Patrizia Porcu

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, 3027 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychoneuroendocrinology 33:214-26. 2008
  2. ncbi request reprint Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis
    Patrizia Porcu
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 84:618-27. 2006
  3. pmc Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans
    Patrizia Porcu
    Department of Psychiatry and Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 34:432-42. 2010
  4. pmc Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis
    Kevin N Boyd
    Curriculum in Toxicology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Neurochem 112:784-96. 2010
  5. pmc The role of neuroactive steroids in ethanol/stress interactions: proceedings of symposium VII at the Volterra conference on alcohol and stress, May 2008
    A Leslie Morrow
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Alcohol 43:521-30. 2009
  6. pmc Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation
    Patrizia Porcu
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e18405. 2011
  7. pmc Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior
    A Leslie Morrow
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Dialogues Clin Neurosci 8:463-77. 2006
  8. ncbi request reprint Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7178, USA
    Psychopharmacology (Berl) 186:293-301. 2006
  9. pmc Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration
    Jason B Cook
    Bowles Center for Alcohol Studies, Curriculum in Neurobiology, Departments of Psychiatry and Pharmacology, and Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, Department of Psychology, Center for Development and Behavioral Neuroscience, Binghamton University State University of New York, Binghamton, New York 13902, and Institute of Neuroscience, National Research Council of Italy, 09129 Cagliari, Italy
    J Neurosci 34:5824-34. 2014
  10. pmc A history of depression in women is associated with an altered GABAergic neuroactive steroid profile
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Psychoneuroendocrinology 37:543-53. 2012

Collaborators

Detail Information

Publications17

  1. pmc Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, 3027 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychoneuroendocrinology 33:214-26. 2008
    ..Further, alcohol-dependent patients show a blunted PREG-S response to adrenal stimulation and a delayed deoxycorticosterone response to oCRH challenge...
  2. ncbi request reprint Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis
    Patrizia Porcu
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 84:618-27. 2006
    ..These data suggest that PREG responses to dexamethasone challenge may represent a trait marker of alcohol drinking. The lack of effect of ethanol on PREG levels suggests differential regulation in non-human primates vs. rodents...
  3. pmc Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans
    Patrizia Porcu
    Department of Psychiatry and Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 34:432-42. 2010
    ....
  4. pmc Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis
    Kevin N Boyd
    Curriculum in Toxicology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Neurochem 112:784-96. 2010
    ..As GABAergic steroids contribute to ethanol actions and ethanol sensitivity, the mechanisms of this effect of ethanol may be important factors that contribute to the behavioral actions of ethanol and risk for alcohol abuse disorders...
  5. pmc The role of neuroactive steroids in ethanol/stress interactions: proceedings of symposium VII at the Volterra conference on alcohol and stress, May 2008
    A Leslie Morrow
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Alcohol 43:521-30. 2009
    ..Professor Patrizia Porcu of the University of North Carolina, USA described a potential neuroactive steroid biomarker that may predict ..
  6. pmc Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation
    Patrizia Porcu
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e18405. 2011
    ..These steroids are elevated following stress or ethanol administration, contribute to ethanol sensitivity, and their elevation is blunted in ethanol dependence...
  7. pmc Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior
    A Leslie Morrow
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Dialogues Clin Neurosci 8:463-77. 2006
    ..Neurosteroids may have therapeutic use in alcohol withdrawal or for relapse prevention...
  8. ncbi request reprint Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7178, USA
    Psychopharmacology (Berl) 186:293-301. 2006
    ..However, little data are available for male nonhuman primates...
  9. pmc Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration
    Jason B Cook
    Bowles Center for Alcohol Studies, Curriculum in Neurobiology, Departments of Psychiatry and Pharmacology, and Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, Department of Psychology, Center for Development and Behavioral Neuroscience, Binghamton University State University of New York, Binghamton, New York 13902, and Institute of Neuroscience, National Research Council of Italy, 09129 Cagliari, Italy
    J Neurosci 34:5824-34. 2014
    ....
  10. pmc A history of depression in women is associated with an altered GABAergic neuroactive steroid profile
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Psychoneuroendocrinology 37:543-53. 2012
    ....
  11. pmc Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum
    Patrizia Porcu
    Department of Psychiatry and Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Steroids 74:463-73. 2009
    ..This method can be used to investigate the physiological and pathological role of neuroactive steroids and to develop biomarkers and new therapeutics for neurological and psychiatric disorders...
  12. pmc The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress
    Sandeep Kumar
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 205:529-64. 2009
    ....
  13. ncbi request reprint Neurosteroids in nicotine and morphine dependence
    Alessandra Concas
    Department of Experimental Biology, Center of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
    Psychopharmacology (Berl) 186:281-92. 2006
    ..The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties...
  14. ncbi request reprint Characterization of the discriminative stimulus effects of the neuroactive steroid pregnanolone in DBA/2J and C57BL/6J inbred mice
    Erin E Shannon
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    J Pharmacol Exp Ther 314:675-85. 2005
    ..The present data suggest that many of the previously documented neurosteroid-induced behavioral differences between the DBA/2J and C57BL/6J are acute effects and are not apparent in a drug discrimination procedure...
  15. ncbi request reprint Failure of gamma-hydroxybutyric acid both to increase neuroactive steroid concentrations in adrenalectomized-orchiectomized rats and to induce tolerance to its steroidogenic effect in intact animals
    Patrizia Porcu
    Department of Experimental Biology, Center of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
    Brain Res 1012:160-8. 2004
    ..These results indicate that repeated exposure to GHB fails to induce tolerance or cross-tolerance to the steroidogenic action of GHB or ethanol, respectively...
  16. ncbi request reprint Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands
    Andrea Cappelli
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via A Moro, 53100 Siena, Italy
    J Med Chem 46:3568-71. 2003
    ..Moreover, carborane derivative 3q, representing the first example of PBR ligand bearing a carborane cage, can be useful to explore an alternative mechanism in BNCT...
  17. ncbi request reprint Nicotine-induced changes in cerebrocortical neuroactive steroids and plasma corticosterone concentrations in the rat
    Patrizia Porcu
    Department of Experimental Biology, Center of Excellence for Neurobiology of Drug Dependence, University of Cagliari, Cagliari, Italy
    Pharmacol Biochem Behav 74:683-90. 2003
    ..These results suggest that the changes in emotional behavior elicited by nicotine, similar to those induced by stressful stimuli or other anxiogenic drugs, are associated with an increase in neuroactive steroids content of the brain...