Edward Postlethwait

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Scavenger receptors clear the air
    Edward M Postlethwait
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    J Clin Invest 117:601-4. 2007
  2. pmc Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter
    Praveen K Vayalil
    Dept of Environmental Health Sciences, School of Public Health, Univ of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1281-92. 2007
  3. pmc Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implications
    Giuseppe L Squadrito
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Am J Physiol Lung Cell Mol Physiol 299:L289-300. 2010
  4. pmc Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts
    Rui Ming Liu
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:16239-47. 2010
  5. pmc On the hydrophobicity of nitrogen dioxide: could there be a "lens" effect for NO(2) reaction kinetics?
    Giuseppe L Squadrito
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Nitric Oxide 21:104-9. 2009
  6. pmc Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite
    Amit K Yadav
    Departments of Environmental Health Sciences, Schools of Public Health and Medicine, University of Alabama at Birmingham, USA
    Am J Physiol Lung Cell Mol Physiol 300:L362-9. 2011
  7. ncbi request reprint Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen
    Praveen K Vayalil
    Dept of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Physiol Lung Cell Mol Physiol 289:L937-45. 2005
  8. pmc Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis
    Gin C Chuang
    Department of Pathology, University of Alabama at Birmingham, USA
    Am J Physiol Lung Cell Mol Physiol 297:L209-16. 2009
  9. ncbi request reprint Antioxidant-mediated augmentation of ozone-induced membrane oxidation
    Carol A Ballinger
    Department of Environmental Health Sciences, School of Public Health, RBPH 530, 1530 3rd Avenue South, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Free Radic Biol Med 38:515-26. 2005
  10. ncbi request reprint Prenatal environmental tobacco smoke exposure promotes adult atherogenesis and mitochondrial damage in apolipoprotein E-/- mice fed a chow diet
    Zhen Yang
    Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, AL, USA
    Circulation 110:3715-20. 2004

Research Grants

  1. Mechanisms of Species-Dependent Environmental Lung Injury
    Edward Postlethwait; Fiscal Year: 2007
  2. Surface Lining Layer-Dependent Oxidant Lung Injury
    Edward Postlethwait; Fiscal Year: 2006
  3. LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURY
    Edward Postlethwait; Fiscal Year: 2003

Collaborators

Detail Information

Publications13

  1. pmc Scavenger receptors clear the air
    Edward M Postlethwait
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    J Clin Invest 117:601-4. 2007
    ..Further investigations to elucidate more precise mechanisms and to determine the influence of SRs on airway epithelial injury, repair, and remodeling are warranted...
  2. pmc Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter
    Praveen K Vayalil
    Dept of Environmental Health Sciences, School of Public Health, Univ of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1281-92. 2007
    ....
  3. pmc Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implications
    Giuseppe L Squadrito
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Am J Physiol Lung Cell Mol Physiol 299:L289-300. 2010
    ....
  4. pmc Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts
    Rui Ming Liu
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:16239-47. 2010
    ..Our data suggest that increased generation of ROS by Nox4 mediates TGF-beta1-induced PAI-1 gene expression at least in part through oxidative modification and inhibition of MKP-1 leading to a sustained activation of JNK and p38 MAPKs...
  5. pmc On the hydrophobicity of nitrogen dioxide: could there be a "lens" effect for NO(2) reaction kinetics?
    Giuseppe L Squadrito
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Nitric Oxide 21:104-9. 2009
    ..In comparison to other gases, nitrogen dioxide is less hydrophobic than NO, O(2) and N(2)...
  6. pmc Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite
    Amit K Yadav
    Departments of Environmental Health Sciences, Schools of Public Health and Medicine, University of Alabama at Birmingham, USA
    Am J Physiol Lung Cell Mol Physiol 300:L362-9. 2011
    ..F(2)-isoprostane levels increased at 6 and 24 h after Cl(2) exposure in NO(2)(-)- and saline-injected rats. This is the first demonstration that systemic NO(2)(-) administration mitigates airway and epithelial injury...
  7. ncbi request reprint Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen
    Praveen K Vayalil
    Dept of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Physiol Lung Cell Mol Physiol 289:L937-45. 2005
    ..This study provides mechanistic evidence for GSH's putative therapeutic effect in the treatment of fibrotic disorders...
  8. pmc Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis
    Gin C Chuang
    Department of Pathology, University of Alabama at Birmingham, USA
    Am J Physiol Lung Cell Mol Physiol 297:L209-16. 2009
    ..Consequently, inhaled ozone, in the absence of other environmental toxicants, promotes increased vascular dysfunction, oxidative stress, mitochondrial damage, and atherogenesis...
  9. ncbi request reprint Antioxidant-mediated augmentation of ozone-induced membrane oxidation
    Carol A Ballinger
    Department of Environmental Health Sciences, School of Public Health, RBPH 530, 1530 3rd Avenue South, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Free Radic Biol Med 38:515-26. 2005
    ....
  10. ncbi request reprint Prenatal environmental tobacco smoke exposure promotes adult atherogenesis and mitochondrial damage in apolipoprotein E-/- mice fed a chow diet
    Zhen Yang
    Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, AL, USA
    Circulation 110:3715-20. 2004
    ..We hypothesized that in utero ETS exposure promotes adult atherosclerotic lesion formation and mitochondrial damage...
  11. pmc Mechanisms and modification of chlorine-induced lung injury in animals
    Amit K Yadav
    Department of Anesthesiology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294, USA
    Proc Am Thorac Soc 7:278-83. 2010
    ..The clinical challenge is to deliver sufficient quantities of antioxidants noninvasively, after Cl(2) exposure, to decrease morbidity and mortality...
  12. ncbi request reprint Interfacial phospholipids inhibit ozone-reactive absorption-mediated cytotoxicity in vitro
    Lydia M Connor
    Department of Human Biological Chemistry, University of Texas Medical Branch, Galveston 77555, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1169-78. 2004
    ..Finally, because O(3) local dose and tissue damage likely correlate, we propose that interfacial phospholipids may modulate intrapulmonary distribution of inhaled O(3) and the extent of site-specific cell injury...
  13. ncbi request reprint Influence of epithelial lining fluid lipids on NO(2)-induced membrane oxidation and nitration
    Leonard W Velsor
    Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
    Free Radic Biol Med 34:720-33. 2003
    ....

Research Grants12

  1. Mechanisms of Species-Dependent Environmental Lung Injury
    Edward Postlethwait; Fiscal Year: 2007
    ..abstract_text> ..
  2. Surface Lining Layer-Dependent Oxidant Lung Injury
    Edward Postlethwait; Fiscal Year: 2006
    ..experiments will reveal new insights regarding the pathways of oxidant lung injury, especially related to the mechanisms that govern the magnitude of biological responses, and the potential to ameliorate lung injury ..
  3. LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURY
    Edward Postlethwait; Fiscal Year: 2003
    ....