M M Poo

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Neurotrophins as synaptic modulators
    M M Poo
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    Nat Rev Neurosci 2:24-32. 2001
  2. ncbi request reprint Electrical activity and development of neural circuits
    L I Zhang
    Keck Center of Integrative Neuroscience, University of California, San Francisco, California 94143-0732, USA
    Nat Neurosci 4:1207-14. 2001
  3. ncbi request reprint Spike timing-dependent plasticity of neural circuits
    Yang Dan
    Division of Neurobiology, Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720 USA
    Neuron 44:23-30. 2004
  4. ncbi request reprint Excitatory GABA action is essential for morphological maturation of cortical neurons in vivo
    Laura Cancedda
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, California 94720 3200, USA
    J Neurosci 27:5224-35. 2007
  5. ncbi request reprint Spike-timing-dependent synaptic plasticity depends on dendritic location
    Robert C Froemke
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 3200, USA
    Nature 434:221-5. 2005
  6. ncbi request reprint Activity-dependent matching of excitatory and inhibitory inputs during refinement of visual receptive fields
    Huizhong W Tao
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, CA 94720, USA
    Neuron 45:829-36. 2005
  7. ncbi request reprint Modulation of GABAergic transmission by activity via postsynaptic Ca2+-dependent regulation of KCC2 function
    Hubert Fiumelli
    Division of Neurobiology, Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA
    Neuron 48:773-86. 2005
  8. ncbi request reprint Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors
    Cheng Chang Lien
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California Berkeley, California 94720 3200, USA
    Nat Neurosci 9:372-80. 2006
  9. ncbi request reprint Coincidence detection of synaptic inputs is facilitated at the distal dendrites after long-term potentiation induction
    Ning long Xu
    Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 26:3002-9. 2006
  10. ncbi request reprint Spike timing-dependent LTP/LTD mediates visual experience-dependent plasticity in a developing retinotectal system
    Yangling Mu
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
    Neuron 50:115-25. 2006

Collaborators

  • L I Zhang
  • Yang Dan
  • Shumin Duan
  • Michael B Orger
  • Robert C Froemke
  • James Q Zheng
  • Jian Ping Zhao
  • Guo li Ming
  • Qing Song Liu
  • Katsunori Kobayashi
  • Jiu Lin Du
  • Mariana Vargas-Caballero
  • Hung Teh Kao
  • Chien Ping Wu
  • Xiao Bing Yuan
  • Qiang Zhou
  • Huizhong W Tao
  • Laura Cancedda
  • Ming Jin
  • Xiao hui Zhang
  • Chen Bing Guan
  • Yangling Mu
  • Jiang teng Lu
  • Hubert Fiumelli
  • Cheng Yu Li
  • Ning long Xu
  • Xiaohua Xu
  • Byung Kook Lim
  • Maya Shelly
  • Xiaodong Chen
  • Matthew C Smear
  • Lu Pu
  • Cheng Chang Lien
  • Gordon X Wang
  • Chang quan Ye
  • John Henley
  • Yuan quan Song
  • Kai Cui
  • Rinda A Wardle
  • Jing Ming Zhang
  • Makoto Nishiyama
  • Zhiru Wang
  • Melanie A Woodin
  • Yang Xiang
  • Florian Engert
  • Naoto Matsuda
  • Wendy Staub
  • Herwig Baier
  • Yan Liu
  • Nathan J Gosse
  • Sarah Heilshorn
  • Koji Takahashi
  • Hua Tai Xu
  • Feng Han
  • Karen Chen
  • German Sumbre
  • Yun ai Jiang
  • Fanny C F Ip
  • Amy K Y Fu
  • Chun tao Zhao
  • Gang Chen
  • Nancy Y Ip
  • Koichi J Homma
  • Marc Tessier-Lavigne
  • Hui Kun Wang
  • Zheng Lin Jiang
  • Yiren Chen
  • Kyonsoo Hong
  • Yoshio Goshima
  • Akemi Hoshino
  • Karunesh Ganguly
  • John R Henley
  • Wooping Ge
  • Lily Tsai
  • Zhe Zhang
  • Sheng Wang
  • Yan Li

Detail Information

Publications43

  1. ncbi request reprint Neurotrophins as synaptic modulators
    M M Poo
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    Nat Rev Neurosci 2:24-32. 2001
    ..By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections...
  2. ncbi request reprint Electrical activity and development of neural circuits
    L I Zhang
    Keck Center of Integrative Neuroscience, University of California, San Francisco, California 94143-0732, USA
    Nat Neurosci 4:1207-14. 2001
    ..Selective findings discussed here illustrate some of our current understanding of the effects of electrical activity on circuit development and highlight areas that await further study...
  3. ncbi request reprint Spike timing-dependent plasticity of neural circuits
    Yang Dan
    Division of Neurobiology, Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720 USA
    Neuron 44:23-30. 2004
    ..Finally, we discuss timing-dependent modification of neuronal receptive fields and human visual perception and the computational significance of STDP as a synaptic learning rule...
  4. ncbi request reprint Excitatory GABA action is essential for morphological maturation of cortical neurons in vivo
    Laura Cancedda
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, California 94720 3200, USA
    J Neurosci 27:5224-35. 2007
    ..Thus, membrane depolarization caused by early GABA excitation is critical for morphological maturation of neonatal cortical neurons in vivo...
  5. ncbi request reprint Spike-timing-dependent synaptic plasticity depends on dendritic location
    Robert C Froemke
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 3200, USA
    Nature 434:221-5. 2005
    ..Such location-dependent tuning of inputs, together with the dendritic heterogeneity of postsynaptic processing, could enhance the computational capacity of cortical pyramidal neurons...
  6. ncbi request reprint Activity-dependent matching of excitatory and inhibitory inputs during refinement of visual receptive fields
    Huizhong W Tao
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, CA 94720, USA
    Neuron 45:829-36. 2005
    ..Thus, appropriate inhibitory activity is essential for the coordinated refinement of excitatory and inhibitory connections...
  7. ncbi request reprint Modulation of GABAergic transmission by activity via postsynaptic Ca2+-dependent regulation of KCC2 function
    Hubert Fiumelli
    Division of Neurobiology, Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA
    Neuron 48:773-86. 2005
    ..Thus, repetitive postsynaptic spiking reduces the inhibitory action of GABA through a Ca2+-dependent downregulation of KCC2 function...
  8. ncbi request reprint Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors
    Cheng Chang Lien
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California Berkeley, California 94720 3200, USA
    Nat Neurosci 9:372-80. 2006
    ..Thus, the presynaptic NMDAR may function as a coincidence detector for adjacent glutamatergic and GABAergic activities, leading to coordinated synaptic modification by sensory experience...
  9. ncbi request reprint Coincidence detection of synaptic inputs is facilitated at the distal dendrites after long-term potentiation induction
    Ning long Xu
    Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 26:3002-9. 2006
    ....
  10. ncbi request reprint Spike timing-dependent LTP/LTD mediates visual experience-dependent plasticity in a developing retinotectal system
    Yangling Mu
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
    Neuron 50:115-25. 2006
    ..Together, these findings suggest that STDP can mediate sensory experience-dependent circuit refinement in the developing nervous system...
  11. ncbi request reprint BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal
    Lu Pu
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
    Nat Neurosci 9:605-7. 2006
    ..The elevated BDNF expression in the VTA after cocaine withdrawal may prime these synapses for potentiation by cue-associated activity, triggering drug craving and relapse...
  12. ncbi request reprint Spike timing-dependent plasticity: from synapse to perception
    Yang Dan
    Division of Neurobiology, Department of Molecular and Cell Biology, and Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
    Physiol Rev 86:1033-48. 2006
    ..Such STDP at the synaptic and cellular level is likely to play important roles in activity-induced functional changes in neuronal receptive fields and human perception...
  13. pmc Some recent advances in basic neuroscience research in China
    Mu ming Poo
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, Peoples s Republic of China
    Philos Trans R Soc Lond B Biol Sci 362:1083-92. 2007
    ..Based on our own expertise, this review is focused mainly on findings that have contributed to our understanding of the mechanisms underlying brain development, neural plasticity and cognitive processes, and neural degeneration...
  14. ncbi request reprint Spike-timing-dependent plasticity of neocortical excitatory synapses on inhibitory interneurons depends on target cell type
    Jiang teng Lu
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 27:9711-20. 2007
    ..Such dependence of both the induction and expression of STDP on the type of postsynaptic interneurons may contribute to differential processing and storage of information in cortical local circuits...
  15. pmc Excitatory and suppressive receptive field subunits in awake monkey primary visual cortex (V1)
    Xiaodong Chen
    Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Proc Natl Acad Sci U S A 104:19120-5. 2007
    ..Together, the excitatory and suppressive subunits form a compact description of RFs in awake monkey V1, allowing prediction of the responses to arbitrary visual stimuli...
  16. doi request reprint Ephrin-B reverse signaling promotes structural and functional synaptic maturation in vivo
    Byung Kook Lim
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 3200, USA
    Nat Neurosci 11:160-9. 2008
    ..This ephrin-B-dependent synapse maturation supports the notion that the ephrin/Eph protein families have multiple functions in neural development...
  17. ncbi request reprint Reversal and consolidation of activity-induced synaptic modifications
    Qiang Zhou
    Division of Neurobiology, Department of Molecular and Cell Biology University of California, Berkeley, CA 94720, USA
    Trends Neurosci 27:378-83. 2004
    ..The requirement of spaced stimulus patterns for stable synaptic modifications could ensure appropriate refinement of developing connections...
  18. ncbi request reprint Rapid BDNF-induced retrograde synaptic modification in a developing retinotectal system
    Jiu Lin Du
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
    Nature 429:878-83. 2004
    ....
  19. pmc Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons
    Qing Song Liu
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
    Nature 437:1027-31. 2005
    ..This cocaine-induced enhancement of synaptic plasticity in the VTA may be important for the formation of drug-associated memory...
  20. ncbi request reprint A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth
    Hung Teh Kao
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Neurosci 5:431-7. 2002
    ..These results provide a potential molecular approach for stimulating neuron regeneration, after injury and in neurodegenerative diseases...
  21. ncbi request reprint Moving visual stimuli rapidly induce direction sensitivity of developing tectal neurons
    Florian Engert
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nature 419:470-5. 2002
    ..Thus, developing neural circuits can be modified rapidly and specifically by visual inputs of defined spatiotemporal patterns, in a manner consistent with predictions based on spike-time-dependent synaptic modification...
  22. ncbi request reprint Coincident pre- and postsynaptic activity modifies GABAergic synapses by postsynaptic changes in Cl- transporter activity
    Melanie A Woodin
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Neuron 39:807-20. 2003
    ..Thus, GABAergic synapses can detect and be modified by coincident pre- and postsynaptic spiking, allowing the level of inhibition to be modulated in accordance to the temporal pattern of postsynaptic excitation...
  23. ncbi request reprint Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications
    Zhiru Wang
    Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Neuron 37:463-72. 2003
    ..Thus, correlated pre- and postsynaptic activity alters not only the strength of the activated input but also its dendritic integration with other inputs...
  24. ncbi request reprint Reversal and stabilization of synaptic modifications in a developing visual system
    Qiang Zhou
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Science 300:1953-7. 2003
    ..These findings underscore the vulnerable nature of activity-induced synaptic modifications in vivo and suggest a temporal constraint on the pattern of visual inputs for effective induction of stable synaptic modifications...
  25. ncbi request reprint Brain-derived neurotrophic factor modulation of GABAergic synapses by postsynaptic regulation of chloride transport
    Rinda A Wardle
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    J Neurosci 23:8722-32. 2003
    ..Thus, BDNF may decrease the efficacy of inhibitory transmission by acute postsynaptic downregulation of Cl- transport, in addition to its well known presynaptic effect...
  26. ncbi request reprint Spike train timing-dependent associative modification of hippocampal CA3 recurrent synapses by mossy fibers
    Katsunori Kobayashi
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 41:445-54. 2004
    ..Thus, the timing of spike trains in individual MFs may code information that is crucial for the associative modification of CA3 recurrent synapses...
  27. ncbi request reprint Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticity
    Cheng Yu Li
    Institute of Neuroscience, Chinese Academy of Sciences, Shanghai Institute of Biological Sciences
    Neuron 41:257-68. 2004
    ....
  28. ncbi request reprint Cultural reflections
    Mu ming Poo
    Division of Neurobiology, Department of Molecular and Cell Biology at University of California, Berkeley, California, USA
    Nature 428:204-5. 2004
  29. ncbi request reprint Nerve growth cone guidance mediated by G protein-coupled receptors
    Yang Xiang
    Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Nat Neurosci 5:843-8. 2002
    ..Thus, GPCRs can mediate both repulsive and attractive axon guidance in vitro, and chemokines may serve as guidance cues for axon pathfinding...
  30. ncbi request reprint Calcium signaling in neuronal motility
    James Q Zheng
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Annu Rev Cell Dev Biol 23:375-404. 2007
    ..Recent studies have revealed common Ca(2+)-dependent signaling pathways that are deployed for regulating cytoskeletal dynamics associated with neuronal migration, axon and dendrite development and regeneration, and synaptic plasticity...
  31. ncbi request reprint Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
    Qiang Zhou
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Will Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 44:749-57. 2004
    ..This activity-induced spine shrinkage may contribute to activity-dependent elimination of synaptic connections...
  32. ncbi request reprint Ca2+-dependent regulation of rho GTPases triggers turning of nerve growth cones
    Ming Jin
    Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 25:2338-47. 2005
    ..Thus, Rho GTPases may mediate axon guidance by linking upstream Ca2+ signals triggered by guidance factors to downstream cytoskeletal rearrangements...
  33. ncbi request reprint LKB1/STRAD promotes axon initiation during neuronal polarization
    Maya Shelly
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Cell 129:565-77. 2007
    ..Thus local LKB1/STRAD accumulation and PKA-dependent LKB1 phosphorylation represents an early signal for axon initiation...
  34. ncbi request reprint Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by slit-2
    Chen Bing Guan
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell 129:385-95. 2007
    ..Thus, long-range Ca(2+) signaling coordinates the Slit-2-induced changes in motility at two distant parts of migrating neurons by regulating RhoA distribution...
  35. ncbi request reprint Agrin regulates growth cone turning of Xenopus spinal motoneurons
    Xiaohua Xu
    Institute of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China
    Development 132:4309-16. 2005
    ..Taken together, our findings suggest that agrin regulates neurite extension and provide evidence for an unanticipated role of agrin in growth-cone steering in developing neurons...
  36. pmc Vesicular glutamate transport at a central synapse limits the acuity of visual perception in zebrafish
    Matthew C Smear
    University of California, San Francisco, Department of Physiology, Program in Neuroscience, 1550 4th Street, San Francisco, CA 94143, USA
    Neuron 53:65-77. 2007
    ..Our studies successfully link the disruption of a synaptic protein to complex changes in neural circuitry and behavior...
  37. ncbi request reprint Signalling and crosstalk of Rho GTPases in mediating axon guidance
    Xiao Bing Yuan
    Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Nat Cell Biol 5:38-45. 2003
    ....
  38. ncbi request reprint Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones
    Gordon X Wang
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
    Nature 434:898-904. 2005
    ..Thus, TRPC currents reflect early events in the growth cone's detection of some extracellular guidance signals, resulting in membrane depolarization and cytoplasmic Ca2+ elevation that mediates the turning of growth cones...
  39. ncbi request reprint Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning
    Makoto Nishiyama
    Department of Biochemistry, New York University School of Medicine, New York, New York 10016 6402, USA
    Nature 423:990-5. 2003
    ..By linking cAMP and cGMP signalling and modulation of Ca2+ channel activity in growth cones, these findings delineate an early membrane-associated event responsible for signal transduction during bi-directional axon guidance...
  40. ncbi request reprint Localized synaptic potentiation by BDNF requires local protein synthesis in the developing axon
    Xiao hui Zhang
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 36:675-88. 2002
    ..Thus, presynaptic local TrkB signaling and protein synthesis allow a localized source of BDNF to potentiate transmitter secretion from nearby synapses, a property suited for spatially restricted synaptic modification by neurotrophins...
  41. ncbi request reprint ATP released by astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression
    Jing Ming Zhang
    Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031 China
    Neuron 40:971-82. 2003
    ..Thus, neuron-glia crosstalk may participate in activity-dependent synaptic modulation...
  42. pmc Guiding neuronal growth cones using Ca2+ signals
    John Henley
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Trends Cell Biol 14:320-30. 2004
    ..Modulating Ca2+ levels in the growth cone might overcome inhibitory signals that normally prevent regeneration in the central nervous system...
  43. doi request reprint Asian promise: the state and future of collaborations in neuroscience
    Mu ming Poo
    Nat Rev Neurosci 9:881-4. 2008
    ..Nature Reviews Neuroscience asks four neuroscientists about their collaborative experiences and the impact that such collaborations are having on neuroscience research...