Jill A Poole

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Protein kinase C epsilon is important in modulating organic-dust-induced airway inflammation
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Exp Lung Res 38:383-95. 2012
  2. pmc CD11c(+)/CD11b(+) cells are critical for organic dust-elicited murine lung inflammation
    Jill A Poole
    Pulmonary, Critical Care, Sleep, and Allergy Division, Department of Medicine, University of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Respir Cell Mol Biol 47:652-9. 2012
  3. ncbi request reprint αβ T cells and a mixed Th1/Th17 response are important in organic dust-induced airway disease
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Division Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Ann Allergy Asthma Immunol 109:266-273.e2. 2012
  4. pmc Immunological and inflammatory responses to organic dust in agriculture
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Curr Opin Allergy Clin Immunol 12:126-32. 2012
  5. pmc Organic dust augments nucleotide-binding oligomerization domain expression via an NF-{kappa}B pathway to negatively regulate inflammatory responses
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Division Dept of Medicine, Univ of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 301:L296-306. 2011
  6. pmc Toll-like receptor 2 regulates organic dust-induced airway inflammation
    Jill A Poole
    Omaha Veterans Affairs Medical Center, Omaha, Nebraska, USA
    Am J Respir Cell Mol Biol 45:711-9. 2011
  7. pmc Organic dust exposure alters monocyte-derived dendritic cell differentiation and maturation
    Jill A Poole
    Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA
    Am J Physiol Lung Cell Mol Physiol 297:L767-76. 2009
  8. pmc Muramic acid, endotoxin, 3-hydroxy fatty acids, and ergosterol content explain monocyte and epithelial cell inflammatory responses to agricultural dusts
    Jill A Poole
    Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA
    J Toxicol Environ Health A 73:684-700. 2010
  9. pmc Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice
    Jill A Poole
    Pulmonary, Critical Care, Sleep, and Allergy Section, Univ of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1085-95. 2009
  10. pmc Repetitive organic dust exposure in vitro impairs macrophage differentiation and function
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Neb 68198 5300, USA
    J Allergy Clin Immunol 122:375-82, 382.e1-4. 2008

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Protein kinase C epsilon is important in modulating organic-dust-induced airway inflammation
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Exp Lung Res 38:383-95. 2012
    ..Dampening of ODE-induced NO may contribute to these enhanced inflammatory findings...
  2. pmc CD11c(+)/CD11b(+) cells are critical for organic dust-elicited murine lung inflammation
    Jill A Poole
    Pulmonary, Critical Care, Sleep, and Allergy Division, Department of Medicine, University of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Respir Cell Mol Biol 47:652-9. 2012
    ..These studies demonstrate that DE elicits activated CD11c(+)/CD11b(+) macrophages in the lung, which play a critical role in regulating the outcome of DE-induced airway inflammation...
  3. ncbi request reprint αβ T cells and a mixed Th1/Th17 response are important in organic dust-induced airway disease
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Division Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Ann Allergy Asthma Immunol 109:266-273.e2. 2012
    ..Animal models resembling this chronic lung inflammatory response have been developed, yet the underlying cellular mechanisms are not well defined...
  4. pmc Immunological and inflammatory responses to organic dust in agriculture
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Curr Opin Allergy Clin Immunol 12:126-32. 2012
    ..This article will review the literature regarding new knowledge of important etiologic agents in the dusts and focus on the immunologic responses following acute and repetitive organic dust exposures...
  5. pmc Organic dust augments nucleotide-binding oligomerization domain expression via an NF-{kappa}B pathway to negatively regulate inflammatory responses
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Division Dept of Medicine, Univ of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 301:L296-306. 2011
    ..In summary, ODE-induced NOD2 expression is directly dependent on NF-κB signaling, and NOD2 is a negative regulator of complex, organic dust-induced inflammatory cytokine/chemokine production in mononuclear phagocytes...
  6. pmc Toll-like receptor 2 regulates organic dust-induced airway inflammation
    Jill A Poole
    Omaha Veterans Affairs Medical Center, Omaha, Nebraska, USA
    Am J Respir Cell Mol Biol 45:711-9. 2011
    ....
  7. pmc Organic dust exposure alters monocyte-derived dendritic cell differentiation and maturation
    Jill A Poole
    Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA
    Am J Physiol Lung Cell Mol Physiol 297:L767-76. 2009
    ..The first 48 h of monocyte differentiation appears to be the susceptible period to exposure. Environmental exposures present during early monocyte differentiation may impact the critical balance of DCs in the lung...
  8. pmc Muramic acid, endotoxin, 3-hydroxy fatty acids, and ergosterol content explain monocyte and epithelial cell inflammatory responses to agricultural dusts
    Jill A Poole
    Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA
    J Toxicol Environ Health A 73:684-700. 2010
    ..Large animal farming dust(s)-induced inflammation is not entirely dependent on endotoxin. Addition of muramic acid to endotoxin in large animal farming environment monitoring is warranted...
  9. pmc Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice
    Jill A Poole
    Pulmonary, Critical Care, Sleep, and Allergy Section, Univ of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1085-95. 2009
    ..Collectively, intranasal exposure to DE results in significant lung inflammatory and pathological responses marked by a modulated innate immune response to single and repetitive dust exposures that is associated with PKC activity...
  10. pmc Repetitive organic dust exposure in vitro impairs macrophage differentiation and function
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Neb 68198 5300, USA
    J Allergy Clin Immunol 122:375-82, 382.e1-4. 2008
    ..Organic dust exposure in the agricultural industry results in significant airway disease and lung function decrease. Mononuclear phagocytes are key cells that mediate the inflammatory and innate immune response after dust exposure...
  11. ncbi request reprint Repeat organic dust exposure-induced monocyte inflammation is associated with protein kinase C activity
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    J Allergy Clin Immunol 120:366-73. 2007
    ..Organic dust exposure results in an inflammatory response that attenuates over time, but repetitive exposures can result in chronic respiratory diseases. Mechanisms underlying this modulated response are not clear...
  12. ncbi request reprint Anti-CD23 monoclonal antibody, lumiliximab, inhibited allergen-induced responses in antigen-presenting cells and T cells from atopic subjects
    Jill A Poole
    National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Division of Allergy and Clinical Immunology, Department of Medicine, Denver, USA
    J Allergy Clin Immunol 116:780-8. 2005
    ..A novel anti-CD23 monoclonal antibody, lumiliximab, is a potential therapeutic antibody recently demonstrated to be safe in human beings...
  13. pmc Myeloid differentiation factor 88-dependent signaling is critical for acute organic dust-induced airway inflammation in mice
    Christopher Bauer
    Pulmonary, Critical Care, Sleep, and Allergy Division, Department of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Am J Respir Cell Mol Biol 48:781-9. 2013
    ..Collectively, the acute organic dust-induced airway inflammatory response is highly dependent on MyD88 signaling, and is dictated, in part, by important contributions from upstream TLRs and IL-18R...
  14. pmc Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor
    Todd A Wyatt
    Department of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Section, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Respir Cell Mol Biol 42:706-15. 2010
    ..These results suggest a temporal ordering of events responsible for the release of cytokines, which initiate and exacerbate inflammatory events in the airways of people exposed to agricultural dust...
  15. pmc Alcohol exposure alters mouse lung inflammation in response to inhaled dust
    Michael L McCaskill
    Department of Environmental, Agricultural, and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Nutrients 4:695-710. 2012
    ..These data also define alcohol as an important co-exposure agent to consider in the study of inhalation injury responses...
  16. ncbi request reprint Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences
    Gregory A Golden
    Pulmonary, Critical Care, Sleep and Allergy Division, Department of Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
    J Biochem Mol Toxicol 27:77-86. 2013
    ..Collectively, vitamin D plays a role in modulating organic dust-induced airway inflammatory outcomes...
  17. ncbi request reprint Motile cilia harbor serum response factor as a mechanism of environment sensing and injury response in the airway
    Tara M Nordgren
    988090 Nebraska Medical Center, Omaha, NE 68198
    Am J Physiol Lung Cell Mol Physiol 306:L829-39. 2014
    ....
  18. ncbi request reprint Chronic obstructive pulmonary disease patients have greater systemic responsiveness to ex vivo stimulation with swine dust extract and its components versus healthy volunteers
    Janel R Harting
    Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA
    J Toxicol Environ Health A 75:1456-70. 2012
    ....
  19. pmc Alcohol reduces airway hyperresponsiveness (AHR) and allergic airway inflammation in mice
    Peter J Oldenburg
    Nebraska Medical Center, Univ of Nebraska Medical Ctr, Omaha, NE 68198 5910, USA
    Am J Physiol Lung Cell Mol Physiol 302:L308-15. 2012
    ....
  20. pmc Co-exposure to cigarette smoke and alcohol decreases airway epithelial cell cilia beating in a protein kinase Cε-dependent manner
    Todd A Wyatt
    VA Nebraska Western Iowa Health Care System Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska, USA
    Am J Pathol 181:431-40. 2012
    ..No decreases in CBF were observed in PKCε knockout mice co-exposed to smoke and alcohol. These data identify PKCε as a key regulator of cilia slowing in response to combined smoke and alcohol-induced lung injury...
  21. ncbi request reprint The role of immunoglobulin E and immune inflammation: implications in allergic rhinitis
    Jill A Poole
    National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver 80206, USA
    Curr Allergy Asthma Rep 5:252-8. 2005
    ..Understanding the role of the IgE molecule is necessary to appreciate the development and use of novel therapies targeting its actions...
  22. ncbi request reprint Respiratory health effects of large animal farming environments
    Sara May
    Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Toxicol Environ Health B Crit Rev 15:524-41. 2012
    ....
  23. ncbi request reprint Bronchodilator responsiveness in swine veterinarians
    Jill A Poole
    Department of Medicine, University of Nebraska Medical Center, Omaha 68198 5300, USA
    J Agromedicine 12:49-54. 2007
    ..The present study reassessed the prevalence of respiratory complaints and pulmonary function abnormalities in swine veterinarians and sought to characterize their response to bronchodilators...
  24. ncbi request reprint Shotgun pyrosequencing metagenomic analyses of dusts from swine confinement and grain facilities
    Robert J Boissy
    University of Nebraska Medical Center, Department of Pathology and Microbiology, Omaha, Nebraska, United States of America
    PLoS ONE 9:e95578. 2014
    ..g. from resident mammals. ..
  25. ncbi request reprint Targeting the IgE molecule in allergic and asthmatic diseases: review of the IgE molecule and clinical efficacy
    Jill A Poole
    National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver 80206, USA
    J Allergy Clin Immunol 115:S376-85. 2005
  26. ncbi request reprint Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study
    Andy Rorie
    Pulmonary, Critical Care, Sleep, and Allergy Division, Department of Medicine, College of Medicine, University of Nebraska Medical Center, The Nebraska Medical Center, Omaha, Nebraska
    Ann Allergy Asthma Immunol 112:376-82. 2014
    ..Observational reports have linked vitamin D with chronic urticaria, yet no randomized controlled trial has been conducted...
  27. ncbi request reprint Food intolerance, flushing, and diarrhea in a 44-year-old woman
    Jill A Poole
    National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Ann Allergy Asthma Immunol 94:621-6. 2005
  28. ncbi request reprint Immunology of pregnancy. Implications for the mother
    Jill A Poole
    National Jewish Medical and Research Center, and Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Clin Rev Allergy Immunol 26:161-70. 2004
    ..This review presents investigations and developments relevant to an understanding as to why the fetus is not rejected by the maternal immune system...

Research Grants3

  1. Chronic Innate Immune Adaptation to Organic Dust
    JILL POOLE; Fiscal Year: 2007
    ..She is a well-supported candidate with a long-standing interest in becoming a physician scientist who will benefit highly from a Clinical Scientist Development Award. ..
  2. Role of pattern recognition receptors in organic dust-induced airway inflammation
    Jill A Poole; Fiscal Year: 2010
    ..This project will help identify novel inflammatory targets that could lead to new prevention and treatment strategies of individuals subjected to repeated organic dust exposure. ..