Vittorio Porciatti

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Retinal ganglion cell functional plasticity and optic neuropathy: a comprehensive model
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Neuroophthalmol 32:354-8. 2012
  2. pmc Normative data for a user-friendly paradigm for pattern electroretinogram recording
    Vittorio Porciatti
    Bascom Palmer Eye Institute, Miami, Florida 33136, USA
    Ophthalmology 111:161-8. 2004
  3. pmc The mouse pattern electroretinogram
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Doc Ophthalmol 115:145-53. 2007
  4. pmc The pattern electroretinogram as a tool to monitor progressive retinal ganglion cell dysfunction in the DBA/2J mouse model of glaucoma
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 48:745-51. 2007
  5. pmc Physiologic significance of steady-state pattern electroretinogram losses in glaucoma: clues from simulation of abnormalities in normal subjects
    Vittorio Porciatti
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, 900 N W 17th Street, Miami, FL 33136, USA
    J Glaucoma 18:535-42. 2009
  6. pmc Head-up tilt lowers IOP and improves RGC dysfunction in glaucomatous DBA/2J mice
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136, USA
    Exp Eye Res 90:452-60. 2010
  7. pmc Habituation of retinal ganglion cell activity in response to steady state pattern visual stimuli in normal subjects
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 46:1296-302. 2005
  8. pmc Adaptive changes of inner retina function in response to sustained pattern stimulation
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900, N W 17th Street, Miami, FL 33136, USA
    Vision Res 49:505-13. 2009
  9. pmc C57BL/6J, DBA/2J, and DBA/2J.Gpnmb mice have different visual signal processing in the inner retina
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Mol Vis 16:2939-47. 2010
  10. pmc Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice
    Hong Yu
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, USA
    Mol Vis 18:1668-83. 2012

Research Grants

  1. RETINAL GANGLION CELL PLASTICITY IN GLAUCOMA
    Vittorio Porciatti; Fiscal Year: 2010
  2. Reversible Ganglion Cell Dysfunction in Glaucoma
    Vittorio Porciatti; Fiscal Year: 2010
  3. RETINAL GANGLION CELL PLASTICITY IN GLAUCOMA
    Vittorio Porciatti; Fiscal Year: 2009
  4. LIFE AND DEATH OF RETINAL GANGLION CELLS
    Vittorio Porciatti; Fiscal Year: 2007
  5. Reversible Ganglion Cell Dysfunction in Glaucoma
    Vittorio Porciatti; Fiscal Year: 2007
  6. Reversible Ganglion Cell Dysfunction in Glaucoma
    Vittorio Porciatti; Fiscal Year: 2005
  7. Reversible Ganglion Cell Dysfunction in Glaucoma
    Vittorio Porciatti; Fiscal Year: 2011

Collaborators

Detail Information

Publications42

  1. pmc Retinal ganglion cell functional plasticity and optic neuropathy: a comprehensive model
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Neuroophthalmol 32:354-8. 2012
    ..Identification and characterization of this stage of modifiable retinal ganglion cell function represents both a rationale and a target for treatment to change the natural history of the disease...
  2. pmc Normative data for a user-friendly paradigm for pattern electroretinogram recording
    Vittorio Porciatti
    Bascom Palmer Eye Institute, Miami, Florida 33136, USA
    Ophthalmology 111:161-8. 2004
    ..To provide normative data for a user-friendly paradigm for the pattern electroretinogram (PERG) optimized for glaucoma screening (PERGLA)...
  3. pmc The mouse pattern electroretinogram
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Doc Ophthalmol 115:145-53. 2007
    ..While the use of the PERG as a tool to probe inner retina function in mammals is known since 25 years, relatively less information is available for the mouse. Here, the PERG technique and the main applications in the mouse are reviewed...
  4. pmc The pattern electroretinogram as a tool to monitor progressive retinal ganglion cell dysfunction in the DBA/2J mouse model of glaucoma
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 48:745-51. 2007
    ....
  5. pmc Physiologic significance of steady-state pattern electroretinogram losses in glaucoma: clues from simulation of abnormalities in normal subjects
    Vittorio Porciatti
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, 900 N W 17th Street, Miami, FL 33136, USA
    J Glaucoma 18:535-42. 2009
    ..To better understand pathophysiologic mechanisms underlying pattern electroretinogram (PERG) losses in glaucoma by simulating either retinal ganglion cell (RGC) dysfunction or RGC loss in normal subjects...
  6. pmc Head-up tilt lowers IOP and improves RGC dysfunction in glaucomatous DBA/2J mice
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136, USA
    Exp Eye Res 90:452-60. 2010
    ..The head-up IOP/PERG protocol may represent a non-invasive way to probe the potential for recovery of RGC dysfunction in D2 mice...
  7. pmc Habituation of retinal ganglion cell activity in response to steady state pattern visual stimuli in normal subjects
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 46:1296-302. 2005
    ..To evaluate autoregulatory changes of retinal ganglion cell (RGC) activity, as measured by the pattern electroretinogram (PERG), when the eye is exposed to a steady state presentation of stimuli that maximize PERG amplitude and blood flow...
  8. pmc Adaptive changes of inner retina function in response to sustained pattern stimulation
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900, N W 17th Street, Miami, FL 33136, USA
    Vision Res 49:505-13. 2009
    ..An energy-budget model of neural-vascular-glial interaction is provided together with an equivalent electrical circuit that accounts for the results...
  9. pmc C57BL/6J, DBA/2J, and DBA/2J.Gpnmb mice have different visual signal processing in the inner retina
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Mol Vis 16:2939-47. 2010
    ..DBA/2J.Gpnmb(+) (D2.Gpnmb(+)) is the wild type for the Gpnmb mutation and does not develop IOP elevation and glaucoma...
  10. pmc Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice
    Hong Yu
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, USA
    Mol Vis 18:1668-83. 2012
    ....
  11. pmc Induction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus
    Rajeshwari D Koilkonda
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Ave, Miami, FL 33136, USA
    Arch Ophthalmol 128:876-83. 2010
    ....
  12. pmc Longitudinal evaluation of retinal ganglion cell function and IOP in the DBA/2J mouse model of glaucoma
    Maher Saleh
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 48:4564-72. 2007
    ..To characterize progressive changes of retinal ganglion cell (RGC) function and intraocular pressure (IOP) in the DBA/2J mouse model of spontaneous glaucoma...
  13. pmc Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model
    Hong Yu
    Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 109:E1238-47. 2012
    ....
  14. pmc Leber hereditary optic neuropathy gene therapy clinical trial recruitment: year 1
    Byron L Lam
    Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Arch Ophthalmol 128:1129-35. 2010
    ....
  15. pmc Pattern electroretinogram progression in glaucoma suspects
    Lori M Ventura
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Glaucoma 22:219-25. 2013
    ..To prospectively monitor progressive changes of retinal ganglion cell function in early glaucoma using the pattern electroretinogram (PERG)...
  16. pmc IOP-dependent retinal ganglion cell dysfunction in glaucomatous DBA/2J mice
    Mahesh Nagaraju
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 48:4573-9. 2007
    ..To characterize the effect of postural IOP elevation and pharmacological IOP lowering on retinal ganglion cell (RGC) function in the DBA/2J mouse model of glaucoma...
  17. pmc The relationship between retinal ganglion cell function and retinal nerve fiber thickness in early glaucoma
    Lori M Ventura
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 47:3904-11. 2006
    ....
  18. pmc Head-down posture induces PERG alterations in early glaucoma
    Lori M Ventura
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Glaucoma 22:255-64. 2013
    ..To probe susceptibility of retinal ganglion cells (RGC) to physiological stressors associated with moderate head-down body tilt in patients with suspicion of glaucoma or early manifest glaucoma (EMG)...
  19. pmc Restoration of retinal ganglion cell function in early glaucoma after intraocular pressure reduction: a pilot study
    Lori M Ventura
    Bascom Palmer Eye Institute, Miami, Florida 33136, USA
    Ophthalmology 112:20-7. 2005
    ..To investigate the changes of pattern electroretinogram (PERG) after intraocular pressure lowering in glaucoma patients and normal controls...
  20. pmc The PERG in diabetic glaucoma suspects with no evidence of retinopathy
    Lori M Ventura
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136, USA
    J Glaucoma 19:243-7. 2010
    ..To better understand the role of diabetes mellitus on retinal ganglion cell function of glaucoma suspects...
  21. pmc Postnatal elongation of eye size in DBA/2J mice compared with C57BL/6J mice: in vivo analysis with whole-eye OCT
    Tsung Han Chou
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 52:3604-12. 2011
    ..To characterize postnatal changes in eye size in glaucomatous DBA/2J (D2) mice and in nonglaucomatous C57BL/6J mice (B6) in vivo by means of whole-eye optical coherence tomography (OCT)...
  22. pmc Reversible dysfunction of retinal ganglion cells in non-secreting pituitary tumors
    Lori M Ventura
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 N W 17th Street, Miami, FL 33136, USA
    Doc Ophthalmol 118:155-62. 2009
    ..The results suggest that PERG is a useful tool in the early diagnosis and management of patients with chiasmal mass lesions...
  23. pmc Deimination restores inner retinal visual function in murine demyelinating disease
    Mabel Enriquez-Algeciras
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA
    J Clin Invest 123:646-56. 2013
    ..Thus, protein deimination and dendritic outgrowth play key roles in visual function and may be a general feature of demyelinating diseases...
  24. pmc The bioelectric field of the pattern electroretinogram in the mouse
    Tsung Han Chou
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 53:8086-92. 2012
    ..To compare the bioelectric field associated with the pattern electroretinogram (PERG) with that of the flash electroretinogram (FERG) in the mouse...
  25. pmc Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual system
    John Guy
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 50:4205-14. 2009
    ..To evaluate the efficiency and safety of AAV-mediated gene delivery of a normal human ND4 complex I subunit in the mouse visual system...
  26. pmc Pattern electroretinogram abnormality and glaucoma
    Lori M Ventura
    Bascom Palmer Eye Institute, Miami, Florida 33136, USA
    Ophthalmology 112:10-9. 2005
    ..To determine the existence of retinal ganglion cell dysfunction and associated risk factors in glaucoma suspects with increased optic disc cupping and normal visual field...
  27. pmc Progressive loss of retinal ganglion cell function precedes structural loss by several years in glaucoma suspects
    Michael R Banitt
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 54:2346-52. 2013
    ..We determined the time lag between loss of retinal ganglion cell function and retinal nerve fiber layer (RNFL) thickness...
  28. pmc A new mouse model of inducible, chronic retinal ganglion cell dysfunction not associated with cell death
    Xu Yang
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 54:1898-904. 2013
    ..To develop a mouse model of inducible, chronic retinal ganglion cell (RGC) dysfunction not associated with cell death...
  29. pmc Retrograde signaling in the optic nerve is necessary for electrical responsiveness of retinal ganglion cells
    Tsung Han Chou
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Invest Ophthalmol Vis Sci 54:1236-43. 2013
    ..We investigated the role of retrograde signaling in the optic nerve on retinal ganglion cell (RGC) electrical responsiveness in the mouse model...
  30. pmc Progressive loss of retinal ganglion cell function is hindered with IOP-lowering treatment in early glaucoma
    Lori M Ventura
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 53:659-63. 2012
    ..To investigate progressive changes of retinal ganglion cell (RGC) function in glaucoma suspects before and after IOP-lowering treatment...
  31. pmc Reproducibility of pattern electroretinogram in glaucoma patients with a range of severity of disease with the new glaucoma paradigm
    Marie Josée Fredette
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida, USA
    Ophthalmology 115:957-63. 2008
    ..To determine the reproducibility of the pattern electroretinogram with the new Pattern Electroretinogram for Glaucoma (PERGLA) recording paradigm in glaucoma patients with a range of severity...
  32. pmc Noninvasive assessments of optic nerve neurodegeneration in transgenic mice with isolated optic neuritis
    Venu Talla
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 54:4440-50. 2013
    ..To determine if phosphorylated neurofilament heavy chain (pNF-H) released into the bloodstream and the pattern ERG are noninvasive indicators of neurodegeneration in experimental optic neuritis...
  33. pmc Pattern electroretinogram in glaucoma
    Lori M Ventura
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Curr Opin Ophthalmol 17:196-202. 2006
    ..Renewed interest in the pattern electroretinogram for early detection of pre-perimetric glaucoma has been sparked by noninvasive and reproducible methods of recording using skin electrodes...
  34. pmc Evaluation of a transgenic mouse model of multiple sclerosis with noninvasive methods
    Mabel Enriquez-Algeciras
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 52:2405-11. 2011
    ..To evaluate the ND4 transgenic mouse model of multiple sclerosis using noninvasive methods...
  35. pmc Scale for photographic grading of vitreous haze in uveitis
    Janet L Davis
    University of Miami Miller School of Medicine, Bascom Palmer Eye Institute, Florida 33136, USA
    Am J Ophthalmol 150:637-641.e1. 2010
    ..To validate a scale for grading vitreous haze in uveitis using digitized photographs and standardized scoring...
  36. pmc Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 179:1523-37. 2007
    ..These experiments provide strong evidence for a local insult to axons in the optic nerve...
  37. pmc Visual-evoked potentials to onset of chromatic red-green and blue-yellow gratings in Parkinson's disease never treated with L-dopa
    F Sartucci
    Department of Neuroscience, Neurological Clinic, Pisa University Medical School, Pisa, Italy
    J Clin Neurophysiol 23:431-5. 2006
    ..However, the overall sensitivity of chromatic VEPs in detecting early visual impairment in PD is comparable with that of achromatic VEPs...
  38. ncbi request reprint Changes in pattern electroretinograms to equiluminant red-green and blue-yellow gratings in patients with early Parkinson's disease
    Ferdinando Sartucci
    Department of Neuroscience, Institute of Neurology, University of Pisa, Pisa, Italy
    J Clin Neurophysiol 20:375-81. 2003
    ..The results suggest that the koniocellular subpopulation of RGCs may be particularly vulnerable in early stages of Parkinson's disease...
  39. ncbi request reprint Electrophysiology of the postreceptoral visual pathway in mice
    Vittorio Porciatti
    Institute of Neurophysiology, CNR, Pisa, Italy
    Doc Ophthalmol 104:69-82. 2002
    ..Pattern VEPs provide a means for characterizing the visual phenotype of mutant mice and for the evaluation of the effects induced by experimental manipulation...
  40. ncbi request reprint Morphological and functional abnormalities in the inner retina of the rd/rd mouse
    Enrica Strettoi
    Istituto di Neurofisiologia del Consiglio Nazionale delle Ricerche, 56100 Pisa, Italy
    J Neurosci 22:5492-504. 2002
    ..This is even more important when considering that although intervention can be performed before the onset of any symptoms in animals carrying inherited retinopathies, this is obviously not true for human subjects...
  41. ncbi request reprint Remodeling of second-order neurons in the retina of rd/rd mutant mice
    Enrica Strettoi
    Laboratorio di Neurofisiologia, Istituto di Neuroscienze del CNR, Area della Ricerca, Via G Moruzzi 1, 56100, Pisa, Italy
    Vision Res 43:867-77. 2003
    ..B-wave abnormalities indicate specific postreceptoral dysfunction. Morphological and ERG changes in rd/rd retinas are consistent with substantial inner retinal remodeling associated to photoreceptor degeneration...
  42. ncbi request reprint Physiology of human photosensitivity
    Arnold J Wilkins
    Department of Psychology, University of Essex, Colchester, Essex, England
    Epilepsia 45:7-13. 2004
    ..This has revealed abnormalities in the cortical mechanisms that control the response to strong visual stimulation...

Research Grants12

  1. RETINAL GANGLION CELL PLASTICITY IN GLAUCOMA
    Vittorio Porciatti; Fiscal Year: 2010
    ..Our research team includes experts in experimental glaucoma, visual electrophysiology, retinal imaging, biophysics, and biostatistics. ..
  2. Reversible Ganglion Cell Dysfunction in Glaucoma
    Vittorio Porciatti; Fiscal Year: 2010
    ....
  3. RETINAL GANGLION CELL PLASTICITY IN GLAUCOMA
    Vittorio Porciatti; Fiscal Year: 2009
    ..Our research team includes experts in experimental glaucoma, visual electrophysiology, retinal imaging, biophysics, and biostatistics. ..
  4. LIFE AND DEATH OF RETINAL GANGLION CELLS
    Vittorio Porciatti; Fiscal Year: 2007
    ..Such outcomes are significant, since exploiting an animal model for testing neuroprotective strategies that preserve visual function is an important component of future research on treatments for glaucoma. ..
  5. Reversible Ganglion Cell Dysfunction in Glaucoma
    Vittorio Porciatti; Fiscal Year: 2007
    ..Since blindness from glaucoma is steadily growing with increasing longevity, these results are expected to have a high potential impact on alleviating the health care burden in our country. ..
  6. Reversible Ganglion Cell Dysfunction in Glaucoma
    Vittorio Porciatti; Fiscal Year: 2005
    ....
  7. Reversible Ganglion Cell Dysfunction in Glaucoma
    Vittorio Porciatti; Fiscal Year: 2011
    ....