Michael Portman

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Kawasaki disease and soy: potential role for isoflavone interaction with Fcγ receptors
    Michael A Portman
    Division of Cardiology, Department of Pediatrics, University of Washington, Seattle, Washington, USA
    Pediatr Res 73:130-4. 2013
  2. doi request reprint Etanercept as adjunctive treatment for acute Kawasaki disease: study design and rationale
    Michael A Portman
    Seattle Children s Hospital, WA 98101, USA
    Am Heart J 161:494-9. 2011
  3. doi request reprint Thyroid hormone regulation of heart metabolism
    Michael A Portman
    Department of Cardiology, Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Washington 98105, USA
    Thyroid 18:217-25. 2008
  4. ncbi request reprint The Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study: design and rationale
    Michael A Portman
    Division of Cardiology, Department of Pediatrics, Children s Hospital and Regional Medical Center, Seattle, Wash 98105, USA
    Am Heart J 148:393-8. 2004
  5. ncbi request reprint Direct action of T3 on phosphorylation potential in the sheep heart in vivo
    Michael A Portman
    Division of Cardiology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Wahington 98105, USA
    Am J Physiol Heart Circ Physiol 288:H2484-90. 2005
  6. pmc Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis
    Michael A Portman
    Seattle Children s Research Hospital and University of Washington, Seattle, WA 98101, USA
    Circulation 122:S224-33. 2010
  7. doi request reprint Thyroid hormone regulation of perinatal cardiovascular function
    Michael A Portman
    Division of Cardiology, University of Washington, Seattle, WA, USA
    Semin Perinatol 32:419-22. 2008
  8. ncbi request reprint Thyroid hormone interacts with PPARalpha and PGC-1 during mitochondrial maturation in sheep heart
    Timothy D McClure
    University of Washington, School of Medicine, and Children s Hospital and Regional Medical Center W4841, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Am J Physiol Heart Circ Physiol 289:H2258-64. 2005
  9. ncbi request reprint Moderate hypothermia (30 degrees C) maintains myocardial integrity and modifies response of cell survival proteins after reperfusion
    Xue Han Ning
    Pediatric Cardiology, Univ of Washington, CHRMC W4841, 4800 Sand Point Way NE, Seattle, WA 98105 0371, USA
    Am J Physiol Heart Circ Physiol 293:H2119-28. 2007
  10. ncbi request reprint Thyroid hormone controls myocardial substrate metabolism through nuclear receptor-mediated and rapid posttranscriptional mechanisms
    Outi M Hyyti
    Division of Cardiology, Department of Pediatrics, University of Washington, Seattle, USA
    Am J Physiol Endocrinol Metab 290:E372-9. 2006

Research Grants

  1. Triostat in Children During CPB
    Michael Portman; Fiscal Year: 2007
  2. FcR Mutations in Kawasaki Disease
    Michael Portman; Fiscal Year: 2007
  3. Etanercept for Acute Kawasaki Disease IND 101,223
    Michael A Portman; Fiscal Year: 2010
  4. Metabolism During Mechanical Circulatory Support in the Developing Heart
    Michael A Portman; Fiscal Year: 2010
  5. UW Stipends for Training Aspiring Researchers (STAR)
    Michael Portman; Fiscal Year: 2007
  6. Triostat in Children During CPB
    Michael Portman; Fiscal Year: 2005
  7. THYROID REGULATION IN DEVELOPING HEART
    Michael Portman; Fiscal Year: 2001
  8. Thyroid Regulation in the Developing Heart
    Michael Portman; Fiscal Year: 2006
  9. Metabolism During Mechanical Circulatory Support in the Developing Heart
    Michael A Portman; Fiscal Year: 2010

Collaborators

Detail Information

Publications21

  1. doi request reprint Kawasaki disease and soy: potential role for isoflavone interaction with Fcγ receptors
    Michael A Portman
    Division of Cardiology, Department of Pediatrics, University of Washington, Seattle, Washington, USA
    Pediatr Res 73:130-4. 2013
    ..These observations form the basis of a hypothesis: isoflavones participate in KD pathogenesis by modulating function of the FcGRs and by disrupting the balance between activation and inhibition of the inflammatory response...
  2. doi request reprint Etanercept as adjunctive treatment for acute Kawasaki disease: study design and rationale
    Michael A Portman
    Seattle Children s Hospital, WA 98101, USA
    Am Heart J 161:494-9. 2011
    ..Patients, refractory to standard treatment with intravenous immunoglobulin and aspirin, show higher rates of coronary artery dilation. Early tumor necrosis factor α receptor antagonism in KD may provide effective adjunctive therapy...
  3. doi request reprint Thyroid hormone regulation of heart metabolism
    Michael A Portman
    Department of Cardiology, Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Washington 98105, USA
    Thyroid 18:217-25. 2008
    ..Finally, thyroid through ligand binding may play a direct role in transactivation of mitochondrial DNA. This review will explore these newly identified modes of thyroid action on metabolism in heart...
  4. ncbi request reprint The Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study: design and rationale
    Michael A Portman
    Division of Cardiology, Department of Pediatrics, Children s Hospital and Regional Medical Center, Seattle, Wash 98105, USA
    Am Heart J 148:393-8. 2004
    ..A double-blind, randomized, placebo-controlled trial is needed to define clinical safety and efficacy of triiodothyronine supplementation in infants...
  5. ncbi request reprint Direct action of T3 on phosphorylation potential in the sheep heart in vivo
    Michael A Portman
    Division of Cardiology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Wahington 98105, USA
    Am J Physiol Heart Circ Physiol 288:H2484-90. 2005
    ..These T3-induced effects are not due to changes in ADP/ATP exchange efficiency through action at the adenine nucleotide translocator but may be due to T3 mediation of substrate utilization, confirmed in other models...
  6. pmc Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis
    Michael A Portman
    Seattle Children s Research Hospital and University of Washington, Seattle, WA 98101, USA
    Circulation 122:S224-33. 2010
    ..We tested the primary hypothesis that triiodothyronine (T3) repletion is safe in this population and produces improvements in postoperative clinical outcome...
  7. doi request reprint Thyroid hormone regulation of perinatal cardiovascular function
    Michael A Portman
    Division of Cardiology, University of Washington, Seattle, WA, USA
    Semin Perinatol 32:419-22. 2008
    ..Thyroid hormone plays an important role in regulating cardiovascular function during the transition to extrauterine physiology. Multiple mechanisms participate, ranging from transcriptional to more immediate nongenomic modes of regulation...
  8. ncbi request reprint Thyroid hormone interacts with PPARalpha and PGC-1 during mitochondrial maturation in sheep heart
    Timothy D McClure
    University of Washington, School of Medicine, and Children s Hospital and Regional Medical Center W4841, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Am J Physiol Heart Circ Physiol 289:H2258-64. 2005
    ..Also, the paradoxical expression pattern between mRNA and protein, particularly for PGC-1, suggests a feedback control mechanism...
  9. ncbi request reprint Moderate hypothermia (30 degrees C) maintains myocardial integrity and modifies response of cell survival proteins after reperfusion
    Xue Han Ning
    Pediatric Cardiology, Univ of Washington, CHRMC W4841, 4800 Sand Point Way NE, Seattle, WA 98105 0371, USA
    Am J Physiol Heart Circ Physiol 293:H2119-28. 2007
    ..These data also show that 34 degrees C proffers less protection and loss of myocardial integrity...
  10. ncbi request reprint Thyroid hormone controls myocardial substrate metabolism through nuclear receptor-mediated and rapid posttranscriptional mechanisms
    Outi M Hyyti
    Division of Cardiology, Department of Pediatrics, University of Washington, Seattle, USA
    Am J Physiol Endocrinol Metab 290:E372-9. 2006
    ..T3 also moderates forward glutamine flux, possibly by increasing the overall activity of GS...
  11. ncbi request reprint Hypothermia preserves myocardial function and mitochondrial protein gene expression during hypoxia
    Xue Han Ning
    Division of Cardiology, University of Washington Medical Center, Seattle, WA 98195 6320, USA
    Am J Physiol Heart Circ Physiol 285:H212-9. 2003
    ..In conclusion, hypothermia preserves cardiac function after hypoxia in the hypoxic high-CF model. Thus hypothermic protection does not occur exclusively through cold-induced alterations in anaerobic metabolism...
  12. ncbi request reprint Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNA
    Fionnuala Morrish
    Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Mitochondrion 6:143-8. 2006
    ..Thus, TRalpha isoforms may directly regulate T(3) responses at mtDNA in the heart...
  13. pmc Superior cardiac function via anaplerotic pyruvate in the immature swine heart after cardiopulmonary bypass and reperfusion
    Aaron K Olson
    Department of Pediatrics, University of Washington, Children s Hospital and Regional Medical Center, MSW 4841, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Am J Physiol Heart Circ Physiol 295:H2315-20. 2008
    ..These data show that robust PC operates in the neonatal pig heart and is maintained during reperfusion under conditions that emulate CPB and reperfusion in human infants...
  14. ncbi request reprint Molecular mechanisms of cross-talk between thyroid hormone and peroxisome proliferator activated receptors: focus on the heart
    Outi M Hyyti
    Division of Cardiology, Department of Pediatrics, Childrens Hospital and Regional Medical Center, 4800 Sandpoint Way NE, 4G 1, Seattle, WA 98105, USA
    Cardiovasc Drugs Ther 20:463-9. 2006
    ..We review here the fundamental ways TRs and PPARs are regulated and how their cross-talk patterns mediate transcription of their target genes...
  15. pmc Cardioselective dominant-negative thyroid hormone receptor (Delta337T) modulates myocardial metabolism and contractile efficiency
    Outi M Hyyti
    Children s Hospital and Regional Medical Center MSW 4841, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Am J Physiol Endocrinol Metab 295:E420-7. 2008
    ..Some of these changes are heart rate dependent, indicating that the substrate shift may represent an accommodation to altered contractile protein kinetics, which can be disrupted by pacing stress...
  16. ncbi request reprint Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis
    Xue Han Ning
    Division of Cardiology, Department of Pediatrics, University of Washington, Seattle 98195, USA
    J Appl Physiol 92:2200-7. 2002
    ..These data imply that hypothermia modifies signaling pathways for apoptosis and suggest possible mechanisms for hypothermia-induced myocardial protection...
  17. ncbi request reprint Short-cycle hypoxia in the intact heart: hypoxia-inducible factor 1alpha signaling and the relationship to injury threshold
    Xue Han Ning
    Cardiology MS W4841, Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Am J Physiol Heart Circ Physiol 292:H333-41. 2007
    ..Posttranscriptional suppression of these proteins occurs under conditions of altered energy state, exemplified by ATP depletion...
  18. pmc Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice
    Outi M Hyyti
    Division of Cardiology and Department of Pediatrics, University of Washington, and Seattle Children s Hospital Research Institute, Center for Developmental Therapeutics, Seattle, Washington, USA
    Am J Physiol Heart Circ Physiol 299:H868-75. 2010
    ..However, fatty acid oxidation capacity is limited. Impaired insulin-stimulated anaplerosis may contribute to elevated cardiac efficiency, but may also limit response to acute stress through depletion of CAC intermediates...
  19. ncbi request reprint The adenine nucleotide translocator: regulation and function during myocardial development and hypertrophy
    Michael A Portman
    Division of Cardiology, Department of Pediatrics, University of Washington School of Medicine and Children s Hospital and Medical Center, Seattle, Washington, USA
    Clin Exp Pharmacol Physiol 29:334-8. 2002
    ..Thus, ANT deficits and alterations in mitochondrial respiratory function may contribute to the pathogenesis of myocardial remodelling and heart failure...
  20. ncbi request reprint The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart
    Norman E Buroker
    Division of Cardiology, Children s Hospital and Regional Medical Center, 4800 Sand Point Way N E, Seattle, WA 98105, USA
    Am J Physiol Endocrinol Metab 292:E453-60. 2007
    ..These results indicate that therapeutic response to PPARalpha ligands may be determined by thyroid hormone state and TR function...
  21. ncbi request reprint Effect of triiodothyronine on gene transcription during cardiopulmonary bypass in infants with ventricular septal defect
    Sara Danzi
    Division of Endocrinology, Department of Medicine, North Shore University Hospital New York University School of Medicine, Manhasset, New York, USA
    Am J Cardiol 95:787-9. 2005
    ..To our knowledge, a novel heteronuclear assay demonstrated for the first time in human heart that rapid change in T3 levels altered the adenine nucleotide translocase-1 transcription rate during cardiopulmonary bypass...

Research Grants21

  1. Triostat in Children During CPB
    Michael Portman; Fiscal Year: 2007
    ....
  2. FcR Mutations in Kawasaki Disease
    Michael Portman; Fiscal Year: 2007
    ....
  3. Etanercept for Acute Kawasaki Disease IND 101,223
    Michael A Portman; Fiscal Year: 2010
    ..To test this hypothesis a double-blinded placebo controlled trial in 220 children with KD will be performed and data will be obtained in order to achieve an orphan designation for etanercept. ..
  4. Metabolism During Mechanical Circulatory Support in the Developing Heart
    Michael A Portman; Fiscal Year: 2010
    ..In particular, we will examine how thyroid hormone influences how the heart generates and uses important energy molecules. ..
  5. UW Stipends for Training Aspiring Researchers (STAR)
    Michael Portman; Fiscal Year: 2007
    ..increasing the numbers of underrepresented minority investigators involved in heart, lung, blood, and sleep disorder research. ..
  6. Triostat in Children During CPB
    Michael Portman; Fiscal Year: 2005
    ..Abstract Not Provided. ..
  7. THYROID REGULATION IN DEVELOPING HEART
    Michael Portman; Fiscal Year: 2001
    ....
  8. Thyroid Regulation in the Developing Heart
    Michael Portman; Fiscal Year: 2006
    ..b. Determine if TH deficiency caused by CPB alters substrate utilization and triiodothyronine repletion reverses such alterations. ..
  9. Metabolism During Mechanical Circulatory Support in the Developing Heart
    Michael A Portman; Fiscal Year: 2010
    ..In particular, we will examine how thyroid hormone influences how the heart generates and uses important energy molecules. ..