Research Topics
| M M PooSummaryAffiliation: University of California Country: USA Publications
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Publications
Neurotrophins as synaptic modulatorsM M Poo
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
Nat Rev Neurosci 2:24-32. 2001..By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections...- Electrical activity and development of neural circuitsL I Zhang
Keck Center of Integrative Neuroscience, University of California, San Francisco, California 94143-0732, USA
Nat Neurosci 4:1207-14. 2001..Selective findings discussed here illustrate some of our current understanding of the effects of electrical activity on circuit development and highlight areas that await further study... - Spike timing-dependent plasticity of neural circuitsYang Dan
Division of Neurobiology, Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720 USA
Neuron 44:23-30. 2004..Finally, we discuss timing-dependent modification of neuronal receptive fields and human visual perception and the computational significance of STDP as a synaptic learning rule... - Excitatory GABA action is essential for morphological maturation of cortical neurons in vivoLaura Cancedda
Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, California 94720 3200, USA
J Neurosci 27:5224-35. 2007..Thus, membrane depolarization caused by early GABA excitation is critical for morphological maturation of neonatal cortical neurons in vivo... - Spike-timing-dependent synaptic plasticity depends on dendritic locationRobert C Froemke
Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720-3200, USA
Nature 434:221-5. 2005..Such location-dependent tuning of inputs, together with the dendritic heterogeneity of postsynaptic processing, could enhance the computational capacity of cortical pyramidal neurons... - Activity-dependent matching of excitatory and inhibitory inputs during refinement of visual receptive fieldsHuizhong W Tao
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, CA 94720, USA
Neuron 45:829-36. 2005..Thus, appropriate inhibitory activity is essential for the coordinated refinement of excitatory and inhibitory connections... - Modulation of GABAergic transmission by activity via postsynaptic Ca2+-dependent regulation of KCC2 functionHubert Fiumelli
Division of Neurobiology, Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA
Neuron 48:773-86. 2005..Thus, repetitive postsynaptic spiking reduces the inhibitory action of GABA through a Ca2+-dependent downregulation of KCC2 function... - Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptorsCheng-Chang Lien
Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California Berkeley, California 94720-3200, USA
Nat Neurosci 9:372-80. 2006..Thus, the presynaptic NMDAR may function as a coincidence detector for adjacent glutamatergic and GABAergic activities, leading to coordinated synaptic modification by sensory experience... - Coincidence detection of synaptic inputs is facilitated at the distal dendrites after long-term potentiation inductionNing-long Xu
Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
J Neurosci 26:3002-9. 2006.... - Spike timing-dependent LTP/LTD mediates visual experience-dependent plasticity in a developing retinotectal systemYangling Mu
Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
Neuron 50:115-25. 2006..Together, these findings suggest that STDP can mediate sensory experience-dependent circuit refinement in the developing nervous system... - BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawalLu Pu
Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
Nat Neurosci 9:605-7. 2006..The elevated BDNF expression in the VTA after cocaine withdrawal may prime these synapses for potentiation by cue-associated activity, triggering drug craving and relapse... - Spike timing-dependent plasticity: from synapse to perceptionYang Dan
Division of Neurobiology, Department of Molecular and Cell Biology, and Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
Physiol Rev 86:1033-48. 2006..Such STDP at the synaptic and cellular level is likely to play important roles in activity-induced functional changes in neuronal receptive fields and human perception... 
Some recent advances in basic neuroscience research in ChinaMu ming Poo
Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, Peoples s Republic of China
Philos Trans R Soc Lond B Biol Sci 362:1083-92. 2007..Based on our own expertise, this review is focused mainly on findings that have contributed to our understanding of the mechanisms underlying brain development, neural plasticity and cognitive processes, and neural degeneration...- Spike-timing-dependent plasticity of neocortical excitatory synapses on inhibitory interneurons depends on target cell typeJiang teng Lu
Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
J Neurosci 27:9711-20. 2007..Such dependence of both the induction and expression of STDP on the type of postsynaptic interneurons may contribute to differential processing and storage of information in cortical local circuits... - Excitatory and suppressive receptive field subunits in awake monkey primary visual cortex (V1)Xiaodong Chen
Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Proc Natl Acad Sci U S A 104:19120-5. 2007..Together, the excitatory and suppressive subunits form a compact description of RFs in awake monkey V1, allowing prediction of the responses to arbitrary visual stimuli... 
Ephrin-B reverse signaling promotes structural and functional synaptic maturation in vivoByung Kook Lim
Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 3200, USA
Nat Neurosci 11:160-9. 2008..This ephrin-B-dependent synapse maturation supports the notion that the ephrin/Eph protein families have multiple functions in neural development...- Reversal and consolidation of activity-induced synaptic modificationsQiang Zhou
Division of Neurobiology, Department of Molecular and Cell Biology University of California, Berkeley, CA 94720, USA
Trends Neurosci 27:378-83. 2004..The requirement of spaced stimulus patterns for stable synaptic modifications could ensure appropriate refinement of developing connections... - Rapid BDNF-induced retrograde synaptic modification in a developing retinotectal systemJiu-Lin Du
Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
Nature 429:878-83. 2004.... - Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neuronsQing Song Liu
Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
Nature 437:1027-31. 2005..This cocaine-induced enhancement of synaptic plasticity in the VTA may be important for the formation of drug-associated memory... - A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowthHung-Teh Kao
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nat Neurosci 5:431-7. 2002..These results provide a potential molecular approach for stimulating neuron regeneration, after injury and in neurodegenerative diseases... - Moving visual stimuli rapidly induce direction sensitivity of developing tectal neuronsFlorian Engert
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Nature 419:470-5. 2002..Thus, developing neural circuits can be modified rapidly and specifically by visual inputs of defined spatiotemporal patterns, in a manner consistent with predictions based on spike-time-dependent synaptic modification... - Coincident pre- and postsynaptic activity modifies GABAergic synapses by postsynaptic changes in Cl- transporter activityMelanie A Woodin
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Neuron 39:807-20. 2003..Thus, GABAergic synapses can detect and be modified by coincident pre- and postsynaptic spiking, allowing the level of inhibition to be modulated in accordance to the temporal pattern of postsynaptic excitation... - Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modificationsZhiru Wang
Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Neuron 37:463-72. 2003..Thus, correlated pre- and postsynaptic activity alters not only the strength of the activated input but also its dendritic integration with other inputs... - Reversal and stabilization of synaptic modifications in a developing visual systemQiang Zhou
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA
Science 300:1953-7. 2003..These findings underscore the vulnerable nature of activity-induced synaptic modifications in vivo and suggest a temporal constraint on the pattern of visual inputs for effective induction of stable synaptic modifications... - Brain-derived neurotrophic factor modulation of GABAergic synapses by postsynaptic regulation of chloride transportRinda A Wardle
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
J Neurosci 23:8722-32. 2003..Thus, BDNF may decrease the efficacy of inhibitory transmission by acute postsynaptic downregulation of Cl- transport, in addition to its well known presynaptic effect... - Spike train timing-dependent associative modification of hippocampal CA3 recurrent synapses by mossy fibersKatsunori Kobayashi
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
Neuron 41:445-54. 2004..Thus, the timing of spike trains in individual MFs may code information that is crucial for the associative modification of CA3 recurrent synapses... - Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticityCheng-yu Li
Institute of Neuroscience, Chinese Academy of Sciences, Shanghai Institute of Biological Sciences
Neuron 41:257-68. 2004.... - Cultural reflectionsMu-ming Poo
Division of Neurobiology, Department of Molecular and Cell Biology at University of California, Berkeley, California, USA
Nature 428:204-5. 2004 - Nerve growth cone guidance mediated by G protein-coupled receptorsYang Xiang
Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China
Nat Neurosci 5:843-8. 2002..Thus, GPCRs can mediate both repulsive and attractive axon guidance in vitro, and chemokines may serve as guidance cues for axon pathfinding... - Calcium signaling in neuronal motilityJames Q Zheng
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Annu Rev Cell Dev Biol 23:375-404. 2007..Recent studies have revealed common Ca(2+)-dependent signaling pathways that are deployed for regulating cytoskeletal dynamics associated with neuronal migration, axon and dendrite development and regeneration, and synaptic plasticity... - Shrinkage of dendritic spines associated with long-term depression of hippocampal synapsesQiang Zhou
Division of Neurobiology, Department of Molecular and Cell Biology, Helen Will Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
Neuron 44:749-57. 2004..This activity-induced spine shrinkage may contribute to activity-dependent elimination of synaptic connections... - Ca2+-dependent regulation of rho GTPases triggers turning of nerve growth conesMing Jin
Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
J Neurosci 25:2338-47. 2005..Thus, Rho GTPases may mediate axon guidance by linking upstream Ca2+ signals triggered by guidance factors to downstream cytoskeletal rearrangements... - LKB1/STRAD promotes axon initiation during neuronal polarizationMaya Shelly
Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
Cell 129:565-77. 2007..Thus local LKB1/STRAD accumulation and PKA-dependent LKB1 phosphorylation represents an early signal for axon initiation... - Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by slit-2Chen Bing Guan
Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Cell 129:385-95. 2007..Thus, long-range Ca(2+) signaling coordinates the Slit-2-induced changes in motility at two distant parts of migrating neurons by regulating RhoA distribution... - Agrin regulates growth cone turning of Xenopus spinal motoneuronsXiaohua Xu
Institute of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China
Development 132:4309-16. 2005..Taken together, our findings suggest that agrin regulates neurite extension and provide evidence for an unanticipated role of agrin in growth-cone steering in developing neurons... - Vesicular glutamate transport at a central synapse limits the acuity of visual perception in zebrafishMatthew C Smear
University of California, San Francisco, Department of Physiology, Program in Neuroscience, 1550 4th Street, San Francisco, CA 94143, USA
Neuron 53:65-77. 2007..Our studies successfully link the disruption of a synaptic protein to complex changes in neural circuitry and behavior... - Signalling and crosstalk of Rho GTPases in mediating axon guidanceXiao-Bing Yuan
Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China
Nat Cell Biol 5:38-45. 2003.... - Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth conesGordon X Wang
Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
Nature 434:898-904. 2005..Thus, TRPC currents reflect early events in the growth cone's detection of some extracellular guidance signals, resulting in membrane depolarization and cytoplasmic Ca2+ elevation that mediates the turning of growth cones... - Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turningMakoto Nishiyama
Department of Biochemistry, New York University School of Medicine, New York, New York 10016-6402, USA
Nature 423:990-5. 2003..By linking cAMP and cGMP signalling and modulation of Ca2+ channel activity in growth cones, these findings delineate an early membrane-associated event responsible for signal transduction during bi-directional axon guidance... - Localized synaptic potentiation by BDNF requires local protein synthesis in the developing axonXiao hui Zhang
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
Neuron 36:675-88. 2002..Thus, presynaptic local TrkB signaling and protein synthesis allow a localized source of BDNF to potentiate transmitter secretion from nearby synapses, a property suited for spatially restricted synaptic modification by neurotrophins... - ATP released by astrocytes mediates glutamatergic activity-dependent heterosynaptic suppressionJing-ming Zhang
Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031 China
Neuron 40:971-82. 2003..Thus, neuron-glia crosstalk may participate in activity-dependent synaptic modulation... - Guiding neuronal growth cones using Ca2+ signalsJohn Henley
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA
Trends Cell Biol 14:320-30. 2004..Modulating Ca2+ levels in the growth cone might overcome inhibitory signals that normally prevent regeneration in the central nervous system... - Asian promise: the state and future of collaborations in neuroscienceMu-ming Poo
Nat Rev Neurosci 9:881-4. 2008..Nature Reviews Neuroscience asks four neuroscientists about their collaborative experiences and the impact that such collaborations are having on neuroscience research...