Michael Portman

..Patients, refractory to standard treatment with intravenous immunoglobulin and aspirin, show higher rates of coronary artery dilation. Early tumor necrosis factor α receptor antagonism in KD may provide effective adjunctive therapy...

..Finally, thyroid through ligand binding may play a direct role in transactivation of mitochondrial DNA. This review will explore these newly identified modes of thyroid action on metabolism in heart...

..Thyroid hormone plays an important role in regulating cardiovascular function during the transition to extrauterine physiology. Multiple mechanisms participate, ranging from transcriptional to more immediate nongenomic modes of regulation...

..These T3-induced effects are not due to changes in ADP/ATP exchange efficiency through action at the adenine nucleotide translocator but may be due to T3 mediation of substrate utilization, confirmed in other models...

..A double-blind, randomized, placebo-controlled trial is needed to define clinical safety and efficacy of triiodothyronine supplementation in infants...

..We tested the primary hypothesis that triiodothyronine (T3) repletion is safe in this population and produces improvements in postoperative clinical outcome...

..Also, the paradoxical expression pattern between mRNA and protein, particularly for PGC-1, suggests a feedback control mechanism...

..These data also show that 34 degrees C proffers less protection and loss of myocardial integrity...

..T3 also moderates forward glutamine flux, possibly by increasing the overall activity of GS...

..In conclusion, hypothermia preserves cardiac function after hypoxia in the hypoxic high-CF model. Thus hypothermic protection does not occur exclusively through cold-induced alterations in anaerobic metabolism...

..Thus, TRalpha isoforms may directly regulate T(3) responses at mtDNA in the heart...

..Some of these changes are heart rate dependent, indicating that the substrate shift may represent an accommodation to altered contractile protein kinetics, which can be disrupted by pacing stress...

..We review here the fundamental ways TRs and PPARs are regulated and how their cross-talk patterns mediate transcription of their target genes...

..These data show that robust PC operates in the neonatal pig heart and is maintained during reperfusion under conditions that emulate CPB and reperfusion in human infants...

..These data imply that hypothermia modifies signaling pathways for apoptosis and suggest possible mechanisms for hypothermia-induced myocardial protection...

..Posttranscriptional suppression of these proteins occurs under conditions of altered energy state, exemplified by ATP depletion...

..However, fatty acid oxidation capacity is limited. Impaired insulin-stimulated anaplerosis may contribute to elevated cardiac efficiency, but may also limit response to acute stress through depletion of CAC intermediates...

..Thus, ANT deficits and alterations in mitochondrial respiratory function may contribute to the pathogenesis of myocardial remodelling and heart failure...

..These results indicate that therapeutic response to PPARalpha ligands may be determined by thyroid hormone state and TR function...

..To our knowledge, a novel heteronuclear assay demonstrated for the first time in human heart that rapid change in T3 levels altered the adenine nucleotide translocase-1 transcription rate during cardiopulmonary bypass...

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..To test this hypothesis a double-blinded placebo controlled trial in 220 children with KD will be performed and data will be obtained in order to achieve an orphan designation for etanercept. ..

..In particular, we will examine how thyroid hormone influences how the heart generates and uses important energy molecules. ..

..increasing the numbers of underrepresented minority investigators involved in heart, lung, blood, and sleep disorder research. ..

..Abstract Not Provided. ..

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..b. Determine if TH deficiency caused by CPB alters substrate utilization and triiodothyronine repletion reverses such alterations. ..

..In particular, we will examine how thyroid hormone influences how the heart generates and uses important energy molecules. ..