Wayne W Poon

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1
    Wayne W Poon
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697, USA
    J Biol Chem 288:16937-48. 2013
  2. pmc β-Amyloid impairs axonal BDNF retrograde trafficking
    Wayne W Poon
    Institute for Brain Aging and Dementia, University of California, Irvine, 1226 Gillespie NRF, Irvine, CA 92697, United States
    Neurobiol Aging 32:821-33. 2011
  3. pmc Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
    Mathew Blurton-Jones
    Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:13594-9. 2009
  4. ncbi request reprint The role of caspase cleavage of tau in Alzheimer disease neuropathology
    Carl W Cotman
    Institute for Brain Aging and Dementia, University of California, Irvine, 92697, USA
    J Neuropathol Exp Neurol 64:104-12. 2005
  5. pmc Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid
    Kathryn E Nichol
    Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, CA, USA
    J Neuroinflammation 5:13. 2008
  6. pmc Caspase-mediated degeneration in Alzheimer's disease
    David H Cribbs
    Institute for Brain Aging and Dementia, Irvine CA 92697 4540, USA
    Am J Pathol 165:353-5. 2004
  7. pmc Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology
    Robert A Rissman
    Institute for Brain Aging and Dementia, University of California, Irvine 92697, USA
    J Clin Invest 114:121-30. 2004

Collaborators

Detail Information

Publications7

  1. pmc β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1
    Wayne W Poon
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697, USA
    J Biol Chem 288:16937-48. 2013
    ..Further, our results support the idea that in AD, Aβ may down-regulate UCH-L1 in the AD brain, which in turn impairs BDNF/TrkB-mediated retrograde signaling, compromising synaptic plasticity and neuronal survival...
  2. pmc β-Amyloid impairs axonal BDNF retrograde trafficking
    Wayne W Poon
    Institute for Brain Aging and Dementia, University of California, Irvine, 1226 Gillespie NRF, Irvine, CA 92697, United States
    Neurobiol Aging 32:821-33. 2011
    ..Furthermore, Aβ oligomers alone impair BDNF retrograde transport. Thus, Aβ reduces BDNF signaling by impairing axonal transport and this may underlie the synaptic dysfunction observed in AD...
  3. pmc Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
    Mathew Blurton-Jones
    Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:13594-9. 2009
    ..Taken together, our findings demonstrate that neural stem cells can ameliorate complex behavioral deficits associated with widespread Alzheimer disease pathology via BDNF...
  4. ncbi request reprint The role of caspase cleavage of tau in Alzheimer disease neuropathology
    Carl W Cotman
    Institute for Brain Aging and Dementia, University of California, Irvine, 92697, USA
    J Neuropathol Exp Neurol 64:104-12. 2005
    ..In addition, a model is presented whereby caspase cleavage of tau provides a mechanistic link between the development of amyloid and tangle pathologies...
  5. pmc Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid
    Kathryn E Nichol
    Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, CA, USA
    J Neuroinflammation 5:13. 2008
    ..Our objective was to determine if exercise could induce a shift from the immune profile in aged (17-19 months) Tg2576 mice to a response that reduces Abeta pathology...
  6. pmc Caspase-mediated degeneration in Alzheimer's disease
    David H Cribbs
    Institute for Brain Aging and Dementia, Irvine CA 92697 4540, USA
    Am J Pathol 165:353-5. 2004
  7. pmc Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology
    Robert A Rissman
    Institute for Brain Aging and Dementia, University of California, Irvine 92697, USA
    J Clin Invest 114:121-30. 2004
    ..These results suggest that therapeutics aimed at inhibiting tau caspase-cleavage may prove beneficial not only in preventing NFT formation, but also in slowing cognitive decline...