Carlos Portera-Cailliau

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Which comes first in fragile X syndrome, dendritic spine dysgenesis or defects in circuit plasticity?
    Carlos Portera-Cailliau
    Departments of Neurology and Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Neuroscientist 18:28-44. 2012
  2. pmc Diverse modes of axon elaboration in the developing neocortex
    Carlos Portera-Cailliau
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e272. 2005
  3. ncbi Movement disorders fellowship training program at Columbia University Medical Center in 2001-2002
    Carlos Portera-Cailliau
    Department of Neurology, Columbia University Medical Center, New York, New York, USA
    Mov Disord 21:479-85. 2006
  4. ncbi A familial form of pallidoluysionigral degeneration and amyotrophic lateral sclerosis with divergent clinical presentations
    Carlos Portera-Cailliau
    UCLA Department of Neurology, Reed Neurological Research Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    J Neuropathol Exp Neurol 66:650-9. 2007
  5. pmc Circuit level defects in the developing neocortex of Fragile X mice
    J Tiago Goncalves
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Nat Neurosci 16:903-9. 2013
  6. pmc Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning
    Seanna M Martin
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 137:3985-94. 2010
  7. doi Altered synaptic dynamics during normal brain aging
    Ricardo Mostany
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 33:4094-104. 2013
  8. doi Local hemodynamics dictate long-term dendritic plasticity in peri-infarct cortex
    Ricardo Mostany
    Departments of Neurology and Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:14116-26. 2010
  9. pmc Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice
    Alberto Cruz-Martín
    Department of Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e32446. 2012
  10. pmc Delayed stabilization of dendritic spines in fragile X mice
    Alberto Cruz-Martín
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:7793-803. 2010

Research Grants

Collaborators

Detail Information

Publications18

  1. doi Which comes first in fragile X syndrome, dendritic spine dysgenesis or defects in circuit plasticity?
    Carlos Portera-Cailliau
    Departments of Neurology and Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Neuroscientist 18:28-44. 2012
    ..The resulting data will be vital in guiding translational research that can identify novel molecular targets for therapy in this devastating disorder...
  2. pmc Diverse modes of axon elaboration in the developing neocortex
    Carlos Portera-Cailliau
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e272. 2005
    ..Given the identical layer 1 territory upon which CR and TC axons grow, the differences in their structure and dynamics likely reflect distinct intrinsic growth programs for axons of long projection neurons versus local interneurons...
  3. ncbi Movement disorders fellowship training program at Columbia University Medical Center in 2001-2002
    Carlos Portera-Cailliau
    Department of Neurology, Columbia University Medical Center, New York, New York, USA
    Mov Disord 21:479-85. 2006
    ..Video rounds allow greater exposure to uncommon diagnoses. Similar data from other movement disorder training programs are needed to help create guidelines for formal accreditation and to improve clinical training in this subspecialty...
  4. ncbi A familial form of pallidoluysionigral degeneration and amyotrophic lateral sclerosis with divergent clinical presentations
    Carlos Portera-Cailliau
    UCLA Department of Neurology, Reed Neurological Research Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    J Neuropathol Exp Neurol 66:650-9. 2007
    ..Thus, this disorder may represent a novel autosomal dominantly inherited and rapidly progressive neurodegenerative disorder with a spectrum of clinical presentations but common neuropathologic features...
  5. pmc Circuit level defects in the developing neocortex of Fragile X mice
    J Tiago Goncalves
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Nat Neurosci 16:903-9. 2013
    ..These state-dependent network defects could explain the intellectual, sleep and sensory integration dysfunctions associated with FXS. ..
  6. pmc Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning
    Seanna M Martin
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 137:3985-94. 2010
    ..We propose that spontaneously pruned fragments of peripheral sensory axons must be removed by a WD-like mechanism to permit efficient innervation of the epidermis...
  7. doi Altered synaptic dynamics during normal brain aging
    Ricardo Mostany
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 33:4094-104. 2013
    ..The changes we describe here likely result in weaker synapses that are less capable of short-term plasticity in aged individuals, and therefore to less efficient circuits...
  8. doi Local hemodynamics dictate long-term dendritic plasticity in peri-infarct cortex
    Ricardo Mostany
    Departments of Neurology and Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:14116-26. 2010
    ..Our data suggest that maintaining tissue perfusion in the area surrounding the infarct could hasten or augment synaptic plasticity and functional recovery after stroke...
  9. pmc Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice
    Alberto Cruz-Martín
    Department of Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e32446. 2012
    ..Thus, absence of FMRP may impair the ability of cortical pyramidal neurons to respond to glutamate released from nearby pre-synaptic terminals, which may be a critical step to initiate synaptogenesis and stabilize spines...
  10. pmc Delayed stabilization of dendritic spines in fragile X mice
    Alberto Cruz-Martín
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:7793-803. 2010
    ..Thus, absence of FMRP delays spine stabilization and dysregulated mGluR signaling in FXS may partially normalize this early synaptic defect...
  11. doi Absence of large-scale dendritic plasticity of layer 5 pyramidal neurons in peri-infarct cortex
    Ricardo Mostany
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Neurosci 31:1734-8. 2011
    ..These results help resolve a long-standing debate regarding the role of large-scale dendritic plasticity of pyramidal neurons in functional recovery after cortical injury...
  12. ncbi Activity-regulated dynamic behavior of early dendritic protrusions: evidence for different types of dendritic filopodia
    Carlos Portera-Cailliau
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurosci 23:7129-42. 2003
    ....
  13. pmc Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window
    Anthony Holtmaat
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA
    Nat Protoc 4:1128-44. 2009
    ..The entire dendritic and axonal arbor of individual neurons can be reconstructed...
  14. pmc Chronic in vivo imaging shows no evidence of dendritic plasticity or functional remapping in the contralesional cortex after stroke
    David G Johnston
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cereb Cortex 23:751-62. 2013
    ....
  15. pmc Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS
    David L Rousso
    Department of Neurobiology, David Geffen School of Medicine at UCLA, 610 Charles Young Drive East, Los Angeles, CA 90095, USA
    Neuron 74:314-30. 2012
    ..Together, these data reveal a Foxp-based transcriptional mechanism that regulates the integrity and cytoarchitecture of neuroepithelial progenitors...
  16. pmc Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing
    Adrian Cheng
    Department of Physics and Astronomy, University of California Los Angeles, Los Angeles, California, USA
    Nat Methods 8:139-42. 2011
    ..We demonstrate calcium imaging at multiple axial planes in the intact mouse brain to monitor network activity of ensembles of cortical neurons in three spatial dimensions...
  17. pmc Internally mediated developmental desynchronization of neocortical network activity
    PEYMAN GOLSHANI
    Departmens of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 29:10890-9. 2009
    ..Therefore, developmental desynchronization of spontaneous neuronal activity is a fundamental network transition in the neocortex that appears to be intrinsically generated...
  18. pmc Developmentally regulated impediments to skin reinnervation by injured peripheral sensory axon terminals
    Georgeann S O'Brien
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Curr Biol 19:2086-90. 2009
    ..Thus, as in the CNS, impediments to reinnervation in the PNS arise after initial establishment of axon arbor structure...

Research Grants6

  1. Imaging the origin of dendritic spine abnormalities in fragile X mice
    Carlos Portera Cailliau; Fiscal Year: 2007
    ..Because spine abnormalities are common to several other types of mental retardation and autism disorders, these studies are of broad clinical significance. ..
  2. Imaging the origin of dendritic spine abnormalities in fragile X mice
    Carlos Portera Cailliau; Fiscal Year: 2010
    ..Because spine abnormalities are common to several other types of mental retardation and autism disorders, these studies are of broad clinical significance. ..
  3. Imaging the origin of dendritic spine abnormalities in fragile X mice
    Carlos Portera Cailliau; Fiscal Year: 2010
    ..Because spine abnormalities are common to several other types of mental retardation and autism disorders, these studies are of broad clinical significance. ..