Whitney B Pope

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Differential gene expression in glioblastoma defined by ADC histogram analysis: relationship to extracellular matrix molecules and survival
    W B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1721, USA
    AJNR Am J Neuroradiol 33:1059-64. 2012
  2. doi request reprint Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study
    Whitney B Pope
    Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1721, USA
    J Neurooncol 108:491-8. 2012
  3. pmc Advances in MRI assessment of gliomas and response to anti-VEGF therapy
    Whitney B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, BL 428 CHS, Los Angeles, CA 90095 1721, USA
    Curr Neurol Neurosci Rep 11:336-44. 2011
  4. doi request reprint Characterizing brain tumor research: the role of the National Institutes of Health
    W B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at the University of California Los Angeles, 90095 1721, USA
    AJNR Am J Neuroradiol 31:605-9. 2010
  5. pmc Relationship between gene expression and enhancement in glioblastoma multiforme: exploratory DNA microarray analysis
    Whitney B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at University of California Los Angeles UCLA Medical Center, 10833 Le Conte Ave, BL 428 CHS, Los Angeles, CA 90095 1721, USA
    Radiology 249:268-77. 2008
  6. doi request reprint Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma
    W B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at the University of California, Los Angeles, 90095 1721, USA
    AJNR Am J Neuroradiol 32:882-9. 2011
  7. doi request reprint Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab
    W B Pope
    Department of Radiologic Sciences, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, CHS, BL 428, Los Angeles, CA 90095 1721, USA
    Neurology 76:432-7. 2011
  8. ncbi request reprint MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy
    W B Pope
    Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Neurology 66:1258-60. 2006
  9. doi request reprint Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment
    Whitney B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA Medical Center, 10833 Le Conte Ave, BL 428 CHS, Los Angeles, CA 90095 1721, USA
    Radiology 252:182-9. 2009
  10. pmc Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcome
    Shadi Lalezari
    Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
    Neuro Oncol 15:370-81. 2013

Collaborators

Detail Information

Publications42

  1. doi request reprint Differential gene expression in glioblastoma defined by ADC histogram analysis: relationship to extracellular matrix molecules and survival
    W B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1721, USA
    AJNR Am J Neuroradiol 33:1059-64. 2012
    ..Therefore, we compared gene expression between high-versus-low ADC tumors to identify gene expression modules that could underlie this difference and impact patient prognosis...
  2. doi request reprint Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study
    Whitney B Pope
    Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1721, USA
    J Neurooncol 108:491-8. 2012
    ..The predictive value of ADC histogram analysis, in which low ADC-L was associated with poor outcome, was confirmed in bevacizumab-treated patients with recurrent GBM in a post hoc analysis from the multi-center (BRAIN) study...
  3. pmc Advances in MRI assessment of gliomas and response to anti-VEGF therapy
    Whitney B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, BL 428 CHS, Los Angeles, CA 90095 1721, USA
    Curr Neurol Neurosci Rep 11:336-44. 2011
    ..An active area of research is the use of physiologic imaging, which can potentially detect treatment effects before changes in tumor size are evident...
  4. doi request reprint Characterizing brain tumor research: the role of the National Institutes of Health
    W B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at the University of California Los Angeles, 90095 1721, USA
    AJNR Am J Neuroradiol 31:605-9. 2010
    ..Thus a substantial proportion of brain tumor publications originate from radiology departments, and the percentage of this research that is funded by the NIH has grown significantly during a period of increasing NIH budgets...
  5. pmc Relationship between gene expression and enhancement in glioblastoma multiforme: exploratory DNA microarray analysis
    Whitney B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at University of California Los Angeles UCLA Medical Center, 10833 Le Conte Ave, BL 428 CHS, Los Angeles, CA 90095 1721, USA
    Radiology 249:268-77. 2008
    ..To determine the difference in gene expression between completely versus incompletely enhancing glioblastoma multiforme (GBM)...
  6. doi request reprint Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma
    W B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at the University of California, Los Angeles, 90095 1721, USA
    AJNR Am J Neuroradiol 32:882-9. 2011
    ..Our aim was to determine if ADC histogram analysis can stratify progression-free and overall survival in patients with newly diagnosed GBM treated "up-front" (ie, before tumor recurrence) with bevacizumab...
  7. doi request reprint Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab
    W B Pope
    Department of Radiologic Sciences, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, CHS, BL 428, Los Angeles, CA 90095 1721, USA
    Neurology 76:432-7. 2011
    ..We evaluated patterns of tumor progression in patients with recurrent glioblastoma who were treated with bevacizumab (BEV) alone or in combination with irinotecan (CPT-11) while participating in the BRAIN study...
  8. ncbi request reprint MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy
    W B Pope
    Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Neurology 66:1258-60. 2006
    ..Contrast-enhancing tumor shrank in 7 patients, with reductions evident in as little as 2 weeks after initiation of therapy. Treatment seemed more effective for heterogeneously enhancing tumor compared with solidly enhancing tumor...
  9. doi request reprint Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment
    Whitney B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA Medical Center, 10833 Le Conte Ave, BL 428 CHS, Los Angeles, CA 90095 1721, USA
    Radiology 252:182-9. 2009
    ..To determine if apparent diffusion coefficient (ADC) histogram analysis can stratify progression-free survival in patients with recurrent glioblastoma multiforme (GBM) prior to bevacizumab treatment...
  10. pmc Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcome
    Shadi Lalezari
    Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
    Neuro Oncol 15:370-81. 2013
    ....
  11. doi request reprint Quantification of edema reduction using differential quantitative T2 (DQT2) relaxometry mapping in recurrent glioblastoma treated with bevacizumab
    Benjamin M Ellingson
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90095, USA
    J Neurooncol 106:111-9. 2012
    ..5T) following anti-VEGF treatment (Wilcoxon signed rank test, P < 0.0001). An elevated residual, post-treatment, median T2 was predictive of both progression-free (Log-rank, P = 0.0074) and overall survival (Log-rank, P = 0.0393)...
  12. ncbi request reprint Relationship between survival and edema in malignant gliomas: role of vascular endothelial growth factor and neuronal pentraxin 2
    Marc R J Carlson
    Department of Human Genetics, University of California at Los Angeles and David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, California 90095 1271, USA
    Clin Cancer Res 13:2592-8. 2007
    ..VEGF inhibition reduces edema and tumor burden in some patients with malignant glioma, whereas others show no response. The role of VEGF expression in edema production and the relationship to survival is not well understood...
  13. doi request reprint Cell invasion, motility, and proliferation level estimate (CIMPLE) maps derived from serial diffusion MR images in recurrent glioblastoma treated with bevacizumab
    Benjamin M Ellingson
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
    J Neurooncol 105:91-101. 2011
    ..0001) as well as overall survival (OS; P = 0.0093). Similarly, the mean proliferation rate was able to stratify patients with early and late PFS as well as OS...
  14. pmc Identifying the mesenchymal molecular subtype of glioblastoma using quantitative volumetric analysis of anatomic magnetic resonance images
    Kourosh M Naeini
    Department of Radiological Sciences, David Geffen School of Medicine, University of California LosAngeles, Los Angeles, CA, USA
    Neuro Oncol 15:626-34. 2013
    ..The purpose of the current study was to identify a potential relationship between imaging features and the mesenchymal (MES) GBM subtype, which has the worst patient prognosis...
  15. pmc Quantitative probabilistic functional diffusion mapping in newly diagnosed glioblastoma treated with radiochemotherapy
    Benjamin M Ellingson
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd, Ste 615, Los Angeles, CA 90024, USA
    Neuro Oncol 15:382-90. 2013
    ..The current study introduces a probabilistic approach to fDM quantification to overcome some of these limitations...
  16. pmc 18F-FDOPA and 18F-FLT positron emission tomography parametric response maps predict response in recurrent malignant gliomas treated with bevacizumab
    Robert J Harris
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
    Neuro Oncol 14:1079-89. 2012
    ....
  17. doi request reprint Comparison between intensity normalization techniques for dynamic susceptibility contrast (DSC)-MRI estimates of cerebral blood volume (CBV) in human gliomas
    Benjamin M Ellingson
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
    J Magn Reson Imaging 35:1472-7. 2012
    ..The use of image intensity transformation algorithms provides a mechanism for obtaining quantitatively similar CBV maps with the same intensity scaling...
  18. pmc Functional diffusion maps (fDMs) evaluated before and after radiochemotherapy predict progression-free and overall survival in newly diagnosed glioblastoma
    Benjamin M Ellingson
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd, Suite 615, Los Angeles, CA 90024, USA
    Neuro Oncol 14:333-43. 2012
    ..The current study supports the hypothesis that fDM is a sensitive imaging biomarker for predicting survival in glioblastoma...
  19. doi request reprint Nonlinear registration of diffusion-weighted images improves clinical sensitivity of functional diffusion maps in recurrent glioblastoma treated with bevacizumab
    Benjamin M Ellingson
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Magn Reson Med 67:237-45. 2012
    ..Results suggest that nonlinear registration of pretreatment ADC maps to post-treatment ADC maps improves the clinical predictability, sensitivity, and specificity of fDMs for both progression-free and overall survival...
  20. pmc Quantitative volumetric analysis of conventional MRI response in recurrent glioblastoma treated with bevacizumab
    Benjamin M Ellingson
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuro Oncol 13:401-9. 2011
    ..Initial contrast-enhancing volume was predictive of PFS but not OS. The pretreatment relative nonenhancing tumor ratio, defined as the ratio of FLAIR to contrast-enhancing volume, was found to be predictive of both PFS and OS...
  21. pmc Pre- and post-contrast three-dimensional double inversion-recovery MRI in human glioblastoma
    Robert J Harris
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
    J Neurooncol 112:257-66. 2013
    ..Additional discrepancies between FLAIR and DIR abnormal regions were also observed, together suggesting DIR may provide additional information beyond that of FLAIR...
  22. pmc Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone
    Melanie Kappadakunnel
    University of California Los Angeles, Los Angeles, CA 90095, USA
    J Neurooncol 96:359-67. 2010
    ..More research is required to clarify the relationship between the SVZ, cancer stem cells and survival...
  23. doi request reprint High order diffusion tensor imaging in human glioblastoma
    Benjamin M Ellingson
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1721, USA
    Acad Radiol 18:947-54. 2011
    ..The purpose of the current study was to examine higher order diffusion characteristics in human glioblastoma prior to surgical resection using the fourth-order diffusion tensor model...
  24. pmc Graded functional diffusion map-defined characteristics of apparent diffusion coefficients predict overall survival in recurrent glioblastoma treated with bevacizumab
    Benjamin M Ellingson
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd, Suite 650, Los Angeles, CA 90024, USA
    Neuro Oncol 13:1151-61. 2011
    ..001). These results demonstrate that spatially resolved diffusion-based tumor metrics are a powerful imaging biomarker of survival in patients with recurrent GBM treated with bevacizumab...
  25. doi request reprint Increased sensitivity to radiochemotherapy in IDH1 mutant glioblastoma as demonstrated by serial quantitative MR volumetry
    Anh N Tran
    Duke National University of Singapore Graduate Medical School, 8 College Road, Singapore A N T Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California A T, W B P, S T, R J H, D C W, P L N, B M E Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California A N T, A L, S L, P L N, T F C Department of Biomedical Physics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California R J H, D C W, B M E Department of Bioengineering, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California B M E
    Neuro Oncol 16:414-20. 2014
    ..We hypothesized that radiographic treatment response would be significantly different between IDH1 mutant versus wild-type GBMs after radiotherapy (RT) and concurrent temozolomide (TMZ)...
  26. doi request reprint Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomas
    Benjamin M Ellingson
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuroimage 59:908-16. 2012
    ....
  27. pmc Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
    Albert Lai
    David Geffen School of Medicine at UCLA, Reed Neurological Research Center, Los Angeles, CA 90095, USA
    J Clin Oncol 29:142-8. 2011
    ..The objectives were to determine the efficacy of this treatment combination and the associated toxicity...
  28. pmc Safety of anticoagulation use and bevacizumab in patients with glioma
    Phioanh Leia Nghiemphu
    Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, RNRC 1 230, Los Angeles, CA 90095, USA
    Neuro Oncol 10:355-60. 2008
    ..In this retrospective review, anticoagulation did not lead to any major hemorrhages and does not appear to be a contraindication for starting bevacizumab therapy...
  29. doi request reprint Nonlinear distortion correction of diffusion MR images improves quantitative DTI measurements in glioblastoma
    Davis C Woodworth
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, 924 Westwood Blvd, Suite 615, Los Angeles, CA, USA
    J Neurooncol 116:551-8. 2014
    ..0045 for ADCL and P = 0.0370 for ADCH). Nonlinear distortion correction better aligns neuro-anatomical structures between DTI and anatomical scans, and significantly alters the measurement of values within tumor ROIs for GBM patients. ..
  30. doi request reprint Regional and Voxel-Wise Comparisons of Blood Flow Measurements Between Dynamic Susceptibility Contrast Magnetic Resonance Imaging (DSC-MRI) and Arterial Spin Labeling (ASL) in Brain Tumors
    Carissa M White
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095
    J Neuroimaging 24:23-30. 2014
    ..These results suggest DSC and ASL may provide regionally similar, but spatially different measurements of CBF. ..
  31. pmc Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation
    Jelena Lazovic
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Neuro Oncol 14:1465-72. 2012
    ..Our results establish a model system where 2-HG can be monitored noninvasively, which should be helpful in validating 2-HG levels as a prognostic and/or predictive biomarker in glioma...
  32. pmc Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
    Albert Lai
    David Geffen School of Medicine at theUniversity of California at Los Angeles, Los Angeles, CA, USA
    J Clin Oncol 29:4482-90. 2011
    ..To determine how GBMs arising with IDH1(R132MUT) differ from other GBMs, we undertook a comprehensive comparison of patients presenting clinically with primary GBM as a function of IDH1(R132) mutation status...
  33. doi request reprint Time course of imaging changes of GBM during extended bevacizumab treatment
    Suchitra Ananthnarayan
    Department of Radiology, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1721, USA
    J Neurooncol 88:339-47. 2008
    ....
  34. doi request reprint C-terminally truncated form of αB-crystallin is associated with IDH1 R132H mutation in anaplastic astrocytoma
    Nuraly K Avliyakulov
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, 615 Charles E Young Dr South, Los Angeles, CA, 90095, USA
    J Neurooncol 117:53-65. 2014
    ..In conclusion, the association of a C-terminally truncated form of αB-crystallin protein with the IDH1(R132H) mutation is a novel finding that could impact apoptosis and stress response in IDH1 mutant glioma. ..
  35. doi request reprint Short-interval estimation of proliferation rate using serial diffusion MRI predicts progression-free survival in newly diagnosed glioblastoma treated with radiochemotherapy
    Taryar M Zaw
    UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Blvd, Suite 615, Los Angeles, CA, 90024, USA
    J Neurooncol 116:601-8. 2014
    ....
  36. ncbi request reprint MR imaging correlates of survival in patients with high-grade gliomas
    Whitney B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA Medical Center, Los Angeles, CA 90095 1721, USA
    AJNR Am J Neuroradiol 26:2466-74. 2005
    ..The purpose of this study was to assess the validity of these results and determine whether other imaging features are useful in predicting survival...
  37. pmc Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
    Whitney B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Neurooncol 107:197-205. 2012
    ..In addition to 2-HG, alterations in several other metabolites measured by MRS correlate with IDH1 mutation status...
  38. doi request reprint Cortical dysplasia with prominent Rosenthal fiber formation in a case of intractable pediatric epilepsy
    Negar Khanlou
    Department of Pathology and Laboratory Medicine Neuropathology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095 1732, USA
    Hum Pathol 40:1200-4. 2009
    ..This case is unique among several hundred cortical resection specimens that we have studied, including numerous cases of severe cortical dysplasia...
  39. pmc Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience
    P L Nghiemphu
    Department of Neurology, Jonsson Comprehensive Cancer Center, University of California at Los Angeles and David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Neurology 72:1217-22. 2009
    ..Bevacizumab has been shown to be effective in the treatment of recurrent glioblastoma in combination with chemotherapy compared with historic controls but not in randomized trials...
  40. pmc The value of arterial spin-labeled perfusion imaging in acute ischemic stroke: comparison with dynamic susceptibility contrast-enhanced MRI
    Danny J J Wang
    Department of Neurology, University of California Los Angeles, 660 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Stroke 43:1018-24. 2012
    ..The purpose of this study was to evaluate the potential clinical value of arterial spin-labeled (ASL) perfusion MRI in acute ischemic stroke (AIS) through comparison with dynamic susceptibility contrast (DSC) enhanced perfusion MRI...
  41. pmc 3'-deoxy-3'-18F-fluorothymidine PET and MRI for early survival predictions in patients with recurrent malignant glioma treated with bevacizumab
    Johannes Schwarzenberg
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90005 6942, USA
    J Nucl Med 53:29-36. 2012
    ..This study compares the value of 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET and MRI for early outcome predictions in patients with recurrent malignant glioma on bevacizumab therapy...
  42. ncbi request reprint Supraaortic arteries: contrast-enhanced MR angiography at 3.0 T--highly accelerated parallel acquisition for improved spatial resolution over an extended field of view
    Kambiz Nael
    Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 10945 Le Conte Ave, Suite 3371, Los Angeles, CA 90095 7206, USA
    Radiology 242:600-9. 2007
    ....