NICHOLAS POOLOS

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites
    Nicholas P Poolos
    Division of Neuroscience, Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Neurosci 5:767-74. 2002
  2. ncbi request reprint The h-channel: a potential channelopathy in epilepsy?
    Nicholas P Poolos
    Department of Neurology and Regional Epilepsy Center, University of Washington, Seattle, WA, USA
    Epilepsy Behav 7:51-6. 2005
  3. ncbi request reprint Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase
    Nicholas P Poolos
    Department of Neurology and Regional Epilepsy Center, Neurobiology and Behavior Program, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 26:7995-8003. 2006
  4. ncbi request reprint Males with epilepsy, complete subcortical band heterotopia, and somatic mosaicism for DCX
    N P Poolos
    Department of Neurology, Division of Neuroscience, Baylor College of Medicine, Houston, TX, USA
    Neurology 58:1559-62. 2002
  5. pmc Reversed somatodendritic I(h) gradient in a class of rat hippocampal neurons with pyramidal morphology
    James B Bullis
    Neurobiology and Behavior, University of Washington, Seattle, WA 98195 7290, USA
    J Physiol 579:431-43. 2007
  6. ncbi request reprint Acquired dendritic channelopathy in temporal lobe epilepsy
    Christophe Bernard
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Science 305:532-5. 2004
  7. ncbi request reprint Position statement on the coverage of anticonvulsant drugs for the treatment of epilepsy: what's the problem with generic antiepileptic drugs? A call to action
    John W Miller
    Neurology 69:1806-8. 2007
  8. pmc Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy
    Sangwook Jung
    Department of Neurology, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 27:13012-21. 2007
  9. doi request reprint Patch-clamp recording from neuronal dendrites
    Nicholas P Poolos
    University of Washington, Seattle, Washington, USA
    Curr Protoc Neurosci . 2004

Research Grants

  1. Modulation of h-channels in hippocampal dendrities
    NICHOLAS POOLOS; Fiscal Year: 2007
  2. Epilepsy and dendritic excitability
    NICHOLAS POOLOS; Fiscal Year: 2007
  3. Epilepsy and dendritic excitability
    Nicholas P Poolos; Fiscal Year: 2010

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites
    Nicholas P Poolos
    Division of Neuroscience, Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Neurosci 5:767-74. 2002
    ..These results demonstrate that neuronal excitability can be altered by drugs acting selectively on dendrites, and suggest an important role for I(h) in controlling dendritic excitability and epileptogenesis...
  2. ncbi request reprint The h-channel: a potential channelopathy in epilepsy?
    Nicholas P Poolos
    Department of Neurology and Regional Epilepsy Center, University of Washington, Seattle, WA, USA
    Epilepsy Behav 7:51-6. 2005
    ..This review summarizes the evidence for the contribution of h-channels to seizures and epilepsy, and outlines hypotheses concerning the existence of an "h-channelopathy" in human epilepsy...
  3. ncbi request reprint Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase
    Nicholas P Poolos
    Department of Neurology and Regional Epilepsy Center, Neurobiology and Behavior Program, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 26:7995-8003. 2006
    ..These results show that p38 MAPK is a strong modulator of h-channel biophysical properties and may deserve additional exploration as a link between altered I(h) and pathological conditions such as epilepsy...
  4. ncbi request reprint Males with epilepsy, complete subcortical band heterotopia, and somatic mosaicism for DCX
    N P Poolos
    Department of Neurology, Division of Neuroscience, Baylor College of Medicine, Houston, TX, USA
    Neurology 58:1559-62. 2002
    ..This article reports two cases of males with SBH indistinguishable from the female phenotype, both resulting from somatic mosaicism for DCX mutation...
  5. pmc Reversed somatodendritic I(h) gradient in a class of rat hippocampal neurons with pyramidal morphology
    James B Bullis
    Neurobiology and Behavior, University of Washington, Seattle, WA 98195 7290, USA
    J Physiol 579:431-43. 2007
    ..Thus, we have characterized a principal neuronal subtype in the hippocampus with a similar morphology but reversed I(h) somatodendritic gradient to that previously observed in CA1 hippocampal and neocortical pyramidal neurons...
  6. ncbi request reprint Acquired dendritic channelopathy in temporal lobe epilepsy
    Christophe Bernard
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Science 305:532-5. 2004
    ..Kinase inhibition partly reversed dendritic excitability to control levels. Such acquired channelopathy is likely to amplify neuronal activity and may contribute to the initiation and/or propagation of seizures in TLE...
  7. ncbi request reprint Position statement on the coverage of anticonvulsant drugs for the treatment of epilepsy: what's the problem with generic antiepileptic drugs? A call to action
    John W Miller
    Neurology 69:1806-8. 2007
  8. pmc Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy
    Sangwook Jung
    Department of Neurology, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 27:13012-21. 2007
    ..This early and progressive downregulation of dendritic HCN channel function increases neuronal excitability and may be associated with both the process of epileptogenesis and maintenance of the epileptic state...
  9. doi request reprint Patch-clamp recording from neuronal dendrites
    Nicholas P Poolos
    University of Washington, Seattle, Washington, USA
    Curr Protoc Neurosci . 2004
    ..The procedures underlying these techniques are described in this unit...

Research Grants7

  1. Modulation of h-channels in hippocampal dendrities
    NICHOLAS POOLOS; Fiscal Year: 2007
    ..If funded, this proposal will enable the PI's transition to an independent clinician-scientist with a career focus on both basic and clinical aspects of epilepsy. ..
  2. Epilepsy and dendritic excitability
    NICHOLAS POOLOS; Fiscal Year: 2007
    ..abstract_text> ..
  3. Epilepsy and dendritic excitability
    Nicholas P Poolos; Fiscal Year: 2010
    ..The outcome of this study may identify specific biochemical pathways that could be targeted for development of novel antiepileptic drugs, improving the likelihood that currently poorly-controlled patients may one day be seizure-free. ..