Daniel Pomp

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice
    Jason B Wolf
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Evol Dev 8:468-76. 2006
  2. pmc Genetic variation for body weight change in mice in response to physical exercise
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Genet 10:58. 2009
  3. doi request reprint Epistatic interactions of genes influence within-individual variation of physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
    Genetica 139:813-21. 2011
  4. ncbi request reprint Fine mapping of mouse QTLs for fatness using SNP data
    Armin O Schmitt
    Institute for Animal Sciences, Humboldt Universitat zu Berlin, Berlin, Germany
    OMICS 11:341-50. 2007
  5. pmc Inferring genetic architecture of complex traits using Bayesian integrative analysis of genome and transcriptome data
    Alireza Ehsani
    Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University, Tjele, DK 8830, Denmark
    BMC Genomics 13:456. 2012
  6. pmc Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease
    Radu Dobrin
    Rosetta Inpharmatics, LLC, Merck and Co, Inc, Seattle, Washington 98109, USA
    Genome Biol 10:R55. 2009
  7. pmc Genetic variation in the pleiotropic association between physical activity and body weight in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Genet Sel Evol 41:41. 2009
  8. pmc A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Genet 11:83. 2010
  9. pmc Obesity genes: so close and yet so far
    Daniel Pomp
    Departments of Nutrition, Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7461, USA
    J Biol 7:36. 2008
  10. pmc Complex genetics of obesity in mouse models
    Daniel Pomp
    Department of Nutrition, Carolina Center for Genome Science, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Annu Rev Nutr 28:331-45. 2008

Research Grants

Detail Information

Publications48

  1. ncbi request reprint The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice
    Jason B Wolf
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Evol Dev 8:468-76. 2006
    ..Thus, although epistatic pleiotropy made a smaller contribution than single-locus pleiotropy, it clearly made a significant contribution to the genetic architecture of variation/covariation...
  2. pmc Genetic variation for body weight change in mice in response to physical exercise
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Genet 10:58. 2009
    ....
  3. doi request reprint Epistatic interactions of genes influence within-individual variation of physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
    Genetica 139:813-21. 2011
    ..It was concluded that epistasis is more important than single-locus effects of genes on activity traits at specific ages and it is therefore an essential component of the genetic architecture of physical activity...
  4. ncbi request reprint Fine mapping of mouse QTLs for fatness using SNP data
    Armin O Schmitt
    Institute for Animal Sciences, Humboldt Universitat zu Berlin, Berlin, Germany
    OMICS 11:341-50. 2007
    ..Viewing the genomic region of fatness-related QTLs under several different aspects is appropriate to assess the many thousands of genes that reside in such QTLs and to produce lists of more robust candidate genes...
  5. pmc Inferring genetic architecture of complex traits using Bayesian integrative analysis of genome and transcriptome data
    Alireza Ehsani
    Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University, Tjele, DK 8830, Denmark
    BMC Genomics 13:456. 2012
    ..Bayesian mixed models and variable selection models were used and, based on parameter samples from the model posterior distributions, explained variances were further partitioned at the level of chromosomes and genome segments...
  6. pmc Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease
    Radu Dobrin
    Rosetta Inpharmatics, LLC, Merck and Co, Inc, Seattle, Washington 98109, USA
    Genome Biol 10:R55. 2009
    ....
  7. pmc Genetic variation in the pleiotropic association between physical activity and body weight in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Genet Sel Evol 41:41. 2009
    ....
  8. pmc A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Genet 11:83. 2010
    ....
  9. pmc Obesity genes: so close and yet so far
    Daniel Pomp
    Departments of Nutrition, Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7461, USA
    J Biol 7:36. 2008
    ....
  10. pmc Complex genetics of obesity in mouse models
    Daniel Pomp
    Department of Nutrition, Carolina Center for Genome Science, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Annu Rev Nutr 28:331-45. 2008
    ..And third, we explore the effects of recent findings indicating increasing levels of complexity in the nature of variation underlying, and the heritability of, complex traits such as obesity...
  11. pmc Architecture of energy balance traits in emerging lines of the Collaborative Cross
    Wendy Foulds Mathes
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Endocrinol Metab 300:E1124-34. 2011
    ..These results suggest that the CC will be a powerful, high-precision tool for examining the genetic architecture of complex traits such as those involved in regulation of energy balance...
  12. pmc Genetic architecture of voluntary exercise in an advanced intercross line of mice
    Scott A Kelly
    Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Rd, Chapel Hill, NC 27599 7264, USA
    Physiol Genomics 42:190-200. 2010
    ....
  13. doi request reprint Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis
    Ryan R Gordon
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 19:179-89. 2008
    ..These findings highlight the importance of accurately modeling not only the human cancer characteristics in mice but also the environmental exposures of human populations...
  14. pmc Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat
    Michele La Merrill
    Curriculum in Toxicology, Carolina Center for Genome Sciences, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Endocrinol Metab 296:E203-10. 2009
    ..Rather, the HFD-dependent changes were cancer model dependent. These results show that cancer models can have differential effects on metabolic syndrome-associated phenotypes even before cancers arise...
  15. pmc Parent-of-origin effects on voluntary exercise levels and body composition in mice
    Scott A Kelly
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Physiol Genomics 40:111-20. 2010
    ..e., X-linked or mtDNA variations), epigenetic (i.e., genomic imprinting), and environmental (i.e., in utero environment or maternal care) phenomena potentially modulating these effects...
  16. pmc Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain
    Scott A Kelly
    Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Genetics 191:643-54. 2012
    ..These results develop a potential initial model of the underlying functional genomic architecture of predisposition to voluntary exercise and its effects on body weight and composition within a neurophysiological framework...
  17. ncbi request reprint Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis
    Ryan R Gordon
    Department of Nutrition, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Exp Metastasis 27:279-93. 2010
    ....
  18. pmc Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture
    Scott A Kelly
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Physiol Genomics 43:199-212. 2011
    ..Finally, we present unique QTL providing insight regarding variation in weight loss and reduction in adiposity in response to exercise...
  19. pmc Dopaminergic dysregulation in mice selectively bred for excessive exercise or obesity
    Wendy Foulds Mathes
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7264, USA
    Behav Brain Res 210:155-63. 2010
    ....
  20. pmc Genomic mapping of social behavior traits in a F2 cross derived from mice selectively bred for high aggression
    Derrick L Nehrenberg
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Genet 11:113. 2010
    ....
  21. ncbi request reprint Voluntary exercise and its effects on body composition depend on genetic selection history
    Derrick L Nehrenberg
    Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 17:1402-9. 2009
    ..It is important to carefully consider genetic background and/or selection history when using mice to model effects of exercise on body composition, and perhaps, other complex traits as well...
  22. pmc QTL underlying voluntary exercise in mice: interactions with the "mini muscle" locus and sex
    Derrick L Nehrenberg
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7264, USA
    J Hered 101:42-53. 2010
    ....
  23. ncbi request reprint Rescue of the mouse DDK syndrome by parent-of-origin-dependent modifiers
    Folami Y Ideraabdullah
    Department of Genetics, Curriculum in Genetics and Molecular Biology, Carolina Center for Genome Sciences, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Biol Reprod 76:286-93. 2007
    ..In addition, rescue of the lethal phenotype depends on the parental origin of the Rmod1 alleles; transmission through the dam leads to rescue, while transmission through the sire has no effect...
  24. pmc Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors
    Michele La Merrill
    Department of Genetics, Center for Environmental Health and Susceptibility, University of North Carolina at Chapel Hill, Chapel Hill, NC 27695, USA
    Environ Health Perspect 117:1414-9. 2009
    ..Increased fat intake is associated with obesity and may make obese individuals uniquely susceptible to the effects of lipophilic aryl hydrocarbon receptor (AHR) ligands...
  25. pmc Genetic analysis of complex traits in the emerging Collaborative Cross
    David L Aylor
    Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Genome Res 21:1213-22. 2011
    ....
  26. doi request reprint Advances in comparative genetics: influence of genetics on obesity
    Wendy Foulds Mathes
    Department of Genetics, University of North Carolina at Chapel Hill, NC, USA
    Br J Nutr 106:S1-10. 2011
    ..Knowledge obtained from advances in mouse models will inform human health and provide insight into inter-individual variability in the aetiology of obesity-related diseases...
  27. doi request reprint Genotype X diet interactions in mice predisposed to mammary cancer. I. Body weight and fat
    Ryan R Gordon
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 19:163-78. 2008
    ..QTL x diet and/or gender interactions were present at 15 of these QTL, indicating that such interactions play a significant role in defining the genetic architecture of complex traits such as body weight and obesity...
  28. pmc Strain screen and haplotype association mapping of wheel running in inbred mouse strains
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina, Charlotte, NC, USA
    J Appl Physiol (1985) 109:623-34. 2010
    ..Additionally, results suggest that potential genetic mechanisms arising from traditional noncoding regions of the genome may be involved in regulation of physical activity...
  29. pmc Fine mapping of "mini-muscle," a recessive mutation causing reduced hindlimb muscle mass in mice
    John Hartmann
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    J Hered 99:679-87. 2008
    ..Identification of the genetic variation that underlies MM could potentially be very important in understanding both normal muscle function and disregulation of muscle physiology leading to disease...
  30. ncbi request reprint Collateral density, remodeling, and VEGF-A expression differ widely between mouse strains
    Dan Chalothorn
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599 7545, USA
    Physiol Genomics 30:179-91. 2007
    ..These findings suggest these strains offer a model to investigate genetic determinants of collateral formation and growth in ischemia...
  31. pmc Quantitative trait loci for physical activity traits in mice
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina, Charlotte, NC 28223, USA
    Physiol Genomics 32:401-8. 2008
    ..1, DIST13.1, SPD13.1, and SPD9.1 were subsequently replicated by haplotype association mapping. The results of this study suggest a genetic basis of voluntary activity in mice and provide a foundation for future candidate gene studies...
  32. pmc An efficient Bayesian model selection approach for interacting quantitative trait loci models with many effects
    Nengjun Yi
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, Alabama 35294 0022, USA
    Genetics 176:1865-77. 2007
    ..Our method has been implemented in the freely available package R/qtlbim (http://www.qtlbim.org) to facilitate the general usage of the Bayesian methodology for genomewide interacting QTL analysis...
  33. ncbi request reprint The M16 mouse: an outbred animal model of early onset polygenic obesity and diabesity
    Mark F Allan
    Department of Animal Science, University of Nebraska, Lincoln, NE 68583 0908, USA
    Obes Res 12:1397-407. 2004
    ..To characterize the phenotypic consequences of long-term selective breeding for rapid weight gain, with an emphasis on obesity and obesity-induced diabetes (diabesity)...
  34. pmc Bayesian mapping of genomewide interacting quantitative trait loci for ordinal traits
    Nengjun Yi
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294 0022, USA
    Genetics 176:1855-64. 2007
    ....
  35. ncbi request reprint Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Physiol Genomics 10:21-9. 2002
    ..The direction of the effect of these QTLs was almost always consistent within and between characters, with little evidence for antagonistic pleiotropy...
  36. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
  37. ncbi request reprint A large-sample QTL study in mice: I. Growth
    Joao L Rocha
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583 0908, USA
    Mamm Genome 15:83-99. 2004
    ..Only a few epistatic interactions among detected QTL, little statistical support for gender-specific QTL, and significant age effects on genetic architecture were other primary observations from this study...
  38. ncbi request reprint A large-sample QTL study in mice: II. Body composition
    Joao L Rocha
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583 0908, USA
    Mamm Genome 15:100-13. 2004
    ..In this study, growth and body weight are interpreted in terms of organ subcomponents underlying the macro aggregate traits, and anchored on the corresponding genomic locations...
  39. ncbi request reprint High-resolution comparative mapping of pig Chromosome 4, emphasizing the FAT1 region
    Maria Moller
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, 75124, Uppsala, Sweden
    Mamm Genome 15:717-31. 2004
    ..This refined SSC4 map and the comparative analysis will be a great aid in the search for the genes underlying the FAT1 locus...
  40. ncbi request reprint Characterization of QTL with major effects on fatness and growth on mouse chromosome 2
    Nancy C Jerez-Timaure
    Animal Science, University of Nebraska, Lincoln, NE 68583 0908, USA
    Obes Res 12:1408-20. 2004
    ..To isolate and characterize a region on mouse chromosome 2 harboring quantitative trait loci with large influences on growth and fatness...
  41. ncbi request reprint A large-sample QTL study in mice: III. Reproduction
    Joao L Rocha
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583 0908, USA
    Mamm Genome 15:878-86. 2004
    ..This is unfortunate as traits with low heritability are among those that could most benefit from QTL-complemented breeding and selection strategies in food animal production...
  42. ncbi request reprint Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2
    Nancy C Jerez-Timaure
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583 0908, USA
    Physiol Genomics 21:411-22. 2005
    ....
  43. pmc Bayesian model selection for genome-wide epistatic quantitative trait loci analysis
    Nengjun Yi
    Department of Biostatistics, University of Alabama, Birmingham 35294, USA
    Genetics 170:1333-44. 2005
    ..We illustrate the proposed method by detecting new epistatic QTL for obesity in a backcross of CAST/Ei mice onto M16i...
  44. pmc Genomic mapping of direct and correlated responses to long-term selection for rapid growth rate in mice
    Mark F Allan
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583, USA
    Genetics 170:1863-77. 2005
    ..Several QTL demonstrating differential regulation of regional adipose deposition and age-dependent regulation of growth and energy consumption were identified...
  45. pmc Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, 28223, USA
    Genet Sel Evol 37:151-73. 2005
    ..The independence of body weight and adiposity suggests that this advanced intercross population is ideal for a comprehensive discovery of genes controlling regulation of mammalian adiposity that are distinct from those for body weight...
  46. ncbi request reprint Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice
    Nengjun Yi
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294, USA
    Genet Res 87:45-60. 2006
    ..Several main and epistatic effects were shared by the body composition and body weight traits, suggesting that pleiotropy plays an important role in growth and obesity...
  47. pmc An epistatic genetic basis for physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Hered 99:639-46. 2008
    ....
  48. ncbi request reprint QTL analysis in livestock
    Joao L Rocha
    Department of Animal Science, University of Nebraska Lincoln, Lincoln, NE, USA
    Methods Mol Biol 195:311-46. 2002

Research Grants8

  1. FINE MAPPING OF GENES REGULATING HEAT LOSS
    Daniel Pomp; Fiscal Year: 1999
    ..These efforts will contribute to the long-term battle against human obesity by facilitating improved methods for diagnosis, treatment and prevention. ..
  2. FINE MAPPING OF GENES REGULATING HEAT LOSS
    Daniel Pomp; Fiscal Year: 2000
    ..These efforts will contribute to the long-term battle against human obesity by facilitating improved methods for diagnosis, treatment and prevention. ..
  3. FINE MAPPING OF GENES REGULATING HEAT LOSS
    Daniel Pomp; Fiscal Year: 2001
    ..These efforts will contribute to the long-term battle against human obesity by facilitating improved methods for diagnosis, treatment and prevention. ..
  4. FINE MAPPING OF GENES REGULATING HEAT LOSS
    Daniel Pomp; Fiscal Year: 2002
    ..These efforts will contribute to the long-term battle against human obesity by facilitating improved methods for diagnosis, treatment and prevention. ..
  5. Genetic Architecture of Voluntary Exercise in Mice
    Daniel Pomp; Fiscal Year: 2007
    ..This research will discover QTL for voluntary exercise, a poorly understood yet important component of obesity and overall health, and advance to identify their underlying genes. ..
  6. Genetic Architecture of Voluntary Exercise in Mice
    Daniel Pomp; Fiscal Year: 2009
    ..This research will discover QTL for voluntary exercise, a poorly understood yet important component of obesity and overall health, and advance to identify their underlying genes. ..
  7. Genetic Architecture of Voluntary Exercise in Mice
    Daniel Pomp; Fiscal Year: 2010
    ..This research will discover QTL for voluntary exercise, a poorly understood yet important component of obesity and overall health, and advance to identify their underlying genes. ..