injection in zebrafish
    Y L Yan
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Genomics 50:287-9. 1998
    ..We conclude that the injection of large-insert genomic clones will speed the isolation of zebrafish genes disrupted by mutation and hence the identification of gene functions necessary for development of vertebrate embryos...
  10. ncbi request reprint Expression of a type II collagen gene in the zebrafish embryonic axis
    Y L Yan
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Dev Dyn 203:363-76. 1995
    ....
  11. pmc Centromere-linkage analysis and consolidation of the zebrafish genetic map
    S L Johnson
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Genetics 142:1277-88. 1996
    ..This work makes possible centromere-linkage analysis, a novel, rapid method to assign mutations to a specific linkage group using half-tetrads...
  12. doi request reprint The zebrafish genome: a review and msx gene case study
    J H Postlethwait
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    Genome Dyn 2:183-97. 2006
    ..Genomic analysis suggests orthologs for this difficult to understand group of paralogs...
  13. ncbi request reprint Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas
    C Thisse
    Institute of Molecular Biology, University of Oregon, Eugene 97403
    Dev Biol 164:420-9. 1994
    ..We propose that in the gastrula head, goosecoid may be important in organizing the ventral neurectoderm...
  14. ncbi request reprint Zebrafish smoothened functions in ventral neural tube specification and axon tract formation
    Z M Varga
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Development 128:3497-509. 2001
    ..We propose that smoothened is required for induction of lateral floor plate and a subpopulation of hypothalamic cells and for maintenance of medial floor plate and hypothalamic cells...
  15. ncbi request reprint MeV-ion microprobe analyses of whole Drosophila suggest that zinc and copper accumulation is regulated storage not deposit excretion
    R M Schofield
    Department of Physics, University of Oregon, Eugene, OR 97403, USA
    J Exp Biol 200:3235-43. 1997
    ..For these reasons, we suggest that regulated biological availability, not detoxification, may be the primary benefit of zinc and copper storage...
  16. ncbi request reprint Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos
    C Thisse
    Institute of Molecular Biology, University of Oregon, Eugene 97403
    Development 119:1203-15. 1993
    ..The work presented here suggests that snail1 is involved in morphogenetic events during gastrulation, somitogenesis and development of the cephalic neural crest, and that no tail may act as a positive regulator of snail1...
  17. ncbi request reprint Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis
    A C Oates
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia
    Blood 94:2622-36. 1999
    ..Taken together with recent gene knockout data in the mouse, we suggest that jak2a may be functionally equivalent to mammalian Jak2, with a role in early erythropoiesis...
  18. pmc Radiation hybrid mapping of the zebrafish genome
    N A Hukriede
    Laboratory of Molecular Genetics and Unit on Biological Computation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:9745-50. 1999
    ..Mapping expressed sequence tags and cloned genes by using the LN54 panel should prove to be a valuable method for the identification of candidate genes for specific mutations in zebrafish...
  19. ncbi request reprint Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily
    A J Davidson
    Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand
    Genome Res 9:121-9. 1999
    ..Portions of LG16 and LG19 appear to be duplicate chromosomes, thus suggesting that radar and dynamo are both orthologs of Gdf6. Finally, the mapping data is consistent with contact being the zebrafish ortholog of mammalian GDF5/Gdf5...
  20. ncbi request reprint Expression of snail2, a second member of the zebrafish snail family, in cephalic mesendoderm and presumptive neural crest of wild-type and spadetail mutant embryos
    C Thisse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, Illkirch, C U de Strasbourg, France
    Dev Biol 172:86-99. 1995
    ....
  21. ncbi request reprint Uneven evolutionary rates of bradykinin B1 and B2 receptors in vertebrate lineages
    T Bromée
    Department of Neuroscience, Pharmacology, Uppsala University, P O Box 593, SE 751 24 Uppsala, Sweden
    Gene 373:100-8. 2006
    ..In conclusion, the receptor tandem duplication predates the divergence of ray-finned fish and tetrapods and no additional duplicates of the receptors or bradykinin seem to have survived the ray-finned fish tetraploidization...
  22. ncbi request reprint Assignment of zebrafish genetic linkage groups to chromosomes
    R B Phillips
    Department of Biological Sciences, Washington State University, Vancouver 98686 9600, USA
    Cytogenet Genome Res 114:155-62. 2006
    ..However, these duplicate linkage groups are not associated with chromosomes of similar size or morphology. This suggests that considerable chromosome restructuring occurred subsequent to the genome duplication in teleosts...
  23. ncbi request reprint Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula
    V Willot
    U 368 INSERM, Ecole Normale Superieure, 46 rue d Ulm, Paris, 75005, France
    Dev Biol 241:59-78. 2002
    ....
  24. ncbi request reprint In situ hybridization screen in zebrafish for the selection of genes encoding secreted proteins
    P S Crosier
    Division of Molecular Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Dev Dyn 222:637-44. 2001
    ....
  25. pmc Genetic analysis of chromosomal rearrangements in the cyclops region of the zebrafish genome
    W S Talbot
    Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Genetics 148:373-80. 1998
    ..These results show that chromosomal rearrangements can provide useful resources for mapping and genetic analyses in zebrafish...
  26. ncbi request reprint The zebrafish klf gene family
    A C Oates
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia
    Blood 98:1792-801. 2001
    ..These findings further the understanding of the KLF genes in vertebrate development and indicate an ancient role in hematopoiesis for the Krüppel-like factor gene family...
  27. pmc The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in the zebrafish, Danio rerio
    S J Rajarao
    Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Genome Res 11:1211-20. 2001
    ..Our studies form a framework for analyzing structure function relationships for sodium pump isoforms using reverse genetic approaches...
  28. ncbi request reprint Functional characterization and genetic mapping of alk8
    T L Payne
    Department of Cytokine Biology and Harvard Forsyth Department of Oral Biology, The Forsyth Institute, Boston, MA 02115, USA
    Mech Dev 100:275-89. 2001
    ..Altogether, these functional, gene mapping and phylogenetic analyses suggest that alk8 may be the zebrafish orthologue to human ACVRI (alk2), and therefore extend previous studies of Alk2 conducted in Xenopus...
  29. pmc Sequence homologies among the three yolk polypeptide (Yp) genes in Drosophila melanogaster
    Y L Yan
    Nucleic Acids Res 15:67-85. 1987
    ..These results identify sequences to mutate in order to define elements that regulate Yp gene expression and govern YP polypeptide function...
  30. ncbi request reprint The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis
    M A Thompson
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    Dev Biol 197:248-69. 1998
    ..These studies demonstrate that the molecular mechanisms that regulate hematopoiesis and vasculogenesis have been conserved throughout vertebrate evolution and the clo and spt genes are key regulators of these programs...
  31. pmc SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish
    E C Liao
    Division of Hematology Oncology, Children s Hospital, Department of Pediatrics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 12:621-6. 1998
    ..Forced expression of SCL in clo embryos rescues the blood and vascular defects, suggesting that SCL acts downstream of clo to specify hematopoietic and vascular differentiation...
  32. ncbi request reprint Regulation of acid phosphatase activity in the ovary of Drosophila melanogaster
    J H Postlethwait
    Dev Biol 47:196-205. 1975