Research Topics
| Edward PostlethwaitSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Detail Information
Publications
Scavenger receptors clear the airEdward M Postlethwait
Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
J Clin Invest 117:601-4. 2007..Further investigations to elucidate more precise mechanisms and to determine the influence of SRs on airway epithelial injury, repair, and remodeling are warranted...
Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoterPraveen K Vayalil
Dept of Environmental Health Sciences, School of Public Health, Univ of Alabama at Birmingham, Birmingham, AL 35294, USA
Am J Physiol Lung Cell Mol Physiol 293:L1281-92. 2007....- Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implicationsGiuseppe L Squadrito
Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Am J Physiol Lung Cell Mol Physiol 299:L289-300. 2010.... - Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblastsRui Ming Liu
Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 285:16239-47. 2010..Our data suggest that increased generation of ROS by Nox4 mediates TGF-beta1-induced PAI-1 gene expression at least in part through oxidative modification and inhibition of MKP-1 leading to a sustained activation of JNK and p38 MAPKs... - On the hydrophobicity of nitrogen dioxide: could there be a "lens" effect for NO(2) reaction kinetics?Giuseppe L Squadrito
Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
Nitric Oxide 21:104-9. 2009..In comparison to other gases, nitrogen dioxide is less hydrophobic than NO, O(2) and N(2)... - Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitriteAmit K Yadav
Departments of Environmental Health Sciences, Schools of Public Health and Medicine, University of Alabama at Birmingham, USA
Am J Physiol Lung Cell Mol Physiol 300:L362-9. 2011..F(2)-isoprostane levels increased at 6 and 24 h after Cl(2) exposure in NO(2)(-)- and saline-injected rats. This is the first demonstration that systemic NO(2)(-) administration mitigates airway and epithelial injury... - Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogenPraveen K Vayalil
Dept. of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Physiol Lung Cell Mol Physiol 289:L937-45. 2005..This study provides mechanistic evidence for GSH's putative therapeutic effect in the treatment of fibrotic disorders... - Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesisGin C Chuang
Department of Pathology, University of Alabama at Birmingham, USA
Am J Physiol Lung Cell Mol Physiol 297:L209-16. 2009..Consequently, inhaled ozone, in the absence of other environmental toxicants, promotes increased vascular dysfunction, oxidative stress, mitochondrial damage, and atherogenesis... - Antioxidant-mediated augmentation of ozone-induced membrane oxidationCarol A Ballinger
Department of Environmental Health Sciences, School of Public Health, RBPH 530, 1530 3rd Avenue South, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA
Free Radic Biol Med 38:515-26. 2005.... - Prenatal environmental tobacco smoke exposure promotes adult atherogenesis and mitochondrial damage in apolipoprotein E-/- mice fed a chow dietZhen Yang
Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, AL, USA
Circulation 110:3715-20. 2004..All parameters were significantly altered in male mice exposed in utero to ETS. CONCLUSIONS: These data support the hypothesis that prenatal ETS exposure is sufficient to promote adult cardiovascular disease development... - Mechanisms and modification of chlorine-induced lung injury in animalsAmit K Yadav
Department of Anesthesiology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294, USA
Proc Am Thorac Soc 7:278-83. 2010..The clinical challenge is to deliver sufficient quantities of antioxidants noninvasively, after Cl(2) exposure, to decrease morbidity and mortality... - Interfacial phospholipids inhibit ozone-reactive absorption-mediated cytotoxicity in vitroLydia M Connor
Department of Human Biological Chemistry, University of Texas Medical Branch, Galveston 77555, USA
Am J Physiol Lung Cell Mol Physiol 286:L1169-78. 2004..Finally, because O(3) local dose and tissue damage likely correlate, we propose that interfacial phospholipids may modulate intrapulmonary distribution of inhaled O(3) and the extent of site-specific cell injury... - Influence of epithelial lining fluid lipids on NO(2)-induced membrane oxidation and nitrationLeonard W Velsor
Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
Free Radic Biol Med 34:720-33. 2003....
Research Grants
- Mechanisms of Species-Dependent Environmental Lung InjuryEdward Postlethwait; Fiscal Year: 2007..abstract_text> ..
- Surface Lining Layer-Dependent Oxidant Lung InjuryEdward Postlethwait; Fiscal Year: 2006..experiments will reveal new insights regarding the pathways of oxidant lung injury, especially related to the mechanisms that govern the magnitude of biological responses, and the potential to ameliorate lung injury ..
- LUNG SURFACE ANTIOXIDANT KINETICS MEDIATE OXIDANT INJURYEdward Postlethwait; Fiscal Year: 2003....