Rodica Pop-Busui

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Impact of glycemic control strategies on the progression of diabetic peripheral neuropathy in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Cohort
    Rodica Pop-Busui
    Corresponding author Rodica Pop Busui
    Diabetes Care 36:3208-15. 2013
  2. pmc Effects of triple antioxidant therapy on measures of cardiovascular autonomic neuropathy and on myocardial blood flow in type 1 diabetes: a randomised controlled trial
    R Pop-Busui
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Diabetologia 56:1835-44. 2013
  3. pmc Association between cardiovascular autonomic neuropathy and left ventricular dysfunction: DCCT/EDIC study (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications)
    Rodica Pop-Busui
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan 48105, USA
    J Am Coll Cardiol 61:447-54. 2013
  4. pmc What do we know and we do not know about cardiovascular autonomic neuropathy in diabetes
    Rodica Pop-Busui
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Cardiovasc Transl Res 5:463-78. 2012
  5. pmc Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC)
    Rodica Pop-Busui
    University of Michigan, Department of Internal Medicine, Division of Metabolism, Endocrinology, Diabetes, Ann Arbor, MI, USA
    Circulation 119:2886-93. 2009
  6. pmc Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    Rodica Pop-Busui
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 33:1578-84. 2010
  7. pmc DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history
    Rodica Pop-Busui
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Curr Diab Rep 10:276-82. 2010
  8. ncbi request reprint Diabetic neuropathy and oxidative stress
    Rodica Pop-Busui
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA
    Diabetes Metab Res Rev 22:257-73. 2006
  9. pmc Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort
    Rodica Pop-Busui
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Peripher Nerv Syst 14:1-13. 2009
  10. pmc Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study
    James W Albers
    Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Diabetes Care 33:1090-6. 2010

Research Grants

Detail Information

Publications38

  1. pmc Impact of glycemic control strategies on the progression of diabetic peripheral neuropathy in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Cohort
    Rodica Pop-Busui
    Corresponding author Rodica Pop Busui
    Diabetes Care 36:3208-15. 2013
    ..We evaluated the effects of randomized glycemic control strategy (IS vs. IP) on the prevalence and incidence of diabetic peripheral neuropathy (DPN)...
  2. pmc Effects of triple antioxidant therapy on measures of cardiovascular autonomic neuropathy and on myocardial blood flow in type 1 diabetes: a randomised controlled trial
    R Pop-Busui
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Diabetologia 56:1835-44. 2013
    ..We evaluated the effects of a combination triple antioxidant therapy on measures of cardiovascular autonomic neuropathy (CAN) and myocardial blood flow (MBF) in patients with type 1 diabetes...
  3. pmc Association between cardiovascular autonomic neuropathy and left ventricular dysfunction: DCCT/EDIC study (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications)
    Rodica Pop-Busui
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan 48105, USA
    J Am Coll Cardiol 61:447-54. 2013
    ....
  4. pmc What do we know and we do not know about cardiovascular autonomic neuropathy in diabetes
    Rodica Pop-Busui
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Cardiovasc Transl Res 5:463-78. 2012
    ..This review covers current understanding and gaps in that understanding of the clinical implications of CAN and prevention and treatment of CAN...
  5. pmc Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC)
    Rodica Pop-Busui
    University of Michigan, Department of Internal Medicine, Division of Metabolism, Endocrinology, Diabetes, Ann Arbor, MI, USA
    Circulation 119:2886-93. 2009
    ..We evaluated the effects of prior intensive insulin therapy on the prevalence and incidence of cardiac autonomic neuropathy (CAN) in former DCCT intensive and conventional therapy subjects 13 to 14 years after DCCT closeout...
  6. pmc Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    Rodica Pop-Busui
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 33:1578-84. 2010
    ....
  7. pmc DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history
    Rodica Pop-Busui
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Curr Diab Rep 10:276-82. 2010
    ..The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review...
  8. ncbi request reprint Diabetic neuropathy and oxidative stress
    Rodica Pop-Busui
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA
    Diabetes Metab Res Rev 22:257-73. 2006
    ..Potential therapies for preventing increased oxidative stress in diabetic nerve dysfunction will be discussed...
  9. pmc Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort
    Rodica Pop-Busui
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Peripher Nerv Syst 14:1-13. 2009
    ....
  10. pmc Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study
    James W Albers
    Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Diabetes Care 33:1090-6. 2010
    ....
  11. doi request reprint Impact of rosiglitazone and glyburide on nitrosative stress and myocardial blood flow regulation in type 2 diabetes mellitus
    Rodica Pop-Busui
    Department of Internal Medicine, Division of Metabolism, University of Michigan, Ann Arbor, MI 48109, USA
    Metabolism 58:989-94. 2009
    ..Rosiglitazone, but not glyburide, ameliorated markers of nitrosative stress and inflammation in subjects with T2DM without impairing myocardial perfusion...
  12. doi request reprint Functional neuroimaging of emotional processing in women with polycystic ovary syndrome: a case-control pilot study
    Courtney A Marsh
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109 0276, USA
    Fertil Steril 100:200-7.e1. 2013
    ..To evaluate emotional processing in women with insulin-resistant polycystic ovary syndrome (IR-PCOS) and its relationship to glucose regulation and the mu-opioid system...
  13. pmc Effects of cyclooxygenase-2 gene inactivation on cardiac autonomic and left ventricular function in experimental diabetes
    Aaron P Kellogg
    University of Michigan, Department of Internal Medicine, Ann Arbor, MI, USA
    Am J Physiol Heart Circ Physiol 296:H453-61. 2009
    ..These data suggest that in experimental diabetes, selective COX-2 inactivation confers protection against sympathetic denervation and LV dysfunction by reducing intramyocardial oxidative stress, inflammation, and myocardial fibrosis...
  14. ncbi request reprint Sympathetic dysfunction in type 1 diabetes: association with impaired myocardial blood flow reserve and diastolic dysfunction
    Rodica Pop-Busui
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0678, USA
    J Am Coll Cardiol 44:2368-74. 2004
    ..This study was designed to explore the relationships of early diabetic microangiopathy to alterations of cardiac sympathetic tone and myocardial blood flow (MBF) regulation in subjects with stable type 1 diabetes...
  15. pmc Predictors of heart rate variability and its prognostic significance in chronic kidney disease
    Preeti Chandra
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Nephrol Dial Transplant 27:700-9. 2012
    ..Heart rate variability (HRV), a noninvasive measure of autonomic dysfunction and a risk factor for cardiovascular disease (CVD), has not been systematically studied in nondialysis chronic kidney disease (CKD)...
  16. pmc Vibration perception threshold as a measure of distal symmetrical peripheral neuropathy in type 1 diabetes: results from the DCCT/EDIC study
    Catherine L Martin
    University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 33:2635-41. 2010
    ....
  17. pmc Relation of severe coronary artery narrowing to insulin or thiazolidinedione use in patients with type 2 diabetes mellitus (from the Bypass Angioplasty Revascularization Investigation 2 Diabetes Study)
    Rodica Pop-Busui
    University of Michigan, Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Ann Arbor, MI, USA
    Am J Cardiol 104:52-8. 2009
    ....
  18. ncbi request reprint Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes
    Aaron P Kellogg
    University of Michigan, Department of Internal Medicine, 5570D MSRB II, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
    Diabetes 56:2997-3005. 2007
    ....
  19. ncbi request reprint Cyclooxygenase-2 pathway as a potential therapeutic target in diabetic peripheral neuropathy
    Aaron P Kellogg
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, USA
    Curr Drug Targets 9:68-76. 2008
    ..This review will summarize current evidence supporting the role of COX-2 activation in inducing diabetic neurovascular dysfunction and that modulation of the COX-2 pathway is a potential therapeutic target for DPN...
  20. ncbi request reprint Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase
    Eitaro Nakashima
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Antioxid Redox Signal 7:1530-42. 2005
    ..Abnormal expression of AR may therefore impair antioxidant defense, which may determine tissue susceptibility to chronic diabetic complications...
  21. pmc Rapid, noninvasive detection of diabetes-induced retinal metabolic stress
    Matthew G Field
    Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall St, Ann Arbor, MI 48105, USA
    Arch Ophthalmol 126:934-8. 2008
    ..To test whether subjects with diabetes mellitus (DM) have enhanced retinal flavoprotein autofluorescence compared with age-matched control subjects using a rapid, noninvasive clinical imaging method...
  22. pmc Elevated triglycerides correlate with progression of diabetic neuropathy
    Timothy D Wiggin
    Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Diabetes 58:1634-40. 2009
    ..To evaluate mechanisms underlying diabetic neuropathy progression using indexes of sural nerve morphometry obtained from two identical randomized, placebo-controlled clinical trials...
  23. pmc Effect of intensive compared with standard glycemia treatment strategies on mortality by baseline subgroup characteristics: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    Jorge Calles-Escandon
    Department of Internal Medicine, Wake Forest UniversityHealth Sciences, Winston Salem, North Carolina, USA
    Diabetes Care 33:721-7. 2010
    ..To determine if baseline subgroups in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial can be identified for whom intensive compared with standard glycemia treatment had different effects on all-cause mortality...
  24. doi request reprint Hyperlipidemia: a new therapeutic target for diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    J Peripher Nerv Syst 14:257-67. 2009
    ..We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration...
  25. doi request reprint Thiazolidinediones in type 2 diabetes: a cardiology perspective
    Ujjaini Khanderia
    College of Pharmacy, University of Michigan, Ann Arbor, MI, USA
    Ann Pharmacother 42:1466-74. 2008
    ..To examine the cardiovascular effects of thiazolidinediones (TZDs), discuss concerns regarding this drug class and its relation to heart failure (HF) and myocardial infarction (MI), and address the clinical implications of HF and MI...
  26. pmc Dietary, lifestyle and pharmacogenetic factors associated with arteriole endothelial-dependent vasodilatation in schizophrenia patients treated with atypical antipsychotics (AAPs)
    Vicki L Ellingrod
    University of Michigan, College of Pharmacy, Department of Clinical Social and Administrative Sciences, 428 Church Street, Ann Arbor, Michigan 48109, USA
    Schizophr Res 130:20-6. 2011
    ..This study examined the status of endothelial function within the schizophrenia population and determined pharmacogenetic, medication, dietary, and lifestyle factors associated with this functioning...
  27. pmc Subclinical neuropathy among Diabetes Control and Complications Trial participants without diagnosable neuropathy at trial completion: possible predictors of incident neuropathy?
    James W Albers
    DCCT EDIC Research Group, Box DCCT EDIC, Bethesda, MD 20892, USA
    Diabetes Care 30:2613-8. 2007
    ..We sought to evaluate the prevalence of subclinical neuropathy in intensive and conventional treatment groups at completion of the Diabetes Control and Complications Trial (DCCT)...
  28. pmc Triglycerides and amputation risk in patients with diabetes: ten-year follow-up in the DISTANCE study
    Brian C Callaghan
    University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 34:635-40. 2011
    ..To determine the association between triglyceride levels and lower-extremity amputation (LEA) risk in a large diabetic cohort...
  29. pmc Altered excitation-inhibition balance in the brain of patients with diabetic neuropathy
    Myria Petrou
    Department of Radiology, Division of Neuroradiology, University of Michigan, 1500 E Medical Center Drive, SPC 5030, UH B2 A209, Ann Arbor, MI 48109 5030, USA
    Acad Radiol 19:607-12. 2012
    ....
  30. pmc Insulin resistance influences central opioid activity in polycystic ovary syndrome
    Alison Berent-Spillson
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA
    Fertil Steril 95:2494-8. 2011
    ....
  31. pmc Evaluation of hemoglobin A1c criteria to assess preoperative diabetes risk in cardiac surgery patients
    Roma Y Gianchandani
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Domino s Farms, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48109, USA
    Diabetes Technol Ther 13:1249-54. 2011
    ..Its performance compared with fasting plasma glucose (FPG) and 2-h post-glucose load (2HPG) is not well delineated. We compared the performance of A1C with that of FPG and 2HPG in preoperative cardiac surgery patients...
  32. pmc Urine glycoprotein profile reveals novel markers for chronic kidney disease
    Anuradha Vivekanandan-Giri
    Division of Nephrology, University of Michigan, Ann Arbor, MI 48105, USA
    Int J Proteomics 2011:214715. 2011
    ..Collectively, our observations suggest that the human urinary glycoproteome may serve as a discovery source for novel mechanism-based biomarkers of CKD...
  33. pmc Translating glucose variability metrics into the clinic via Continuous Glucose Monitoring: a Graphical User Interface for Diabetes Evaluation (CGM-GUIDE©)
    Renata A Rawlings
    Center for Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109 1055, USA
    Diabetes Technol Ther 13:1241-8. 2011
    ..As a consequence, and because of the tedious coding necessary during quantification, most investigators and clinicians have not yet adopted the use of multiple glucose variability metrics to evaluate glycemic variation...
  34. pmc Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics
    Vicki L Ellingrod
    Department of Clinical Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    J Clin Psychopharmacol 32:261-5. 2012
    ..Use of this information clinically may help to reduce the risk for AAP metabolic complications in those whose clinical care necessitates the use of AAPs...
  35. doi request reprint Diabetes and stress hyperglycemia in the intensive care unit: outcomes after cardiac surgery
    Roma Y Gianchandani
    Assistant Professor, Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI
    Hosp Pract (1995) 40:22-30. 2012
    ....
  36. ncbi request reprint Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration
    Rodica Pop-Busui
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Michigan Diabetes Research and Training Center, University of Michigan, Ann Arbor Veterans Administration Hospitals, 48109 0678, USA
    Diabetes 51:2619-28. 2002
    ....
  37. ncbi request reprint Peripheral nerve dysfunction in experimental diabetes is mediated by cyclooxygenase-2 and oxidative stress
    Aaron P Kellogg
    Medical College of Ohio, Department of Medicine and Physiology, Toledo, OH, USA
    Antioxid Redox Signal 7:1521-9. 2005
    ..These findings also suggest that the COX-2 pathway seems to be an important modulator of oxidative stress in EDN...

Research Grants2

  1. Cyclooxygenase Pathway and Diabetic Neuropathy
    Rodica Pop Busui; Fiscal Year: 2005
    ..abstract_text> ..
  2. Cardiac Autonomic Neuropathy and Myocardial Dysfunction in Type 1 Diabetes
    Rodica Pop Busui; Fiscal Year: 2010
    ....