Douglas S Portman

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Sex differences in behavioral decision-making and the modulation of shared neural circuits
    William R Mowrey
    Center for Neural Development and Disease, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 645, Rochester, NY 14642, USA
    Biol Sex Differ 3:8. 2012
  2. ncbi request reprint Identification of C. elegans sensory ray genes using whole-genome expression profiling
    Douglas S Portman
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 270:499-512. 2004
  3. pmc A latent capacity of the C. elegans polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5
    Renee M Miller
    Center for Neural Development and Disease, University of Rochester, Rochester, NY 14642, USA
    Dis Model Mech 3:441-50. 2010
  4. pmc Distributed effects of biological sex define sex-typical motor behavior in Caenorhabditis elegans
    William R Mowrey
    Center for Neural Development and Disease, Department of Biomedical Genetics, and Department of Biology, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642
    J Neurosci 34:1579-91. 2014
  5. ncbi request reprint Neural sex modifies the function of a C. elegans sensory circuit
    KyungHwa Lee
    Interdepartmental Graduate Program in Neuroscience, University of Rochester, Rochester, New York 14642, USA
    Curr Biol 17:1858-63. 2007
  6. pmc The Wnt/beta-catenin asymmetry pathway patterns the atonal ortholog lin-32 to diversify cell fate in a Caenorhabditis elegans sensory lineage
    Renee M Miller
    Center for Neural Development and Disease, Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 31:13281-91. 2011
  7. ncbi request reprint dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans
    D Adam Mason
    Center for Neural Development and Disease, University of Rochester, Rochester, NY 14642, USA
    Development 135:2373-82. 2008
  8. ncbi request reprint Genetic control of sex differences in C. elegans neurobiology and behavior
    Douglas S Portman
    Department of Biomedical Genetics and Center for Aging and Developmental Biology, University of Rochester, Rochester, New York 14642, USA
    Adv Genet 59:1-37. 2007
  9. pmc Specific alpha- and beta-tubulin isotypes optimize the functions of sensory Cilia in Caenorhabditis elegans
    Daryl D Hurd
    Biology Department, St John Fisher College, Rochester, New York 14618, USA
    Genetics 185:883-96. 2010
  10. ncbi request reprint Toward the computable transcriptome
    Douglas S Portman
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Cell 14:693-4. 2004

Collaborators

Detail Information

Publications10

  1. pmc Sex differences in behavioral decision-making and the modulation of shared neural circuits
    William R Mowrey
    Center for Neural Development and Disease, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 645, Rochester, NY 14642, USA
    Biol Sex Differ 3:8. 2012
    ..As men and women differ in their susceptibility to a variety of neuropsychiatric disorders affecting shared behaviors, these findings may ultimately have important implications for human health...
  2. ncbi request reprint Identification of C. elegans sensory ray genes using whole-genome expression profiling
    Douglas S Portman
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 270:499-512. 2004
    ..Our strategy provides a complementary foundation for modeling the genetic network that controls the development of a simple sensory organ...
  3. pmc A latent capacity of the C. elegans polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5
    Renee M Miller
    Center for Neural Development and Disease, University of Rochester, Rochester, NY 14642, USA
    Dis Model Mech 3:441-50. 2010
    ..elegans polycystin signaling, demonstrates that the polycystins have a latent capacity to hinder sensory transduction, and suggests that aberrant functions of the polycystins could contribute to the pathogenesis of PKD...
  4. pmc Distributed effects of biological sex define sex-typical motor behavior in Caenorhabditis elegans
    William R Mowrey
    Center for Neural Development and Disease, Department of Biomedical Genetics, and Department of Biology, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642
    J Neurosci 34:1579-91. 2014
    ..Our results suggest shared motor behaviors may be sex-specifically optimized though distributed modifications to several aspects of morphology and physiology. ..
  5. ncbi request reprint Neural sex modifies the function of a C. elegans sensory circuit
    KyungHwa Lee
    Interdepartmental Graduate Program in Neuroscience, University of Rochester, Rochester, New York 14642, USA
    Curr Biol 17:1858-63. 2007
    ..elegans sensory behavior that is exhibited by both sexes. Our results indicate that these differences are a function of the chromosomally determined sexual identity of shared neural circuitry...
  6. pmc The Wnt/beta-catenin asymmetry pathway patterns the atonal ortholog lin-32 to diversify cell fate in a Caenorhabditis elegans sensory lineage
    Renee M Miller
    Center for Neural Development and Disease, Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 31:13281-91. 2011
    ..Moreover, they reveal a central role for the Wnt/β-catenin asymmetry pathway in patterning neural and glial fates in a simple sensory lineage...
  7. ncbi request reprint dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans
    D Adam Mason
    Center for Neural Development and Disease, University of Rochester, Rochester, NY 14642, USA
    Development 135:2373-82. 2008
    ..These findings indicate that an important conserved function of DM genes is to link the general sex determination hierarchy to specific effectors of differentiation and morphogenesis...
  8. ncbi request reprint Genetic control of sex differences in C. elegans neurobiology and behavior
    Douglas S Portman
    Department of Biomedical Genetics and Center for Aging and Developmental Biology, University of Rochester, Rochester, New York 14642, USA
    Adv Genet 59:1-37. 2007
    ..Continuing research into the genetic control of neural sex differences in C. elegans is likely to yield insight into conserved mechanisms of cell-autonomous cross talk between cell fate patterning and sexual differentiation pathways...
  9. pmc Specific alpha- and beta-tubulin isotypes optimize the functions of sensory Cilia in Caenorhabditis elegans
    Daryl D Hurd
    Biology Department, St John Fisher College, Rochester, New York 14618, USA
    Genetics 185:883-96. 2010
    ..While there is likely to be some functional redundancy among C. elegans tubulin genes, our results indicate that specific tubulins optimize the functional properties of C. elegans sensory cilia...
  10. ncbi request reprint Toward the computable transcriptome
    Douglas S Portman
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Cell 14:693-4. 2004
    ..elegans, an article in the latest Developmental Cell (Wenick and Hobert, 2004) gives hope that reading the genome's transcriptional regulatory code may one day be possible...