Christine Posavad

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Long term persistence of herpes simplex virus-specific CD8+ CTL in persons with frequently recurring genital herpes
    C M Posavad
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 165:1146-52. 2000
  2. ncbi request reprint T cell immunity to herpes simplex viruses in seronegative subjects: silent infection or acquired immunity?
    Christine M Posavad
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98104, USA
    J Immunol 170:4380-8. 2003
  3. ncbi request reprint Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy
    Christine M Posavad
    Department of Laboratory Medicine, University of Washington, and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Infect Dis 190:693-6. 2004
  4. pmc Detailed characterization of T cell responses to herpes simplex virus-2 in immune seronegative persons
    Christine M Posavad
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    J Immunol 184:3250-9. 2010
  5. pmc Diversity of the CD8+ T-cell response to herpes simplex virus type 2 proteins among persons with genital herpes
    Nancy Hosken
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98109, USA
    J Virol 80:5509-15. 2006
  6. ncbi request reprint CTL are inactivated by herpes simplex virus-infected cells expressing a viral protein kinase
    Derek D Sloan
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 171:6733-41. 2003
  7. pmc Phase I study of a herpes simplex virus type 2 (HSV-2) DNA vaccine administered to healthy, HSV-2-seronegative adults by a needle-free injection system
    Ashok Cattamanchi
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Clin Vaccine Immunol 15:1638-43. 2008
  8. ncbi request reprint Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals
    Frank Struyf
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Infect Dis 185:36-44. 2002

Research Grants

  1. HSV-SERONEGATIVE PERSONS WITH AQUIRED IMMUNITY TO HSV
    Christine Posavad; Fiscal Year: 2002
  2. Human Resistance to Herpes Simplex Virus Infections
    Christine Posavad; Fiscal Year: 2005

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Long term persistence of herpes simplex virus-specific CD8+ CTL in persons with frequently recurring genital herpes
    C M Posavad
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 165:1146-52. 2000
    ..Thus, HSV recurs in the face of persistent CD8+ CTL with no evidence of clonal exhaustion or mutation of CTL epitopes as mechanisms of viral persistence...
  2. ncbi request reprint T cell immunity to herpes simplex viruses in seronegative subjects: silent infection or acquired immunity?
    Christine M Posavad
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98104, USA
    J Immunol 170:4380-8. 2003
    ..Understanding the basis of these acquired immune responses may be critical in developing effective vaccines for genital herpes...
  3. ncbi request reprint Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy
    Christine M Posavad
    Department of Laboratory Medicine, University of Washington, and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Infect Dis 190:693-6. 2004
    ..8% vs. 11.3% of days, respectively; P=.001). Thus, mucosal HSV shedding and HSV-2 reactivation were still frequent among treated subjects, even though HAART was associated with fewer days with HSV lesions...
  4. pmc Detailed characterization of T cell responses to herpes simplex virus-2 in immune seronegative persons
    Christine M Posavad
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    J Immunol 184:3250-9. 2010
    ..Understanding the mechanism(s) by which such responses are elicited may provide important insights in developing novel strategies for preventing acquisition of sexually acquired HSV-2...
  5. pmc Diversity of the CD8+ T-cell response to herpes simplex virus type 2 proteins among persons with genital herpes
    Nancy Hosken
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98109, USA
    J Virol 80:5509-15. 2006
    ..Whether this variability in the CD8(+) T-cell response within individuals is associated with the frequency of viral reactivation warrants further study...
  6. ncbi request reprint CTL are inactivated by herpes simplex virus-infected cells expressing a viral protein kinase
    Derek D Sloan
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 171:6733-41. 2003
    ..HSV-infected cells require the expression of U(S)3, a viral protein kinase, to transmit the inactivating signal. Elucidation of the molecular nature of this signaling pathway may allow targeted manipulation of CTL function...
  7. pmc Phase I study of a herpes simplex virus type 2 (HSV-2) DNA vaccine administered to healthy, HSV-2-seronegative adults by a needle-free injection system
    Ashok Cattamanchi
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Clin Vaccine Immunol 15:1638-43. 2008
    ..A DNA-based vaccination strategy against HSV-2 appears to be safe and may generate a vaccine-specific cellular immune response, but high vaccine doses are likely needed to elicit an immune response in most vaccinees...
  8. ncbi request reprint Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals
    Frank Struyf
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Infect Dis 185:36-44. 2002
    ....

Research Grants5

  1. HSV-SERONEGATIVE PERSONS WITH AQUIRED IMMUNITY TO HSV
    Christine Posavad; Fiscal Year: 2002
    ..abstract_text> ..
  2. Human Resistance to Herpes Simplex Virus Infections
    Christine Posavad; Fiscal Year: 2005
    ..The data generated will be relevant to designing and evaluating strategies for HSV-2 preventative vaccines and immunotherapy. ..